- •1.1. Overview
- •1.7. For information about the teachers:
- •1.8. Contact Information:
- •2. Program:
- •2.1. Introduction
- •2.2. The purpose of discipline:
- •2.3. Learning objectives:
- •2.4. Learning outcomes:
- •2.5.Prerequisites and Postdetails.
- •2.6. Summary of discipline:
- •2.7. Thematic plan of lectures, practical classes, srps and the siw Thematic plan of lectures
- •The practical classes thematic plan
- •Topical Plan for siwp
- •Thematic plan for independent student work
- •2.8. Tasks for independent students work : Topics for independent work of students:
- •2.9 Recommended literature :
- •In Russian :
- •In Kazakh:
- •In English :
- •2.11. Criteria and assessment rules:
- •The evaluation system of students' knowledge
- •Competence assessment in discipline "Molecular Biology and Medical Genetics," for 1 course students "General Medicine" specialty.
- •2.Check control
- •Presentation
- •Assessments grading scale
- •It is discussed and approved at faculty meeting from April "12" of 2012 y., the protocol No. 15
- •1. Theme: Implementation of heriditary information
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature
- •6. Control questions (feedback):
- •Specialty – general medicine
- •Year 2012
- •Theme: Introduction to Molecular Biology. Molecular Principles of Heredity
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Theme: Gene Molecular Biology
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •Theme: Realization of Hereditary Information. Dna Replication
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Problem
- •Theme: Transcription
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Theme: Regulation of Gene Expression
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •8.1.Control:
- •8.2. Rating of competence skills.
- •Theme: Genetic Apparatus of the Cell
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •7.2. Evaluation of competence – practical skills
- •Theme: Mitotic cycle, Mitosis, Meiosis
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •7.2.6. Solution of standard tasks:
- •1. Theme: Heredity. Types of inheritance. Independent monogenic inheritance of characteristics
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge):
- •7.2. Assessment of competence skills
- •7.3. Assessment of the skills of self-improvement:
- •1.Theme: Heredity. Types of inheritance. Monogenic traits linked inheritance
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •7.1. Assessment of cognitive competences (knowledge):
- •1. Theme: Effects of gene
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge)
- •7.2. Assessment of competence skills
- •1. Theme: Cellular mechanisms of ontogenetic development
- •2. Purpose:
- •3.Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •1.Theme: Genetic mechanisms of ontogenetic development
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •7.2. Assessment of competence skills
- •1. Title: Basics of Genetics populyatsioinoy
- •6. Handout: Test questions. 7. Literature:
- •1.Theme: Fundamentals of Ecological Genetics
- •4. Key questions the theme:
- •6. Литература:
- •7. Control:
- •7.1. Assessment of competencies - knowledge.
- •Some environmental disease caused by
- •Air pollution
- •Contamination of drinking water
- •Intestinal infections
- •7.1.6. The decision of situational problems:
- •7.2. Assessment of competence - legal competence.
- •Theme: Fundamentals of Pharmacogenetics
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •4.Osnovnye topic questions:
- •Specialty-general medicine methodology recommendation for independent work teacher-led
- •8. Control:
- •8.1.3. Filling out tables:escribe the types of apoptosis
- •1. Theme: Variability not hereditary and hereditary.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •7.2. An assessment of competences – legal competence.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •3.Learning objectives:
- •5.Key questions the theme:
- •7. References:
- •8. Control:
- •3.Learning objectives:
- •5.Tasks related to:
- •6.Handout material: test-2 version with 10 questions
- •7.References:
- •7.3.Konichev a .S. Sevyastanova g.A. Molecular biology m. 2005 p.N 150-196.351-379.
- •7.4.Teylor d.Grin. N.Staut u.Biology m.2002 part 3 p.N 215-242.
- •8. Control:
- •8.1.1 Quiz on topics.
- •8.1.5.The solution to the problem of restriction of dna.
- •8.1.6. Working with the human genomic databases: problem solving.
- •8.3. Control:
- •1 . Title: Control of landmark forum: "Molecular Biology of the Cell"
- •7. References: The main
- •Theme: Human Hereditary Diseases. Chromosomal Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Impairment related to different types of human aneuploidy
- •Evaluation of competence – practical skills
- •Theme: Human Hereditary Diseases. MonogenicMendelian Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence –communicative skills
- •Solution of situational problems
- •Title: Monogenic nonmendelian human disease
- •Aims: To generate in students the knowledge of nonmendelian monogenic human disease.
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •Theme: Polygenic (Multifactor) Human Diseases
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Collection of anamnesis (determine the data that permit to reveal families with increased risk of birth of a child with hereditary pathology)
- •In case of chromosomal diseases In case of genic diseases
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •6. Handout: test questions.
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •6. Handout: test questions.
- •7. References:
- •8. Control:
- •1.Theme: Section control on the section "Basis of medical genetics"
- •3.Tasks of teaching:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •Title: Monogenic nonmendelian human disease
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •6. Handout: test questions.
