- •Preface
- •List of contributers
- •History, epidemiology, prevention and education
- •A history of burn care
- •“Black sheep in surgical wards”
- •Toxaemia, plasmarrhea, or infection?
- •The Guinea Pig Club
- •Burns and sulfa drugs at Pearl Harbor
- •Burn center concept
- •Shock and resuscitation
- •Wound care and infection
- •Burn surgery
- •Inhalation injury and pulmonary care
- •Nutrition and the “Universal Trauma Model”
- •Rehabilitation
- •Conclusions
- •References
- •Epidemiology and prevention of burns throughout the world
- •Introduction
- •Epidemiology
- •The inequitable distribution of burns
- •Cost by age
- •Cost by mechanism
- •Limitations of data
- •Risk factors
- •Socioeconomic factors
- •Race and ethnicity
- •Age-related factors: children
- •Age-related factors: the elderly
- •Regional factors
- •Gender-related factors
- •Intent
- •Comorbidity
- •Agents
- •Non-electric domestic appliances
- •War, mass casualties, and terrorism
- •Interventions
- •Smoke detectors
- •Residential sprinklers
- •Hot water temperature regulation
- •Lamps and stoves
- •Fireworks legislation
- •Fire-safe cigarettes
- •Children’s sleepwear
- •Acid assaults
- •Burn care systems
- •Role of the World Health Organization
- •Conclusions and recommendations
- •Surveillance
- •Smoke alarms
- •Gender inequality
- •Community surveys
- •Acknowledgements
- •References
- •Prevention of burn injuries
- •Introduction
- •Burns prevalence and relevance
- •Burn injury risk factors
- •WHERE?
- •Burn prevention types
- •Burn prevention: The basics to design a plan
- •Flame burns
- •Prevention of scald burns
- •Conclusions
- •References
- •Burns associated with wars and disasters
- •Introduction
- •Wartime burns
- •Epidemiology of burns sustained during combat operations
- •Fluid resuscitation and initial burn care in theater
- •Evacuation of thermally-injured combat casualties
- •Care of host-nation burn patients
- •Disaster-related burns
- •Epidemiology
- •Treatment of disaster-related burns
- •The American Burn Association (ABA) disaster management plan
- •Summary
- •References
- •Education in burns
- •Introduction
- •Surgical education
- •Background
- •Simulation
- •Education in the internet era
- •Rotations as courses
- •Mentorship
- •Peer mentorship
- •Hierarchical mentorship
- •What is a mentor
- •Implementation
- •Interprofessional education
- •What is interprofessional education
- •Approaches to interprofessional education
- •References
- •European practice guidelines for burn care: Minimum level of burn care provision in Europe
- •Foreword
- •Background
- •Introduction
- •Burn injury and burn care in general
- •Conclusion
- •References
- •Pre-hospital and initial management of burns
- •Introduction
- •Modern care
- •Early management
- •At the accident
- •At a local hospital – stabilization prior to transport to the Burn Center
- •Transportation
- •References
- •Medical documentation of burn injuries
- •Introduction
- •Medical documentation of burn injuries
- •Contents of an up-to-date burns registry
- •Shortcomings in existing documentation systems designs
- •Burn depth
- •Burn depth as a dynamic process
- •Non-clinical methods to classify burn depth
- •Burn extent
- •Basic principles of determining the burn extent
- •Methods to determine burn extent
- •Computer aided three-dimensional documentation systems
- •Methods used by BurnCase 3D
- •Creating a comparable international database
- •Results
- •Conclusion
- •Financing and accomplishment
- •References
- •Pathophysiology of burn injury
- •Introduction
- •Local changes
- •Burn depth
- •Burn size
- •Systemic changes
- •Hypovolemia and rapid edema formation
- •Altered cellular membranes and cellular edema
- •Mediators of burn injury
- •Hemodynamic consequences of acute burns
- •Hypermetabolic response to burn injury
- •Glucose metabolism
- •Myocardial dysfunction
- •Effects on the renal system
- •Effects on the gastrointestinal system
- •Effects on the immune system
- •Summary and conclusion
- •References
