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Ugrumov M.V.

Mechanisms of neuroendocrine regulation. - M.: Nauka, 1999. - 299 p.,

il.

ISBN 5-02-004495-4

The monograph evaluates current ideas about the mechanisms of the neuroendocrine regulation in adult mammals and its development in ontogenesis. The importance of this basic problem is accounted for by the key role of the neuroendocrine system and of the biologically active substances produced by its elements in the regulation of the growth and development of the organism as well as in the integration and the maintaining of homeostasis in the whole organism. Peculiar attention was paid to the cellular and molecular mechanisms providing an integration of the nervous system and the endocrine system by means of the hypothalamo-hypwphysial complex. In the monograph, a general survey was made of: a) differentiation and functioning of peptidergic and monoaminergic hypothalamic neurons and their afferents; b) differentiation of the adenohypophysial glandular cells; c) mechanisms of the neuroendocrine regulation, direct and feedback; d) mechanisms of generation of circadian rhythms in the neuroendocrine regulation. It is emphasized that in addition to the activating short-term reversible effects, signalling molecules can exert prenatally long-lasting irreversible action on the differentiating target-cells. This information is of particular importance for the understanding of the pathogenesis of some inborn diseases being a result of the disturbed metabolism of the biologically active substances in the pregnant mother or of its treatment with the drugs having teratogenic side-effects. An importance of this monograph for the clinical medicine is not limited by this idea. Indeed, one of the chapters is devoted to the experimental imitation of some neruodegenerative diseases and to the attempts to compensate the deficiency in neurohormones or neurotrasmitters by the grafting of the respective normal neurons from the donor. This was considered at the basis for the using of neurotransplantation for the treatment at the neuroendocrine diseases provoked by degeneration of the hypothalamic neurosecretory neurons.

The monograph might be of interest for the wide range of the biologists and physicians as well as for the students in biology and medicine.

ОГЛАВЛЕНИЕ

ВВЕДЕНИЕ

3

Глава /

 

НЕЙРОНАЛЬНЫЕ СИСТЕМЫ, ПРОДУЦИРУЮЩИЕ

 

АДЕНОГИПОФИЗОТРОПНЫЕ ПЕПТИДЫ

 

Гонадотропин-рилизинг гормонпродуцирующая система

12

Тиреотропин-рилизинг гормонпродуцирующая система

23

Кортикотропин-рилизинг гормонпродуцирующая система

32

Соматостатинпродуцирующая система

38

Рилизинг-гормон гормона-роста-продуцирующая система

47

Глава II

 

НЕЙРОНАЛЬНЫЕ СИСТЕМЫ, ПРОДУЦИРУЮЩИЕ

 

"НЕЙРОГИПОФИЗАРНЫЕ" ГОРМОНЫ

 

Вазопрессинергическая система

54

Окситоцинергическая система

72

Глава III

 

МОНОАМИНЕРГИЧЕСКИЕ СИСТЕМЫ

 

ГИПОТАЛАМУСА

 

Катехоламинергическая система

81

Серотонинергическая система

111

Глава IV

 

ЖЕЛЕЗИСТЫЕ КЛЕТКИ ГИПОФИЗА

 

Гонадотропоциты

122

Тиреотропоциты

131

Лактотропоциты

136

Соматотропоциты

143

Проопиомеланокортинпродуцирующие клетки

148

Кортикотропоциты

152

Меланотропоциты

156

296

 

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Глава

V

 

НЕЙРОЭНДОКРИННАЯ РЕГУЛЯЦИЯ

 

Регуляция гонадотропной функции

 

159

Регуляция тиреотропной функции

 

167

Регуляция соматотропной функции

 

170

Регуляция лактотропной функции

 

176

Регуляция адренокортикотропной функции

 

183

Регуляция меланотропной функции

 

190

Гпава

VI

 

СУПРАХИАЗМАТИЧЕСКОЕ ЯДРО - ГЕНЕРАТОР

 

ЦИРКАДНЫХ РИТМОВ

 

Супрахиазматическое ядро взрослых млекопитающих

193

Супрахиазматическое ядро в онтогенезе

 

205

Гпава

VII

 

ИСПОЛЬЗОВАНИЕ НЕЙРОТРАНСПЛАНТАЦИИ

 

В НЕЙРОЭНДОКРИНОЛОГИИ

 

Введение

 

216

Общая характеристика трансплантации гипоталамуса

219

Трансплантация специфических нейронов реципиентам с дефицитом нейро-

 

гормонов

 

222

Перспективы клинической нейротрансплантации при нейроэндокринопа-

 

тиях

 

235

СПИСОК СОКРАЩЕНИЙ

 

237

ЛИТЕРАТУРА

 

238

CONTENTS

INTRODUCTION

Chapter I

N E U R O N A L S Y S T E M S P R O D U C I N G

A D E N O H Y P O P H Y S I O T R O P I C

PEPTIDES

Gonadotropin-releasing hormone-producing system

12

Thyrotropin-releasing hormone-producing system

23

Corticotropin-releasing hormone-producing system

32

Somatostatin-producing system

38

Growth hormone releasing hormone-producing system

47

Chapter П

N E U R O N A L S Y S T E M S " N E U R O H Y P O P H Y S I A L "

P R O D U C I N G H O R M O N E S

Vasopressinergic system

54

Oxytocinergic system

72

Chapter III

H Y P O T H A L A M I C M O N O A M I N E R G I C S Y S T E M S

Catecholaminergic system

81

Serotoninergic system

111

Chapter IV

PITUITARY G L A N D U L A R

C E L L S

Gonadotropocytes

122

Thyrotropocytes

131

Lactotropocytes

136

Somatotropocytes

143

Proopiomelanocortin-producing cells

148

Corticotropocytes

152

Melanotropocytes

156

298

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