- •Preface and Acknowledgments
- •Contents
- •Contributors
- •1: Embryology for Urologists
- •Introduction
- •Renal Development
- •Pronephros
- •Mesonephros
- •Metanephros
- •Development of the Collecting System
- •Critical Steps in Further Development
- •Anomalies of the Kidney
- •Renal Agenesis
- •Renal Aplasia
- •Renal Hypoplasia
- •Renal Ectopia
- •Renal Fusion
- •Ureteral Development
- •Anomalies of Origin
- •Anomalies of Number
- •Incomplete Ureteral Duplication
- •Complete Ureteral Duplication
- •Ureteral Ectopia
- •Embryology of Ectopia
- •Clinical Correlation
- •Location of Ectopic Ureteral Orifices – Male (in Descending Order According to Incidence)
- •Symptoms
- •Ureteroceles
- •Congenital Ureteral Obstruction
- •Pipestem Ureter
- •Megaureter-Megacystis Syndrome
- •Prune Belly Syndrome
- •Vascular Ureteral Obstructions
- •Division of the Urogenital Sinus
- •Bladder Development
- •Urachal Anomalies
- •Cloacal Duct Anomalies
- •Other Bladder Anomalies
- •Bladder Diverticula
- •Bladder Extrophy
- •Gonadal Development
- •Testicular Differentiation
- •Ovarian Differentiation
- •Gonadal Anomalies
- •Genital Duct System
- •Disorders of Testicular Function
- •Female Ductal Development
- •Prostatic Urethral Valves
- •Gonadal Duct Anomalies
- •External Genital Development
- •Male External Genital Development
- •Female External Genital Development
- •Anomalies of the External Genitalia
- •References
- •2: Gross and Laparoscopic Anatomy of the Upper Urinary Tract and Retroperitoneum
- •Overview
- •The Kidneys
- •The Renal Vasculature
- •The Renal Collecting System
- •The Ureters
- •Retroperitoneal Lymphatics
- •Retroperitoneal Nerves
- •The Adrenal Glands
- •References
- •3: Gross and Laparoscopic Anatomy of the Lower Urinary Tract and Pelvis
- •Introduction
- •Female Pelvis
- •Male Pelvis
- •Pelvic Floor
- •Urinary Bladder
- •Urethra
- •Male Urethra
- •Female Urethra
- •Sphincter Mechanisms
- •The Bladder Neck Component
- •The Urethral Wall Component
- •The External Urethral Sphincter
- •Summary
- •References
- •4: Anatomy of the Male Reproductive System
- •Testis and Scrotum
- •Spermatogenesis
- •Hormonal Regulation of Spermatogenesis
- •Genetic Regulation of Spermatogenesis
- •Epididymis and Ductus Deferens
- •Accessory Sex Glands
- •Prostate
- •Seminal Vesicles
- •Bulbourethral Glands
- •Penis
- •Erection and Ejaculation
- •References
- •5: Imaging of the Upper Tracts
- •Anatomy of the Upper Tracts and Introduction to Imaging Modalities
- •Introduction
- •Renal Upper Tract Basic Anatomy
- •Modalities Used for Imaging the Upper Tracts
- •Ultrasound
- •Radiation Issues
- •Contrast Issues
- •Renal and Upper Tract Tumors
- •Benign Renal Tumors
- •Transitional Cell Carcinoma
- •Renal Mass Biopsy
- •Renal Stone Disease
- •Ultrasound
- •Plain Radiographs and IVU
- •Renal Cystic Disease
- •Benign Renal Cysts
- •Hereditary Renal Cystic Disease
- •Complex Renal Cysts
- •Renal Trauma
- •References
- •Introduction
- •Pathophysiology
- •Susceptibility and Resistance
- •Epidemiological Breakpoints
- •Clinical Breakpoints
- •Pharmacodynamic Parameters
- •Pharmacokinetic Parameters
- •Fosfomycin
- •Nitrofurantoin
- •Pivmecillinam
- •b-Lactam-Antibiotics
- •Penicillins
- •Cephalosporins
- •Carbapenems
- •Aminoglycosides
- •Fluoroquinolones
- •Trimethoprim, Cotrimoxazole
- •Glycopeptides
- •Linezolid
- •Conclusion
- •References
- •7: An Overview of Renal Physiology
- •Introduction
- •Body Fluid Compartments
- •Regulation of Potassium Balance
- •Regulation of Acid–Base Balance
- •Diuretics
- •Suggested Reading
