Добавил:
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:

Книги по МРТ КТ на английском языке / The Embryonic Human Brain An Atlas of Developmental Stages. Third Edition. 2006. By Ronan O'Rahilly

.pdf
Скачиваний:
2
Добавлен:
05.10.2023
Размер:
37.7 Mб
Скачать

198

C h a p t e r 2 1 : THE FIRST APPEARANCE OF THE CORTICAL PLATE IN THE CEREBRAL HEMISPHERES

Figure 21–14. The ventral part of the lateral geniculate body at the level of the sulcus medius, and the entopeduncular nucleus of the subthalamus. The entopeduncular nucleus (globus pallidus internus) is at first at a more

caudal level than the globus pallidus externus.

21 – 14

15

Lat. geniculate body

Marginal ridge

Zona limitans intrathalamica

Sulcus

medius

Thal. v.

Entopeduncular nucleus

Medial ventricular

eminence

Thalamus ventralis

 

Hypothalamic

 

sulcus

 

Lat.

Subthalamus

pros.

fasc.

 

 

Globus

 

pallidus

 

ext.

 

Optic

 

tract

Hypothalamus

 

 

N.-H.

A.-H.

 

21 –

17

16

Figure 21–15. Fibers of the optic tract, the globus pallidus externus, and the lateral prosencephalic bundle (Stammbundel¨ of His). The cellular bridge between the medial ventricular eminence and the thalamus (cf. Fig. 21–6) is important in the formation of the pulvinar during the fetal period (Rakic and Sidman, 1969). The central part of the neurohypophysis is visible between the lateral parts of the adenohypophysis.

Lat. pros. fasciculus Di-telencephalic sulcus

Globus pallidus ext.

Figure 21–16. The globus pallidus externus in a more rostral area. The lateral prosencephalic bundle is surrounded by fibers of the fasciculus lenticularis (arrowhead).

200

C h a p t e r 2 1 : THE FIRST APPEARANCE OF THE CORTICAL PLATE IN THE CEREBRAL HEMISPHERES

21 – 19

20

Hipp.

Roof

of V3

 

Area dentata

 

 

 

Area

Corpus

Wall of

Stria

cerebelli

lat. recess

epithelialis

 

 

medullaris

 

 

 

 

 

thalami

 

 

 

 

 

Sulcus

 

 

 

limitans

 

Figure 21–17. The hippocampus and adjacent areas. The root of the choroid plexus continues into the area epithelialis. From there, the following zones can be traced upwards: area dentata, hippocampus and subiculum, and mesocortex. In the hippocampus, marginal and pyramidal cells can already be distinguished (Muller¨ and O’Rahilly, 1990b). The telencephalon is separated from the diencephalon by loose mesenchyme. The stria medullaris thalami and the folded roof of the third ventricle are visible.

Intermediate layer

Figure 21–19. General view of the cerebellum at the level shown above. Choroid villi are present in the choroid fold and in the wall of the lateral recess of the fourth ventricle. The internal cerebellar swelling, which is lateral to the sulcus limitans, consists mainly of cellular columns of the ventricular layer. A lighter area represents the intermediate layer, followed by the internal fiber layer. The dark area near the lower part of the section is the primordium of the dentate nucleus (between arrowheads). The external fiber layer is entirely at the periphery. Bar: 0.2 mm.

Figure 21–18. Schematic representation of the development of the tentorium cerebelli at stage 21. The medial part is shown by hatching, the lateral parts by black arrows.

THE FIRST APPEARANCE OF THE CORTICAL PLATE IN THE CEREBRAL HEMISPHERES

201

Ventricular layer

Sulcus limitans

. Dent

Rhombic lip

Flocculus

Dentate

Int. fiber

Flocculus

layer

nucleus

 

 

 

Figure 21–20. The internal cerebellar swellings. The vertical columns of the ventricular layer are distinct. Numerous blood vessels penetrate almost as far as the ventricular surface. The rhombic lip has no marginal layer. Bar: 0.2 mm.

Above, in the schematic interpretation of the section the open arrow indicates the ascending fibers of the inferior cerebellar peduncle, the black arrows the direction of the migrating cells. Asterisk, intermediate layer.

202

C h a p t e r 2 1 : THE FIRST APPEARANCE OF THE CORTICAL PLATE IN THE CEREBRAL HEMISPHERES

 

Stage

15

Figure 21–21. Right lateral views to show the

13

 

1

1

 

ventricular cavities at approximately 4 /2–7

/2

 

 

weeks. The ventricles at stage 23 are illustrated

 

 

in Figure 23–27.