- •Anesthesia for patients with acute burn injuries
- •Introduction
- •Preoperative evaluation
- •Monitors
- •Pharmacology
- •Postoperative care
- •References
- •Diagnosis and management of inhalation injury
- •Introduction
- •Effects of inhaled gases
- •Carbon monoxide
- •Cyanide toxicity
- •Upper airway injury
- •Lower airway injury
- •Diagnosis
- •Resuscitation after inhalation injury
- •Other treatment issues
- •Prognosis
- •Conclusions
- •References
- •Respiratory management
- •Airway management
- •(a) Endotracheal intubation
- •(b) Elective tracheostomy
- •Chest escharotomy
- •Conventional mechanical ventilation
- •Introduction
- •Pathophysiological principles
- •Low tidal volume and limited plateau pressure approaches
- •Permissive hypercapnia
- •The open-lung approach
- •PEEP
- •Lung recruitment maneuvers
- •Unconventional mechanical ventilation strategies
- •High-frequency percussive ventilation (HFPV)
- •High-frequency oscillatory ventilation
- •Airway pressure release ventilation (APRV)
- •Ventilator associated pneumonia (VAP)
- •(a) Prevention
- •(b) Treatment
- •References
- •Organ responses and organ support
- •Introduction
- •Burn shock and resuscitation
- •Post-burn hypermetabolism
- •Individual organ systems
- •Central nervous system
- •Peripheral nervous system
- •Pulmonary
- •Cardiovascular
- •Renal
- •Gastrointestinal tract
- •Conclusion
- •References
- •Critical care of thermally injured patient
- •Introduction
- •Oxidative stress control strategies
- •Fluid and cardiovascular management beyond 24 hours
- •Other organ function/dysfunction and support
- •The nervous system
- •Respiratory system and inhalation injury
- •Renal failure and renal replacement therapy
- •Gastro-intestinal system
- •Glucose control
- •Endocrine changes
- •Stress response (Fig. 2)
- •Low T3 syndrome
- •Gonadal depression
- •Thermal regulation
- •Metabolic modulation
- •Propranolol
- •Oxandrolone
- •Recombinant human growth hormone
- •Insulin
- •Electrolyte disorders
- •Sodium
- •Chloride
- •Calcium, phosphate and magnesium
- •Calcium
- •Bone demineralization and osteoporosis
- •Micronutrients and antioxidants
- •Thrombosis prophylaxis
- •Conclusion
- •References
- •Treatment of infection in burns
- •Introduction
- •Clinical management strategies
- •Pathophysiology of the burn wound
- •Burn wound infection
- •Cellulitis
- •Impetigo
- •Catheter related infections
- •Urinary tract infection
- •Tracheobronchitis
- •Pneumonia
- •Sepsis in the burn patient
- •The microbiology of burn wound infection
- •Sources of organisms
- •Gram-positive organisms
- •Gram-negative organisms
- •Infection control
- •Pharmacological considerations in the treatment of burn infections
- •Topical antimicrobial treatment
- •Systemic antimicrobial treatment (Table 3)
- •Gram-positive bacterial infections
- •Enterococcal bacterial infections
- •Gram-negative bacterial infections
- •Treatment of yeast and fungal infections
- •The Polyenes (Amphotericin B)
- •Azole antifungals
- •Echinocandin antifungals
- •Nucleoside analog antifungal (Flucytosine)
- •Conclusion
- •References
- •Acute treatment of severely burned pediatric patients
- •Introduction
- •Initial management of the burned child
- •Fluid resuscitation
- •Sepsis
- •Inhalation injury
- •Burn wound excision
- •Burn wound coverage
- •Metabolic response and nutritional support
- •Modulation of the hormonal and endocrine response
- •Recombinant human growth hormone
- •Insulin-like growth factor
- •Oxandrolone
- •Propranolol
- •Glucose control
- •Insulin
- •Metformin
- •Novel therapeutic options
- •Long-term responses
- •Conclusion
- •References
- •Adult burn management
- •Introduction
- •Epidemiology and aetiology
- •Pathophysiology
- •Assessment of the burn wound
- •Depth of burn
- •Size of the burn
- •Initial management of the burn wound
- •First aid
- •Burn blisters
- •Escharotomy
- •General care of the adult burn patient
- •Biological/Semi biological dressings
- •Topical antimicrobials
- •Biological dressings
- •Other dressings
- •Exposure
- •Deep partial thickness wound