- •8: Ureteral Physiology and Pharmacology
- •Ureteral Anatomy
- •Modulation of Peristalsis
- •Ureteral Pharmacology
- •Conclusion
- •References
- •Introduction
- •Afferent Signaling Pathways
- •Efferent Signaling
- •Parasympathetic Nerves
- •Sympathetic Nerves
- •Vesico-Spinal-Vesical Micturition Reflex
- •Peripheral Targets
- •Afferent Signaling Mechanisms
- •Urothelium
- •Myocytes
- •Cholinergic Receptors
- •Muscarinic Receptors
- •Nicotinic Receptors
- •Adrenergic Receptors (ARs)
- •a-Adrenoceptors
- •b-Adrenoceptors
- •Transient Receptor Potential (TRP) Receptors
- •Phosphodiesterases (PDEs)
- •CNS Targets
- •Opioid Receptors
- •Serotonin (5-HT) Mechanisms
- •g-Amino Butyric Acid (GABA) Mechanisms
- •Gabapentin
- •Neurokinin and Neurokinin Receptors
- •Summary
- •References
- •10: Pharmacology of Sexual Function
- •Introduction
- •Sexual Desire/Arousal
- •Endocrinology
- •Steroids in the Male
- •Steroids in the Female
- •Neurohormones
- •Neurotransmitters
- •Dopamine
- •Serotonin
- •Pharmacological Strategies
- •CNS Drugs
- •Enzyme-inducing Antiepileptic Drugs
- •Erectile Function
- •Ejaculatory Function
- •Premature Ejaculation
- •Abnormal Ejaculation
- •Conclusions
- •References
- •Epidemiology
- •Calcium-Based Urolithiasis
- •Uric Acid Urolithiasis
- •Infectious Urolithiasis
- •Cystine-Based Urolithiasis
- •Aims
- •Who Deserves Metabolic Evaluation?
- •Metabolic Workup for Stone Producers
- •Medical History and Physical Examination
- •Stone Analysis
- •Serum Chemistry
- •Urine Evaluation
- •Urine Cultures
- •Urinalysis
- •Twenty-Four Hour Urine Collections
- •Radiologic Imaging
- •Medical Management
- •Conservative Management
- •Increased Fluid Intake
- •Citrus Juices
- •Dietary Restrictions
- •Restricted Oxalate Diet
- •Conservative Measures
- •Selective Medical Therapy
- •Absorptive Hypercalciuria
- •Thiazide
- •Orthophosphate
- •Renal Hypercalciuria
- •Primary Hyperparathyroidism
- •Hyperuricosuric Calcium Oxalate Nephrolithiasis
- •Enteric Hyperoxaluria
- •Hypocitraturic Calcium Oxalate Nephrolithiasis
- •Distal Renal Tubular Acidosis
- •Chronic Diarrheal States
- •Thiazide-Induced Hypocitraturia
- •Idiopathic Hypocitraturic Calcium Oxalate Nephrolithiasis
- •Hypomagnesiuric Calcium Nephrolithiasis
- •Gouty Diathesis
- •Cystinuria
- •Infection Lithiasis
- •Summary
- •References
- •12: Molecular Biology for Urologists
- •Introduction
- •Inherited Changes in Cancer Cells
- •VEGR and Cell Signaling
- •Targeting mTOR
- •Conclusion
- •References
- •13: Chemotherapeutic Agents for Urologic Oncology
- •Introduction
- •Bladder Cancer
- •Muscle Invasive Bladder Cancer
- •Metastatic Bladder Cancer
- •Conclusion
- •Prostate Cancer
- •Other Chemotherapeutic Drugs or Combinations for Treating HRPC
- •Conclusion
- •Renal Cell Carcinoma
- •Chemotherapy
- •Immunotherapy
- •Angiogenesis Inhibitor Drugs
- •Conclusion
- •Testicular Cancer
- •Stage I Seminoma
- •Stage I non-seminomatous Germ Cell Tumours (NSGCT)
- •Metastatic Germ Cell Tumours
- •Low-Volume Metastatic Disease (Stage II A/B)
- •Advanced Metastatic Disease
- •Salvage Chemotherapy for Relapsed or Refractory Disease
- •Conclusion
- •Penile Cancer
- •Side Effects of Chemotherapy
- •Conclusion
- •References
- •14: Tumor and Transplant Immunology
- •Antibodies
- •Cytotoxic and T-helper Cells
- •Immunosuppression
- •Induction Therapy
- •Maintenance Therapy
- •Rejection
- •Posttransplant Lymphoproliferative Disease
- •Summary
- •References
- •15: Pathophysiology of Renal Obstruction
- •Causes of Renal Obstruction
- •Effects on Prenatal Development
