even more a1A-selective silodosin. Interestingly,

9.

Motofei IG, Rowland DL. The physiological basis of

34

abnormal ejaculation occurs mostly in younger

human sexual arousal: neuroendocrine sexual asymme-

patients, and when occurring in the context of

try. Int J Androl. 2005;28:78-87.

10.

Behre HM, Heinemann L, Morales A, et al. Rationale,

treatment of lower urinary function suggestive

design and methods of the ESPRIT study: energy, sexual

of benign prostatic hyperplasia, it apparently is

desire and body PropoRtions wIth AndroGel®, testoster-

associated with greater therapeutic efficacy. This

one 1% gel therapy, in hypogonadal men. Aging Male.

may also be the reason why abnormal ejacula-

2008;11:101-106.

tion rarely has been a cause for premature study

11.

Rochira V, Balestrieri A, Madeo B, et al. Congenital estro-

discontinuation, even with tamsulosin

or

gen deficiency in men: a new syndrome with different

phenotypes; clinical and therapeutic implications in

silodosin.

men. Mol Cell Endocrinol. 2002;193:19-28.

12.

Wallen K. Sex and context: hormones and primate sex-

Conclusions

ual motivation. Horm Behav. 2001;40:339-357.

13.

Stuckey BG. Female sexual function and dysfunction in the

reproductive years: the influence of endogenous and exog-

The various aspects of human sexual function

enous sex hormones. J Sex Med. 2008;5:2282-2290.

14.

Davis SR, Moreau M, Kroll R, et al. Testosterone for low

are regulated in the central nervous system and

libido in postmenopausal women not taking estrogen. N

also in the periphery. This regulation involves a

Engl J Med. 2008;359:2005-2017.

complex neural and endocrine network, which

15.

Schover LR. Androgen therapy for loss of desire in

makes extrapolation from animal models

to

women: is the benefit worth the breast cancer risk? Fertil

humans difficult. Moreover, sexual dysfunction

Steril. 2008;90:129-140.

16.

Bancroft J. The endocrinology of sexual arousal.

is not a life-threatening disorder which implies

J Endocrinol. 2005;186:411-427.

very high safety thresholds for drugs used in its

17.

Westheide J, Cvetanovska G, Albrecht C, et al. Prolactin,

treatment. Therefore, it is not surprising that

subjective well-being and sexual dysfunction: an open

only few drugs have been approved for sexual

label observational study comparing quetiapine with

dysfunction treatment. On the other hand, sev-

18.

risperidone. J Sex Med. 2008;5:2816-2826.

eral important drug classes, for example, antide-

Krüger THC, Hartmann U, Schedlowski M. Pro-

lactinergic and dopaminergic mechanisms underlying

pressants, may have important adverse effects

sexual arousal and orgasm in humans. World J Urol.

on sexual function. Disorders of sexual arousal

2005;23:130-138.

remain difficult to treat.

19.

Stimmel GL, Gutierrez MA. Sexual dysfunction and psy-

chotropic medications. CNS Spectr. 2006;11 (8 Suppl 9):

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