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31  Management of Portal Hypertension

327

 

 

The data at this time would therefore indicate the following:

Patients with cirrhosis and moderate to large varices should receive prophylactic therapy with non-cardioselective beta-blocker prior to the initial bleed.

Patients with acute variceal bleeding should be managed in an intensive care unit with careful monitoring, adequate transfusion, pharmacologic and endoscopic therapy.

Patients with recurrent variceal bleeding should be managed with endoscopic banding and a non-cardioselective beta-blocker. Only those patients who have well-preserved liverfunction,andrebleedthroughfirst-linetreatment,shouldbeconsideredfordecom- pression. This can be achieved with either a surgical shunt or TIPS. Patients with endstageliverdiseaseneedtobeevaluatedfortheirsuitabilityfortransplantandtransplanted if appropriate. [Q5: B]

References

1.Schepke M, Kleber G, Nurnberg D, et al. Ligation versus propanolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology. 2004;40:65-72.

2.Sarin SK, Lamba GS, Kumar M, Murthy NS. Comparison of endoscopic ligation and propanolol for the primary prevention of variceal bleeding. N Engl J Med. 1999;340:988-993.

3.Grace ND, Groszmann RJ, Garcia-Tsao G, et al. Portal hypertension and variceal bleeding: an AASLD single topic symposium. Hepatology. 1998;28:868-880.

4.Boyer TD, Haskal ZJ. The role of transjugular intrahepatic portosystemic shunt in management of portal hypertension. AASLD Pract Guidel Hepatology. 2005;41:386-400.

5.Henderson JM. Distal splenorenal shunt. In: Blumgart LH, ed. Surgery if the Liver, Biliary Tract, and Pancreas, 4th ed.; Sect XV, Chap 98. 2005; in press.

6.RosemurgyAS,SerafiniFM,ZweibelBR,etal.Transjugularintrahepaticportosystemeicshunt vs. small-diameter prosthetic H-graft portacaval shunt: extended follow-up of an expanded randomized prospective trial. J Gastrointest Surg. 2000;4:589-597.

7.Henderson JM, Boyer TD, Kutner MH et al. and the DIVERT study group. DSRS vs. TIPS for refractory variceal bleeding: a prospective randomized controlled trial. Gastroenterology. 2006;130:1643-1651.

8.Bureau C, Garcia-Pagan JC, Otal P, et al. Improved clinical outcome using PTFE coated stents for TIPS: results of a randomized study. Gastroenterology. 2004;126:469.

Part VI

Management of Extracranial

Cerebrovascular Disease

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