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Essential

Neurology

Dedication

To both Biddies with love

FOURTH EDITION

Essential

Neurology

Iain Wilkinson

BSc, MD, MA, FRCP

Formerly Consultant Neurologist Addenbrooke’s Hospital Cambridge

and

Fellow of Wolfson College and Associate Lecturer

University of Cambridge Medical School

Graham Lennox

BA FRCP

Consultant Neurologist Addenbrooke’s Hospital Cambridge

and

West Suffolk Hospital Bury St Edmunds

© 2005 by Blackwell Publishing Ltd

Blackwell Publishing, Inc., 350 Main Street, Malden, Massachusetts 02148-5020, USA

Blackwell Publishing Ltd, 9600 Garsington Road, Oxford OX4 2DQ, UK Blackwell Publishing Asia Pty Ltd, 550 Swanston Street, Carlton,

Victoria 3053, Australia

The right of the Author to be identified as the Author of this Work has been asserted in accordance with the Copyright, Designs and Patents Act 1988.

All rights reserved. No part of this publication may be reproduced, stored

in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted

by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher.

First published 1988 Reprinted 1989, 1992 Four Dragons edition 1989 Reprinted 1992

Second edition 1993 Reprinted 1994, 1995, 1996

Four Dragons edition 1993 Reprinted 1994, 1997, 1998 Third edition 1999

Reprinted 2000, 2001, 2002, 2004 Fourth edition 2005

Library of Congress Cataloging-in-Publication Data

Wilkinson, I.M.S.

Essential neurology / Iain Wilkinson, Graham Lennox.—4th ed.

p.; cm.

Includes bibliographical references and index. ISBN-13: 978-1-4051-1867-5

ISBN-10: 1-4051-1867-9

1. Neurology. 2. Nervous system—Diseases.

[DNLM:

1. Nervous System Diseases. WL 140 W686e 2005]

I. Lennox, Graham. II. Title.

RC346.W55

2005

616.8—dc22

2004019636

ISBN-13: 978-1-4051-1867-5

ISBN-10: 1-4051-1867-9

Acatalogue record for this title is available from the British Library

Set in 9.25 on 12 pt Palatino

by SNP Best-set Typesetter Ltd., Hong Kong

Printed and bound in India by Replika Press Pvt, Ltd, Kundli

Commissioning Editor: Vicki Noyes

Editorial Assistant: Nicola Ulyatt

Development Editor: Lorna Hind

Production Controller: Kate Charman

For further information on Blackwell Publishing, visit our website: http://www.blackwellpublishing.com

The publisher’s policy is to use permanent paper from mills that operate a sustainable forestry policy, and which has been manufactured from pulp processed using acid-free and elementary chlorine-free practices.

Furthermore, the publisher ensures that the text paper and cover board used have met acceptable environmental accreditation standards.

Contents

Preface to the fourth edition, vii

Preface to the first edition, viii

Acknowledgements, ix

Abbreviations, x

1Clinical skills, physical signs and anatomy, 1

2Stroke, 25

3Brain tumour, 40

4Head injury, 55

5Parkinsonism, involuntary movements and ataxia, 67

6Paraplegia, 83

7Multiple sclerosis, 99

8Cranial nerve disorders, 111

9Nerve root, nerve plexus and peripheral nerve lesions, 137

10Motor neurone disease, peripheral neuropathy, myasthenia gravis and muscle disease, 155

11Unconsciousness, 175

12Epilepsy, 192

13Headache and facial pain, 213

14Dementia, 224

15Infections of the nervous system, 238 Answers to case histories, 255 Index, 269

v

Preface to

the fourth edition

The three previous editions of this book were written by only one of us. The addition of a younger and enthusiastic second author has undoubtedly improved the book. It is more accurate and thoroughly modern. Both authors have been singleminded in their intention to present, clearly and concisely, that neurology and neurosurgery which is required by medical students at the time of graduation.

The revision of diagrams, use of colour, clarification of text, and inclusion of illustrative case histories have all helped, but it is the authors’ discipline to adhere closely to the title of the book, Essential Neurology, which makes them hope that the textbook remains helpful to its readers.

I.W. and G.L.

vii

Preface to

the first edition

Excellent textbooks of neurology already exist, which deal with the subject in a detailed and comprehensive manner. This is not what the majority of clinical medical students require.

In writing this textbook, I have been preoccupied with the following questions:

Have I kept to basic principles?

Have I made each topic as easy as possible to understand, both in the text and in the diagrams?

Have I omitted all unnecessary detail?

There is no section in the book specifically dedicated to ‘How

to examine the nervous system’. I believe each student has to learn this by apprenticeship to clinical neurologists in the ward and in the clinic.

Every effort has been made to ensure that this book lives up to its name, in setting out clearly all that the student needs to know about the common neurological and neurosurgical conditions.

I.W.

viii

Acknowledgements

We both want to acknowledge the very great help of Drs N. Antoun and J. Gillard in preparation of the neuroradiological images.

ix

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