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Lorne H. Blackbourne-Surgical recall, Sixth Edition 2011.pdf
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Chapter 59 / Parathyroid 457

Tertiary HPTH? Correct calcium and phosphate; perform surgical operation to remove all parathyroid glands and reimplant 30 to 40 mg in the forearm if REFRACTORY to medical management

Why place 30 to 40 mg of sliced parathyroid gland in the forearm?

What must be ruled out in the patient with HPTH from hyperplasia?

To retain parathyroid function; if HPTH recurs, remove some of the parathyroid gland from the easily accessible forearm

MEN type I and MEN type IIa

What carcinomas are commonly associated with hypercalcemia?

What is the most likely diagnosis if a patient has a PALPABLE neck mass, hypercalcemia, and elevated PTH?

PARATHYROID CARCINOMA

Breast cancer metastases, prostate cancer, kidney cancer, lung cancer, pancreatic cancer, multiple myeloma

Parathyroid carcinoma (vast majority of other causes of primary HPTH have nonpalpable parathyroids)

What is it?

Primary carcinoma of the parathyroid

 

gland

What is the number of

1

glands usually affected?

 

What are the signs/

Hypercalcemia, elevated PTH,

symptoms?

PALPABLE parathyroid gland (50%),

 

pain in neck, recurrent laryngeal nerve

 

paralysis (change in voice), hypercalcemic

 

crisis (usually associated with calcium

 

levels 14)

What is the common tumor

Human Chorionic Gonadotropin

marker?

(HCG)

What is the treatment?

Surgical resection of parathyroid mass

 

with ipsilateral thyroid lobectomy,

 

ipsilateral lymph node resection

458 Section II / General Surgery

 

What percentage of all

1%

cases of primary HPTH are caused by parathyroid carcinoma?

POSTOPERATIVE COMPLICATIONS OF PARATHYROIDECTOMY

What are the possible postoperative complications after a parathyroidectomy?

Recurrent nerve injury (unilateral: voice change; bilateral: airway obstruction), neck hematoma (open at bedside if breathing is compromised), hypocalcemia, superior laryngeal nerve injury

What is “hungry bone

Severe hypocalcemia seen after surgical

syndrome”?

correction of HPTH as chronically

 

calcium-deprived bone aggressively

 

absorbs calcium

What are the signs/

Perioral tingling, paresthesia,

symptoms of postoperative

Chvostek’s sign, Trousseau’s sign,

hypocalcemia?

tetany

What is the treatment of

Acute: IV calcium

hypoparathyroidism?

Chronic: PO calcium, and vitamin D

What is parathyromatosis?

Multiple small hyperfunctioning

 

parathyroid tissue masses found over the

 

neck and mediastinum—thought to be

 

from congenital rests or spillage during

 

surgery—remove surgically (RARE)

C h a p t e r 60

Which arteries supply the spleen?

What is the venous drainage of the spleen?

Spleen and

Splenectomy

Splenic artery (a branch of the celiac trunk) and the short gastric arteries that arise from the gastroepiploic arteries

Portal vein, via the splenic vein and the left gastroepiploic vein

 

Chapter 60 / Spleen and Splenectomy 459

What is said to “tickle” the

Tail of the pancreas

spleen?

 

What percentage of people

20%

have an accessory spleen?

 

What percentage of the total

33%

body platelets are stored in

 

the spleen?

 

What are the functions of the human spleen?

Filters abnormal RBCs (does NOT store RBCs like canine spleen!), stores platelets, produces tuftsin and properdin (opsins), produces antibodies (especially IGM) and is site of phagocytosis

What is “delayed splenic

Subcapsular hematoma or

rupture”?

pseudoaneurysm may rupture some time

 

after blunt trauma, causing “delayed

 

splenic rupture”; rupture classically

 

occurs about 2 weeks after the injury and

 

presents with shock/abdominal pain

What are the signs/symptoms

Hemoperitoneum and Kehr’s sign, LUQ

of ruptured/injured spleen?

abdominal pain, Ballance’s sign

What is Kehr’s sign?

Left shoulder pain seen with splenic

 

rupture

What is Ballance’s sign?

LUQ dullness to percussion

What is Seagesser’s sign?

Phrenic nerve compression causing neck

 

tenderness in splenic rupture

How is a spleen injury

Abdominal CT, if the patient is stable;

diagnosed?

DPL or FAST exam if the patient is

 

unstable

What is the treatment? 1. Nonoperative in a stable patient with an isolated splenic injury without hilar involvement/complete rupture

2.If patient is unstable, DPL/FAST laparotomy with splenorrhaphy or splenectomy

3.Embolization is an option in selected patients

460 Section II / General Surgery

 

What is a splenorrhaphy?

Splenic salvage operation: wrapping vicral

 

mesh, aid of topical hemostatic agents or

 

partial splenectomy, sutures (buttressed)

What are the other

 

indications for splenectomy:

 

Malignant diseases?

Hodgkin’s staging not conclusive by CT

 

scan (rare)

 

Splenic tumors (primary/metastatic/

 

locally invasive)

 

Hypersplenism caused by other

 

leukemias/non-Hodgkin’s lymphomas

Anemias?

