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Lorne H. Blackbourne-Surgical recall, Sixth Edition 2011.pdf
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Why do -adrenergic blockers work?

What is Proscar®?

Chapter 76 / Urology 755

1.Relax sphincter

2.Relax prostate capsule

Finasteride: 5- -reductase inhibitor; blocks transformation of testosterone to dihydrotestosterone; may shrink and slow progression of BPH

What is Hytrin®?

What are the indications for surgery in BPH?

Terazosin: -blocker; may increase urine outflow by relaxing prostatic smooth muscles

Due to obstruction:

Urinary retention

Hydronephrosis

UTIs

Severe symptoms

What is TURP?

What is TUIP?

What percentage of tissue removed for BPH will have malignant tissue on histology?

TransUrethral Resection of Prostate: resection of prostate tissue via a scope

TransUrethral Incision of Prostate

Up to 10%!

What are the possible

Immediate:

complications of TURP?

Failure to void

 

Bleeding

 

Clot retention

 

UTI

 

Incontinence

TESTICULAR CANCER

What is the incidence? Rare; 2 to 3 new cases per 100,000 men per year in the United States

What is its claim to fame? Most common solid tumor of young adult males (20 to 40 years)

What are the risk factors? Cryptorchidism (6% of testicular tumors develop in patients with a history of cryptorchidism)

756 Section III / Subspecialty Surgery

 

What is cryptorchidism?

Failure of the testicle to descend into the

 

scrotum

Does orchiopexy as an adult

NO

remove the risk of testicular

 

cancer?

 

What are the symptoms?

Most patients present with a painless lump,

 

swelling, or firmness of the testicle; they often

 

notice it after incidental trauma to the groin

What percentage of patients

10%

present with an acute

 

hydrocele?

 

What percentage present

10%

with symptoms of metastatic

 

disease (back pain, anorexia)?

 

What are the classifications?

Germ cell tumors (95%):

 

Seminomatous ( 35%)

 

Nonseminomatous ( 65%)

 

Embryonal cell carcinoma

 

Teratoma

 

Mixed cell

 

Choriocarcinoma

 

Nongerminal (5%):

 

Leydig cell

 

Sertoli cell

 

Gonadoblastoma

What is the major classification based on therapy?

What are the tumor markers for testicular tumors?

What are the tumor markers by tumor type?

Seminomatous and nonseminomatous tumors

1.Beta-human chorionic gonadotropin ( -HCG)

2.Alpha-fetoprotein (AFP)

-HCG—c in choriocarcinoma (100%), embryonal carcinoma (50%), and rarely in pure seminomas (10%); nonseminomatous tumors (50%)

AFP—c in embryonal carcinoma and yolk sac tumors; nonseminomatous tumors (50%)

Define the difference between seminomatous and NONseminomatous germ cell testicular tumor markers.

Which tumors almost never have an elevated AFP?

In which tumor is -HCG almost always found elevated?

How often is -HCG elevated in patients with pure seminoma?

How often is -HCG elevated with nonseminoma?

What other tumor markers may be elevated and useful for recurrence surveillance?

What are the steps in workup?

Define the stages according to TMN staging (AJCC):

Stage I?

Stage II?

Stage III?

What is the initial treatment for all testicular tumors?

What is the treatment of seminoma at the various stages:

Stage I and II?

Stage III?

Chapter 76 / Urology 757

NONseminomatous common 90% have a positive AFP and/or -HCG

Seminomatous rare only 10% are AFP positive

Choriocarcinoma and seminoma

Choriocarcinoma

Only about 10% of the time!

65%

LDH, CEA, Human Chorionic

Somatomammotropic (HCS),

Gamma-Glutamyl Transpeptidase (GGT),

PLacental Alkaline Phosphate (PLAP)

PE, scrotal U/S, check tumor markers, CXR, CT (chest/pelvis/abd)

Any tumor size, no nodes, no metastases

Positive nodes, no metastases, any tumor

Distant metastases (any nodal status, any size tumor)

Inguinal orchiectomy (removal of testicle through a groin incision)

Inguinal orchiectomy and radiation to retroperitoneal nodal basins

Orchiectomy and chemotherapy

758 Section III / Subspecialty Surgery

 

What is the treatment of

 

NONseminomatous disease

 

at the various stages:

 

Stages I and II?

Orchiectomy and retroperitoneal lymph

 

node dissection versus close follow-up

 

for retroperitoneal nodal involvement

Stage III?

Orchiectomy and chemotherapy

What percentage of stage I

95%

seminomas are cured after

 

treatment?

 

Which type is most radiosensitive?

Why not remove testis with cancer through a scrotal incision?

What is the major side effect of retroperitoneal lymph node dissection?

TESTICULAR TORSION

Seminoma (Think: Seminoma Sensitive to radiation)

It could result in tumor seeding of the scrotum

Erectile dysfunction

What is it?

Torsion (twist) of the spermatic cord,

 

resulting in venous outflow obstruction,

 

and subsequent arterial occlusion S

 

infarction of the testicle

What is the classic history?

What is a “bell clapper” deformity?

Acute onset of scrotal pain usually after vigorous activity or minor trauma

Bilateral nonattachment of the testicles by the gubernaculum to the scrotum (free like the clappers of a bell)

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