- •Prenatal Hydronephrosis
- •Spectrum of Renal Abnormalities
- •Renal Functional Changes
- •Renal Growth/Counterbalance
- •Vascular Changes
- •Inflammatory Mediators
- •Glomerular Development Changes
- •Mechanical Stretch of Renal Tubules
- •Unilateral Versus Bilateral
- •Limitations of Animal Models
- •Future Research
- •Issues in Patient Management
- •Diagnostic Imaging
- •Ultrasound
- •Intravenous Urography
- •Antegrade Urography and the Whitaker Test
- •Nuclear Renography
- •Computed Tomography
- •Magnetic Resonance Urography
- •Hypertension
- •Postobstructive Diuresis
- •References
- •Introduction
- •The Normal Lower Urinary Tract
- •Anatomy
- •Storage Function
- •Voiding Function
- •Neural Control
- •Symptoms
- •Flow Rate and Post-void Residual
- •Voiding Cystometry
- •Male
- •Female
- •Neurourology
- •Conclusions
- •References
- •17: Urologic Endocrinology
- •The Testis
- •Normal Androgen Metabolism
- •Epidemiological Aspects
- •Prostate
- •Brain
- •Muscle Mass and Adipose Tissue
- •Bones
- •Ematopoiesis
- •Metabolism
- •Cardiovascular System
- •Clinical Assessment
- •Biochemical Assessment
- •Treatment Modalities
- •Oral Preparations
- •Parenteral Preparations
- •Transdermal Preparations
- •Side Effects and Treatment Monitoring
- •Body Composition
- •Cognitive Decline
- •Bone Metabolism
- •The Kidneys
- •Endocrine Functions of the Kidney
- •Erythropoietin
- •Calcitriol
- •Renin
- •Paraneoplastic Syndromes
- •Hypercalcemia
- •Hypertension
- •Polycythemia
- •Other Endocrine Abnormalities
- •References
- •General Physiology
- •Prostate Innervation
- •Summary
- •References
- •Wound Healing
- •Inflammation
- •Proliferation
- •Remodeling
- •Principles of Plastic Surgery
- •Tissue Characteristics
- •Grafts
- •Flap
- •References
- •Lower Urinary Tract Symptoms
- •Storage Phase
- •Voiding Phase
- •Return to Storage Phase
- •Urodynamic Parameters
- •Urodynamic Techniques
- •Volume Voided Charts
- •Pad Testing
- •Typical Test Schedule
- •Uroflowmetry
- •Post Voiding Residual
- •Further Diagnostic Evaluation of Patients
- •Cystometry with or Without Video
- •Cystometry
- •Videocystometrography (Cystometry + Cystourethrography)
- •Cystometric Findings
- •Comment:
- •Measurements During the Storage Phase:
- •Measurements During the Voiding Phase:
- •Abnormal Function
- •Disorders of Sensation
- •Causes of Hypersensitive Bladder Sensation
- •Causes of Hyposensitive Bladder Sensation
- •Disorders of Detrusor Motor Function
- •Bladder Outflow Tract Dysfunction
- •Detrusor–Urethral Dyssynergia
- •Detrusor–Bladder Neck Dyssynergia
- •Detrusor–Sphincter Dyssynergia
- •Complex Urodynamic Investigation
- •Urethral Pressure Measurement
- •Technique
- •Neurophysiological Evaluation
- •Conclusion
- •References
- •Endoscopy
- •Cystourethroscopy
- •Ureteroscopy and Ureteropyeloscopy
- •Nephroscopy
- •Virtual Reality Simulators
- •Lasers
- •Clinical Application of Lasers
- •Condylomata Acuminata
- •Urolithiasis
- •Benign Prostatic Hyperplasia
- •Ureteral and Urethral Strictures
- •Conclusion
- •References
- •Introduction
- •The Prostatitis Syndromes
- •The Scope of the Problem
- •Category III CP/CPPS
- •The Goal of Treatment
- •Conservative Management
- •Drug Therapy
- •Antibiotics
- •Anti-inflammatories
- •Alpha blockers
- •Hormone Therapies
- •Phytotherapies
- •Analgesics, muscle relaxants and neuromodulators
- •Surgery
- •A Practical Management Plan
- •References
- •Orchitis
- •Definition and Etiology
- •Clinical Signs and Symptoms
- •Diagnostic Evaluation
- •Treatment of Infectious Orchitis
- •Epididymitis
- •Definition and Etiology
- •Clinical Signs and Symptoms
- •Diagnostic Evaluation of Epididymitis
- •Treatment of Acute Epididymitis
- •Treatment of Chronic Epididymitis
- •Treatment of Spermatic Cord Torsion
- •Fournier’s Gangrene
- •Definition and Etiology
- •Risk Factors
- •Clinical Signs and Symptoms
- •Diagnostic Evaluation
- •Treatment
- •References
- •Fungal Infections
- •Candidiasis
- •Aspergillosis
- •Cryptococcosis
- •Blastomycosis
- •Coccidioidomycosis
- •Histoplasmosis
- •Radiographic Findings
- •Treatment
- •Tuberculosis
- •Clinical Manifestations
- •Diagnosis
- •Treatment
- •Schistosomiasis
- •Clinical Manifestations
- •Diagnosis
- •Treatment
- •Filariasis
- •Clinical Manifestations
- •Diagnosis
- •Treatment
- •Onchocerciasis
- •References
- •25: Sexually Transmitted Infections
- •Introduction
- •STIs Associated with Genital Ulcers
- •Herpes Simplex Virus
- •Diagnosis
- •Treatment
- •Chancroid
- •Diagnosis
- •Treatment
- •Syphilis
- •Diagnosis
- •Treatment
- •Lymphogranuloma Venereum
- •Diagnosis
- •Treatment
- •Chlamydia
- •Diagnosis
- •Treatment
- •Gonorrhea
- •Diagnosis
- •Treatment
- •Trichomoniasis
- •Diagnosis
- •Treatment
- •Human Papilloma Virus
- •Diagnosis
- •Treatment
- •Scabies
- •Diagnosis
- •Treatment
- •References
- •26: Hematuria: Evaluation and Management
- •Introduction
- •Classification of Hematuria
- •Macroscopic Hematuria
- •Microscopic Hematuria
- •Dipstick Hematuria
- •Pseudohematuria
- •Factitious Hematuria
- •Menstruation
- •Aetiology
- •Malignancy
- •Urinary Calculi
- •Infection and Inflammation
- •Benign Prostatic Hyperplasia
- •Trauma
- •Drugs
- •Nephrological Causes
- •Assessment
- •History
- •Examination
- •Investigations
- •Dipstick Urinalysis
- •Cytology
- •Molecular Tests
- •Blood Tests
- •Flexible Cystoscopy
- •Upper Urinary Tract Evaluation
- •Renal USS
- •KUB Abdominal X-Ray
- •Intravenous Urography (IVU)
- •Computed Tomography (CT)
- •Retrograde Urogram Studies
- •Magnetic Resonance Imaging (MRI)
- •Additional Tests and Renal Biopsy
- •Intractable Hematuria
- •Loin Pain Hematuria Syndrome
- •References
- •27: Benign Prostatic Hyperplasia (BPH)
- •Historical Background
- •Pathophysiology
- •Patient Assessment
- •Treatment of BPH
- •Watchful Waiting
- •Drug Therapy
- •Interventional Therapies
- •Conclusions
- •References
- •28: Practical Guidelines for the Treatment of Erectile Dysfunction and Peyronie´s Disease
- •Erectile Dysfunction
- •Introduction
- •Diagnosis
- •Basic Evaluation
- •Cardiovascular System and Sexual Activity
- •Optional Tests
- •Treatment
- •Medical Treatment
- •Oral Agents
- •Phosphodiesterase Type 5 (PDE 5) Inhibitors
- •Nonresponders to PDE5 Inhibitors
- •Apomorphine SL
- •Yohimbine
- •Intracavernosal and Intraurethral Therapy
- •Intracavernosal Injection (ICI) Therapy
- •Intraurethral Therapy
- •Vacuum Constriction Devices
- •Surgical Therapy
- •Conclusion
- •Peyronie´s Disease (PD)
- •Introduction
- •Oral Drug Therapy
- •Intralesional Drug Therapy
- •Iontophoresis
- •Radiation Therapy
- •Surgical Therapy
- •References
- •29: Premature Ejaculation
- •Introduction
- •Epidemiology
- •Defining Premature Ejaculation
- •Voluntary Control
- •Sexual Satisfaction
- •Distress
- •Psychosexual Counseling
- •Pharmacological Treatment
- •On-Demand Treatment with Tramadol
- •Topical Anesthetics
- •Phosphodiesterase Inhibitors
- •Surgery
- •Conclusion
- •References
- •30: The Role of Interventional Management for Urinary Tract Calculi
- •Contraindications to ESWL
- •Complications of ESWL
- •PCNL Access
- •Instrumentation for PCNL
