- •1.1. Overview
- •1.7. For information about the teachers:
- •1.8. Contact Information:
- •2. Program:
- •2.1. Introduction
- •2.2. The purpose of discipline:
- •2.3. Learning objectives:
- •2.4. Learning outcomes:
- •2.5.Prerequisites and Postdetails.
- •2.6. Summary of discipline:
- •2.7. Thematic plan of lectures, practical classes, srps and the siw Thematic plan of lectures
- •The practical classes thematic plan
- •Topical Plan for siwp
- •Thematic plan for independent student work
- •2.8. Tasks for independent students work : Topics for independent work of students:
- •2.9 Recommended literature :
- •In Russian :
- •In Kazakh:
- •In English :
- •2.11. Criteria and assessment rules:
- •The evaluation system of students' knowledge
- •Competence assessment in discipline "Molecular Biology and Medical Genetics," for 1 course students "General Medicine" specialty.
- •2.Check control
- •Presentation
- •Assessments grading scale
- •It is discussed and approved at faculty meeting from April "12" of 2012 y., the protocol No. 15
- •1. Theme: Implementation of heriditary information
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature
- •6. Control questions (feedback):
- •Specialty – general medicine
- •Year 2012
- •Theme: Introduction to Molecular Biology. Molecular Principles of Heredity
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Theme: Gene Molecular Biology
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •Theme: Realization of Hereditary Information. Dna Replication
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Problem
- •Theme: Transcription
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Theme: Regulation of Gene Expression
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •8.1.Control:
- •8.2. Rating of competence skills.
- •Theme: Genetic Apparatus of the Cell
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •7.2. Evaluation of competence – practical skills
- •Theme: Mitotic cycle, Mitosis, Meiosis
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •7.2.6. Solution of standard tasks:
- •1. Theme: Heredity. Types of inheritance. Independent monogenic inheritance of characteristics
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge):
- •7.2. Assessment of competence skills
- •7.3. Assessment of the skills of self-improvement:
- •1.Theme: Heredity. Types of inheritance. Monogenic traits linked inheritance
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •7.1. Assessment of cognitive competences (knowledge):
- •1. Theme: Effects of gene
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge)
- •7.2. Assessment of competence skills
- •1. Theme: Cellular mechanisms of ontogenetic development
- •2. Purpose:
- •3.Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •1.Theme: Genetic mechanisms of ontogenetic development
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •7.2. Assessment of competence skills
- •1. Title: Basics of Genetics populyatsioinoy
- •6. Handout: Test questions. 7. Literature:
- •1.Theme: Fundamentals of Ecological Genetics
- •4. Key questions the theme:
- •6. Литература:
- •7. Control:
- •7.1. Assessment of competencies - knowledge.
- •Some environmental disease caused by
- •Air pollution
- •Contamination of drinking water
- •Intestinal infections
- •7.1.6. The decision of situational problems:
- •7.2. Assessment of competence - legal competence.
- •Theme: Fundamentals of Pharmacogenetics
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •4.Osnovnye topic questions:
- •Specialty-general medicine methodology recommendation for independent work teacher-led
- •8. Control:
- •8.1.3. Filling out tables:escribe the types of apoptosis
- •1. Theme: Variability not hereditary and hereditary.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •7.2. An assessment of competences – legal competence.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •3.Learning objectives:
- •5.Key questions the theme:
- •7. References:
- •8. Control:
- •3.Learning objectives:
- •5.Tasks related to:
- •6.Handout material: test-2 version with 10 questions
- •7.References:
- •7.3.Konichev a .S. Sevyastanova g.A. Molecular biology m. 2005 p.N 150-196.351-379.
- •7.4.Teylor d.Grin. N.Staut u.Biology m.2002 part 3 p.N 215-242.
- •8. Control:
- •8.1.1 Quiz on topics.
- •8.1.5.The solution to the problem of restriction of dna.
- •8.1.6. Working with the human genomic databases: problem solving.
- •8.3. Control:
- •1 . Title: Control of landmark forum: "Molecular Biology of the Cell"
- •7. References: The main
- •Theme: Human Hereditary Diseases. Chromosomal Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Impairment related to different types of human aneuploidy
- •Evaluation of competence – practical skills
- •Theme: Human Hereditary Diseases. MonogenicMendelian Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence –communicative skills
- •Solution of situational problems
- •Title: Monogenic nonmendelian human disease
- •Aims: To generate in students the knowledge of nonmendelian monogenic human disease.
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •Theme: Polygenic (Multifactor) Human Diseases
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Collection of anamnesis (determine the data that permit to reveal families with increased risk of birth of a child with hereditary pathology)
- •In case of chromosomal diseases In case of genic diseases
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •6. Handout: test questions.
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •6. Handout: test questions.
- •7. References:
- •8. Control:
- •1.Theme: Section control on the section "Basis of medical genetics"
- •3.Tasks of teaching:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •Title: Monogenic nonmendelian human disease
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •6. Handout: test questions.
- •7. References:
- •6. Handout: tests
- •7.Bibliography:
- •8. Control:
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •3.Tasks of teaching:
- •5. The main themes:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •1. Theme #1. Telomers. Telomerase activity
- •3. The tasks:
- •5. Performance criteria:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #5. Genomics, proteomics and metabolonomics
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •9. Check:
- •1. Theme #6. Cloning of organisms and cells
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #9. Molecular and genetic mechanisms of aging
- •3. The tasks:
- •5. Requirements to presentation making up:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #13. Human genetic passport
- •3. The tasks:
- •5. Requirements to abstract work design:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •Control and measuring means for the assessment of knowledge, skills in molecular biology and medical genetics
- •2012 Year
- •I. Examination questions:
- •II. The test exam questions:
- •Molecular biology
- •Replication
- •II. Molecular Cell Biology
- •Cell Cycle
- •Ontogenezis
- •Mutations
- •Oncogenetics
- •III. Fundamentals of general genetics
- •Ekogenetic
- •Pharmacogenetics
- •IV. Fundamentals of medical genetics
- •The list of questions to assess the practical skills: Molecular biology
- •Genetics
7. Control:
7.1. Assessment of cognitive competences (knowledge):
7.1.1. Quizzes on topics.
7.1.2. Test Control - 4 options for the 10 questions.
7.2. Assessment of competence skills
7.2.1. Show, identify and characterize the allelic genes, homozygous,
heterozygous and hemizygous.
