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20  Endovascular Management of Non-Healing Leg Ulceration

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placementhasalsogainedinpopularitywithimprovedoutcomes.15 Unfortunately,stentfractures with diminished patency rates have limited universal adaptation of these practices. Forces on the SFA at the adductor canal, including compression, expansion, torsion, and flexion, adversely impact metallic devices. Mechanical limitations of current stent designs haveledtonew,longerstentdesignswhichmayincreaselongtermpatencyrates.Development of better drug eluting stent and balloon technology may also help to improve outcomes.

Restenosis of stented arterial beds creates a future problem regarding management of in-stent restenosis when it occurs. Plain and cutting balloon angioplasty, cryoplasty, and drug-eluting balloon technology may offer future solutions but currently only anecdotal data exist.16 Research with bioabsorbable stent technology may lead to the elimination of long-term mechanical stent problems and may be a vector for drug delivery directly to diseased segments.17

Other areas of concern for infrainguinal interventions include the common femoral and popliteal arteries which lie at flexion points and the SFA origin where the major branch vessel, the profunda femoris, offers a significant source of collateral flow in cases of limb threatening ischemia. Laser, directional, and rotational atherectomy techniques have been devised as the primary procedure or for debulking diseased segments so that ballooning may be performed with fewer complications. Atherectomy may be a good adjunct in these problem areas and even in highly calcified segments where ballooning and stenting may not be feasible.

Patient treatment and management should not end at the completion of the interventional procedure. Risk factor modification, including diabetic and hypertensive control, statin therapy, smoking cessation, and addition of anti-platelet medication should be individualized for each patient. Personalized health care will continue to become an important aspect of vascular patient care, combining individual genomic information and clinical data with available health information technologies. More aggressive and earlier risk reduction may avert many of the late complications of vascular disease. Health care agencies have clearly begun to recognize the importance of individualized care.18

Optimal wound treatment should be instituted and healing status closely monitored. Patients should be educated about signs of deteriorating vascular status, including recurrent claudication or rest pain and development of new ulcerations. Non-invasive vascular testing may be a helpful addition to physical examination if there is a clinical change. Less circulation is needed to maintain intact skin, so once a wound heals, a decrease in arterial inflow may not necessarily require restoration. This patient is appropriately managed by close follow up, risk factor management, counseling, and protective orthotics. [Q5: D]

References

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2. Deo A, Fogel M, Cowper SE. Nephrogenic systemic fibrosis: a population study examining the relationship of disease development to gadolinium exposure. Clin J Am Soc Nephrol. 2007;2:264-267.

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3. Ouwendijk R, Kock MC, van Dijk LC, et al. Vessel wall calcifications at multi-detector row CT angiography in patients with peripheral arterial disease: effect on clinical utility and clinical predictors. Radiology. 2006 Nov;241(2):603-608.

4. Fowkes FG, Murray GD, Butcher I, et al. Ankle brachial index combined with framingham risk score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008 Jul 9;300(2):197-208.

5. Ramsey DE, Manke DA, Sumner DS. Toe blood pressure. A valuable adjunct to ankle pressure measurement for assessing peripheral arterial disease. J Cardiovasc Surg. 1983 ­Jan-Feb; 24(1):43-48.

6. Nicholas GG, Myers JL, DeMuth WE Jr. The role of vascular laboratory criteria in the selection of patients for lower extremity amputation. Ann Surg. 1982 Apr;195(4):469-473.

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8. Dormandy JA, Rutherford RB. Management of Peripheral Arterial Disease (PAD). TASC Working Group. TransAtlantic Intersociety Concensus (TASC). J Vasc Surg. 2000 Jan;31 (1 part 2):S1-S296.

9. TASC II Working Group, Norgren L, Hiatt WR, et al. Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg. 2007 Jan;45(Suppl S):S5-S67.

10.Reichman W, Nichols B, Toner J, Jenvey W, Sobel M. Strategies in the treatment of major tissue loss and gangrene: results of 100 consecutive vascular reconstructions. Ann Vasc Surg. 1990 May;4(3):233-237.

11.BASIL trial participants, Adam DJ, Beard JD, Cleveland T, et al. Bypass versus angioplasty in severe ischemia of the leg (BASIL): multicenter, randomized controlled trial. Lancet. 2005 Dec;366(9501):1925-1934.

12.Haider SN, Kavanagh EG, Forlee M, et al. Two-year outcome with preferential use of infrainguinal angioplasty for critical ischemia. J Vasc Surg. 2006 Mar;43(3):504-512.

13.Giles KA, Pomposelli FB, Hamdan AD, et al. Infrapopliteal angioplasty for critical limb ischemia: relation of TransAtlantic InterSociety Consensus class to outcome in 176 limbs. J Vasc Surg. 2008 Jul;48(1):128-136.

14.Schillinger M, Sabeti S, Loewe C, et al. Balloon angioplasty versus implantation of nitinol stents in the superficial femoral artery. NEJM. 2006 May;354(18):1879-1888.

15.Saxon RR, Dake MD, Volgelzang RL, Katzen BT, Becker GJ. Randomized multi-center study comparingexpandedpolytetrafluoroethylene-coveredendoprosthesisplacementwithpercuta- neous transluminal angioplasty in the treatment of superficial femoral occlusive disease. J Vasc Interv Radiol. 2008 Jun;19(6):823-832.

16.Shammas NW. Restenosis after lower extremity interventions: current status and future directions. J Endovasc Ther. 2009 Feb;16(Supp 1):170-182.

17.Brown DA, Lee EW, Loh CT, Kee ST. A new wave in the treatment of vascular occlusive disease: Biodegradable stents – animal experience and scientific principles. J Vasc Interv Radiol. 2009 Mar;20(3):315-324.

18.Personalized Health Care Expert Panel Meeting: Summary Report. Submitted to US Depart­ ment of Health and Human Services by the Lewin Group, Inc. Sept. 10, 2007.

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