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Copyright

Elsevier

1600 John F. Kennedy Blvd.

Ste 1800

Philadelphia, PA 19103-2899

PRINCIPLES OF PULMONARY MEDICINE, EIGHTH EDITION           ISBN: 978-0-323-88056-5

Copyright © 2024 by Elsevier, Inc. All rights reserved.

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.

This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Notice

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds or experiments described herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors or contributors for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.

Previous editions copyrighted 2019, 2014, 2008, 2004, 1998, 1992, and 1986.

Senior Content Strategist: Charlotta Kryhl

Senior Content Development Specialist: Vasowati Shome

Publishing Services Manager: Jameel Shereen

Project Manager: Nandhini Thanga Alagu

Design Direction: Bridget Hoette

Printed in India

Last digit is the print number: 9 8 7 6 5 4 3 2 1

Dedication

To our families and to the students and trainees we have had the privilege of teaching over many years.

Introduction to the eighth edition

Steven E. Weinberger, MD, MACP, FRCP, Barbara A. Cockrill, MD, Jess Mandel, MD, MACP, FRCP

Principles of Pulmonary Medicine was first published in 1986 as a “concise, core reference [that] emphasizes pathophysiology and diagnosis as the basis for optimal management of respiratory disorders. Physiologic, radiologic, and pathologic features of diseases are correlated with clinical findings providing an integrated, comprehensive approach.” Much has changed over eight editions of the book and the more than 35 years that have elapsed since the first edition. Our understanding of many disease processes has improved, our diagnostic tests have become more sophisticated, and our therapeutic armamentarium has been expanded and improved. The single author of the first four editions, Steven E. Weinberger, MD, MACP, FRCP, was joined starting with the fifth edition by two additional authors, Barbara A. Cockrill, MD, and Jess Mandel, MD, MACP, FRCP; their knowledge, experience, and perspectives have greatly enhanced the quality of the book. Since the fifth edition, we added and subsequently expanded supplementary images and self-assessment questions accessible on the internet, recognizing the importance of learners being able to assess their knowledge and their understanding of concepts that can at times be difficult to grasp.

Although the primary audience has always been the medical student taking a respiratory pathophysiology course, the book has also been extensively used by residents and practicing physicians and by other healthcare professionals who care for patients with pulmonary disease. A persistent goal throughout all editions of the book has been to present physiologic concepts, pathogenetic and pathophysiologic mechanisms, and radiologic and pathologic correlates of disease in a clear fashion that can be easily understood even by the beginning student of pulmonary medicine. We have also continued to include margin notes throughout the text, which summarize the major points and concepts and allow the reader to quickly review the material. Starting with the second edition, we included three appendices that provide simplified methods for interpreting pulmonary function tests and arterial blood gases, while also presenting sample problems that test the reader’s ability to use respiratory equations, assess pulmonary function abnormalities, and interpret arterial blood gases.

Many changes and updates have been incorporated in the eighth edition. Whereas histopathologic and other images were printed in black and white in previous editions, these and additional images are shown in color in the current edition. We have also added more images—particularly plain chest radiographs and computed tomographic scans—to provide additional examples of the appearance of many clinical disorders on imaging studies. Finally, in the era of COVID-19 and new diagnostic and therapeutic options for a number of disorders, we have updated the text to include information about organisms such as SARS-CoV-2 and expanded coverage of new biologic and immunologic treatments available for a variety of diseases.

We have been most gratified by the popularity of the textbook, which has been used extensively not only in the United States and Canada but also in other countries throughout the world. Various editions have been translated into Spanish, Portuguese, Italian, Japanese, Chinese, and Polish. Although there may be

some differences in diagnostic and therapeutic approaches to pulmonary diseases in different countries, the conceptual underpinnings of physiology, pathophysiology, and disease mechanisms that we are trying to convey in a readable fashion are universal.

It has been a pleasure to work with the editorial staff at Elsevier in development of this edition, just as it has been for past editions. We particularly want to express our appreciation to Robin Carter, Content Strategist; Vasowati Shome, Content Development Specialist; Nandhini Thanga Alagu, Project Manager; Bridget Hoette, Book Designer; and the efforts of Elsevier. Finally, we are most grateful to our families for their support and understanding as we had to sacrifice time with them to prepare this new edition of the book.