- •Contents
- •Contributors
- •Brain Tumor Imaging
- •1 Introduction
- •1.1 Overview
- •2 Clinical Management
- •3 Glial Tumors
- •3.1 Focal Glial and Glioneuronal Tumors Versus Diffuse Gliomas
- •3.3 Astrocytomas Versus Oligodendroglial Tumors
- •3.4.1 Diffuse Astrocytoma (WHO Grade II)
- •3.5 Anaplastic Glioma (WHO Grade III)
- •3.5.1 Anaplastic Astrocytoma (WHO Grade III)
- •3.5.3 Gliomatosis Cerebri
- •3.6 Glioblastoma (WHO Grade IV)
- •4 Primary CNS Lymphomas
- •5 Metastatic Tumors of the CNS
- •References
- •MR Imaging of Brain Tumors
- •1 Introduction
- •2 Brain Tumors in Adults
- •2.1 Questions to the Radiologist
- •2.2 Tumor Localization
- •2.3 Tumor Malignancy
- •2.4 Tumor Monitoring
- •2.5 Imaging Protocol
- •Computer Tomography
- •2.6 Case Illustrations
- •3 Pediatric Brain Tumors
- •3.1 Standard MRI
- •3.2 Differential Diagnosis of Common Pediatric Brain Tumors
- •3.3 Early Postoperative Imaging
- •3.4 Meningeal Dissemination
- •References
- •MR Spectroscopic Imaging
- •1 Methods
- •1.1 Introduction to MRS
- •1.2 Summary of Spectroscopic Imaging Techniques Applied in Tumor Diagnostics
- •1.3 Partial Volume Effects Due to Low Resolution
- •1.4 Evaluation of Metabolite Concentrations
- •1.5 Artifacts in Metabolite Maps
- •2 Tumor Metabolism
- •3 Tumor Grading and Heterogeneity
- •3.1 Some Aspects of Differential Diagnosis
- •4 Prognostic Markers
- •5 Treatment Monitoring
- •References
- •MR Perfusion Imaging
- •1 Key Points
- •2 Methods
- •2.1 Exogenous Tracer Methods
- •2.1.1 Dynamic Susceptibility Contrast MRI
- •2.1.2 Dynamic Contrast-Enhanced MRI
- •3 Clinical Application
- •3.1 General Aspects
- •3.3 Differential Diagnosis of Tumors
- •3.4 Tumor Grading and Prognosis
- •3.5 Guidance for Biopsy and Radiation Therapy Planning
- •3.6 Treatment Monitoring
- •References
- •Diffusion-Weighted Methods
- •1 Methods
- •2 Microstructural Changes
- •4 Prognostic Marker
- •5 Treatment Monitoring
- •Conclusion
- •References
- •1 MR Relaxometry Techniques
- •2 Transverse Relaxation Time T2
- •4 Longitudinal Relaxation Time T1
- •6 Cest Method
- •7 CEST Imaging in Brain Tumors
- •References
- •PET Imaging of Brain Tumors
- •1 Introduction
- •2 Methods
- •2.1 18F-2-Fluoro-2-Deoxy-d-Glucose
- •2.2 Radiolabeled Amino Acids
- •2.3 Radiolabeled Nucleoside Analogs
- •2.4 Imaging of Hypoxia
- •2.5 Imaging Angiogenesis
- •2.6 Somatostatin Receptors
- •2.7 Radiolabeled Choline
- •3 Delineation of Tumor Extent, Biopsy Guidance, and Treatment Planning
- •4 Tumor Grading and Prognosis
- •5 Treatment Monitoring
- •7 PET in Patients with Brain Metastasis
- •8 Imaging of Brain Tumors in Children
- •9 Perspectives
- •References
- •1 Treatment of Gliomas and Radiation Therapy Techniques
- •2 Modern Methods and Strategies
- •2.2 3D Conformal Radiation Therapy
- •2.4 Stereotactic Radiosurgery (SRS) and Radiotherapy
- •2.5 Interstitial Brachytherapy
- •2.6 Dose Prescription
- •2.7 Particle Radiation Therapy
- •3 Role of Imaging and Treatment Planning
- •3.1 Computed Tomography (CT)
- •3.2 Magnetic Resonance Imaging (MRI)
- •3.3 Positron Emission Tomography (PET)
- •4 Prognosis
- •Conclusion
- •References
- •1 Why Is Advanced Imaging Indispensable for Modern Glioma Surgery?
