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Chapter 54 / Biliary Tract 377

What are the signs and

Same as those for obstructive jaundice:

symptoms of sclerosing

Jaundice

cholangitis?

Itching (pruritus)

 

Dark urine

 

Clay-colored stools

 

Loss of energy

 

Weight loss

 

(Many patients are asymptomatic)

What are the complications?

Cirrhosis

 

Cholangiocarcinoma (10%)

 

Cholangitis

 

Obstructive jaundice

How is it diagnosed?

Elevated alkaline phosphatase, and PTC

 

or ERCP revealing “beads on a string”

 

appearance on contrast study

What are the management

Hepatoenteric anastomosis (if primarily

options?

extrahepatic ducts are involved)

 

and resection of extrahepatic

 

bile ducts because of the risk of

 

cholangiocarcinoma

 

Transplant (if primarily intrahepatic

 

disease or cirrhosis)

 

Endoscopic balloon dilations

What percentage of patients

5%

with IBD develops sclerosing

 

cholangitis?

 

GALLSTONE ILEUS

 

 

 

What is it?

Small bowel obstruction from a large

 

gallstone ( 2.5 cm) that has eroded

 

through the gallbladder and into the

 

duodenum/small bowel

What is the classic site of obstruction?

Ileocecal valve (but may cause obstruction in the duodenum, sigmoid colon)

378 Section II / General Surgery

What are the classic findings of gallstone ileus?

Air in the hepatic bile ducts

SBO with air fluid levels

Gallstone in ileocecal valve

h rf

‘ 0 7

What is the population at risk?

What are the signs/ symptoms?

Gallstone ileus causes what percentage of cases of SBO?

What are the diagnostic tests of choice?

Gallstone ileus is most commonly seen in women older than 70 years

Symptoms of SBO: distention, vomiting, hypovolemia, RUQ pain

1%

Abdominal x-ray: occasionally reveals radiopaque gallstone in the bowel;

40% of patients show air in the biliary tract, small bowel distention, and air fluid levels secondary to ileus

UGI: used if diagnosis is in question; will show cholecystenteric fistula and the obstruction

Abdominal CT: reveals air in biliary tract, SBO /– gallstone in intestine

What is the management? Surgery: enterotomy with removal of the stone interval cholecystectomy (intervaldelayed)

CARCINOMA OF THE GALLBLADDER

What is it?

Malignant neoplasm arising in the

 

gallbladder, vast majority are

 

adenocarcinoma (90%)

 

Chapter 54 / Biliary Tract 379

What are the risk factors?

Gallstones, porcelain gallbladder,

 

cholecystenteric fistula

What is the female:male ratio?

4:1

What is the most common

60% in fundus

site of gallbladder cancer in

 

the gallbladder?

 

What is a porcelain

Calcified gallbladder

gallbladder?

 

What percentage of patients

50% (20%–60%)

with a porcelain gallbladder

 

will have gallbladder cancer?

 

What is the incidence?

1% of all gallbladder specimens

What are the symptoms?

Biliary colic, weight loss, anorexia; many

 

patients are asymptomatic until late; may

 

present as acute cholecystitis

What are the signs?

Jaundice (from invasion of the common duct

 

or compression by involved pericholedochal

 

lymph nodes), RUQ mass, palpable

 

gallbladder (advanced disease)

What are the diagnostic tests of choice?

What is the route of spread?

What is the management under the following conditions?

Confined to mucosa

Confined to muscularis/ serosa

Ultrasound, abdominal CT, ERCP

Contiguous spread to the liver is most common

Cholecystectomy

Radical cholecystectomy: cholecystectomy and wedge resection of overlying liver, and lymph node dissection chemotherapy/XRT

What is the main complication of a lap chole for gallbladder cancer?

Trocar site tumor implants (Note: if known preoperatively, perform open cholecystectomy)

380 Section II / General Surgery

What is the prognosis for gallbladder cancer?

CHOLANGIOCARCINOMA

Dismal overall: 5% 5-year survival as most are unresectable at diagnosis

T1 with cholecystectomy: 95% 5-year survival

What is it?

What is the histology?

Average age at diagnosis?

What are the signs and symptoms?

What is the most common location?

What are the risk factors?

What is a Klatskin tumor?

Malignancy of the extrahepatic or intrahepatic ducts—primary bile duct cancer

Almost all are adenocarcinomas

65 years, equally affects male/female

Those of biliary obstruction: jaundice, pruritus, dark urine, clay-colored stools, cholangitis

Proximal bile duct

Choledochal cysts Ulcerative colitis

Thorotrast contrast dye (used in 1950s) Sclerosing cholangitis

Liver flukes (clonorchiasis)

Toxin exposures (e.g., Agent Orange)

Tumor that involves the junction of the right and left hepatic ducts

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