7.2.2. Show monohybrid scheme, and dihybrid and polyhybrid crossing, determine the types of gametes with independent inheritance, genotypes, and paintphenotypes of F1.
7.2.3. The solution of typical problems and situation of allowance: Medical Biology and Genetics. A textbook for students, ed. Professor. Kuandykova E.U. Almaty, 2004. Solving (Medical Biology and Genetics. Under. Ed. Kuandykova E.U. task on page 87-89, the task № 1-5).
7.3. Assessment of the skills of self-improvement:
7.3.1. The solution of typical problems and situation of allowance: Medical Biology and
genetics. A textbook for students, ed. Professor. Kuandykov E.U. Almaty,
2004, p. 87-89 b., № 8-12).
Lesson № 12
1.Theme: Heredity. Types of inheritance. Monogenic traits linked inheritance
2. Purpose:
- Create the students' knowledge of the monogenic linked inheritance of normal
and pathological features of autosomal and X-and Y sex chromosomes;
- To develop the motivation of the need to study the linked inheritance of genes for
understanding the genetic mechanisms of hereditary diseases;
- To develop communication skills in the analysis of linked inheritance of monogenic human disease with autosomal and X-and Y sex chromosomes;
- Develop practical competence by applying knowledge of the mechanisms linked inheritance of normal and pathological features in human and model solutions and situational problems in genetics.
3. Learning objectives:
- Explain the nature of genetic terms: linked inheritance, linkage group, autosomal linkage group, linkage group with the sexual X-and Y-chromosomes,
- To reveal the genetic mechanisms of the full clutch, clutch, and violations of the basic provisions of the chromosome theory of heredity,
- To reveal the genetic mechanisms linked inheritance of normal and pathological signs of human
- Explain the need for knowledge of the types and mechanisms linked inheritance of genes in the diagnosis of hereditary diseases
- To reveal the genetic basis of making a genetic map of chromosome with the full clutch.
4. Key questions the theme:
4.1. The laws of inheritance established T.Morganom. Linked inheritance and its genetic basis.
4.2. Linkage group. Autosomal linkage groups and gonosomnye man.
4.3. Violations of the clutch and its genetic basis.
4.4. The main provisions of the chromosome theory of heredity.
4.5. Preparation of the genetic maps of chromosomes.
5. Teaching methods: oral questioning aimed at clarifying the understanding of the nature of student goals and objectives of the training, skills, short, clear, logically presented and the ability to depict the digested material in the form of charts, graphs, drawings, testing and subsequent analysis of errors in the work group: an explanation and demonstration solving problems, filling schemes.
5.1.Reshenie problems (Medical Biology and Genetics. Under. Ed. Kuandykova EW tasks on page 98-101, № 1-3, 9, 15).
5.2. Fill in the table "during gamete formation of linkage and clutch abuse."
The formation of gametes in linkage and clutch abuse
Inheritance types |
Genotypes |
Being formed gametes |
Linked inheritance |
Вс / вС, АД / ад |
|
Debonding, the distance between genes B and C is 3 map units, and between genes A and D = 5 map units |
Вс / вС, АД / ад |
|
5.3. To make a genetic map: the distance between genes A and C is 12 map units, and the frequency of crossing over between genes A and B are equal to 4 percent of crossing over. Determine the distance between genes A, B, C, and make a map.
6. Literature:
The main:
6.1. Genetics. Under the editorship of Ivanov V. I. M, 2006, page 116-125.
6.2. Zhimulev I.F. General and molecular genetics. Novosibirsk, 2006, page 35-39,55-57.
6.3. Medical biology and genetics. The manual for students under the editorship of prof. Kuandykov E.U. Almaty, 2004, page 98-101.
6.4. Kuandykov E.U. Bases of the general and medical genetics (course of lectures). Almaty, 2007, page 81-98.
The additional:
6.5. Alikhanyan S. I., Akifyev A.P., Chernin L.S. General genetics of M, 1 volume, 1985, page 53-56.
6.6. Biology. Under the editorship of Yarygin V. N. M., book 1, 81-98.
6.7. Dorian Dzh. Pritchard, Bruce R. Korf. Evident medical genetics. The translation from English under edition Akkad. N.P.Bochkov's Russian Academy of Medical Science. - M: GEOTAR-media, 2009, page 42-60.
6.8. Hare of River of, Butvilovsky Century Э., etc. General and medical genetics. R - on - Don., 2002, page 76-80, 84-87.
6.9. Questions and tasks in the general biology and the general and medical genetics (with explanations). Under the editorship of the prof. Itkes A.V. M, 2004, page 68-83.
6.10. To Inga-Vechtomov S.G. Genetics with selection bases. M, 1989, page 23-54.
6.11. Medical genetics: studies. grant / Robert L.Nyyussbaum, Roderich of R, Macque-Innes, Huntington F.Willard: the lane with English. A.Sh.Latypov; under the editorship of N. P. Bochkov. - M: GEOTAR-media, 2010, page 203-205
7. Control: