Практическиерекомендации

1. .Врамкахпервичногообследованиярекомендуетсяпроводитьиммуноблотингдляобнаруженияядерныхантителкаккритериясистемностипроцесса.НастадияхпятнадляисключенияболезниЛаймарекомендованапостановкаИФАивестерн-блотта.

2. .Наружнаятерапияпрепаратомтакролимус0,1%показанадлялеченияпациентовсочаговойсклеродермиейвнезависимостиотстадиипатологическогопроцесса,приограниченныхпоражениях–ввидемонотерапии.Лечениерекомендуетсяпроводить2разавденьвтечение12недель.

3. .Противопоказаниямидляпримененияпредложенногометоданаружнойтерапииочаговойсклеродермииявляютсяобщиепротивопоказанияииндивидуальнаянепереносимостьпрепарататакролимус0,1%.

Списоклитературы

1. АдаскевичВ.П.Диагностическиеиндексывдерматологии//М.,-2004.-160c.

2. БаткаевЭ.А.,ГалямоваЮ.А.Склеродермия//Учебноепособие.Российскаямедицинскаяакадемияпоследипломногообразования.М.,2002.24с.

3. БелоусоваТ.А.,КолмогороваИ.В.,МокинаЕ.В.ГемиатрофиялицаРомбер-га:современныйвзгляднапроблему//Российскийжурналкожныхивене-рическихболезней-1999.-№5.-С.20–23.

4. БелоусоваТ.А.,ТеплюкН.П.,КладоваАЛО.Онозологическойпринадлеж-ностиатрофодермииПазиниПьерини//Клиническаядерматологияивене-рология.- 2003.-№2.-С.16-19.

5. БолотнаяЛ.А.,ШаховаФ.Б.,СербинаИ.М.Новоевпатогенезеитерапииограниченнойсклеродермии//Вестникдерматогииивенерологии-2004.-

№2. -С. 31–34.

6. БутовЮ.С.//Антинуклеарныеантителаубольныхсистемнымизаболевани-ями//Вестн.дерматол.–1980.–II.–C.17–21.

7. ВладимирцевВ.А.,АвдееваЖ.И.,ГусеваН.Г.идр.//ИзучениеклеточногоиммунногоответанаколлагенIтипаубольныхсистемнойсклеродермией.

–Вопр.ревмат.– 1982. –I. –С. 33–38.

8. ВолнухинВ.А.Некоторыевопросытерминологиииклассификациисклеро-дермии//Рос.журн.кожн.ивен.бол.2002.-№4.-С.30-33.

9. ВыборноваО.В.,ВолнухинВ.А.,ВавиловA.M.исоавт.Гистологическое,гистохимическое,электронно-микроскопическоеиэлектронно-цитохими-ческоеисследованиекожибольныхограниченнойсклеродермией//Рос.журн.кожн.ивен.бол.2002.-№4.-С. 33-37.

10. ГончароваЛ.И.,ХаритоноваН.И.СочетаниеидиопатическойатрофодермииПазини-Пьериниибляшечнойсклеродермии//Вестн.дерматол.венерол.1988.-№7.-С. 68-69.

11. ГусеваН.Г.Проблемыдиагностикиилечениясистемнойсклеродермии//

Рус.мед.журн.1998.-Т.6.-№8.-С.486-492.

12. .ГусеваН.Г.Системнаясклеродермияипсевдосклеродермическиесиндромы//М.,Медицина.-1993.-C.268.

13. .ДовжанскийС.И.Клинико-иммунологическиепараллелиприограниченнойисистемнойсклеродермии//Рос.журн.кожн.ивен.бол.2002,№4.С.26–29.

14. .ДолбинА.Г.,ФедороваЕ.Г.,ЗарецкаяЮ.М.АнтигенысистемыHLAуболь-ныхочаговойсклеродермиейиатрофодермиейПазини-Пьерини//Вестн.дерматол.венерол.1978.-№7.-С.16-19

15. .ИвановаС.М.Клинико-иммунологическиеособенностидиффузныхболез-нейсоединительнойтканисантителами,кэкстрагируемымядерным-анти-генам.//Диссертациянасоисканиеученойстепеникандидатамедицинскихнаук.Москва.-1984.-C.130.

16. .ИвановаС.М.,ГусеваН.Г.,ЗацепинаО.В.исоавт.Аутоиммунитетприскле-родермии//Сборниктрудов.Современныепроблемыаллергологии,клини-ческойиммунологииииммунофармакологии.М.,1998.-С.365.

17. .МордовцевВ.Н.,ПрохоровА.Ю.МордовцевВ.Н.идр.Современныеконцеп-циипопатогенезупсориаза//Вестникдерматологии-1987.-№7.-C.28-33.

18. .НовакА.А.,ИоноваТ.И.Руководствопоисследованиюкачестважизнивмедицине.–СПб.,-2002.-320с.

19.ПальцевМ.А.Клинико-морфологическаядиагностиказаболеванийкожи/

ПальцевМ.А.,ПотекаевН.Н.-М.:Медицина,2004.-С.

20.ПирузянЭ.С.,ИшкинА.А.,НикольскаяТ.А.идр.Сравнительныйанализмо-лекулярно-генетическихпроцессовприпатогенезепсориазаиболезниКрона//Молекулярнаябиология-2009.-Т.43,№1-С.175-179.

21.ПирузянЭ.С.,НикольскаяТ.А.,АбдеевР.М.,БрускинС.А.КомпонентытранскрипционногофактораAP-1какгены-кандидаты,участвующиевразвитиипсориатическогопроцесса//Молекулярнаябиология.-2007.-Т.41

-С. 1069-1080.

22. .ПотекаевН. С.,ПотекаевН.Н.БолезньЛаймаиобусловленныееюпоражениякожи//Вестникдерматологииивенерологии- 2006. -№6.-С. 3–9

23. .РазумовА.Н.,ПокровскийВ.И.Здоровьездоровогочеловека.-М.,-2007.-С.

15-24.

22. .СоболевВ.В.,СтародубцеваН.Л.,А.Л.Пирузян,идр.СравнительноеисследованиеэкспрессиигеновATF-3иATF-4впораженныхатеросклеротическимпроцессомсосудахивкожеприпсориатическомпроцессе//Бюллетеньэкспериментальнойбиологииимедицины-2011.-Т.151,№6-С. 659-663.

23. .ТурпаевК.Т.РольфакторатранскрипцииAP-1винтеграциивнутриклеточныхсигнальныхсистем//Молекулярнаябиология-2006.-Т.40,№6.-С. 945-961

24. .ХамагановаИ.В.,СавинаМ.И.,СвешниковаЕ.Е.Характеристикаядерныхкомпонентовлимфоцитовприочаговойсклеродермии//Рос.журн.кожн.ивен.бол.-2002. -№4. -С. 42-44.

27. AnticM, Lautenschlager S,Itin PH. Eosinophilicfasciitis 30 years after—whatdowereallyknow?Reportof11patientsandreviewoftheliterature//Dermatology

-2006. -Vol.213,N 2. - Pp.93–101.

27. ArkachaisriT,VilaiyukS,LiS,O’NeilKM,PopeE,HigginsGC,etal.Thelocalizedsclerodermaskinseverityindexandphysicianglobalassessmentofdiseaseactivity:aworkinprogresstowarddevelopmentoflocalizedscle-rodermaoutcomemeasures//JRheumatol-2009.-Vol.36,N2.-Pp.2819-2829.

28. ArkachaisriT,VilaiyukS,TorokKS,MedsgerTAJr.Develop-mentandinitialvalidationofthelocalizedsclerodermaskindamageindexandphysicianglobalassessmentofdiseasedamage:aproof-of-conceptstudy//Rheumatology(Oxford)- 2010. -Vol.49, N 2. - Pp.373-381.

29. AzadJ,DawnG,ShaffraliFCGetal.Doessolitarymorphoeaprofunduspro-gress?//ClinExpDermatol-2004.-Vol.29,N1.-Pp.25–27.

30. Bakiri,L.,Matsuo,K.,Wisniewska,M.,Wagner,E.F.,andYaniv,M.PromoterspecificityandbiologicalactivityoftetheredAP-1dimers//MolCellBiol-2002.-Vol.22 - Pp.4952-4964.

31. BarbagliG,PalminteriE,BaloSetal.Lichensclerosusofthemalegenitaliaandurethralstricturediseases//UrolInt-2004.-Vol.73,N1.-Pp.1–5.

32. BarbarinoJuliaM,StaatzChristineE,VenkataramananRaman,KleinTeriE,AltmanRussB.PharmGKBsummary:cyclosporineandtacrolimuspathways//Pharmacogeneticsandgenomics-2013.-Vol.23,N10.-Pp563-585.

33. BarnesTC,SpillerD,AndersonME,EdwardsSW,MootsRJ.Endothelialcellactivationandapoptosismediatedbyneutrophil-dependentinterleukin6trans-signalling:anoveltargetforsystemicsclerosis?//AnnalsoftheRheumaticDiseases-2011.-Vol. 70,N.2- Pp.366-372.

34. BirdiN,LaxerRM,ThornerP,FritzlerMJ,SilvermanED:Localizedsclerodermaprogressingtosystemicdisease.Casereportandreviewoftheliterature//Arthritisandrheumatism-1993.-Vol.36,N3.-Pp.410-415.

35. Bohmann,D.,Bos,T.J.,Admon,A.,Nishimura,T.,Vogt,P.K.,andTjian,R.Human proto-oncogenec-junencodes a DNAbindingprotein withstructural andfunctionalpropertiesoftranscriptionfactorAP-1//Science-1987.-Vol.238,N4832. - Pp. 1386-1392.

36. BramleyP,ForbesA.Acaseofprogressivehemiatrophypresentingwithspon-taneousfracturesofthelowerjaw//BMJ-1960.-Vol.1,N584.-Pp.1476–1478.

37. BruckdorferKR,HillaryJB,BunceT,VancheeswaranR,BlackCM.Increasedsusceptibilitytooxidationoflow-densitylipoproteinisolatedfrompatientswithsystemicsclerosis//ArthritisRheum-1995.-Vol.38,N8.-Pp.1060-1067.

38. BuechnerSA,RufliT.AtrophodermaofPasiniandPierini.ClinicalandhistopathologicfindingsandantibodiestoBorreliaburgdorferiinthirty-fourpatients//JAmAcadDermatol-1994.-Vol.30,N3.-Pp.441-446.

39. BurgdorfWHC,WorretW,SchultkaO.Acrodermatitischronicaatrophicans//IntJDermatol-1979.-Vol.18-Pp.595–601

40. Casciola-RosenL,WigleyF,RosenA.Sclerodermaautoantigensareuniquelyfragmentedbymetal-catalyzedoxidationreactions:Implicationsforpathogenesis

//JExp Med- 1997.-Vol.185, N1. -Pp. 71-79.

27. Caubet,J.F.,Mitjavila,M.T.,Dubart,A.,Roten,D.,Weil,S.C.,andVainchenker,

W.Expressionofthec-fosprotooncogenebyhumanandmurineerythroblasts//Blood- 1989.-Vol.74, N3. -Pp. 947-951.

27. Chen,L.,Glover,J.N.,Hogan,P.G.,Rao,A.,Harrison,S.C.StructureoftheDNA-bindingdomainsfromNFAT,FosandJunboundspecificallytoDNA//Nature-1998.-Vol.392 - Pp.42–48.

28. Chinenov,Y.,Kerppola,T.K.Closeencountersofmanykinds:Fos–Juninteractionsthatmediatetranscriptionregulatoryspecificity//Oncogene-2001.

-Vol.20, N19. - Pp.2438–2452.

27. ChoJW,ChaYC,LeeKS:AP-1transcriptionfactordecoyreducestheTGF-beta1-inducedcellgrowthinsclerodermafibroblaststhroughinhibitionofcyclinE//Oncologyreports-2008.-Vol.19,N3.-Pp.737-741.

28. ChoJW,KimJY,KimCW,LeeKS:Down-regulationof TGF-beta1-inducedtypeIcollagensynthesisbyAP-1transcriptionfactordecoyinsclerodermafibroblasts

//Journalofdermatologicalscience-2006-Vol.43,N3.-Pp.207-209.

27. Choi SW,YangJE, ParkHJet al.Acase ofextragenitallichen sclerosusfollowingBlaschko’slines//JAmAcadDermatol-2000.-Vol.43,N5.-Pp.903–904.48.ChristiansonHB,DorseyES,O’LearyPA,KierlandR.Localizedscleroderma:aclinicalstudyof235cases//ArchDermatol-1956.-Vol.74-Pp.629–639.49.ChungKY,AgarwalA,UittoJ,MauvielA.AnAP-1bindingsequenceisessential

forregulationofthehumanalpha2(I)collagen(COL1A2)promoteractivitybytransforminggrowthfactor-beta//TheJournalofbiologicalchemistry-1996.-Vol.271, N6. - Pp.3272-3278.

50. ChungL,LinJ,FurstDE,FiorentinoD.Systemicandlocalizedscleroderma//ClinDermatol-2006.-Vol.24,N5.-Pp.374-392.

51. CottonSA,HerrickAL,JaysonMI,FreemontAJ:TGFbeta--aroleinsystemicsclerosis?//TheJournalofpathology-1998.-Vol.184,N1.-Pp.4-6.

52. CowperSE,RobinHS,SteinbergSMetal.Scleromyxoedema-likecutaneousdiseasesinrenaldialysispatients//Lancet-2000.-Vol.356,N9234.-Pp.1000–1001.

53. D’ArpaO,White-CooperH,ClevelandDW,RothfieldNF,EarnshawWC.UseofmolecularcloningmethodstomapthedistributionofepitopesontopoisomeraseI(Scl-70)recognizedbyseraofsclerodermapatients//ArthritisRheum-1990.-Vol.33,N 10.- Pp.1501–1511.

54. DaoudMS,SuWPD,LeifermanKM,PerniciaroC.Bullousmorphea:clinical,pathologic,andimmunopathologicevaluationof13cases//JAmAcadDermatol

-1994. -Vol.30,N 6. - Pp.937–43.

50. DentonCP,AbrahamDJ:Transforminggrowthfactor-betaandconnectivetissuegrowthfactor:keycytokinesinsclerodermapathogenesis//Currentopinioninrheumatology-2001.-Vol.13,N6.-Pp.505-511.

51. DerynckR,FengXH.TGF-betareceptorsignaling//BiochimBiophysActa-1997.-Vol.1333 - Pp.105–150.

52. DiSilverioA,SerriF.Generalizedbullousandhaemorrhagiclichensclerosusetatrophicus//BrJDermatol-1975.-Vol.93,N2.-Pp.15–7.

53. Diaz-PerezJL,ConnollySM,WinkelmannRK.Disablingpanscleroticmorphoea

ofchildren//ArchDermatol-1980.-Vol.116,N2.-Pp.169–73

50. Dony,C.,andGruss,P.Proto-oncogenec-fosexpressioningrowthregionsoffetalboneandmesodermalwebtissue//Nature-1987.-Vol.328,N6132.-Pp.711-714.

51. Dooley A,Shi-wenX,AdenN,TranahT,DesaiN,DentonCP,etal.ModulationofcollagentypeI,fibronectinanddermalfibroblastfunctionandactivity,insystemicsclerosisbytheantioxidantepigallocatechin-3-gallate//Rheumatology

-2010. -Vol. 49,N11. - Pp.2024-2036.

50. DytocMT,KossintsevaI,TingPT.Firstcaseseriesontheuseofcalcipotriol-betamethasonedipropionateformorphoea//BrJDermatol-2007.-Vol.157,N3. - Pp. 615-618.

51. EickelbergO,PanskyA,KoehlerE,BihlM,TammM,HildebrandP,PerruchoudAP,KashgarianM,RothM.MolecularmechanismsofTGF-betaantagonismbyinterferon-γandcyclosporineAinlungfibroblasts//FASEBJ-2001.-Vol.15,N 3. - Pp. 797–806.

52. ElovicAE, Ohyama H, SautyA, McBride J,TsujiT,Nagai M, et al.IL-4-dependentregulationofTGFalphaandTGFbeta1expressioninhumaneosinophils//JImmunol-1998.-Vol.160,N12.-Pp.6121-6127.

53. FarrellAM,MarrenPM,WojnarowskaF.Genitallichensclerosusassociatedwithmorphoeaorsystemicsclerosus:clinicalandHLAcharacteristics//BrJDermatol-2000.-Vol.143,N3.-Pp.598–603.

54. FerrariN,PfefferU,Dell'EvaR,AmbrosiniC,NoonanDMandAlbiniAThetransforminggrowthfactor-betafamilymembersbonemorphogeneticprotein-2andmacrophageinhibitorycytokine-1asmediatorsoftheantiangiogenicactivityofN-(4-hydroxyphenyl)retinamide//ClinCancerRes-2005-Vol.11,Pp.4610-4619.

55. FlangaV,MedsgerTAJr,ReichlinM.Antinuclearandanti-single-strandedDNAantibodiesinmorpheaandgeneralizedmorphea//ArchDermatol-1987.-Vol.123, N 3. - Pp. 350–353.

56. FleischmajerR,PerlishJS,ReevesJR.Cellularinfiltratesinsclerodermaskin//ArthritisRheum-1977.-Vol.20,N4.-Pp.975–84.

57. Flindt-HansenH,IsagerH.Sclerodermaafteroccupationalexposuretotrichlor-ethyleneandtrichlorethane// ActaDermVenereol(Stockh)-1987.-Vol.67,N3. - Pp. 263–264.

58. GalindoM,SantiagoB,AlcamiJ,RiyeroM,Martin-SerranoJ,PablosJL.Hypoxiainducesexpressionofthechemokinesmonocytechemoattractantprotein-1(MCP-1)andIL-8inhumandermalfibroblasts//ClinExpImmunol-2001.-Vol. 123,N 1. -36-41.

59. Greenberg,M.E.,andZiff,E.B.Stimulationof3T3cellsinducestranscriptionofthec-fosproto-oncogene//Nature-1984-Vol.311,Pp.433-438.

60. Grigoriadis,A.E.,Schellander,K.,Wang,Z.Q.,andWagner,E.F.Osteoblastsaretargetcellsfortransformationinc-fostransgenicmice//JCellBiol-1993.-Vol.122, N 3. - Pp. 685-701.

61. GrobnerT.Gadolinium—aspecifictriggerforthedevelopmentofnephrogenicfibrosingdermopathyandnephrogenicsystemicfibrosis?//NephrolDialTransplant-2006.-Vol.21,N4.-Pp.1104–1108.

62. GuptaRA,FiorentinoD.Localizedsclerodermaandsystemicsclerosis:isthereaconnection?//BestPractResClinRheumatol-2007.-Vol.21,N6.-Pp.1025-1036.

63. Halazonetis,T.D.,Georgopoulos,K.,Greenberg,M.E.,andLeder,P.c-Jundimerizeswithitselfandwithc-Fos,formingcomplexesofdifferentDNAbindingaffinities//Cell-1988.-Vol.55,N5.-Pp.917-924.

64. HardingH,ZhangY,ZengH,NovoaI,LuP,CalfonM,SadriN,YunC,PopkoB,PaulesR,StojdlD,BellJ,HettmannT,LeidenJandRonD.Anintegratedstressresponseregulatesaminoacidmetabolismandresistancetooxidativestress//MolecularCell-2003.-Vol.11,N3.-Pp.619-633.

