- •1.1. Overview
- •1.7. For information about the teachers:
- •1.8. Contact Information:
- •2. Program:
- •2.1. Introduction
- •2.2. The purpose of discipline:
- •2.3. Learning objectives:
- •2.4. Learning outcomes:
- •2.5.Prerequisites and Postdetails.
- •2.6. Summary of discipline:
- •2.7. Thematic plan of lectures, practical classes, srps and the siw Thematic plan of lectures
- •The practical classes thematic plan
- •Topical Plan for siwp
- •Thematic plan for independent student work
- •2.8. Tasks for independent students work : Topics for independent work of students:
- •2.9 Recommended literature :
- •In Russian :
- •In Kazakh:
- •In English :
- •2.11. Criteria and assessment rules:
- •The evaluation system of students' knowledge
- •Competence assessment in discipline "Molecular Biology and Medical Genetics," for 1 course students "General Medicine" specialty.
- •2.Check control
- •Presentation
- •Assessments grading scale
- •It is discussed and approved at faculty meeting from April "12" of 2012 y., the protocol No. 15
- •1. Theme: Implementation of heriditary information
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature
- •6. Control questions (feedback):
- •Specialty – general medicine
- •Year 2012
- •Theme: Introduction to Molecular Biology. Molecular Principles of Heredity
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Theme: Gene Molecular Biology
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •Theme: Realization of Hereditary Information. Dna Replication
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Problem
- •Theme: Transcription
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Theme: Regulation of Gene Expression
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •8.1.Control:
- •8.2. Rating of competence skills.
- •Theme: Genetic Apparatus of the Cell
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •7.2. Evaluation of competence – practical skills
- •Theme: Mitotic cycle, Mitosis, Meiosis
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •7.2.6. Solution of standard tasks:
- •1. Theme: Heredity. Types of inheritance. Independent monogenic inheritance of characteristics
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge):
- •7.2. Assessment of competence skills
- •7.3. Assessment of the skills of self-improvement:
- •1.Theme: Heredity. Types of inheritance. Monogenic traits linked inheritance
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •7.1. Assessment of cognitive competences (knowledge):
- •1. Theme: Effects of gene
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge)
- •7.2. Assessment of competence skills
- •1. Theme: Cellular mechanisms of ontogenetic development
- •2. Purpose:
- •3.Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •1.Theme: Genetic mechanisms of ontogenetic development
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •7.2. Assessment of competence skills
- •1. Title: Basics of Genetics populyatsioinoy
- •6. Handout: Test questions. 7. Literature:
- •1.Theme: Fundamentals of Ecological Genetics
- •4. Key questions the theme:
- •6. Литература:
- •7. Control:
- •7.1. Assessment of competencies - knowledge.
- •Some environmental disease caused by
- •Air pollution
- •Contamination of drinking water
- •Intestinal infections
- •7.1.6. The decision of situational problems:
- •7.2. Assessment of competence - legal competence.
- •Theme: Fundamentals of Pharmacogenetics
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •4.Osnovnye topic questions:
- •Specialty-general medicine methodology recommendation for independent work teacher-led
- •8. Control:
- •8.1.3. Filling out tables:escribe the types of apoptosis
- •1. Theme: Variability not hereditary and hereditary.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •7.2. An assessment of competences – legal competence.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •3.Learning objectives:
- •5.Key questions the theme:
- •7. References:
- •8. Control:
- •3.Learning objectives:
- •5.Tasks related to:
- •6.Handout material: test-2 version with 10 questions
- •7.References:
- •7.3.Konichev a .S. Sevyastanova g.A. Molecular biology m. 2005 p.N 150-196.351-379.
- •7.4.Teylor d.Grin. N.Staut u.Biology m.2002 part 3 p.N 215-242.
- •8. Control:
- •8.1.1 Quiz on topics.
- •8.1.5.The solution to the problem of restriction of dna.
- •8.1.6. Working with the human genomic databases: problem solving.
- •8.3. Control:
- •1 . Title: Control of landmark forum: "Molecular Biology of the Cell"
- •7. References: The main
- •Theme: Human Hereditary Diseases. Chromosomal Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Impairment related to different types of human aneuploidy
- •Evaluation of competence – practical skills
- •Theme: Human Hereditary Diseases. MonogenicMendelian Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence –communicative skills
- •Solution of situational problems
- •Title: Monogenic nonmendelian human disease
- •Aims: To generate in students the knowledge of nonmendelian monogenic human disease.
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •Theme: Polygenic (Multifactor) Human Diseases
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Collection of anamnesis (determine the data that permit to reveal families with increased risk of birth of a child with hereditary pathology)
- •In case of chromosomal diseases In case of genic diseases
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •6. Handout: test questions.
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •6. Handout: test questions.
- •7. References:
- •8. Control:
- •1.Theme: Section control on the section "Basis of medical genetics"
- •3.Tasks of teaching:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •Title: Monogenic nonmendelian human disease
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •6. Handout: test questions.