Medullary fibrosis with myeloid

 

metaplasia

 

Hereditary elliptocytosis

 

Sickle cell anemia (rare, most

 

autosplenectomize)

 

Pyruvate kinase deficiency

 

Autoimmune hemolytic anemia

 

Hereditary spherocytosis

 

Thalassemias (e.g., -thalassemia major

 

a.k.a. Cooley’s)

Thrombocytopenia?

ITP (Idiopathic Thrombocytopenic

 

Purpura)

 

TTP (Thrombotic Thrombocytopenic

 

Purpura)

Miscellaneous

Variceal bleeding with splenic vein

indications?

thrombosis, Gaucher’s disease, splenic

 

abscess, refractory splenic cysts,

 

hypersplenism, Felty’s syndrome

Is G6PD deficiency an

NO

indication for splenectomy?

 

What are the possible

Thrombocytosis, subphrenic abscess,

postsplenectomy

atelectasis, pancreatitis gastric dilation,

complications?

and Overwhelming PostSplenectomy

 

Sepsis (OPSS)

What causes OPSS?

Increased susceptibility to fulminant

 

bacteremia, meningitis, or pneumonia

 

because of loss of splenic function

What is the incidence of OPSS in adults?

What is the incidence and overall mortality of OPSS in children?

Chapter 60 / Spleen and Splenectomy 461

1%

1% to 2% with 50% mortality rate

What is the typical presentation of OPSS?

What are the common organisms associated with OPSS?

What is the most common bacteria in OPSS?

What is the preventive treatment of OPSS?

What is the best time to give immunizations to splenectomy patients?

What lab tests are abnormal after splenectomy?

What are the findings on postsplenectomy RBC smear?

When and how should thrombocytosis be treated?

What is the most common cause of splenic vein thrombosis?

Fever, lethargy, common cold, sore throat, URI followed by confusion, shock, and coma with death ensuing within 24 hours in up to 50% of patients

Encapsulated: Streptococcus pneumoniae, Neisseria meningitides, H. influenzae

Streptococcus pneumoniae

Vaccinations for pneumococcus,

H. influenzae, and meningococcus Prophylactic penicillin for all minor

infections/illnesses and immediate medical care if febrile illness develops

Preoperatively, if at all possible If emergent, then 2 weeks

postoperatively

WBC count increases by 50% over the baseline; marked thrombocytosis occurs; RBC smear is abnormal

Peripheral smear will show Pappenheimer bodies, Howell-Jolly bodies, and Heinz bodies

When platelet count is 1 million, most surgeons will treat with aspirin

Pancreatitis

What opsonins does the

PROperdin, TUFtsin (Think:

spleen produce?

PROfessionally TUF spleen”)

462 Section II / General Surgery

What is the most common cause of ISOLATED GASTRIC varices?

What is the treatment of gastric varices caused by splenic vein thrombosis?

Which patients develop hyposplenism?

What vaccinations should every patient with a splenectomy receive?

Define hypersplenism.

Define splenomegaly.

What is idiopathic thrombocytopenic purpura (ITP)?

What is the most common cause of failure to correct thrombocytopenia after splenectomy for ITP?

What are the “I’s” of ITP?

What is TTP?

Splenic vein thrombosis (usually from pancreatitis)

Splenectomy

Patients with ulcerative colitis

Pneumococcus

Meningococcus

Haemophilus influenzae type B

Hyperfunctioning spleen Documented loss of blood elements

(WBC, Hct, platelets) Large spleen (splenomegaly)

Hyperactive bone marrow (trying to keep up with loss of blood elements)

Enlarged spleen

Autoimmune (antiplatelet antibodies IgG in 90% of patients) platelet destruction leading to troublesome bleeding and purpura

Missed accessory spleen

Immune etiology (IgG antiplatelets ABs) Immunosuppressive treatment (initially

treated with steroids) Immune globulin

Improvement with splenectomy (75% of patients have improved platelet counts after splenectomy)

Thrombotic Thrombocytopenic Purpura

 

Chapter 61 / Surgically Correctable Hypertension 463

What is the treatment of

Plasmapheresis (splenectomy reserved as

choice for TTP?

a last resort—very rare)

What is the most common

Splenomegaly

physical finding of portal

 

hypertension?

 

C h a p t e r 61

Surgically

Correctable HTN

What is it?

What percentage of patients with HTN have a surgically correctable cause?

Hypertension caused by conditions that are amenable to surgical correction

7%

What diseases that cause

Think “CAN I CHURP?”:

HTN are surgically

Cushing’s syndrome

correctable?

Aortic coarctation

 

Neuroblastoma/neoplasia

 

Increased intracranial pressure

 

Conn’s syndrome (primary

 

hyperaldosteronism)

 

Hyperparathyroidism/hyperthyroidism

 

Unilateral renal parenchymal disease

 

Renal artery stenosis

 

Pheochromocytoma

What is the formula for

Pressure flow resistance or P

pressure?

F R (Think: Power FoRward); thus,

 

an increase in flow, resistance, or both,

 

results in an increase in pressure

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