- •1.1. Overview
- •1.7. For information about the teachers:
- •1.8. Contact Information:
- •2. Program:
- •2.1. Introduction
- •2.2. The purpose of discipline:
- •2.3. Learning objectives:
- •2.4. Learning outcomes:
- •2.5.Prerequisites and Postdetails.
- •2.6. Summary of discipline:
- •2.7. Thematic plan of lectures, practical classes, srps and the siw Thematic plan of lectures
- •The practical classes thematic plan
- •Topical Plan for siwp
- •Thematic plan for independent student work
- •2.8. Tasks for independent students work : Topics for independent work of students:
- •2.9 Recommended literature :
- •In Russian :
- •In Kazakh:
- •In English :
- •2.11. Criteria and assessment rules:
- •The evaluation system of students' knowledge
- •Competence assessment in discipline "Molecular Biology and Medical Genetics," for 1 course students "General Medicine" specialty.
- •2.Check control
- •Presentation
- •Assessments grading scale
- •It is discussed and approved at faculty meeting from April "12" of 2012 y., the protocol No. 15
- •1. Theme: Implementation of heriditary information
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature:
- •6. Control questions (feedback):
- •3. Theses of lectures:
- •5. Literature
- •6. Control questions (feedback):
- •Specialty – general medicine
- •Year 2012
- •Theme: Introduction to Molecular Biology. Molecular Principles of Heredity
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Theme: Gene Molecular Biology
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •Theme: Realization of Hereditary Information. Dna Replication
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Problem
- •Theme: Transcription
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Theme: Regulation of Gene Expression
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •8.1.Control:
- •8.2. Rating of competence skills.
- •Theme: Genetic Apparatus of the Cell
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •7.1. Evaluation of competence – knowledge
- •7.2. Evaluation of competence – practical skills
- •Theme: Mitotic cycle, Mitosis, Meiosis
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •7.2.6. Solution of standard tasks:
- •1. Theme: Heredity. Types of inheritance. Independent monogenic inheritance of characteristics
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge):
- •7.2. Assessment of competence skills
- •7.3. Assessment of the skills of self-improvement:
- •1.Theme: Heredity. Types of inheritance. Monogenic traits linked inheritance
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •7.1. Assessment of cognitive competences (knowledge):
- •1. Theme: Effects of gene
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature
- •7. Control:
- •7.1. Assessment of cognitive competences (knowledge)
- •7.2. Assessment of competence skills
- •1. Theme: Cellular mechanisms of ontogenetic development
- •2. Purpose:
- •3.Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •1.Theme: Genetic mechanisms of ontogenetic development
- •2. Purpose:
- •3. Learning objectives:
- •4. Key questions the theme:
- •6. Literature:
- •7. Control:
- •7.1. Assessment of cognitive competence - knowledge
- •7.2. Assessment of competence skills
- •1. Title: Basics of Genetics populyatsioinoy
- •6. Handout: Test questions. 7. Literature:
- •1.Theme: Fundamentals of Ecological Genetics
- •4. Key questions the theme:
- •6. Литература:
- •7. Control:
- •7.1. Assessment of competencies - knowledge.
- •Some environmental disease caused by
- •Air pollution
- •Contamination of drinking water
- •Intestinal infections
- •7.1.6. The decision of situational problems:
- •7.2. Assessment of competence - legal competence.
- •Theme: Fundamentals of Pharmacogenetics
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence – practical skills
- •4.Osnovnye topic questions:
- •Specialty-general medicine methodology recommendation for independent work teacher-led
- •8. Control:
- •8.1.3. Filling out tables:escribe the types of apoptosis
- •1. Theme: Variability not hereditary and hereditary.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •7.2. An assessment of competences – legal competence.
- •3. Problems of training:
- •4. Main questions of a subject:
- •6. Literature:
- •7. Control:
- •7.1. An assessment of competences – knowledge.
- •3.Learning objectives:
- •5.Key questions the theme:
- •7. References:
- •8. Control:
- •3.Learning objectives:
- •5.Tasks related to:
- •6.Handout material: test-2 version with 10 questions
- •7.References:
- •7.3.Konichev a .S. Sevyastanova g.A. Molecular biology m. 2005 p.N 150-196.351-379.
