- •Лечение больных с различными клиническими вариантами гнёздной алопеции с учётом патогенетических особенностей заболевания
- •Оглавление
- •Физиология волосяного фолликула
- •Современные представления об эпидемиологии, этиологии и патогенезе гнёздной алопеции
- •Глава 3. Результаты собственных исследований
- •Глава 4. Эффективность лечения пациентов с гнёздной алопецией
- •Глава 5. Состояние тканевого гомеостаза в очагах га при медикаментозной ремиссии
- •Глава 6. Клинические наблюдения сложных вариантов течения га 133
- •Глава 7. Обсуждение………………………………………………………….146 Выводы…………………………………………………………………………178 Практические рекомендации………………………………………………..181
- •Список сокращений
- •Введение
- •Задачи исследования
- •Глава 1. Обзор литературы
- •Физиология волосяного фолликула
- •Рост и развитие вф, апоптоз и стволовые клетки
- •Состояние региональных сосудов и экспрессия маркёра ангиогенеза в тканях вф в норме
- •Иммунная привилегия вф
- •Современные представления об эпидемиологии, этиологии и патогенезе гнёздной алопеции
- •Эпидемиология га
- •Факторы, инициирующие развитие га: генетические аспекты,
- •Иммуногенетические аспекты га: роль hla-, hla-1 генов и некоторых цитокинов в патогенезе заболевания
- •Обзор современных методов лечения га
- •Мониторинг пациентов с га
- •Глава 2. Материал и методы исследования
- •Общая клиническая характеристика больных
- •Особенности немедикаментозного мониторинга
- •Клиническая характеристика пациентов в соответствии со степенью потери волос
- •Покрова
- •Методы исследования
- •Статистическая обработка данных
- •Глава 3. Результаты собственных исследований
- •3.1. Оценка степени тяжести заболевания и общая характеристика данных с учётом тяжести процесса
- •Морфологические изменения в очагах пораженной кожи у больных га
- •Особенности пролиферации, дифференцировки и апоптоза клеток, а также процесса ангиогенеза при га
- •(Контроль)
- •Глава 4. Эффективность лечения пациентов с гнёздной алопецией (ближайшие и отдаленные результаты)
- •Клиническая характеристика и результаты лечения пациентов 1-й группы
- •Клиническая характеристика и результаты лечения пациентов
- •Результаты лечения
- •Глава 5. Состояние тканевого гомеостаза в очагах гнёздной алопеции при медикаментозной ремиссии
- •Клиническая оценка состояния кожи в очагах га после отрастания волос и особенности дерматоскопической картины
- •Особенности морфологической картины и распределения клеток воспалительного инфильтрата
- •Динамика распределения клеток модуляции иммунитета в образцах с га на фоне лечения с учётом активности патологического процесса (m±m, %)
- •Особенности распределения ключевых молекул дифференцировки, пролиферации, апоптоза и ангиогенеза
- •Динамика распределения ключевых молекул дифференцировки, пролиферации и ангиогенеза при возобновлении роста волос на фоне лечения га с учётом активности патологического процесса (m±m, %)
- •Глава 6. Клинические наблюдения сложных вариантов течения га
- •Глава 7. Обсуждение
- •Практические рекомендации
- •Список литературы
- •Соответствующий анамнез инфекций, имевших место в ближайшие 6 месяцев перед началом потери волос:
- •Оценка распространённости алопеции до лечения.
- •Состояние поражения ногтей.
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Приложение 1.
Протокол исследования пациента с гнёздной алопецией №
Ф.И.О.
Дата приёма
Возраст
1.5 Пол Муж. Жен.
1.6 Расовая принадлежность:
конт. тел.
Дата рождения
Европеоидная 1.6.3 Негроидная
славянин
скандинав
средиземноморский тип
1.6. 2 Монголоидная
1.7 Преимущественный цвет волос
Чернокожий африканец
Чернокожий латиноамериканец
1.6.4 Национальность
Черный
Коричневый
Рыжий
Серый
Блондин
Белый
Анамнез пациента и членов его/ее семьи
Анамнез пациента и членов его/ее семьи |
Пациент |
Мать |
Отец |
Сын |
Дочь |
Брат |
Сестра |
Бабушка по линии матери |
Дедушка по линии матери |
Бабушка по линии отца |
Дедушка по линии отца |
Тетя по линии матери |
Дядя по линии матери |
Тетя по линии отца |
Дядя по линии отца |
Атопический дерматит |
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Аллергический ринит |
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Астма |
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Заб-е щитовид. железы |
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Тиреоидит Хашимото |
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Болезнь Грейвса |
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Витилиго |
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Сахарный диабет |
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типа 1 |
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типа 2 |
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неизвестный тип |
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Систем. красн. волчанка |
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Злокачественная анемия |
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Ревматоидный артрит |
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Язвенный колит |
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Глютен. б-нь (целиакия) |
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Псориаз |
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Прочие а/им заб-я |
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Тип |
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Синдром Дауна |
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Иммунодефицит |
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Тип |
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Гнёздная алопеция |
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Прочие заболевания |
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Анамнез гнездной алопеции:
Количество предшествующих эпизодов гнездного облысения
Возраст в момент начала 1-го эпизода гнездного облысения
Первый эпизод гнездного облысения (месяц/год начала)
Анамнез тотальной формы или тотальной/универсальной формы ГА, возникавшей в какое-либо время:
продолжительностью >2 лет
продолжительностью ≤2 лет
Текущий эпизод гнездного облысения:
Возраст начала
Месяц/год начала
3.5.2 Продолжительность текущего эпизода (месяцы):
3.5.3.1 |
< 3 мес, |
3.5.3.4 |
>2-5 лет, |
3.5.3.2 |
3–12 мес, |
3.5.3.5 |
>5 лет. |
3.5.3.3 |
12–24 мес |
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