65. Harding,H.P.,I.Novoa,Y.Zhang,H.Zeng,R.Wek,M.Schapira,andD.,Ron.

Regulatedtranslationinitiationcontrolsstress-inducedgeneexpressioninmammaliancells//Mol.Cell-2000Vol.6,N5-Pp.1099–1108.

50. HasegawaM,SatoS,FujimotoM,etal.Serumlevelsofinterleukin6(IL-6),oncostatinM,solubleIL-6receptor,andsolublegp130inpatientswithsystemicsclerosis//JRheumatol-1998.-Vol.25,N2.-Pp.308–13.

51. HayakawaI,HasegawaM,TakeharaK,SatoS.Anti-DNAtopoisomeraseII

autoantibodiesinlocalizedscleroderma//ArthritisRheum-2004.-Vol.50,N1.

- Pp.227–232.

50. HessEV.Isthereaphospholipidspecificityoflupusanticoagulants(LAC)inpatientswithautoimmuneanddruginducedLAC?//JRheumatol-1998.-Vol.25, N 2. - Pp. 200–202.

51. HessJ.,AngelP.,Schorpp-KistnerM.AP-1subunits:quarrelandhar-monyamongsiblings//JCellSci-2004.-Vol.117,N25.-Pp.5965—5973.

52. HigleyH,PersichitteK,ChuS,WaegellW,VancheeswaranR,BlackC.Immunocytochemicallocalizationandserologicdetectionoftransforminggrowthfactorbeta1. AssociationwithtypeIprocollagenandinflammatorycellmarkersindiffuseandlimitedsystemicsclerosis,morphea,andRaynaud'sphenomenon//ArthritisRheum-1994.-Vol.37,N2.-Pp.278–288

53. HinnenU,Schmid-GrendelmeierP,MullerEetal.LosungsmittelexpositionbeiSklerodermie:disseminiertezirkumskripteSklerodermie(Morphea)beieinemPerchlorethylen-exponiertenLackierer//SchweizMedWochenschr-1995.-Vol.125- Pp.2433–2437.

54. Hirai,S.I.,Ryseck,R.P.,Mechta,F.,Bravo,R.,andYaniv,M.CharacterizationofjunD:anewmemberof thejunproto-oncogenefamily //EmboJ- 1989 -Vol. 8,N 5. - Pp. 1433-1439.

55. HorstmeyerA,LichtC,ScherrG,EckesB,KriegT.SignalingandregulationofcollagenIsynthesisbyET-1andTGFβ1//FEBSJ-2005.-Vol.272,N24.-Pp. 6297-309.

56. IhnH,FujimotoM,SatoS,etal.Increasedlevelsofcirculatingintercellularadhesionmolecule-1inpatientswithlocalizedscleroderma//JAmAcadDermatol-1994.-Vol.31,N4.-Pp.591–595.

57. IhnH,YamaneK,KuboM,TamakiK.Blockadeofendogenoustransforminggrowthfactorβsignalingpreventsup-regulatedcollagensynthesisinsclerodermafibroblasts:associationwithincreasedexpressionoftransforminggrowthfactorβreceptors//ArthritisRheum-2001.-Vol.44,N2.-Pp.474–80.

58. JablonskaS.Scleroderma-likelesionsinphenylketonuria/S.Jablonska,A.Stachow//SclerodermaandPseudoscleroderma-Warsaw:PolishMedicalPublishers,1975-Pp.489–98.

59. JacobsonL,PalazijR,JaworskyC.Superficialmorphoea//JAmAcadDermatol-2003.-Vol. 49,N 2. - Pp.323–325.

60. JanovskiNA,AmesS.Lichensclerosusetatrophicusofthevulva//ObstetGynecol-1963.-Vol.22-Pp.697–708.

61. JappeU,HolzleE,RingJ.Parry–RombergsyndromZussamenfassungundneueErkenntnisseanlablicheinerungewhnlichenKasuistik//Hautarzt-1996.-Vol.47, N 8. - Pp. 599–603.

62. JenkinsG.Theroleofproteasesintransforminggrowthfactor-betaactivation//Int.J.Biochem.CellBiol.-Vol.40,N6-7.-Pp.1068-1078.

63. Johansen,C.,Kragballe, K.,Rasmussen,M., etal.Activatorprotein 1DNAbindingactivityisdecreasedinlesionalpsoriaticskincomparedwithnonlesionalpsoriaticskin//Br.J.Dermatol.-2004.-Vol.151,N3.-Pp.600-607.

64. KaplanskiG,MarinV,Montero-JulianF,etal.IL-6:aregulatorofthetransitionfrom neutrophiltomonocyte recruitmentduringinflammation//TrendsImmunol

-2003. -Vol. 24,N 1. - Pp.25–29.

50. KarinM,LiuZ,ZandiE.AP-1functionandregulation//CurrOpinCellBiol.-1997.-Vol. 9,N 2. - Pp.240-246.

51. KarinM.TheregulationofAP-1activitybymitogen-activatedproteinkinases//JBiolChem.-1995.-Vol.270,N28.-Pp.16483-6.

52. KawakamiT,IhnH,XuW,SmithE,LeRoyEC,TrojanowskaM.IncreasedexpressionofTGF-βreceptorsbysclerodermafibro-blasts:evidenceforcontributionofautocrineTGF-βsignalingtosclerodermaphenotype//JInvestDermatol-1998.-Vol.110,N1.-Pp.47–51.

53. KenckaD,BlaszczykM,JablonskaS.AtrophodermaPasini-Pieriniisaprimaryatrophicabortivemorphea//Dermatology-1995.-Vol.190,N3.-Pp.203-206.

54. KochAE,Kronfeld-HarringtonLB,SzekaneczZ,etal.Insituexpressionofcytokinesandcellularadhesionmoleculesintheskinofpatientswithsystemicsclerosis.Theirroleinearlyandlatedisease//Pathobiology-1993.-Vol.61,N5-6. - Pp. - 239–246.

55. KornJ.H.,MayesM.,CerinicM.M.etal.Digitalulcersinsystemicsclerosis:preventionbytreatmentwithbosentan,anoralendothelinreceptorantagonist//ArthrRheum-2004.-Vol.50,N2.-Pp.3985—3993.

56. KroftEB,GroeneveldTJ,SeygerMM,deJongEM.Efficacyoftopicaltacrolimus0.1%inactiveplaquemorphea:random-ized,double-blind,

emollient-controlledpilotstudy//AmJClinDermatol-2009.-Vol.10,N3.-Pp.181-187.

50. KuboM,IhnH,YamaneK,TamakiK.Up-regulatedexpressionoftransforminggrowthfactorβreceptorsindermalfibroblastsinskinsectionsfrompatientswithlocalizedscleroderma//ArthritisRheum-2001.-Vol.44,N3.-Pp.731–734.

