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734 Section III / Subspecialty Surgery

What are the blood prolactin levels with a prolactinoma?

Medical treatment of a prolactinoma?

Surgical treatment for a prolactinoma?

What is the treatment of a recurrent prolactinoma after surgical resection?

300 mg/L is diagnostic for prolactinoma ( 100 mg/L is abnormal)

Bromocriptine

Transsphenoidal resection of the pituitary tumor (in cases refractory to bromocriptine)

Radiation therapy

VASCULAR NEUROSURGERY

SUBARACHNOID HEMORRHAGE (SAH)

What are the usual causes?

Most cases are due to trauma; of nontraumatic SAH, the leading cause is ruptured berry aneurysm, followed by arteriovenous malformations

What is a berry aneurysm?

What is the usual location of a berry aneurysm?

What medical disease increases the risk of berry aneurysms?

What is an Arterio-Venous Malformation (AVM)?

Where do they occur?

What are the signs/ symptoms of SAH?

Saccular outpouching of vessels in the circle of Willis, usually at bifurcations

Anterior communicating artery is #1 (30%), followed by posterior communicating artery and middle cerebral artery

Polycystic kidney disease and connective tissue disorders (e.g., Marfan’s syndrome)

Congenital abnormality of the vasculature with connections between the arterial and venous circulations without interposed capillary network

75% are supratentorial

Classic symptom is “the worst headache of my life”; meningismus is documented by neck pain and positive Kernig’s and Brudzinski’s signs; occasionally LOC, vomiting, nausea, photophobia

 

 

Chapter 75 / Neurosurgery 735

What comprises the workup

If SAH is suspected, head CT should

of SAH?

be the first test ordered to look for

 

subarachnoid blood; LP may show

 

xanthochromic CSF, but is not necessary

 

if CT scan is definitive; this test should

 

be followed by arteriogram to look for

 

aneurysms or AVMs

What are the possible

1.

Brain edema leading to increased ICP

complications of SAH?

2.

Rebleeding (most common in the first

 

 

24 to 48 hours posthemorrhage)

 

3.

Vasospasm (most common cause of

 

 

morbidity and mortality)

What is the treatment for vasospasm?

What is the treatment of aneurysms?

Nimodipine (calcium channel blocker)

Surgical treatment by placing a metal clip on the aneurysm is the mainstay of therapy; alternatives include balloon occlusion or coil embolization

What is the treatment of

Many are on the brain surface and

AVMs?

accessible operatively; preoperative

 

embolization can reduce the size of the

 

AVM; for surgically inaccessible lesions,

 

radiosurgery (gamma knife) has been

 

effective in treating AVMs 3 cm in

 

diameter

INTRACEREBRAL HEMORRHAGE

 

 

 

What is it?

Bleeding into the brain parenchyma

What is the etiology?

#1 is hypertensive/atherosclerotic disease

 

giving rise to Charcot-Bouchard

 

aneurysms (small tubular aneurysms

 

along smaller terminal arteries); other

 

causes include coagulopathies, AVMs,

 

amyloid angiopathy, bleeding into a

 

tumor, and trauma

Where does it occur?

66% occur in the basal ganglia; putamen

 

is the structure most commonly affected

736 Section III / Subspecialty Surgery

 

How often does blood

66% of cases

spread to the ventricular

 

system?

 

What is the usual

66% present with coma; large

presentation?

putamen bleeding classically presents

 

with contralateral hemiplegia and

 

hemisensory deficits, lateral gaze

 

preference, aphasia, and homonymous

 

hemianopsia

What is the associated

CT scan

diagnostic study?

 

What are the surgical

CN III palsy, progressive alteration of

indications?

consciousness

What is the prognosis?

Poor, especially with ventricular or

 

diencephalons involvement

SPINE

 

 

 

LUMBAR DISC HERNIATION

 

 

 

What is it?

Extrusion of the inner portion of the

 

intervertebral disc (nucleus pulposus)

 

through the outer annulus fibrosis,

 

causing impingement on nerve roots

 

exiting the spinal canal

Which nerve is affected?

Nerve exiting at the level below (e.g., an

 

L4–L5 disc impinges on the L5 nerve

 

exiting between L5–S1)

Who is affected?

Middle-aged and older individuals

What is the usual cause?

Loss of elasticity of the posterior

 

longitudinal ligaments and annulus

 

fibrosis as a result of aging

What are the most common

L5–S1 (45%)

sites?

L4–L5 (40%)

What is the usual presenting

Low back pain

symptom?

 

What are the signs:

L5–S1?

L4–L5?

L3–L4?

How is the diagnosis made?

What is the treatment?

Chapter 75 / Neurosurgery 737

Decreased ankle jerk reflex Weakness of plantar flexors in foot Pain in back/midgluteal region to

posterior calf to lateral foot Ipsilateral radiculopathy on straight leg

raise

Decreased biceps femoris reflex Weak extensors of foot

Decrease or absence of knee jerks, weakness of the quadriceps femoris, pain in lower back/buttock, pain in lateral thigh and anterior thigh

Pain in hip/groin region to posterolateral thigh, lateral leg, and medial toes

CT scan, CT myelogram, or MRI

Conservative—bed rest and analgesics Surgical—partial hemilaminectomy and

discectomy (removal of herniated disc)

What are the indications for

1. Cauda equina syndrome

emergent surgery?

2. Progressive motor deficits

What is cauda equina

Herniated disc compressing multiple

syndrome?

S1, S2, S3, S4 nerve roots, resulting in

 

bowel/bladder incontinence, “saddle

 

anesthesia” over buttocks/perineum, low

 

back pain, sciatica

What is “sciatica”?

Radicular or nerve root pain

CERVICAL DISC DISEASE

 

 

 

What is it?

Basically the same pathology as lumbar

 

disc herniation, except in the cervical

 

region; the disc impinges on the nerve

 

exiting the canal at the same level of the

 

disease (e.g., a C6–C7 disc impinges on

 

the C7 nerve root exiting at the C6–C7

 

foramen)

738 Section III / Subspecialty Surgery

 

What are the most common

C6–C7 (70%)

sites?

C5–C6 (20%)

 

C7–T1 (10%)

What are the signs/

 

symptoms:

 

C7?

Decreased triceps reflex/strength,

 

weakness of forearm extension

 

Pain from neck, through triceps and into

 

index and middle finger

C6?

Decreased biceps and brachioradialis

 

reflex

 

Weakness in forearm flexion

 

Pain in neck, radial forearm, and thumb

C8?

How is the diagnosis made?

What is the treatment?

What are the symptoms of central cervical cord compression from disc fragments?

Weakness in intrinsic hand muscles, pain in fourth/fifth fingers

CT scan or MRI

Anterior or posterior discectomy with fusion PRN

Myelopathic syndrome with LMN signs at level of compression and UMN signs distally; e.g., C7 compression may cause bilateral loss of triceps reflex and bilateral hyperreflexia, clonus, and Babinski signs in lower extremities

What is Spurling’s sign?

Reproduction of radicular pain by having

 

the patient turn his head to the affected

 

side and applying axial pressure to the

 

top of the head

SPINAL EPIDURAL ABSCESS

 

 

 

What is the etiology?

Hematogenous spread from skin infections

 

is most common; also, distant abscesses/

 

infections, UTIs, postoperative infections,

 

spinal surgery, epidural anesthesia

What is the commonly

Diabetes mellitus

associated medical condition?

 

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