- •2 Preoperative Imaging Strategies
- •2.4 Preoperative Imaging of Function and Functional Anatomy
- •2.4.1 Imaging of Functional Cortex
- •2.4.2 Imaging of Subcortical Tracts
- •3 Intraoperative Allocation of Relevant Anatomy
- •Conclusions
- •References
- •Future Methods in Tumor Imaging
- •1 Special Editing Methods in 1H MRS
- •1.1 Measuring Glycine
- •2 Other Nuclei
- •2.1.1 Spatial Resolution
- •2.1.2 Measuring pH
- •2.1.3 Measuring Lipid Metabolism
- •2.1.4 Energy Metabolism
- •References
MR Imaging of Brain Tumors
Elke Hattingen and Monika Warmuth-Metz
Contents |
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1 |
Introduction ........................................................................ |
12 |
2 |
Brain Tumors in Adults ..................................................... |
12 |
2.1 |
Questions to the Radiologist................................................. |
12 |
2.2 |
Tumor Localization .............................................................. |
16 |
2.3 |
Tumor Malignancy ............................................................... |
18 |
2.4 |
Tumor Monitoring ................................................................ |
20 |
2.5 |
Imaging Protocol .................................................................. |
27 |
2.6 |
Case Illustrations .................................................................. |
34 |
3 |
Pediatric Brain Tumors...................................................... |
38 |
3.1 |
Standard MRI ....................................................................... |
38 |
3.2 |
Differential Diagnosis of Common Pediatric |
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Brain Tumors ........................................................................ |
40 |
3.3 |
Early Postoperative Imaging ................................................ |
43 |
3.4 |
Meningeal Dissemination..................................................... |
43 |
3.5 |
Follow-Up Examinations...................................................... |
48 |
References .................................................................................... |
52 |
Abstract
This chapter gives an overview of important radiological aspects in brain tumor imaging. It was not our aim to deal with the wide differential diagnosis of brain tumors, and this chapter should not replace a neuroradiological textbook. Instead, it addresses important radiological and neurological aspects which should be known by the radiologist reporting brain tumors. In general, age is one of the most important criterion to distinguish different brain neoplasms, since the differential diagnosis differ considerably between ages. Therefore, the chapter is divided into childhood and adulthood brain tumors. Further, important pitfalls in brain tumor diagnosis are treated especially concerning non-neoplastic brain lesions and post-treat- ment changes. The localization of brain tumors in relation to functional brain areas is another important issue which has to be reported by the neuroradiologist, since preservation of important brain function is the ultimate goal and determines the treatment modality. Therefore, this chapter gives some help to localize a tumor with respect to the functional primary motor and language areas.
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Abbreviations |
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MRI |
Magnetic resonance imaging |
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CT |
Computed tomography |
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CNS |
Central nervous system |
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SE |
Spin echo |
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FLAIR |
Fluid-Attenuated Inversion Recovery |
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PD |
Proton density |
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i.v. |
intravenous |
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fMRI |
Functional MRI |
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E. Hattingen (*) |
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DWI |
Diffusion-weighted imaging |
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Neuroradiology, University Hospital of Goethe University |
ADC |
Apparent diffusion coefficient |
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Frankfurt, Schleusenweg 2-16, 60528, Frankfurt |
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DTI |
Diffusion tensor imaging |
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e-mail: Elke.Hattingen@kgu.de |
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SWI |
Susceptibility-weighted imaging |
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M. Warmuth-Metz |
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PNET |
Primitive neuroepithelial tumor |
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Neuroradiology, University Hospital of Würzburg, |
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DNET |
Dysembryoplastic neuroepithelial tumor |
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Josef-Schneider-Str. 2, 97080, Würzburg |
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E. Hattingen, U. Pilatus (eds.), Brain Tumor Imaging, |
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11 |
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Medical Radiology. Diagnostic Imaging, |
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DOI: 10.1007/174_2016_936, © Springer-Verlag Berlin Heidelberg 2016 |
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