51. Kulski JK, KenworthyW,Bellgard M,TaplinR, Okamoto K, OkaA, MabuchiT,OzawaA,TamiyaG,InokoH:GeneexpressionprofilingofJapanesepsoriaticskin revealsanincreasedactivityinmolecularstress andimmuneresponsesignals//Journalofmolecularmedicine(Berlin,Germany)-2005.-Vol.83,N12. - Pp. 964-975.

52. KuwanaM.,OkazakiY.,YasuokaH.,KawakamiY.,IkedaY.Defectivevasculogenesisinsystemicsclerosis//Lancet-2004.-Vol.364,N9434-Pp.603-610.

53. LabandieraJ,Leon-MateosA,Suarez-PenarandaJMetal.Whatisnodular-keloidalscleroderma?//Dermatology-2003.-Vol.207,N2-Pp.130–132.105.LakhampalS,GinsbergWW,MichetCJetal.Eosinophilicfasciitis:clinical

spec-trumandtherapeuticresponsein52cases//SeminArthritisRheum-1988.-Vol. 17,N 4. - Pp.221–231.

106. LarregueM,ZieglerJE,LauretPetal.Sclerodermieenbandechezl’enfant(aproposde27cas)//AnnDermatolVénéréol-1986.-Vol.113,N3.-Pp.207–224

107. LaxerRM,ZulianF.Localizedscleroderma//CurrOpinRheumatol.-2006.-Vol.18, N6. - Pp.606-613.

108. LeaskA.,AbrahamD.J.TGF-βsignalingandthefibroticresponse//FASEBJ.-2004.-Vol. 18,N 7. - Pp.816–827.

109. LebeauxD,FrancèsC,BareteS,WechslerB,DubourgO,RenouxJ,etal.

Eosinophilicfasciitis(Shulmandisease):newinsightsintothetherapeuticmanagementfromaseriesof34patients//Rheumatology(Oxford)-2012.-Vol.51, N 3. - 557-561

106. LeitenbergerJJ,CayceRL,HaleyRW,Adams-HuetB,BergstresserPR,JacobeHT.Distinctautoimmunesyndromesinmorphea:areviewof245adultandpediatriccases//ArchDermatol.-2009.-Vol.145,N5.-Pp.545-50.

107. Li,B.,Tournier,C.,Davis,R.J.,andFlavell,R.A.RegulationofIL-4expressionbythetranscriptionfactorJunBduringThelpercelldifferentiation//EmboJ-1999.-Vol. 18,N 2. - Pp.420-432.

108. LimYL,LeeHY,LowSCSetal.Possibleroleofgadoliniuminnephrogenicsystemicfibrosis:reportoftwocasesandreviewoftheliterature//ClinExpDermatol-2007.-Vol.32,N4.-Pp.353–358.

109. LiskaDJ,SlackJL,BornsteinP.Ahighlyconservedintronicsequenceisinvolvedintranscriptionalregulationoftheα1(I)collagengene//CellRegul-1990.-Vol. 1,N 6. - Pp.487–498.

110. LivakKJ,SchmittgenTD:Analysisofrelativegeneexpressiondatausingreal-timequantitativePCRandthe2(-DeltaDeltaC(T))Method//Methods(SanDiego,Calif)-2001.-Vol.25,N4.-Pp. 402-408.

111. Macian,F.NFATproteins:keyregulatorsofT-celldevelopmentandfunction//NatureReviewsImmunology-2005.-Vol.5,N6.-Pp.472–484.

112. Macian,F.,Garcia-Rodriguez,C.,Rao,A.GeneexpressionelicitedbyNFATinthepresenceorabsenceofcooperativerecruitmentofFosandJun//EMBOJournal-2000.-Vol.19,N17.-Pp.4783–4795.

113. Maki,Y.,Bos,T.J.,Davis,C.,Starbuck,M.,andVogt,P.K.Aviansarcomavirus17carriesthejunoncogene//ProcNatlAcadSciUSA-1987.-Vol.84,N9.-Pp. 2848-2852.

114. MaraghSH,DavisMDP,BruceAJetal.Disablingpanscleroticmorphea:clinicalpresentationintwoadults//JAmAcadDermatol-2005.-Vol.53,N2.,Suppl1. - Pp -115–119.

115. MarkovicsJA,ArayaJ,CambierS,SomanathS,GlineS,JablonsD,HillA,WoltersPJ,NishimuraSL.Interleukin-1betainducesincreasedtranscriptionalactivationofthetransforminggrowthfactor-beta-activatingintegrinsubunit

beta8throughalteringchromatinarchitecture//JBiolChem.-2011.-Vol.286,N 42. - Pp. 36864-36874.

106. MassagueJ.HowcellsreadTGF-betasignals//NatRevMolCellBiol-2000.-Vol.1, N3. - Pp.169–178.

107. MatsudaS,ShibasakiF,TakehanaK,MoriH,NishidaE,KoyasuS.Twodistinctactionmechanismsofimmunophilin-ligandcomplexesfortheblockadeofT-cellactivation//EMBORep.-2000.-Vol.1,N5.-Pp.428-434.

108. MatsushitaT,HasegawaM,HamaguchiY,etal.Longitudinalanalysisofserumcytokineconcentrationsinsystemicsclerosis:associationofinterleukin12elevationwithspontaneousregressionofskinsclerosis//JRheumatol-2006.-Vol.33, N2 - Pp.275–284.

109. MattilaLetal:Activationoftissueinhibitorofmetalloproteinases-3(TIMP-3)mRNAexpressioninsclerodermaskinfibroblasts//JInvestDermatol-1998.-Vol.110, N4. -P.416

110. MauvielA,HeinoJ,KahariVM,HartmannDJ,LoyauG,PujolJP,VuorioE.Comparativeeffectsofinterleukin-1andtumornecrosisfactor-αoncollagenproductionandcorrespondingprocollagenmRNAlevelsinhumandermalfibroblasts//JInvestDermatol-1991.-Vol.96,N2.-Pp.243–249.

111. Meixner,A.,Karreth,F.,Kenner,L.,andWagner,E.F.JunDregulateslymphocyteproliferationandThelpercellcytokineexpression//EmboJ-2004

-Vol. 23, N6. - Pp.1325-1335.

106. MeyrickThomasRH,RidleyCM,BlackMM.Theassociationoflichensclerosusetatrophicusandautoimmune-relateddiseaseinmales//BrJDermatol

-1983. -Vol. 109,N 6. - Pp.661–664.