- •Nephrostomy Drains Post PCNL
- •Contraindications to PCNL
- •Complications of PCNL
- •Semirigid Ureteroscopy
- •Flexible Ureteroscopy
- •Electrohydraulic Lithotripsy (EHL)
- •Ultrasound
- •Ballistic Lithotripsy
- •Laser Lithotripsy
- •Ureteric Stents
- •Staghorn Calculi
- •Lower Pole Stones
- •Horseshoe Kidneys and Stones
- •Calyceal Diverticula Stones
- •Stones and PUJ Obstruction
- •Treatment of Ureteric Colic
- •Medical Expulsive Therapy (MET)
- •Intervention for Ureteric Stones
- •Stones in Pregnancy
- •Morbid Obesity
- •References
- •Anatomy and Function
- •Pathophysiology
- •Management
- •Optical Urethrotomy/Dilatation
- •Urethral Stents
- •Preoperative Assessment
- •Urethroplasty
- •Anastomotic Urethroplasty
- •Substitution Urethroplasty
- •Grafts Versus Flaps
- •Oral Mucosal Grafts
- •Tissue Engineering
- •Graft Position
- •Conclusion
- •References
- •32: Urinary Incontinence
- •Epidemiology and Risk Factors
- •Pathophysiology
- •Urge Incontinence
- •Conservative Treatments
- •Pharmacotherapy
- •Invasive/ Surgical Therapies
- •Stress Urinary Incontinence
- •Male SUI Therapies
- •Female SUI Therapies
- •Mixed Urinary Incontinence
- •Conclusions
- •References
- •33: Neurogenic Bladder
- •Introduction
- •Examination and Diagnostic Tests
- •History and Physical Examination
- •Imaging
- •Urodynamics (UDS)
- •Evoked Potentials
- •Classifications
- •Somatic Pathways
- •Brain Lesions
- •Cerebrovascular Accident (CVA)
- •Parkinson’s Disease (PD)
- •Multiple Sclerosis
- •Huntington’s Disease
- •Dementias
- •Normal Pressure Hydrocephalus (NPH)
- •Tumors
- •Psychiatric Disorders
- •Spinal Lesions and Pathology
- •Intervertebral Disk Prolapse
- •Spinal Cord Injury (SCI)
- •Transverse Myelitis
- •Peripheral Neuropathies
- •Metabolic Neuropathies
- •Pelvic Surgery
- •Treatment
- •Summary
- •References
- •34: Pelvic Prolapse
- •Introduction
- •Epidemiology
- •Anatomy and Pathophysiology
- •Evaluation and Diagnosis
- •Outcome Measures
- •Imaging
- •Urodynamics
- •Indications for Management
- •Biosynthetics
- •Surgical Management
- •Anterior Compartment Repair
- •Uterine/Apical Prolapse
- •Enterocele Repair
- •Conclusion
- •References
- •35: Urinary Tract Fistula
- •Introduction
- •Urogynecologic Fistula
- •Vesicovaginal Fistula
- •Etiology and Risk Factors
- •Clinical Factors
- •Evaluation and Diagnosis
- •Pelvic Examination
- •Cystoscopy
- •Imaging
- •Treatment
- •Conservative Management
- •Surgical Management
- •Urethrovaginal Fistula
- •Etiology and Presentation
- •Diagnosis and Management
- •Ureterovaginal Fistula
- •Etiology and Presentation
- •Diagnosis and Management
- •Vesicouterine Fistula
- •Etiology and Presentation
- •Diagnosis and Management
- •Uro-Enteric Fistula
- •Vesicoenteric Fistula
- •Pyeloenteric Fistula
- •Urethrorectal Fistula
- •References
- •36: Urologic Trauma
- •Introduction
- •Kidney
- •Expectant Management
- •Endovascular Therapy
- •Operative Intervention
- •Operative Management: Follow-up
- •Reno-Vascular Injuries
- •Pediatric Renal Injuries
- •Adrenal
- •Ureter
- •Diagnosis
- •Treatment
- •Delayed Diagnosis
- •Bladder and Posterior Urethra
- •Bladder Injuries: Initial Management
- •Bladder Injuries: Formal Repair
- •Anterior Urethral Trauma
- •Fractured Penis
- •Penile Amputation
- •Scrotal and Testicular Trauma
- •Imaging
- •CT-IVP (CT with Delayed Images)
- •Technique
- •Cystogram
- •Technique
- •Retrograde Urethrogram (RUG)
- •Technique
- •Retrograde Pyelogram (RPG)
- •Technique
- •One-Shot IVP
- •Technique
- •References
- •37: Bladder Cancer
- •Who Should Be Investigated?
