6 курс / Эндокринология / Механизмы_нейроэндокринной_регуляции_Угрюмов_М_В_1999
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Ugrumov M.V.
Mechanisms of neuroendocrine regulation. - M.: Nauka, 1999. - 299 p.,
il.
ISBN 5-02-004495-4
The monograph evaluates current ideas about the mechanisms of the neuroendocrine regulation in adult mammals and its development in ontogenesis. The importance of this basic problem is accounted for by the key role of the neuroendocrine system and of the biologically active substances produced by its elements in the regulation of the growth and development of the organism as well as in the integration and the maintaining of homeostasis in the whole organism. Peculiar attention was paid to the cellular and molecular mechanisms providing an integration of the nervous system and the endocrine system by means of the hypothalamo-hypwphysial complex. In the monograph, a general survey was made of: a) differentiation and functioning of peptidergic and monoaminergic hypothalamic neurons and their afferents; b) differentiation of the adenohypophysial glandular cells; c) mechanisms of the neuroendocrine regulation, direct and feedback; d) mechanisms of generation of circadian rhythms in the neuroendocrine regulation. It is emphasized that in addition to the activating short-term reversible effects, signalling molecules can exert prenatally long-lasting irreversible action on the differentiating target-cells. This information is of particular importance for the understanding of the pathogenesis of some inborn diseases being a result of the disturbed metabolism of the biologically active substances in the pregnant mother or of its treatment with the drugs having teratogenic side-effects. An importance of this monograph for the clinical medicine is not limited by this idea. Indeed, one of the chapters is devoted to the experimental imitation of some neruodegenerative diseases and to the attempts to compensate the deficiency in neurohormones or neurotrasmitters by the grafting of the respective normal neurons from the donor. This was considered at the basis for the using of neurotransplantation for the treatment at the neuroendocrine diseases provoked by degeneration of the hypothalamic neurosecretory neurons.
The monograph might be of interest for the wide range of the biologists and physicians as well as for the students in biology and medicine.
ОГЛАВЛЕНИЕ
ВВЕДЕНИЕ |
3 |
Глава / |
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НЕЙРОНАЛЬНЫЕ СИСТЕМЫ, ПРОДУЦИРУЮЩИЕ |
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АДЕНОГИПОФИЗОТРОПНЫЕ ПЕПТИДЫ |
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Гонадотропин-рилизинг гормонпродуцирующая система |
12 |
Тиреотропин-рилизинг гормонпродуцирующая система |
23 |
Кортикотропин-рилизинг гормонпродуцирующая система |
32 |
Соматостатинпродуцирующая система |
38 |
Рилизинг-гормон гормона-роста-продуцирующая система |
47 |
Глава II |
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НЕЙРОНАЛЬНЫЕ СИСТЕМЫ, ПРОДУЦИРУЮЩИЕ |
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"НЕЙРОГИПОФИЗАРНЫЕ" ГОРМОНЫ |
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Вазопрессинергическая система |
54 |
Окситоцинергическая система |
72 |
Глава III |
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МОНОАМИНЕРГИЧЕСКИЕ СИСТЕМЫ |
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ГИПОТАЛАМУСА |
|
Катехоламинергическая система |
81 |
Серотонинергическая система |
111 |
Глава IV |
|
ЖЕЛЕЗИСТЫЕ КЛЕТКИ ГИПОФИЗА |
|
Гонадотропоциты |
122 |
Тиреотропоциты |
131 |
Лактотропоциты |
136 |
Соматотропоциты |
143 |
Проопиомеланокортинпродуцирующие клетки |
148 |
Кортикотропоциты |
152 |
Меланотропоциты |
156 |
296 |
|
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Глава |
V |
|
НЕЙРОЭНДОКРИННАЯ РЕГУЛЯЦИЯ |
|
|
Регуляция гонадотропной функции |
|
159 |
Регуляция тиреотропной функции |
|
167 |
Регуляция соматотропной функции |
|
170 |
Регуляция лактотропной функции |
|
176 |
Регуляция адренокортикотропной функции |
|
183 |
Регуляция меланотропной функции |
|
190 |
Гпава |
VI |
|
СУПРАХИАЗМАТИЧЕСКОЕ ЯДРО - ГЕНЕРАТОР |
|
|
ЦИРКАДНЫХ РИТМОВ |
|
|
Супрахиазматическое ядро взрослых млекопитающих |
193 |
|
Супрахиазматическое ядро в онтогенезе |
|
205 |
Гпава |
VII |
|
ИСПОЛЬЗОВАНИЕ НЕЙРОТРАНСПЛАНТАЦИИ |
|
|
В НЕЙРОЭНДОКРИНОЛОГИИ |
|
|
Введение |
|
216 |
Общая характеристика трансплантации гипоталамуса |
219 |
|
Трансплантация специфических нейронов реципиентам с дефицитом нейро- |
|
|
гормонов |
|
222 |
Перспективы клинической нейротрансплантации при нейроэндокринопа- |
|
|
тиях |
|
235 |
СПИСОК СОКРАЩЕНИЙ |
|
237 |
ЛИТЕРАТУРА |
|
238 |
CONTENTS
INTRODUCTION
Chapter I
N E U R O N A L S Y S T E M S P R O D U C I N G
A D E N O H Y P O P H Y S I O T R O P I C |
PEPTIDES |
Gonadotropin-releasing hormone-producing system |
12 |
Thyrotropin-releasing hormone-producing system |
23 |
Corticotropin-releasing hormone-producing system |
32 |
Somatostatin-producing system |
38 |
Growth hormone releasing hormone-producing system |
47 |
Chapter П
N E U R O N A L S Y S T E M S " N E U R O H Y P O P H Y S I A L "
P R O D U C I N G H O R M O N E S
Vasopressinergic system |
54 |
Oxytocinergic system |
72 |
Chapter III
H Y P O T H A L A M I C M O N O A M I N E R G I C S Y S T E M S
Catecholaminergic system |
81 |
Serotoninergic system |
111 |
Chapter IV
PITUITARY G L A N D U L A R |
C E L L S |
Gonadotropocytes |
122 |
Thyrotropocytes |
131 |
Lactotropocytes |
136 |
Somatotropocytes |
143 |
Proopiomelanocortin-producing cells |
148 |
Corticotropocytes |
152 |
Melanotropocytes |
156 |
298
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