106. MurotaM,FujimotoM,MatsushitaT,HamaguchiY,HasegawaM,TakeharaK.Clinicalassociationofseruminterleukin-17levelsinsystemicsclerosis:IssystemicsclerosisaTh17disease?//JDermatolSci-2008.-Vol.50,N3.-Pp.240-242.

107. NeedlemannBW,WigleyFM,StairRW.Interleukin-1,interleukin-2,interleukin-4, interleukin-6, tumornecrosis factorαandinterferonγlevels insera

frompatientswithscleroderma//ArthritisRheum-1985.-Vol.28,N7-Pp.775-780.

106. NickoloffB.,NestleF.Recentinsiteintotheimmunopathogenesisofpsoriasisprovidenewtherapeuticopportunities//J.Clin.Invest.-Vol.113,N12.-Pp.1664–1675.

107. O’KaneS,FergusonMW.Transforminggrowthfactorbetaandwoundhealing//IntJBiochemCellBiol.-1997.-Vol.29,N1-Pp.63–78.

108. OgawaF,ShimizuK,MuroiE,HaraT,HasegawaM,TakeharaK,etal.Serumlevelsof8-isoprostane,amarkerofoxidativestress,areelevatedinpatientswithsystemicsclerosis//Rheumatology-2006.-Vol.45,N7.-Pp.815-818.

109. OgawaF,ShimuzuK,HaraT,MuroiE,KomuraK,TakenakaM,etal.

Autoantibodyagainstoneoftheantioxidantrepairenzymes,methioninesulfoxidereductaseA,insystemicsclerosis:associationwithpul-monaryfibrosisandvasculardamage//ArchDermatolRes-2010.-Vol.302,N1-Pp.27-35.

106. OgerE,LernyerC,DueymesM,LeMoigneE,BressoletteL,EscoffreM,etal.

AssociationbetweenIgManticardiolipinantibodiesanddeepvenousthrombosisinpatientswithoutsystemiclupuserythematosus//Lupus-199.-Vol.6,N5-Pp. 455–461.

106. OkanoY.Antinuclearantibodyinsystemicsclerosis(scleroderma)//RheumDisClinNorthAm-1996.-Vol.22,N4.-Pp.709–735.

107. OstlereLS,HarrisD,BuckleyCetal.Atypicalsystemicsclerosisfollowingexposuretovinylchloridemonomer:acasereportandreviewofthecutaneousaspectsofvinylchloridedisease//ClinExpDermatol-1992.-Vol.17,N3.-Pp.208–210.

108. PalumboK,ZerrP,TomcikM,VollathS,DeesC,AkhmetshinaA,AvouacJ,YanivM,DistlerO,SchettG,DistlerJH.ThetranscriptionfactorJunDmediatestransforminggrowthfactor{beta}-inducedfibroblastactivationandfibrosisinsystemicsclerosis//AnnRheumDis-2011.-Vol.70,N7.-1320-1326.

109. PetersonLS,NelsonAM,SuWP.Classificationofmorphoea(localizedsclero-derma)//MayoClinProc-1995.-Vol.70,N11.-Pp.1068–76.

110. PetrozziJW,WoodMG,TisaV.Palmar–plantarlichensclerosusetatrophicus//ArchDermatol-1979.-Vol.115,N7.-P.884.

111. PonticosM,HarveyC,IkedaT,AbrahamD,Bou-GhariosG:JunBmediatesenhancer/promoteractivityofCOL1A2following TGF-betainduction//Nucleicacidsresearch-2009.-Vol.37,N16-Pp.5378-5389.

112. PowellJ,WojnarowskaF,WinseySetal.Lichensclerosuspremenarche:autoimmunityandimmunogenetics//BrJDermatol-2000.-Vol.142,N3.-Pp. 481–484.

113. RaiR,HandaS,GuptaSetal.Bilateralencoupdesabre:arareentity//PediatrDermatol-2000.-Vol.17,N3.-Pp.222–224Rauscher,F.J.,3rd,Sambucetti,L.C.,Curran,T.,Distel,R.J.,andSpiegelman,B.M.CommonDNAbinding site forFos proteincomplexes and transcriptionfactorAP-1// Cell -Vol.52, N 3. - Pp. 471-480.

114. Reich,N.,B.Maurer,A.Akhmetshina,P.Venalis,C.Dees,P.Zerr,K.Palumbo,

J.Zwerina,T.Nevskaya,S.Gay,O.Distler,G.Schett,JHDistlerThetranscriptionfactor Fra-2 regulates theproduction of extracellular matrix insystemicsclerosis//ArthritisRheum-2010.-Vol.62,N1-Pp.280-90.

106. RenaudineauY,GrunebaumE,KrauseI,PraprotnikS,RevelenR,YouinouP,etal.Anti-endothelialcellantibodies(AECA)insystemicsclerosis-increasedsensitivityusingdifferentendothelialcellsubstratesandassociationwithotherautoantibodies//Autoimmunity-2001.-Vol.33,N3-Pp.171–179.

107. RodnanGP,LipinskiE,RabinBS,ReichlinM.Eosinophiliaandserologicabnormalities inlinearlocalizedscleroderma//ArthritisRheum-1977.-Vol.20-P.133.

108. RowellNR,TateGM.Failuretodemonstratethelupusanticoagulantinsystemicsclerosis//BrJDermatol-1988.-Vol.119,N4-P.549.

109. RowellNR.Acralpanscleroticmorphoeawithintractablepain/BurgdorfWHC,KatzSI//ClinicalDermatology:theCMOCaseCollection/WorldCongressofDermatology.Berlin:Scheltauer,1987.-Pp.178–80.

110. RoybalCN,HunsakerLA,BarbashO,VanderJagtDL,AbcouwerSF.TheoxidativestressorarseniteactivatesvascularendothelialgrowthfactormRNAtranscriptionbyanATF4-dependentmechanism//JBiolChem.-2005.-Vol.280, N 21 - Pp. 20331–20339.

111. RoybalCN,YangS,SunCW,etal.HomocysteineincreasestheexpressionofvascularendothelialgrowthfactorbyamechanisminvolvingendoplasmicreticulumstressandtranscriptionfactorATF4//JBiolChem.-2004.-Vol.279,N 15. - Pp. 14844–14852.

112. RuffattiA,PesericoA,GloriosoSetal.Anticentromereantibodyinlocalizedscleroderma//JAmAcadDermatol-1986.-Vol.15,N4-Pp.637–642.

113. RustinMHA,BullHA,ZieglerVetal.Silicaexposureandsilicaassociatedsystemicsclerosis//BrJDermatol-1989.-Vol.121(Suppl.34)-Pp.29.

