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Chapter 76 / Urology 747

BPH

Benign Prostatic Hyperplasia

Epispadias

Abnormal urethral opening on the dorsal

 

surface of the penis

Hypospadiasis

Abnormal urethral opening on the

 

ventral surface of the penis; may occur in

 

anterior, middle, or posterior of penis

Erectile dysfunction

Inability to achieve an erection

Sterility

Inability to reproduce

Appendix testis

Common redundant testicular tissue

VUR

VesicoUreteral Reflux

SCROTAL ANATOMY

What are the layers of the scrotum?

Skin

Dartos

External

spermatic

fascia

Cremaster muscle

Internal

spermatic

fascia Parietal and visceral layers of tunica vaginalis

Tunica albuginea

UROLOGIC DIFFERENTIAL DIAGNOSIS

What is the differential

Cancer, torsion, epididymitis, hydrocele,

diagnosis of scrotal mass?

spermatocele, varicocele, inguinal hernia,

 

testicular appendage, swollen testicle after

 

trauma, nontesticular tumor (paratesticular

 

tumor: e.g., rhabdomyosarcoma,

 

leiomyosarcoma, liposarcoma)

748 Section III / Subspecialty Surgery

What are the causes of hematuria?

What is the most common cause of severe gross hematuria without trauma or chemotherapy/radiation?

Bladder cancer, trauma, UTI, cystitis from chemotherapy or radiation, stones, kidney lesion, BPH

Bladder cancer

What is the differential

BPH, stone, foreign body, urethral

diagnosis for bladder outlet

stricture, urethral valve

obstruction?

 

What is the differential

Stone, tumor, iatrogenic (suture),

diagnosis for ureteral

stricture, gravid uterus, radiation injury,

obstruction?

retroperitoneal fibrosis

What is the differential

Renal cell carcinoma, sarcoma, adenoma,

diagnosis for kidney tumor?

angiomyolipoma, hemangiopericytoma,

 

oncocytoma

RENAL CELL CARCINOMA (RCC)

 

 

What is it?

Most common solid renal tumor (90%);

 

originates from proximal renal tubular

 

epithelium

What is the epidemiology?

Primarily a tumor of adults 40 to 60 years

 

of age with a 3:1 male:female ratio; 5% of

 

cancers overall in adults

What percentage of the

1%

tumors are bilateral?

 

What are the risk factors?

Male sex, tobacco, von Hippel-Lindau

 

syndrome, polycystic kidney

What are the symptoms?

Pain (40%), hematuria (35%), weight loss

 

(35%), flank mass (25%), HTN (20%)

What is the classic TRIAD of

1. Flank pain

renal cell carcinoma?

2. Hematuria

 

3. Palpable mass (triad occurs in only

 

10%–15% of cases)

How are most cases diagnosed these days?

What radiologic tests are performed?

Define the stages (AJCC): Stage I?

Stage II?

Stage III?

Stage IV?

What is the metastatic workup?

What are the sites of metastases?

What is the unique route of spread?

What is the treatment of RCC?

What gland is removed with a radical nephrectomy?

What is the unique treatment for metastatic spread?

What is a syndrome of RCC and liver disease?

Chapter 76 / Urology 749

Found incidentally on an imaging study (CT, MRI, U/S) for another reason

1.IVP

2.Abdominal CT scan with contrast

Tumor 2.5 cm, no nodes, no metastases

Tumor 2.5 cm limited to kidney, no nodes, no metastases

Tumor extends into IVC or main renal vein; positive regional lymph nodes but2 cm in diameter and no metastases

Distant metastasis or positive lymph node2 cm in diameter, or tumor extends past Gerota’s fascia

CXR, IVP, CT scan, LFTs, calcium

Lung, liver, brain, bone; tumor thrombus entering renal vein or IVC is not uncommon

Tumor thrombus into IVC lumen

Radical nephrectomy (excision of the kidney and adrenal, including Gerota’s fascia) for stages I through IV

Adrenal gland

1.-interferon

2.LAK cells (lymphokine-activated killer) and IL-2 (interleukin-2)

Stauffer’s syndrome

750 Section III / Subspecialty Surgery

What is the concern in an Left RCC—the left gonadal vein drains adult with new onset left into the left renal vein

varicocele?

BLADDER CANCER

What is the incidence? Second most common urologic malignancy Male:female ratio of 3:1

White patients are more commonly affected than are African American patients

What is the most common histology?

What are the risk factors?

Transitional Cell Carcinoma (TCC)— 90%; remaining cases are squamous or adenocarcinomas

Smoking, industrial carcinogens (aromatic amines), schistosomiasis, truck drivers, petroleum workers, cyclophosphamide

What are the symptoms?

What is the classic presentation of bladder cancer?

What tests are included in the workup?

Define the AJCC transitional cell bladder cancer stages:

Stage 0?

Stage I?

Stage II?

Stage III?

Stage IV?

Hematuria, with or without irritative symptoms (e.g., dysuria), frequency

“Painless hematuria”

Urinalysis and culture, IVP, cystoscopy with cytology and biopsy

Superficial, carcinoma in situ

Invades subepithelial connective tissue, no positive nodes, no metastases

Invades superficial or deep muscularis propria, no positive nodes, no metastases

Invades perivesical tissues, no positive nodes, no metastases

Positive nodal spread with distant metastases and/or invades abdominal/ pelvic wall

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