- •7. References:
- •6. Handout: tests
- •7.Bibliography:
- •8. Control:
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •3.Tasks of teaching:
- •5. The main themes:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •1. Theme #1. Telomers. Telomerase activity
- •3. The tasks:
- •5. Performance criteria:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #5. Genomics, proteomics and metabolonomics
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •9. Check:
- •1. Theme #6. Cloning of organisms and cells
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #9. Molecular and genetic mechanisms of aging
- •3. The tasks:
- •5. Requirements to presentation making up:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #13. Human genetic passport
- •3. The tasks:
- •5. Requirements to abstract work design:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •Control and measuring means for the assessment of knowledge, skills in molecular biology and medical genetics
- •2012 Year
- •I. Examination questions:
- •II. The test exam questions:
- •Molecular biology
- •Replication
- •II. Molecular Cell Biology
- •Cell Cycle
- •Ontogenezis
- •Mutations
- •Oncogenetics
- •III. Fundamentals of general genetics
- •Ekogenetic
- •Pharmacogenetics
- •IV. Fundamentals of medical genetics
- •The list of questions to assess the practical skills: Molecular biology
- •Genetics
1. Theme #1. Telomers. Telomerase activity
2. The aim: to study the mechanisms of restoration (prereplication) of the terminal sites of daughter chain of DNA.
3. The tasks:
3.1. Telomers and telomerase and their influence on cellular aging.
3.2. Telomerase expression in normal cells of a human.
3.3. Telomerase activity and length of telomers in tumor cells of a human.
3.4. Cancer diagnostics, telomerase activity and malignancy.
4. Performance form: presentation.
5. Performance criteria:
а) studying and selection of recent literary sources;
b) information processing and systematization;
c) plan designing;
d) bibliography compiling;
e) abstract and/or project work making up.
The structure of abstract work:
1) the title page (made up in due form);
2) the table of contents (consecutive statement with indication of the main sections page numbers);
3) introduction (substantiation of the researched problem, its importance and urgency; determination of the aims and tasks of work);
4) the main part (each section should reveal evidentially a particular problem or one of its aspects, be logic continuation of the previous material; tables, schemes, diagrams, figures can be presented in this section or they can be executed as annex to abstract work);
5) conclusion (the results are summed up, the deductions are formulated and recommendations are suggested);
6) the list of bibliography (made up in due form).
Requirements to presentation making up:
а) a presentation should be made on the basis of “Microsoft Power Point” program;
b) the number of slides should be no more than 10-15; slides shouldn't be loaded by a text material;
c) a presentation should be available to perception;
d) the list of bibliography should be presented on the last slide.
6. Deadline: before the midterm control on the chapter “Theory of molecular biology”.
7. Criteria of assessment: - 100 points at maximum that corresponds to 100%
8. Bibliography:
8.1. Биохимия, № 62, 1997.
8.2. Военно-медицинский журнал, № 11, 2000.
8.3. Жимулев И.Ф. Общая и молекулярная генетика. Новосибирск, 2006.
8.4. Мушкамбаров Н.Н., Кузнецов С.Л. Молекулярная биология. М., 2003.
8.5.Российский онкологический журнал, № 2, 2003.
8.6.Соросовский образовательный журнал, № 12, 1998.
9. Check:
9.1. Telomer and telomerase structural and functional organization.
9.2. The basic propositions of the problem of the terminal underreplication.
9.3. Telomeric theory of aging.
1. Theme #2. Bioinformatics: molecular biology between a test tube and computer
2. The aim: to form knowledge at students of contemporary methods of analysis of DNA sequence and their use in molecular biology and medicine.
3. The tasks:
3.1. Problems of bioinformatics.
3.2. The basic bioinformation programs.
3.3. The basic principles of bioinformation work.
3.4. Studying of DNA sequence with use of bioinformation programs.
3.5. The importance of the results of bioinformation researches in medicine.
4. Performance form: presentation compiling.
5. Performance criteria:
а) selection and studying of the basic literary sources on the subject;
b) bibliography compiling;
c) information processing and systematization;
d) presentation plan designing;
e) presentation making up and design in “Microsoft Power Point” program;
f) statement at meeting of the students’ scientific circle “Biologist”.
Requirements to presentation making up:
а) a presentation should be made on the basis of “Microsoft Power Point” program;
b) the number of slides should be no more than 10-15;
c) a presentation should be done skillfully and be available to perception; the slides shouldn't be loaded by excessive text material;
d) the list of bibliography should be presented on the last slide.