114. RutkowskiDT,KaufmanRJ.AllroadsleadtoATF4//DevCell-2003.-Vol.4,N 4. - Pp. 442– 444.

115. SalehZ,AbbasO,DahdahMJ,KibbiAG,ZaynounS,GhosnS.AtrophodermaofPasiniandPierini:aclinicalandhistopathologicalstudy//JCutanPathol.-2008.-Vol. 35,N 12. - Pp.1108-1114.

116. SamboP,BaroniSS,LuchettiM,ParonciniP,DusiS,OrlandiniG,etal.

Oxidativestressinscleroderma:Maintenanceofsclerodermafibroblastphenotypebytheconstitutiveupregulationofreactiveoxygenspe-ciesgenerationthroughtheNADPHoxidasecomplexpathway//ArthritisRheum-2001ю-Vol. 44,N11. - Pp.2653-2664.

106. SamboP,JanninoL,CandelaM,SalviA,DoniniM,DusiS,etal.Monocytesofpatientswithsys-temicsclerosis(scleroderma)spontaneouslyreleaseinvitroincreased amounts ofsuperoxide anion// JInvest Dermatol1999 -Vol.112,N 1.

- Pp. 78-84.

155.Sano,Y.,Harada,J.,Tashiro,S.,Gotoh-Mandeville,R.,Maekawa,T.andIshii,S.ATF-2isacommonnucleartargetofSmadandTAK1pathwaysintransforminggrowthfactor-βsignaling//J.Biol.Chem.-1999.-Vol.274,N3.-Pp.8949-8957.

156. SatoS,FujimotoM,HasegawaM,TakeharaK.Antiphospholipidantibodyinlocalizedscleroderma//AnnRheumDis-2003.-Vol.62,N8.-Pp.771–774.

157. SatoS,FujimotoM,IhnH,KikuchiK,TakeharaK.Clinicalcharacteristicsassociatedwithantihistoneantibodiesinpatientswithlocalizedscleroderma//JAmAcadDermatol-1994.-Vol.31,N4.-Pp.567–571.

158. SatoS,HasegawaM,TakeharaK.Serumlevelsofinterleukin-6andinterleukin-10correlatewithtotalskinthicknessscoreinpatientswithsystemicsclerosis//JDermatolSci-2001.-Vol.27,N2-Pp.140–146.

159. SatoS,IhnH,SomaYetal.Antihistoneantibodiesinpatientswithlocalizedscleroderma//ArthritisRheum-1993.-Vol.36,N8-Pp.1137–1141.

160. SawamuraD,YaguchiT,HashimotoIetal.Coexistenceofgeneralizedmorpheawithhistologicalchangesinlichensclerosusetatrophicusandlichenplanus//JDermatol-1998.-Vol.25,N6-Pp.409–411.

161. Schreiber,S.L.,andG.R.Crabtree.ThemechanismsofactionofcyclosporinAandFK506//Immunol.Today-1992.-Vol.13,N4.-Pp.136–142.

162. Schuermann,M.,Jooss,K.,andMuller,R.fosBisatransforminggeneencodingatranscriptionalactivator//Oncogene-1991.-Vol.6,N4.-Pp.567-576.

163. SederRA,MarthT,SieveMC,StroberW,LetterioJJ,RobertsAB,etal.Factorsinvolvedinthedifferen-tiationofTGFbeta-producingcellsfromnaiveCD4+Tcells:IL-4andIFNgammahaveoppositeeffects,whileTGFbetapositivelyregulatesitsownproduction//JImmunol-1998.-Vol.160,N12-Pp.5719-5728.

164. SerpierH,GilleryP,Salmon-EhrV,GarnotelR,GeorgesN,KalisB,etal.

Antagonisticeffectofinter-feron-gammaandinterleukin-4onfibroblastcultures

//JInvestDermatol-1997.-Vol.109,N2.-Pp.158-162.

156. SerupJ,SerupL,SjoO.Localizedscleroderma‘encoupdesabre’withexternaleyemuscleinvolvementatthesametime//ClinExpDermatol-1984.-Vol.9,N 2. - Pp. 196–200.

157. Shaulian,E.andKarin,M.AP-1incellproliferationandsurvival//Oncogene-2001.-Vol. 20,N 19. - Pp.2390-2400.

158. Shimuzu K,OgawaF,AkiyamaY,MuroiE,YoshizakiA,IwataY,etal.

IncreasedserumlevelsofN(epsilon)-(hexanoyl)lysine,anewmarkerofoxidativestress,insystemicsclerosis//JRheumatol-2008.-Vol.35,N11.-Pp.2214-2219.

156. Shi-WenX, HolmesPD, LeaskA, BradhamD, Beauchamp JR,Fonseca C, etal.

AutocrineoverexpressionofCTGFmaintainsfibrosis:RDAanalysisoffibrosisgenesinsystemicsclerosis//ExpCellRes-2000.-Vol.259,N1.-Pp.213–224.

156. Shi-wenX,KennedyL,RenzoniE,duBoisR,DentonC,BlackC,etal.

Endothelin-1isadownstreammediatorofTGFβinfibroblasts.ArthritisRheum2007-Vol. 56,N 12. - Pp.4189-4194.

156. SlackJL,ParkerMI,BornsteinP.Transcriptionalrepressionoftheα1(I)collagengenebyrasismediatedinpartbyanintronicAP1site//JCellBiochem

-1995. -Vol. 58,N 3. - Pp.380–392.

156. Smeyne,R.J.,Curran,T.,andMorgan,J.I.Temporalandspatialexpressionofafos-lacZtransgeneinthedevelopingnervoussystem//BrainResMolBrainRes

-1992. -Vol. 16,N 1-2. - Pp.158-162.

156. SomaY,FujimotoM.Frontoparietalscleroderma(encoupdesabre)followingBlaschko'slines//JAmAcadDermatol-1998.-Vol.38,N2.-Pp.366-368.

157. SonkolyE,WeiT,JansonPC,SaafA,LundebergL,Tengvall-LinderM,NorstedtG,AleniusH,HomeyB,ScheyniusAetal:MicroRNAs:novelregulatorsinvolvedinthepathogenesisofpsoriasis?//PloSone-2007.-Vol.2,N7. -e610.

158. StanekG,StrleF.Lymeborreliosis//Lancet-2003.-Vol.362,N9396.-Pp.

1639–1647.

156. SubcommitteeforSclerodermaCriteriaoftheAmericanRheumatismAssociationDiagnosticand TherapeuticCriteriaCommittee.Preliminarycriteriafortheclas-sificationofsystemicsclerosis//ArthritisRheum-1980.-Vol.23,N5. - Pp. 581–590.