- •Epidemiology
- •Risk Factors
- •Role of Screening
- •Signs and Symptoms
- •Imaging
- •Cystoscopy
- •Urine Tests
- •PDD-Assisted TUR
- •Pathology
- •NMIBC and Risk Groups
- •Intravesical Chemotherapy
- •Intravesical Immunotherapy
- •Immediate Cystectomy and CIS
- •Radical Cystectomy with Pelvic Lymph Node Dissection
- •sexual function-preserving techniques
- •Bladder-Preservation Treatments
- •Neoadjuvant Chemotherapy
- •Adjuvant Chemotherapy
- •Preoperative Radiotherapy
- •Follow-up After TUR in NMIBC
- •References
- •38: Prostate Cancer
- •Introduction
- •Epidemiology
- •Race
- •Geographic Variation
- •Risk Factors and Prevention
- •Family History
- •Diet and Lifestyle
- •Prevention
- •Screening and Diagnosis
- •Current Screening Recommendations
- •Biopsy
- •Pathology
- •Prognosis
- •Treatment of Prostate Cancer
- •Treatment for Localized Prostate Cancer (T1, T2)
- •Radical Prostatectomy
- •EBRT
- •IMRT
- •Brachytherapy
- •Treatment for Locally Advanced Prostate Cancer (T3, T4)
- •EBRT with ADT
- •Radical Prostatectomy
- •Androgen-Deprivation Therapy
- •Summary
- •References
- •39: The Management of Testis Cancer
- •Presentation and Diagnosis
- •Serum Tumor Markers
- •Primary Surgery
- •Testis Preserving Surgery
- •Risk Stratification
- •Surveillance Versus Primary RPLND
- •Primary RPLND
- •Adjuvant Treatment for High Risk
- •Clinical Stage 1 Seminoma
- •Risk-Stratified Adjuvant Treatment
- •Adjuvant Radiotherapy
- •Adjuvant Low Dose Chemotherapy
- •Primary Combination Chemotherapy
- •Late Toxicity
- •Salvage Strategies
- •Conclusion
- •References
- •Index
503
Urologic traUma
antegrade ureteral stent (retrograde ureteral |
for urethral injury: the finding of an inferomedial |
stent is difficult and often unsuccessful in this |
pubic bone fracture or symphysis diastasis pre- |
situation). Urinomas can be effectively managed |
dicts urethral injury with a sensitivity of 92% and |
by placing a percutaneous drain. Complications |
specificity of 64%.39 |
of nondiagnosed ureteral injuries include fistu- |
An algorithm for the diagnosis and treatment |
las, urinomas, and abscesses. |
of bladder and urethral injuries is presented in |
|
Fig. 36.3. It should be emphasized that CT with |
Bladder and Posterior Urethra |
delayed images is inadequate for the diagnosis |
of bladder injuries: when bladder injury is sus- |
|
|
pected, a cystogram is mandatory.40 Because |
In the adult, the bladder lies in the true pelvis |
coincident upper and lower tract injuries are |
and, when not grossly distended, is well pro- |
rare (occurring in 0.4% of all trauma patients) |
tected from injury. As it fills, the dome, which is |
and bladder injury from blunt abdominal |
covered by peritoneum, rises into the abdomen |
trauma is associated with pelvic fracture in the |
and is no longer protected by the bony pelvis. |
vast majority of cases, it has been suggested that |
Therefore, injuries to the bladder from blunt |
a cystogram should be reserved for those with |
abdominal trauma in an adult nearly always |
gross hematuria and concomitant pelvic frac- |
result from a direct blow to the abdomen in the |
ture or clinical signs of bladder injury.37 |
presence of a distended bladder, or from com- |
Others have suggested that patients with pel- |
pression of the pelvic contents following pelvic |
vic fractures that are known to be associated |
fracture. In the child, the bladder is almost |
with bladder injury (e.g., diastasis of the pubic |
entirely an abdominal organ and is much more |
symphysis or SI joint and sacral fractures) |
susceptible to injury from penetrating and blunt |
should also be evaluated with a cystogram, even |
trauma than the adult bladder. The posterior |
in the absence of hematuria.41 Cystogram is rec- |
urethra is also well protected by the bony pelvis, |
ommended in all cases of gross or microscopic |
but can be partially or completely transected in |
hematuria following penetrating trauma to the |
adults and children following pelvic fracture. |
bladder region. The 2002 Consensus Statement |
Early diagnosis and proper initial management |
on Bladder Injuries42 categorizes these injuries |
of bladder and posterior urethral injuries is crit- |
based on appearance of the cystogram: contu- |
ical to avoiding life-threatening acute complica- |
sion (usually a mucosal or muscularis injury |
tions and potentially debilitating long-term |
without extravasation), intraperitoneal rupture, |
complications. |
extraperitoneal rupture, and combined intra- |
Gross hematuria is the hallmark sign of injury |
and extraperitoneal rupture. |
