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Chapter 71 / Thoracic Surgery 635

What is the treatment in the

 

following cases:

 

Extralobar?

Surgical resection

Intralobar?

Lobectomy

What is the major danger during surgery for sequestration?

Anomalous blood supply from below the diaphragm (these can be cut and retract into the abdomen resulting in exsanguination!)

Always document blood supply by A-gram or U/S with Doppler flow

DISEASES OF THE MEDIASTINUM

MEDIASTINAL ANATOMY

What structures lie in the following locations:

Superior mediastinum? Aortic arch, great vessels, upper trachea, esophagus

Anterior mediastinum? Thymus, ascending aorta, lymph nodes

Middle mediastinum? Heart, lower trachea and bifurcation, lung hila, phrenic nerves, lymph nodes

Posterior mediastinum? Esophagus, descending aorta, thoracic duct, vagus and intercostal nerves, sympathetic trunks, azygous and hemizygous veins, lymph nodes

What is the major differential diagnosis for tumors of the mediastinum:

Anterior mediastinum? Classic “four Ts”: Thyroid tumor,

Thymoma, Terrible lymphoma, Teratoma; also parathyroid tumor, lipoma, vascular aneurysms

Middle mediastinum? Lymphadenopathy (e.g., lymphoma, sarcoid), teratoma, fat pad, cysts, hernias, extension of esophageal mass, bronchogenic cancer

636 Section III / Subspecialty Surgery

 

Posterior mediastinum?

Neurogenic tumors, lymphoma, aortic

 

 

aneurysm, vertebral lesions, hernias

What is the most common

Neurogenic (most commonly in posterior

type of tumor arising in the

mediastinum)

mediastinum?

 

What is the differential

Schwannoma (a.k.a. neurolemmoma),

diagnosis for a neurogenic

neurofibroma, neuroblastoma,

tumor?

ganglioneuroma, ganglioneuroblastoma,

 

 

pheochromocytoma

PRIMARY MEDIASTINAL TUMORS

 

 

 

 

Thymoma

 

 

 

 

Where are they found in the mediastinum?

How is the diagnosis made?

What is the treatment?

What are the indications for postop radiation therapy?

What are the indications for preop chemotherapy?

What percentage of thymomas are malignant?

How is a malignant thymoma diagnosed?

What is myasthenia gravis?

What percentage of patients with myasthenia gravis have a thymoma?

Anterior

CT scan

All thymomas should be surgically resected via midline sternotomy

Invasive malignant tumor

Tumor 6 cm and CT scan with invasion

25%

At surgery with invasion into surrounding structures (not by histology!)

Autoimmune disease with antibodies against the muscle acetylcholine receptors

15%

What percentage of patients 75%! with thymoma have or will

have myasthenia gravis?

 

 

Chapter 71 / Thoracic Surgery 637

Teratomas

 

 

 

 

What are they?

Tumors of branchial cleft cells; the

 

 

tumors contain ectoderm, endoderm, and

 

 

mesoderm

What is a dermoid cyst?

Which age group is affected?

Where in the mediastinum do they occur?

What are the characteristic x-ray findings?

What percentage are malignant?

What is the treatment of benign dermoid cysts?

What is the treatment of malignant teratoma?

Which tumor markers are associated with malignant teratomas?

Neurogenic Tumors

What is the incidence?

Where in the mediastinum do they occur?

What percentage are malignant?

Teratoma made up of ectodermal derivatives (e.g., teeth, skin, hair)

Usually adolescents, but can occur at any age

Anterior

Calcifications or teeth; tumors may be cystic

15%

Surgical excision

Preoperative chemotherapy until tumor markers are normal, then surgical resection

AFP, CEA

Most common mediastinal tumors in all age groups

Posterior, in the paravertebral gutters

50% in children

10% in adults

638 Section III / Subspecialty Surgery

 

 

What are the histologic types

1.

Neurilemmoma or schwannoma

(5)? (Note cells of origin and

 

(benign)—arise from Schwann cell

whether benign or malignant.)

 

sheaths of intercostal nerves

 

2.

Neurofibroma (benign)—arise from

 

 

intercostal nerves; may degenerate into:

 

3.

Neurosarcoma (malignant)

 

4.

Ganglioneuroma (benign)—from

 

 

sympathetic chain

 

5.

Neuroblastoma (malignant)—also

 

 

from sympathetic chain

LYMPHOMA

 

 

 

 

Where in the mediastinum

Anywhere, but most often in the

does it occur?

anterosuperior mediastinum or hilum

 

in the middle mediastinum

What percentage of

50%

lymphomas involve

 

 

mediastinal nodes?

 

 

What are the symptoms?

Cough, fever, chest pain, weight loss,

 

SVC syndrome, chylothorax

How is the diagnosis made? 1. CXR, CT scan

2.Mediastinoscopy or mediastinotomy with node biopsy

What is the treatment? Nonsurgical (chemotherapy, radiation, or both)

MEDIASTINITIS

Acute Mediastinitis

What is it?

Acute suppurative mediastinal infection

Name the six etiologies. 1. Esophageal perforation (Boerhaave’s syndrome)

2.Postoperative wound infection

3.Head and neck infections

4.Lung or pleural infections

5.Rib or vertebral osteomyelitis

6.Distant infections

What are the clinical features?

What is the treatment?

Chronic Mediastinitis

What is it?

What is the most common etiology?

What are the clinical features?

How is the diagnosis made?

What is the treatment?

Chapter 71 / Thoracic Surgery 639

Fever, chest pain, dysphagia (especially with esophageal perforation), respiratory distress, leukocytosis

1.Wide drainage

2.Treatment of primary cause

3.Antibiotics

Mediastinal fibrosis secondary to chronic granulomatous infection

Histoplasma capsulatum

50% are asymptomatic; symptoms are related to compression of adjacent structures: SVC syndrome, bronchial and esophageal strictures, constrictive pericarditis

CXR or CT may be helpful, but surgery/ biopsy often makes the diagnosis

Antibiotics; surgical removal of the granulomas is rarely helpful

SUPERIOR VENA CAVA SYNDROME

What is it?

Obstruction of the superior vena cava,

 

usually by extrinsic compression

What is the #1 cause?

Malignant tumors cause 90% of cases;

 

lung cancer is by far the most common;

 

other tumors include thymoma,

 

lymphoma, and Hodgkin’s disease

What are the clinical

1.

Blue discoloration and puffiness of the

manifestations?

 

face, arms, and shoulders

 

2.

CNS manifestations may include

 

 

headache, nausea, vomiting, visual

 

 

distortion, stupor, and convulsions.

 

3.

Cough, hoarseness, and dyspnea

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