6. Deadline: before the midterm control on the chapter “Theory of molecular biology”.
7. Criteria of assessment: - 100 points at maximum that corresponds to 100%
8. Bibliography:
8.1. http://biomediale.ncca-kaliningrad.ru/?blang=ru&author=gelfand
8.2. http://vechnayamolodost.ru
8.3.http://www.vechnayamolodost.ru/pages/drugienaukiozhizni/molbikobi1a.html
8.4. http://www.rusbiotech.ru/2003/old/bio_lab.html
8.5. http://serjramone.ax3.net/var/176--------.html
8.6. http://www.chem-bio.com.ua/well-known/item/4
9. Check:
9.1. What is the object of bioinformatics?
9.2. What bioinformation program can be used in the genome analysis?
9.3. What is the molecular biology -in silico?
9.4. How the genes search by computing methods can be done?
1. Theme #3. The fundamentals of genetic engineering
2. The aim: to form at students ideas of the basic principles and methods of genetic engineering technology and their application in medicine.
3. The tasks:
3.1. Allocation of the set gene DNA from a genome.
3.2. Transfer of genes into the cells of other organisms.
3.3. Transgene plants.
3.4. DNA diagnostics.
3.4. Gene therapy of hereditary diseases.
4. Performance form: glossary compiling.
4.1. Alternative splicing - _____________________________________
___________________________________________________________
4.2. Amplification - _________________________________________
___________________________________________________________
4.3. Antigen - _______________________________________________
___________________________________________________________
4.4. Autoradiography - ______________________________________
___________________________________________________________
4.5. Bacteriophage - ___________________________________________
___________________________________________________________
4.6. Blotting - _________________________________________________
___________________________________________________________
4.7. Vector - ________________________________________________
___________________________________________________________
4.8. Genetic code - ___________________________________________
___________________________________________________________
4.9. Genetic engineering - _____________________________________
___________________________________________________________
4.10. Gene - __________________________________________________
___________________________________________________________
4.11. Genome - ________________________________________________
___________________________________________________________
4.12. Gene bibliotheque - _______________________________________
___________________________________________________________
4.13. Gene therapy - _________________________________________
___________________________________________________________
4.14. Hybridome - ___________________________________________
_____________________________________________________________
4.15. DNA polymerase - ______________________________________
___________________________________________________________
4.16. Intron - _______________________________________________
___________________________________________________________
4.17. DNA cloning - __________________________________________
__________________________________________________________
4.18. Mapping - _____________________________________________
___________________________________________________________
4.19. Complementary DNA - ____________________________________
___________________________________________________________
4.20. Cosmide - ______________________________________________
___________________________________________________________
4.21. Genetic code - _________________________________________
___________________________________________________________
4.22. Codon (triplet) - ________________________________________
___________________________________________________________
4.23. Ligase - ______________________________________________
____________________________________________________________
4.24. “Cohesive” ends - ________________________________________
____________________________________________________________
4.25. Complementarity - ______________________________________
____________________________________________________________
4.26. Locus - ________________________________________________
____________________________________________________________
4.27. Methylation - __________________________________________
____________________________________________________________
4.28. DNA marker - ___________________________________________
____________________________________________________________
4.29. Modification - __________________________________________
____________________________________________________________
4.30. Mutagen - ______________________________________________
____________________________________________________________
4.31. Mutation - ______________________________________________
____________________________________________________________
4.32. Cistron - ______________________________________________
____________________________________________________________
4.33. Nucleotide - _____________________________________________
_____________________________________________________________
4.34. Northern blotting - ________________________________________
____________________________________________________________
4.35. Gyrase - _______________________________________________
____________________________________________________________
4.36. Polymorphism - __________________________________________
____________________________________________________________
4.37. Promoter - ______________________________________________
_____________________________________________________________
4.38. Reverse transcriptase - ____________________________________
____________________________________________________________
4.39. Restriction - ____________________________________________
____________________________________________________________
4.40. Recombinant DNA - _____________________________________
____________________________________________________________
4.41. Plasmid - _____________________________________________
____________________________________________________________
4.42. PCR - __________________________________________________
____________________________________________________________
4.43. Screening - _____________________________________________
______________________________________________________________
4.44. Splicing - ______________________________________________
____________________________________________________________
4.45. Restriction site - _______________________________________
______________________________________________________________
4.46. Southern blotting - ______________________________________
____________________________________________________________
4.47. Transgenic organism - ___________________________________
____________________________________________________________
4.48. Transduction - __________________________________________
____________________________________________________________
4.49. Transformation - ________________________________________
____________________________________________________________
4.50. Selective medium - ____________________________________
____________________________________________________________
4.51. Phasmid - _______________________________________________
____________________________________________________________
4.52. Chromatin - _____________________________________________
____________________________________________________________
4.53. Chromatids - ____________________________________________
____________________________________________________________
4.54. Chromosomes - ___________________________________________
____________________________________________________________
4.55. Exon – ________________________________________________
____________________________________________________________
4.56. Gene expression - _______________________________________
____________________________________________________________
4.57. Electrophoresis - _________________________________________
____________________________________________________________
4.58. Nuclear genetics - ______________________________________
____________________________________________________________
4.59. Endonuclease - _________________________________________
____________________________________________________________
4.60. Exonuclease - __________________________________________
____________________________________________________________