157. TajimaS,SuzukiY,InazumiT.Acaseofatypicallocalizedsclerodermapresentingwithpseudoainhum:treatmentwithtranilast,ananti-fibroticagent//ActaDermVenereol(Stockh)-1996.-Vol.76,N2-P.162.

158. TakedaK,HatamochiA,UekiH,NakataM,OishiY.Decreasedcollagenaseexpressioninculturedsystemicsclerosisfibroblasts//JInvestDermatol-1994.

-Vol. 103, N3 - Pp.359–363.

156. TakeharaK,SatoS.Localizedsclerodermaisanautoimmunedisorder//Rheumatology(Oxford).-2005.-Vol.44,N3.-Pp.274-279.

157. Tanjore,H.,Blackwell,T.S.andLawson,W.E.Emergingevidenceforendoplasmicreticulumstressinthepathogenesisofidiopathicpulmonaryfibrosis//Am.J.Physiol.LungCell.Mol.Physiol.-2012.-Vol.302,N8.-Pp.721–L729.

158. TaskerGL.WojnarowskaF.Lichensclerosus//ClinExpDermatol-2003.-Vol.

28, N 2 - Pp. 128–133.

156. tenDijkeP.,HillC.S.Newinsightsinto TGFβ–Smadsignaling//TrendsBiochem.Sci.-2004.-Vol.29,N5-Pp.265–273.

157. TollefsonMM,WitmanPM.EncoupdesabremorpheaandParry-Rombergsyndrome: a retrospectivereview of54 patients// JAmAcad Dermatol.- 2007. -Vol.56, N2. - Pp.257-263.

158. TrattnerA,DavidM,SandbankM.Bullousmorphea:adistinctentity?//AmJDermatopathol-1994.-Vol.16,N414–417.

159. TuffanelliDL,WinkelmannRK.Systemicscleroderma//ArchDermatol-1955.-Vol.84 - Pp.359–371.

160. UittoJ,BauerEA,EisenAZ:Scleroderma:increasedbiosynthesisoftriple-helicaltypeIandtypeIIIprocollagensassociatedwithunalteredexpressionof

collagenasebyskinfibroblastsinculture.TheJournalofclinicalinvestigation1979.-Vol. 64,N 4 - Pp.921-930.

156. VargaJ.Systemicsclerosis:anupdate//BullNYUHospJtDis-2008.-Vol.66,N 3. - Pp. 198–202.

157. VeldhoenM,StockingerB:TGFbeta1,a"Jackofalltrades":thelinkwithpro-inflammatoryIL-17-producingTcells//TrendsImmunol-2006.-Vol.27,N8-Pp. 358-361.

158. WeibelL,HarperJI.LinearmorphoeafollowsBlaschko'slines//BrJDermatol.

-2008. -Vol. 159,N 1. -Pp.175-181.

156. WeillJ,DuboisM,Lewinetal.Sclerodermieenbandesetatrophiestissulairesmultiples//BullMemSocMedHopParis-1953.-Vol.69-Pp.490–495.

157. WilsonPR.Porphyriacutaneatardawithcutaneous‘scleroderma’andcalcification//AustralasJDermatol-1989.-Vol.30-Pp.93–96.

158. WollinaU,BuslauM,HeinigB,PetrovI,UngerE,KyriopoulouE,etal.

Disablingpanscleroticmorpheaofchildhoodposesahighriskofchroniculcerationoftheskinandsquamouscellcarcinoma//IntJLowExtremWounds

-2007. -Vol. 6,N 4. - Pp.291-298.

156. WollinaU,BuslauM,WeyersW.Squamouscellcarcinomainpanscleroticmorpheaofchildhood//PediatrDermatol-2002.-Vol.19,N2-Pp.151-154.

157. YamamotoT.Autoimmunemechanismsofsclerodermaandaroleofoxidativestress//SelfNonself.-2011. -Vol.2,N1- Pp.4–10

158. YamamuraY,HuaX,BergelsonS,LodishHF.CriticalroleofSmadsandAP-1complexintransforminggrowthfactor-beta-dependentapoptosis//JBiolChem

-2000. -Vol. 275,N 46 - Pp.36295-36302.

156. YamaneK,IhnH,KuboM,etal.Increasedserumlevelsofsolublevascularcelladhesionmolecule1andE-selectininpatientswithlocalizedscleroderma//JAmAcadDermatol-2000.-Vol.42-Pp.64–9.

157. YaoY.,RichmanL.,MorehouseC.etal.TypeIInterferon:PotentialTherapeuticTargetforPsoriasis?//PLoSOne.-2008.-V.3,N.7.-e2737,Pp.1-14.

158. YaoZ,PainterSL,FanslowWC,UlrichD,MacduffBM,SpriggsMK,ArmitageRJ:HumanIL-17:anovelcytokinederivedfromTcells//JImmunol-1995.-Vol.155, N12. - Pp.5483-5486.

159. YinX,WolfordCC,ChangYS,McConougheySJ,RamseySA,etal.ATF3,anadaptive-responsegene,enhancesTGF{beta}signalingandcancer-initiatingcellfeaturesinbreastcancercells//JCellSci-Vol.123,N20.-Pp.3558–3565

160. YokoyamaY,AkimotoS,IshikawaO.DisaccharideanalysisofskinglycosaminoglycansinatrophodermaofPasiniandPierini//ClinExpDermatol-2000.-Vol. 25,N 5. - Pp.436-40.

161. Zavadil,J., E.P. Böttinger.TGF-beta and epithelial-to-mesenchymal transitions//

Oncogene-2005.-Vol.24-Pp.5764–5774.

156. ZenzR,EferlR,KennerL,FlorinL,HummerichL,MehicD,etal.Psoriasis-likeskindiseaseandarthritiscausedbyinducibleepidermaldeletionofJunproteins//Nature-2005.-Vol.437-Pp.369–375.

157. Zhang,Y.,Feng,X.-H.andDerynck,R.Smad3andSmad4cooperatewithc-Jun/c-FostomediateTGF-β-inducedtranscription//Nature-1998-Vol.394-Pp.909-913.

158. ZulianF,MartiniG. Preliminaryclassificationcriteria forjuvenilesystemicscle-rosis.In:ZulianF,RupertoN,eds.ProceedingsoftheIIWorkshoponNomenclatureandDiagnosticCriteriaforJuvenileSclerodermaSyndromes//Padua:AssociazioneIIVolo,2005.Pp5–16.

159. ZulianF.Systemicmanifestationsinlocalizedscleroderma//CurrRheumatolRep.Dec-2004. -Vol.6. N6.-Pp. 417-424.