to the bladder, present in greater than 95% of |
All patients with suspected urethral injury |
bladder ruptures from both blunt and penetrating |
should undergo retrograde urethrogram (RUG). |
injury37; clinical findings can include suprapubic |
There are a number of classification schemes for |
pain, dysuria, ileus, or an acute abdomen. The |
urethral injury, most of which are modifications |
triad of urinary retention, blood at the meatus, |
of the system proposed in 1977 by Colapinto and |
and high-riding prostate is the classic presenta- |
McCallum.43 However, these have proven to be |
tion of patients with injuries to the posterior ure- |
complex and of minimal clinical utility, and in |
thra, present in 91%, 87%, and 64% of these |
2004,a consensus panel on urethral trauma44 pro- |
patients,respectively.38 DRE is useful for detecting |
posed a new classification system (Table 36.1). |
rectal injuries, which are associated with 5% of |
The essential information to be obtained from |
pelvic fractures and may affect management of an |
the RUG (reflected in this new scheme) is the |
associated bladder injury, but is less useful in |
location of the injury (anterior or posterior), |
diagnosing urethral injury, as swelling and edema |
extent of the injury (partial or complete), and |
can obscure the exam. When urethral or bladder |
whether the bladder neck is involved, as up to |
injury is suspected in a female, a full pelvic exam |
half of these patients have no functional distal |
should be performed to rule out vaginal and rectal |
sphincter at follow-up and presumably rely on |
injuries. Computed tomography, which is rou- |
the bladder neck for continence.45 As concomi- |
tinely performed on patients with pelvic fracture, |
tant bladder injuries occur in 10–20% of patients |
has an increasingly important role in screening |
with posterior urethral injuries, all patients with |
504
Practical Urology: EssEntial PrinciPlEs and PracticE
Blood at meatus
High-riding or Impalpable prostate
Penile fracture
Suspicion for anterior urethral injury
Perineal hematoma
- Public symphysis or |
RUG |
Sl joint diastasis |
-Sacral fracture
-Free fluid in pelvis
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Normal |
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Extraperitoneal |
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Cystogram |
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bladder rupture |
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Intraperitoneal |
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bladder rupture |
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Anterior extravasation
Posterior extravasation
Normal |
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Foley passes easily |
(optional) Yes
Urethrovesical foley
Yes
No
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Yes |
- Penetrating trauma |
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- Vaginal, rectal or bladder neck injuries |
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Formal bladder repair |
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- Open pelvic fracture |
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- Bony fragments projecting into bladder |
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- Laparotomy for other reasons |
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- Candidates for ORIF (consider) |
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-Posterior urethral injury
-Gross hematuria and pelvic fracture
-Penetrating injuries of the buttock, pelvis, or lower abdomen and any degree of hematuria
-Suspicion for bladder injury
Blunt (bulbar): SP catheter Penile fracture: primar repair Penetrating: primary repair†
No
Stable?
Yes No
Endoscopic realignment
Successful?
No
SP catheter with delayed repair
Figure 36.3. algorithm for the management of traumatic injuries to the bladder and urethra.gray boxes indicate presenting features. †large or multiple defects should be repaired in a delayed fashion.
Table 36.1. staging of urethral injuries according to the 2004 consensus panel on urethral trauma
Anterior urethra |
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1 |
Partial disruption |
2 |
complete disruption |
Posterior urethra |
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3 |
stretched but intact |
4 |
Partial disruption |
5 |
complete disruption |
6 |
complex (involves bladder |
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neck/rectum) |
reprinted from chapple et al.44 (with permission of Wiley-Blackwell).