- •7.4.Teylor d.Grin. N.Staut u.Biology m.2002 part 3 p.N 215-242.
- •8. Control:
- •8.1.1 Quiz on topics.
- •8.1.5.The solution to the problem of restriction of dna.
- •8.1.6. Working with the human genomic databases: problem solving.
- •8.3. Control:
- •1 . Title: Control of landmark forum: "Molecular Biology of the Cell"
- •7. References: The main
- •Theme: Human Hereditary Diseases. Chromosomal Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Impairment related to different types of human aneuploidy
- •Evaluation of competence – practical skills
- •Theme: Human Hereditary Diseases. MonogenicMendelian Diseases
- •Object:
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Evaluation of competence –communicative skills
- •Solution of situational problems
- •Title: Monogenic nonmendelian human disease
- •Aims: To generate in students the knowledge of nonmendelian monogenic human disease.
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •Theme: Polygenic (Multifactor) Human Diseases
- •Educational Tasks:
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Principal Questions of the Theme:
- •Literature:
- •Control:
- •Evaluation of competence – knowledge
- •Collection of anamnesis (determine the data that permit to reveal families with increased risk of birth of a child with hereditary pathology)
- •In case of chromosomal diseases In case of genic diseases
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •6. Handout: test questions.
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •6. Handout: test questions.
- •7. References:
- •8. Control:
- •1.Theme: Section control on the section "Basis of medical genetics"
- •3.Tasks of teaching:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •Title: Monogenic nonmendelian human disease
- •Learning objectives:
- •Tasks related to:
- •Handout material: test-2 version with 10 questions
- •References:
- •Control:
- •6. Handout: test questions.
- •7. References:
- •6. Handout: tests
- •7.Bibliography:
- •8. Control:
- •Title: Modern methods of prevention and treatment genetic diseases
- •Key questions the theme:
- •7. References:
- •8.Control:
- •8.5.An algorithm preventing hereditary diseases, to determine the indications
- •3.Tasks of teaching:
- •5. The main themes:
- •7. References:
- •8. Control:
- •8.2. Rating of competence skills.
- •1. Theme #1. Telomers. Telomerase activity
- •3. The tasks:
- •5. Performance criteria:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #5. Genomics, proteomics and metabolonomics
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •9. Check:
- •1. Theme #6. Cloning of organisms and cells
- •3. The tasks:
- •5. Performance criteria:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #9. Molecular and genetic mechanisms of aging
- •3. The tasks:
- •5. Requirements to presentation making up:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •1. Theme #13. Human genetic passport
- •3. The tasks:
- •5. Requirements to abstract work design:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •8. Bibliography:
- •9. Check:
- •Control and measuring means for the assessment of knowledge, skills in molecular biology and medical genetics
- •2012 Year
- •I. Examination questions:
- •II. The test exam questions:
- •Molecular biology
- •Replication
- •II. Molecular Cell Biology
- •Cell Cycle
- •Ontogenezis
- •Mutations
- •Oncogenetics
- •III. Fundamentals of general genetics
- •Ekogenetic
- •Pharmacogenetics
- •IV. Fundamentals of medical genetics
- •The list of questions to assess the practical skills: Molecular biology
- •Genetics
8. Bibliography:
8.1. Бочков Н.П. Клиническая генетика. М., 2004.
8.2. Введение в молекулярную медицину. Под ред. Пальцева М.А. М., 2004.
8.3. Иванов В.И. и др. Генетика. М., 2006.
8.4. Гинтер Е.К. Медицинская генетика. М., 2003.
8.5. Заяц Р.Г., Бутвиловский В.Э., Рачковская И.В., Давыдов В.В. Общая и медицинская генетика. Ростов-на-Дону. 2002.
8.6. Умнов Д.Е. Медицинская генетика. М., 2005.
8.7. Кассирский И. А. Гемоглобинопатии, 4 изд., М., 1970.
8.8. Токарева Ю.Н. Наследственные анемии и гемоглобинопатии, М., 1983.
8.9. Детские болезни. Баранов А.А. // 2002.