- •Total wound excision
- •Serial wound excision and conservative management
- •Full thickness burns
- •Excision and autografting
- •Topical antimicrobials
- •Large full thickness burns
- •Serial excision
- •Mixed depth burn
- •Donor sites
- •Techniques of wound excision
- •Blood loss
- •Antibiotics
- •Anatomical considerations
- •Skin replacement
- •Autograft
- •Allograft
- •Other skin replacements
- •Cultured skin substitutes
- •Skin graft take
- •Rehabilitation and outcome
- •Future care
- •References
- •Burns in older adults
- •Introduction
- •Burn injury epidemiology
- •Pathophysiologic changes and implications for burn therapy
- •Aging
- •Comorbidities
- •Acute management challenges
- •Fluid resuscitation
- •Burn excision
- •Pain and sedation
- •End of life decisions
- •Summary of key points and recommendations
- •References
- •Acute management of facial burns
- •Introduction
- •Anatomy and pathophysiology
- •Management
- •General approach
- •Airway management
- •Facial burn wound management
- •Initial wound care
- •Topical agents
- •Biological dressings
- •Surgical burn wound excision of the face
- •Wound closure
- •Special areas and adjacent of the face
- •Eyelids
- •Nose and ears
- •Lips
- •Scalp
- •The neck
- •Catastrophic injury
- •Post healing rehabilitation and scar management
- •Outcome and reconstruction
- •Summary
- •References
- •Hand burns
- •Introduction
- •Initial evaluation and history
- •Initial wound management
- •Escharotomy and fasciotomy
- •Surgical management: Early excision and grafting
- •Skin substitutes
- •Amputation
- •Hand therapy
- •Secondary reconstruction
- •References
- •Treatment of burns – established and novel technology
- •Introduction
- •Partial thickness burns
- •Biological membranes – amnion and others
- •Xenograft
- •Full thickness burns
- •Dermal analogs
- •Keratinocyte coverage
- •Facial transplantation
- •Tissue engineering and stem cells
- •Gene therapy and growth factors
- •Conclusion
- •References
- •Wound healing
- •History of wound care
- •Types of wounds
- •Mechanisms of wound healing
- •Hemostasis
- •Proliferation
- •Epithelialization
- •Remodeling
- •Fetal wound healing
- •Stem cells
- •Abnormal wound healing
- •Impaired wound healing
- •Hypertrophic scars and keloids
- •Chronic non-healing wounds
- •Conclusions
- •References
- •Pain management after burn trauma
- •Introduction
- •Pathophysiology of pain after burn injuries
- •Nociceptive pain
- •Neuropathic pain
- •Sympathetically Maintained Pain (SMP)
- •Pain rating and documentation
- •Pain management and analgesics
- •Pharmacokinetics in severe burns
- •Form of administration [21]
- •Non-opioids (Table 1)
- •Paracetamol
- •Metamizole
- •Non-steroidal antirheumatics (NSAID)
- •Selective cyclooxygenasis-2-inhibitors
- •Opioids (Table 2)
- •Weak opioids
- •Strong opioids
- •Other analgesics
- •Ketamine (see also intensive care unit and analgosedation)
- •Anticonvulsants (Gabapentin and Pregabalin)
- •Antidepressants with analgesic effects
- •Regional anesthesia
- •Pain management without analgesics
- •Adequate communication
- •Psychological techniques [65]
- •Transcutaneous electrical nerve stimulation (TENS)
- •Particularities of burn pain
- •Wound pain
- •Breakthrough pain
- •Intervention-induced pain
- •Necrosectomy and skin grafting
- •Dressing change of large burn wounds and removal of clamps in skin grafts
- •Dressing change in smaller burn wounds, baths and physical therapy
- •Postoperative pain
- •Mental aspects
- •Intensive care unit
- •Opioid-induced hyperalgesia and opioid tolerance
- •Hypermetabolism
- •Psychic stress factors
- •Risk of infection
- •Monitoring [92]
- •Sedation monitoring
- •Analgesia monitoring (see Fig. 2)
- •Analgosedation (Table 3)
- •Sedation
- •Analgesia
- •References
- •Nutrition support for the burn patient
- •Background
- •Case presentation
- •Patient selection: Timing and route of nutritional support
- •Determining nutritional demands
- •What is an appropriate initial nutrition plan for this patient?