injury to the posterior urethra should undergo antegrade cystoscopy or cystogram through the suprapubic tube to evaluate for bladder injury, specifically injury to the bladder neck.46
Bladder Injuries: Initial Management
All penetrating injuries to the bladder should be explored and repaired. Intraperitoneal injuries are often much larger than suggested on cystogram, are unlikely to heal spontaneously, and should be formally repaired.47 Extraperitoneal bladder ruptures can be managed nonoperatively in select cases, but the incidence of complications such as fistulas, persistent leak, clot retention, and sepsis seem to be lower with open repair than with non-operative management. Therefore, formal repair is indicated if there are any complicating features, such as the presence of vaginal or rectal injuries, injury to the bladder neck, open pelvic fracture, or bony fragments projecting into the bladder.48,49 Furthermore, if the patient is to undergo laparotomy for any reason, extraperitoneal injuries should be repaired, as these patients may be prone to development of vesicocutaneous fistulas if not repaired.48 If internal fixation of the pelvic
505
Urologic traUma
fracture is being considered, then open repair |
be performed at 7–10 days, as up to 15% may |
of the bladder at the same setting should be |
have a persistent leak at that time.54 If there is |
strongly considered in order to minimize the |
no leak, the catheter should be removed; if there |
potential for infected hardware as a result of |
is a leak, the cystogram can be repeated every |
extravasated urine.50 |
3–4 days. |
Maintenance of adequate bladder drainage |
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and minimization of infectious complications |
Posterior Urethral Disruption: |
are critical to successful nonoperative manage- |
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ment.The patient should be started immediately |
Immediate Management |
on prophylaxis for gram-positive and gram- |
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negative organisms, and the bladder should be |
Patients who suffer posterior urethral distrac- |
drained with a large bore Foley catheter, prefer- |
tion injuries typically have a number of associ- |
ably 22-fr or greater. If there is difficulty main- |
ated life-threatening injuries and as many as |
taining reliable drainage after the first 24–48 h, |
50% of these patients will die of related injuries |
the patient should undergo exploration and for- |
during the initial hospitalization. Therefore, |
mal closure. |
the primary objective of the urologist is to |
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establish prompt, reliable drainage of the blad- |
Bladder Injuries: Formal Repair |
der so as to avoid potentially fatal complica- |
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tions related to urinary extravasation and to |
In all cases, the bladder should be approached |
facilitate stabilization of associated injuries.48 |
through a midline incision, with careful inspec- |
This is best accomplished with immediate |
tion of the peritoneal contents for associated |
placement of a suprapubic catheter, though a |
injuries51 or penetrating injuries; the tract should |
single attempt at passing a well lubricated ure- |
be carefully inspected and all foreign bodies |
thral catheter is reasonable. The urethral defect |
should be removed. The bladder should be |
can be treated in a delayed fashion or with early |
inspected for other injuries and repaired trans- |
endoscopic realignment. |
vesically. Intraperitoneal injuries typically have |
In one large study that is consistent with sev- |
large rents, which can be widened in order to |
eral similar but smaller studies, 100% of patients |
adequately inspect the remainder of the bladder. |
who did not undergo endoscopic realignment |
For penetrating and extraperitoneal injuries, we |
developed clinically significant strictures and |
typically make a large longitudinal incision in |
47% eventually required perineal urethroplasty. |
the anterior bladder. |
Among patients who underwent early endo- |
Following penetrating trauma, it is essential |
scopic realignment, 49% developed stricture |
to visualize efflux of clear urine from each ure- |
and 25% eventually required perineal urethro- |
teral orifice; if this is not possible, or if efflux is |
plasty. The early realignment group required |
bloody, retrograde pyelography is indicated to |
fewer procedures (1.6 vs 3.1) and experienced a |
assess for ureteral injury. Bone fragments, for- |
slightly lower incidence of impotence and incon- |
eign bodies, and devitalized tissue should be |
tinence than the delayed reconstruction group. |
removed, and injuries to the bladder neck and |
Though there is a clear selection bias in these |
vagina should be repaired. Pelvic hematomas |
studies (stable patients were more likely to |
should not be entered. The bladder should be |
undergo early realignment), it is clear that early |
closed in 2 layers with 3-0 absorbable suture. |
endoscopic realignment is worthwhile in stable |
Bladder drainage can be safely accomplished |
patients with posterior urethral distraction |
with a large suprapubic tube placed through a |
injuries.38 |
separate stab incision or alternatively with a |
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large urethral Foley.52 |
Posterior Urethral Disruption: |
If internal fixation is being considered, supra- |
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pubic drainage should be avoided because of |
Endoscopic Realignment |
the risk of wound infection and subsequent |
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hardware infection.50,53 Drains are not neces- |
Endoscopic realignment can be performed as |
sary. The suprapubic tube or Foley catheter can |
soon as the patient is stabilized and associated |
be removed 5–7 days after repair of intraperito- |
intraabdominal or pelvic injuries have been |
neal rupture or penetrating trauma. For extrap- |
addressed. The patient should be warm, and any |
eritoneal bladder ruptures, a cystogram should |
coagulopathies should be corrected. Positioning |