- •7. References:
- •6. Handout: tests
- •7.Bibliography:
- •8. Control:
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •3.Tasks of teaching:
- •5. The main themes:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •1. Theme #1. Telomers. Telomerase activity
- •3. The tasks:
- •5. Performance criteria:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #5. Genomics, proteomics and metabolonomics
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •9. Check:
- •1. Theme #6. Cloning of organisms and cells
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #9. Molecular and genetic mechanisms of aging
- •3. The tasks:
- •5. Requirements to presentation making up:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #13. Human genetic passport
- •3. The tasks:
- •5. Requirements to abstract work design:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •Control and measuring means for the assessment of knowledge, skills in molecular biology and medical genetics
- •2012 Year
- •I. Examination questions:
- •II. The test exam questions:
- •Molecular biology
- •Replication
- •II. Molecular Cell Biology
- •Cell Cycle
- •Ontogenezis
- •Mutations
- •Oncogenetics
- •III. Fundamentals of general genetics
- •Ekogenetic
- •Pharmacogenetics
- •IV. Fundamentals of medical genetics
- •The list of questions to assess the practical skills: Molecular biology
- •Genetics
II. Molecular Cell Biology
192. The genetic material of eukaryotic cells contained in
193. The levels of compaction of genetic material cells
194. The number of cell divisions depends on the
195. Chromatin is subdivided into
196. Chromatin cells may exist in the form
197. The structure of chromatin are
198. The genetic material of cells operating at the next level
199. The genetic material of cells may be in
200. The genetic material (genes) is active in the cell stage
201. Define karyotype
202. Refer to eukaryotes
203. What is presented to the genetic material in eukaryotes
204. What is presented to the genetic material in prokaryotes
205. Aggregate of hereditary material in a haploid set of forms
206. Hereditary material of cells located in
207.Tsitoplazmatic determined by heredity in the DNA content
208. Gamic chromatin
Cell Cycle
209. Factors that accelerate mitosis
210. Human somatic cells divide
211. Interphase consists of
212. Factors inhibiting mitosis
213. An important role in cell cycle regulation are
214.For meiosis is characterized by
215.After two meiotic divisions of a single cell formed
218.In result of mitotic division of somatic cells of the daughter cells contain
219.Mitoz provides
220.Gaploid set of chromosomes is characteristic of
221. In the regulation of the mitotic cycle proteins are involved enzymes
222. Regulation of kinase activity is carried out by
223. The initiation process of the mitotic cycle is influenced by complex
224. In the second half of the postmitotic period (G1) is activated complexes
225. In the synthetic period of the mitotic cycle of activated complexes
226. In postsinteticheskom period (G2) of the mitotic cycle of active enzymes
227. Regulation of the mitotic cycle is controlled by genes engaged in
228. Increased activity of p53 protein leads to
229. The cell cycle includes the period
230. A key role in cell cycle are the following enzymes
231. In after mitotic period of the mitotic cycle enzyme complexes function sequentially
232. In the synthetic period of the mitotic cycle regulatory role belongs to the enzymes
233. After sintetic period (G2) is characterized by active regulatory action of protein molecule
234. Extracellular regulators of the process of cell division is
235. Apoptosis is a process
236. In the process of apoptosis in human life manifested in the form
237. To apoptosis include cellular processes
238. The key enzyme of apoptosis are
239. In processes that use apoptotic caspases interact with the following cell structures-targets
240. Physiological cell death (apoptosis) occurs as a result
241. Physiological causes of death (apoptotic) cells can be
242. Programmed cell death (apoptosis) is a consequence
243. Activation of p53 leads to
Ontogenezis
244. Ontogenesis - is
245. Prenatal ontogeny includes periods
246. The first critical period of prenatal ontogenesis accounted for
247. Depending on the cause of congenital malformations can be divided into
248. Violation of any cellular mechanism leading to hypoplasia of organ
249. Monozygotic twins develop from
250. Cellular process, which is important in the ontogenetic development
251. Early ontogeny is characterized by human
252. Ooplazmatic segregation
253. The second critical period of prenatal ontogenesis accounted for
254. Exogenous factors are teratogenic
255. Teratogenesis - the process
256. Embryopathy - a
257. The term "positional information" means
258. The polarity of the oocyte
259. According to the positional information
260. Totipotency - is
261. The embryo is called a fruit in terms of pregnancy
262. Depending on the period of the CDF can be divided into
263. The third critical period of prenatal ontogenesis accounted for
264. Ontogenetic development is determined by
265. In the ontogenetic development of the role played by
266. The processes that determine the ontogenetic development
267. Periods of high sensitivity in the antenatal ontogenesis
268. Crossing-over occurs in the period
269. Congenital malformations occur as a result of teratogenic factors in
270. By embryopathy include
271. To include blastopatiyam
272. To apply fetopathy
273. Classification of congenital malformations
274. Congenital malformations are divided into
275. To include multiple malformations
276. For the system malformations are
277. Congenital malformations can occur under the action
278. By the birth of children with congenital malformations can cause disease
pregnant women
279. Diseases of pregnant women, promoting the development of congenital malformations
280. Teratogenic in early pregnancy has a cure
281. Medications that have teratogenic
282. Congenital malformations, occurring up to 8 weeks of pregnancy
283. In human ontogenesis periods are
284. Genes are "housekeeping"
285. Violations of the ontogenetic development give rise to
286. The action which the quotient in the early stages of pregnancy may cause the ontogenetic development
287. As a result of oogenesis is formed
288. Spermatogenesis ends
289. The primary female sex cells (oogonia) are characterized by
290. Reproduction of the primary female sex cells are
291. Differentiation of the sex of the child begins
292. The cells of the embryo after the first division are called
293. Mutations with maternal effect called mutations, occur in the
294. Homeotic mutations are called mutations, violating processes
295. Homeotic mutations lead to a breach of the processes
296. In utero observed activity of genes controlling the synthesis of
297. Teratogenic factors are called factors of external and internal environment, which are the cause of
298. To teratogenic environmental factors are
299. Teratogenic environmental factors are of biological origin
300. The critical periods of ontogenesis are called periods
301. Primary germ cells of the female body as a result of meiosis forms
302. The primary male sex cell resulting from meiosis generates
303. Prevention of occupational diseases includes
304. The purpose of medical examinations
305. Prevention and restriction of smoking, alcohol abuse directed at
306. Smoking is permitted in
307. Implementation of alcoholic beverages is prohibited
308. Prevention of substance abuse includes