- •Formulations for nutritional support
- •Monitoring nutrition support
- •Optimal monitoring of nutritional status
- •Problems and complications of nutritional support
- •Conclusion
- •References
- •HBO and burns
- •Historical development
- •Contraindications for the use of HBO
- •Conclusion
- •References
- •Nursing management of the burn-injured person
- •Introduction
- •Incidence
- •Prevention
- •Pathophysiology
- •Severity factors
- •Local damage
- •Fluid and electrolyte shifts
- •Cardiovascular, gastrointestinal and renal system manifestations
- •Types of burn injuries
- •Thermal
- •Chemical
- •Electrical
- •Smoke and inhalation injury
- •Clinical manifestations
- •Subjective symptoms
- •Possible complications
- •Clinical management
- •Non-surgical care
- •Surgical care
- •Coordination of care: Burn nursing’s unique role
- •Nursing interventions: Emergent phase
- •Nursing interventions: Acute phase
- •Nursing interventions: Rehabilitative phase
- •Ongoing care
- •Infection prevention and control
- •Rehabilitation medicine
- •Nutrition
- •Pharmacology
- •Conclusion
- •References
- •Outpatient burn care
- •Introduction
- •Epidemiology
- •Accident causes
- •Care structures
- •Indications for inpatient treatment
- •Patient age
- •Total burned body surface area (TBSA)
- •Depth of the burn
- •Pre-existing conditions
- •Accompanying injuries
- •Special injuries
- •Treatment
- •Initial treatment
- •Pain therapy
- •Local treatment
- •Course of treatment
- •Complications
- •Infections
- •Follow-up care
- •References
- •Non-thermal burns
- •Electrical injury
- •Introduction
- •Pathophysiology
- •Initial assessment and acute care
- •Wound care
- •Diagnosis
- •Low voltage injuries
- •Lightning injuries
- •Complications
- •References
- •Symptoms, diagnosis and treatment of chemical burns
- •Chemical burns
- •Decontamination
- •Affection of different organ systems
- •Respiratory tract
- •Gastrointestinal tract
- •Hematological signs
- •Nephrologic symptoms
- •Skin
- •Nitric acid
- •Sulfuric acid
- •Caustic soda
- •Phenol
- •Summary
- •References
- •Necrotizing and exfoliative diseases of the skin
- •Introduction
- •Necrotizing diseases of the skin
- •Cellulitis
- •Staphylococcal scalded skin syndrome
- •Autoimmune blistering diseases
- •Epidermolysis bullosa acquisita
- •Necrotizing fasciitis
- •Purpura fulminans
- •Exfoliative diseases of the skin
- •Stevens-Johnson syndrome
- •Toxic epidermal necrolysis
- •Conclusion
- •References
- •Frostbite
- •Mechanism
- •Risk factors
- •Causes
- •Diagnosis
- •Treatment
- •Rewarming
- •Surgery
- •Sympathectomy
- •Vasodilators
- •Escharotomy and fasciotomy
- •Prognosis
- •Research
- •References
- •Subject index
Medical documentation of burn injuries
parts in expertise. It shows the same problems like Lund Browder Chart, but has often major financial and juristic impact.
3D – computer assisted evaluation
Sage II, Burn Vision 3D [50], BurnCase 3D [19] are existing systems that are currently in use. Sage II is a two-dimensional system, the others are three-di- mensional.
To overcome the drawbacks of existing estimation methods, the three-dimensional structure of the human body surface must be taken into account when determining the TBSAB (Total Body Surface Area Burned) of an individual patient. Modern computer graphics software is an effective, user-friendly way of dealing with three-dimensional surfaces. As already proposed by [39], the estimation and documentation of burned surface area on three-dimen- sional virtual models qualify to overcome difficulties in burn documentation.