9. Check:
9.1. What is hemoglobinopathy?
9.2. What are the reasons of hemoglobinopathy?
9.3. Qualitative hemoglobinopathy.
9.4. Quantitative hemoglobinopathy.
9.5. Mixed hemoglobinopathy.
1. Theme #17. Widespread gene diseases
2. The aim: to study the genetic mechanisms of the widespread gene diseases.
3. The tasks:
3.1. Characteristics and frequency of the widespread gene diseases.
3.2. Genetic mechanisms of the widespread gene diseases.
3.3. Types of the widespread gene diseases.
3.4. Clinical manifestation, diagnostics and prevention of the widespread gene diseases.
4. Performance form: abstract work.
5. Performance criteria:
а) studying and selection of recent literary sources;
b) information processing and systematization;
c) plan designing;
d) bibliography compiling;
e) abstract and/or project work making up.
The structure of abstract work:
1) the title page (made up in due form);
2) the table of contents (consecutive statement with indication of the main sections page numbers);
3) introduction (substantiation of the researched problem, its importance and urgency; determination of the aims and tasks of work);
4) the main part (each section should reveal evidentially a particular problem or one of its aspects, be logic continuation of the previous material; tables, schemes, diagrams, figures can be presented in this section or they can be executed as annex to abstract work);
5) conclusion (the results are summed up, the deductions are formulated and recommendations are suggested);
6) the list of bibliography (made up in due form).
Requirements to abstract work design:
а) the volume of abstract work should not exceed 10-15 printing pages (annexes are not included into a paper volume);
b) a text of abstract work should be carefully edited and grammatically verified;
c) references should be presented in numbers, corresponding to the number in the list of bibliography;
d) the list of bibliography should be at the end of a text according to order of appearance.
6. Deadline: before the midterm control on the chapter “Fundamentals of medical genetics”.
7. Criteria of assessment: - 100 points at maximum that corresponds to 100%
8. Bibliography:
8.1. Введение в молекулярную медицину. Под ред. Пальцева М.А. М., 2004.
8.2. Бочков Н.П. Клиническая генетика. М., 2004.
8.3. Генетика. Под ред. Иванова В.И. М., 2006.
8.4. Гинтер Е.К. Медицинская генетика. М., 2003.
8.5. Жимулев И.Ф. Общая и молекулярная генетика. Новосибирск, 2006.
8.6. Щипков В.П. Кривошеина Г.Н. Общая и медицинская генетика 2003.
8.7. Джеральд М. Фаллер. Молекулярная биология клетки. М. 2006.
9. Check:
9.1. Nature of polygene diseases inheritance.
9.2. What does the additive action of genes mean?
1. Theme #18. Hereditary diseases treatment
2. The aim: to study contemporary methods of hereditary diseases treatment.
3. The tasks:
3.1. Hereditary diseases classification.
3.2. Contemporary methods of hereditary diseases diagnostics and prevention.
3.3. Principles of hereditary diseases treatment.
4. Performance form: abstract work.
5. Performance criteria:
а) studying and selection of recent literary sources;
b) information processing and systematization;
c) plan designing;
d) bibliography compiling;
e) abstract and/or project work making up.
The structure of abstract work:
1) the title page (made up in due form);
2) the table of contents (consecutive statement with indication of the main sections page numbers);
3) introduction (substantiation of the researched problem, its importance and urgency; determination of the aims and tasks of work);
4) the main part (each section should reveal evidentially a particular problem or one of its aspects, be logic continuation of the previous material; tables, schemes, diagrams, figures can be presented in this section or they can be executed as annex to abstract work);
5) conclusion (the results are summed up, the deductions are formulated and recommendations are suggested);
6) the list of bibliography (made up in due form).
Requirements to abstract work design:
а) the volume of abstract work should not exceed 10-15 printing pages (annexes are not included into a paper volume);
b) a text of abstract work should be carefully edited and grammatically verified;
c) references should be presented in numbers, corresponding to the number in the list of bibliography;
d) the list of bibliography should be at the end of a text according to order of appearance.
6. Deadline: before the midterm control on the chapter “Fundamentals of medical genetics”.
7. Criteria of assessment: - 100 points at maximum that corresponds to 100%