It has been shown, that by the use of computerassisted assessment procedures, the variability of results among different observers can be reduced [50]. Discussion:
Three dimensional systems help to avoid of system immanent error: Only a three-dimensional model can ensure a sufficient documentation of the burn injury and its interpretation. In the two dimensional anterior – posterior view it is nearly impossible to classify and to illustrate burns of the lateral part of the body.
Exact documentation needs appropriate graphic resolution. The resolution of BurnVision is too low to get details. Only BurnCase3D has a sufficient resolution of 1 cm2 to illustrate height and weight as well as type of physique sufficiently.
Optical resolution of SageII is not described.
Computer aided three-dimensional documentation systems
Software-based diagnostics and documentation in modern medicine is a growing field, becoming very popular nowadays. In contrast, classification and documentation of human burn injuries and their
follow-up is still a manually performed procedure, based on paper estimation charts, free text records and most of all strongly dependent on individual impression and medical experience of the physician involved.
The exploitation of modern computer graphics technology is an effective and user-friendly way of dealing with 3D surfaces. As stated above, the estimation and documentation of burned surface area by means of 3D computer graphics is appropriate for mastering the difficulties of burn diagnostics and treatment. Electronic systems like BurnCase 3D take the three-dimensional structure of the human body surface into account when determining the TBSA of an individual patient. BurnCase 3D also regards different body shapes caused by sexual differences, age, weight, size and corpulence.
The usage of computer-aided methods can tremendously reduce error rates, but still the problem of incorrect input of burn areas resides. A major reason for input errors by chance or intended is clearly the fact of “subjective cognition” of wound areas for different reasons and the complexity of transferring the three-dimensional wound surface onto a twodimensional estimation chart. Another reason is the fact that every patient is an individual, not exactly fitting the mean human body shape and surface proposed by all common estimation methods; even by models of BurnCase3D. The only way to change this would be the creation of individual models from 3D scanners or tomography, but this till today is not feasible in praxis.
Methods used by BurnCase 3D
To overcome the issues described above, it is essential to find a way to objectively define the burned surface area and link all collected relevant data to be able to reduce the work load on the one hand and support the personnel in making decisions for the further medical treatment on the other hand, with balanced scientific claim and pragmatic feasibility.
A development team consisting of computer scientists and medical scientists has been working on a state-of-the-art software system named BurnCase 3D since 2001. During this research project, which follows the principles of action research, many chal-
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Fig. 1. User interface showing the virtual 3D model different burn degrees, calculated scores and an integrated digital picture archive
lenges of modern burn care have been taken into account by the developers. Its strength is the simple and intuitive user interface; allowing quick data input without the need of sophisticated training (Fig. 1).
Technical description
The system operates on a 3D virtual body representing the real patient. This model is build up as a three-dimensional mesh of over 90 000 connected triangles with each smaller than one cm2. By specifying age, sex, height and weight and choosing an appropriate 3D standard model the system is able to
generate an automatically adapted virtual body surface which accurately fits the patient’s individual body shape. The standard model is precisely adapted to the patient’s height by scaling in longitudinal direction. Afterwards, a surface adaptation algorithm deor inflates the model until its TBSA exactly reaches the predicted value calculated by an established TBSA estimation formula.
BurnCase 3D incorporates the 12 most widely accepted TBSA estimation formulas in scientific literature. The adaptation algorithm also takes into account the growth behavior of different body regions in order to reach a realistic body expansion.
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Medical documentation of burn injuries
3D registration
The burned surface area is marked on the 3D body surface by standard mouse interaction. The user simply sketches the burned area with the mouse or pen cursor and BurnCase 3D projects this twodimensional polygon onto the underlying threedimensional body. Consequently, the marked area appears in a significant color and pattern, thus visualizing different burn degrees of injuries or even surgical procedures, dressings or medications. The covered surface area, as well as the affected percentage of the total body surface area (TBSA) and based on these values several medical scored and indices (ASBI, Baux, Baxter-Parkland, etc.) are calculated in real-time and presented on the user interface immediately after drawing. By rotation and zooming of the model all parts of the body can be assessed and documented.
Work reduction by automated creation of codes
The surface areas classified to burn degrees as well as operative procedures are automatically encoded to the different medical codes, which are often needed for reimbursement.
Objectivities by visual verification
In order to further increase the level of accuracy, an integrated digital picture archive provides visual verification by superimposing pictures on the 3D model. In addition, an intuitive model-picture-regis- tration algorithm has been implemented, which allows the physician to easily move the virtual body in the position of the patient on any digital picture. By doing so, the whole burn surface estimation procedure becomes as easy as sketching the border of burn wounds on a picture, however reducing the drawback of subjective influences.
Archiving photos
The system assigns photos in a simple and intuitive way to patients, dates, areas, burn conditions, procedures and even 3D location. Photos can be searched by these criteria after insertion.
Way to objective assessment of burn extent and burn depth
The combination of this 3D surface area information with available burn depth classification methods
Creation of treatment history
An 3D state of the patient can be created and revisited at different points in time throughout the whole treatment. Thus, a comprehensive three-dimension- al track of the complete treatment history is created and stored in the database for every patient.
Additional burnrelated information
Additional burn-related information such as course of accident, first aid, complications, former illnesses, and condition on admission, etc. can also be acquired and stored to the database. In order to be able to supervise all changes to the stored data, BurnCase 3D keeps track of every data acquisition or deletion in a separate change log. The data collection is compatible to the United States’ National Trauma Registry (NTRACS).
Fig. 2. Model-Picture-Alignment procedure with 2D (red) and 3D (blue) reference points
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leads to an automatic and objective characterization and documentation of burn injuries. For example, a special CCD camera together with appropriate classification software is developed by Dr. Werner Eisenbeiss and Dr. Jörg Marotz in Lübeck, Germany at Delphi-Optics GmbH. Moreover, other methods like Laser-Doppler-Measurement (Moore Instruments, UK) or Infrared Spectroscopy (NRCC, Canada) show different behaviors due to relying on different physical properties, but they can also be used as classification input for BurnCase 3D.
Creating a comparable international database
BurnCase 3D is designed as stand-alone procedure, as hospital network or as national or international database. The system provides necessary data protection by anonymisation and encryption of data to be transferred within the systems.
Results
Fig. 3. Mobile version of the burn injury documentation system BurnCase 3D
In contrast to common estimation methods mentioned above, BurnCase 3D uses an accurate threedimensional model of the patient for the surface calculation. Thus, a very high validity regarding the total body surface area can be achieved. Moreover, visual comparison between the real patient and the adapted virtual model enables verification that has not been possible before.
The benefits of using a computer-aided burn classification and documentation procedure over arbitrary paper estimation charts are obvious. A tremendous reduction of work load for documentation purposes for the physician is the major advantage resulting in more time for patient’s treatment. Secondly, this software system lowers the risk of overand underestimation of burn wounds by less experienced physicians. For the first time, an objective diagnostic method for burn injuries is available, which allows comparison studies even of different institutions and countries on a substantiated data basis. Finally, there is an obvious benefit for the hospital’s accounting since all necessary medical encodings like ICD10 are generated automatically.
First results of the BurnCase 3D project have been published by Dirnberger and Diretzlehner.
BurnCase 3D is currently deployed in several burn units in Europe and the US, since 2004a continuously growing number of hospitals in Linz (AUT), Vienna (AUT), Feldkirch (AUT), Halle/Saale (GER), Lübeck (GER), Mannheim (GER), Rotterdam (NED), Galveston (USA), Phoenix (USA), Birmingham (GB), Rome (IT) and Zürich (CH) are using the system for their burn surface estimation and documentation. The system is available as stand-alone and as network version providing a central database of burn cases directly connected to the institution’s hospital information system (HIS). The integration of classification images as described above is easily possible. The software system is ready to be installed on a common Microsoft Windows personal computer and uses the OpenGL technology for 3D visualization.
As most of the physicians possess smartphones, it is quite reasonable to make use of this existing hardware. The research team has already gained experience in the implementation of three-dimension- al documentation systems into mobile platforms. A mobile version of BurnCase 3D for the platform iPhone OS (iPod , iPhone , iPad ) by Apple is already available.
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