 

 

 

Growth of the medial and lateral ventricular

 

 

eminences transforms the formerly

 

 

 

hemispherical lateral ventricle into a C-shaped

 

 

cavity, which is continuous rostrally with the

 

 

olfactory ventricle. The first indication of

 

 

 

anterior and inferior horns can be seen in stage

 

 

21 in the lateral ventricle (O’Rahilly and Muller,¨

 

 

1990).

 

17

 

21

 

External

contour of brain

Internal

THE FIRST APPEARANCE OF THE CORTICAL PLATE IN THE CEREBRAL HEMISPHERES

203

A

 

B

C

 

 

D

 

AICA

Figure 21–22. The arterial system at about 6 to 7 postfertilizational weeks. The internal carotid artery is shown in black, and the basilar by horizontal hatching. (A) and (B) The arteries at stage 17. New vessels that can now be identified include the anterior and middle cerebral (AC, MC), and the anterior and posterior choroid arteries. The vertebral artery is formed by anastomoses between the cervical segmental arteries.

(C) and (D) The arteries at stage 21 showing the anterior, middle, and posterior cerebral vessels. The anterior communicating artery is present, so that the circulus arteriosus is now complete. The choroid plexuses of the lateral and fourth ventricles are included. These drawings are based on graphic reconstructions made by Padget (1948), whose work should be studied for further details. The venous system at stages 18, 19, 20, and 21 has been illustrated by Padget (1957, Figs. 6, 9, 11, and 10). The arterial system at the end of the embryonic period is shown in Figures 23–33 and 23–34.

Abbreviations: AC, anterior cerebral; AICA, anterior inferior cerebellar artery; DA, ductus arteriosus; MC, middle cerebral; PC, posterior cerebral; P.co., posterior communicating; PICA, posterior inferior cerebellar artery; PT, pulmonary trunk.

204

 

C h a p t e r 2 1 : THE FIRST APPEARANCE OF THE CORTICAL PLATE IN THE CEREBRAL HEMISPHERES

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

4 weeks

 

5

 

 

 

6

 

7

 

 

9

Stages 10 11 12 13

14

15

16

 

17

18

19

20

21

 

 

 

 

 

 

 

 

 

 

 

 

 

Inter-

 

 

 

 

Post. spinal

 

 

 

 

 

segmental

 

Vertebral

 

 

 

 

 

 

 

Longitudinal

 

 

Ant. spinal

 

PICA

 

 

 

 

neural

 

 

Basilar

 

 

Labyrinthine

 

 

 

 

 

 

 

 

Sup.

 

 

 

 

 

 

 

 

 

 

AICA

 

 

 

 

 

 

Trigeminal

 

 

 

cerebellar

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CAROTICO-

 

 

 

 

 

 

 

 

 

Otic

 

BASILAR

 

regresses

 

 

 

 

 

 

 

ANASTOMOSIS

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Aortic

 

 

 

 

 

 

 

 

 

 

 

arch

Hypoglossal

 

 

 

 

 

 

 

1

 

 

 

 

 

 

 

 

 

 

 

 

2

 

 

 

 

 

 

 

 

 

 

 

3

 

 

 

 

Ext. carotid

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Hyoid

 

 

 

 

Stapedial

 

 

 

 

 

 

c

 

 

 

 

Post. choroid

 

 

 

 

 

Post. communicating

 

 

 

 

 

 

 

 

Int.

 

 

 

 

Post. cerebral

 

CIRCULUS

 

 

 

 

 

 

 

 

 

 

carotid

ARTERIOSUS

 

 

Middle cerebral

rOlfactory

Ant. cerebral

Ant. communicating

Ant. choroid

 

Hyaloid

New ophthalmic

Ophthalmic

Development of circulus arteriosus

Stage 19

Stage 21

Figure 21–23. Above, summary of the arterial development. c, caudal division; r, rostral division. Below, the completion of the circuit by the formation of the anterior communicating artery.

C H A P T E R 22

STAGE 22: THE INTERNAL CAPSULE AND THE OLFACTORY BULBS

Approximately 23–28 mm in Greatest Length;

Approximately 52 Postfertilizational Days

The internal capsule and its connections to the neopallium are now present and are as follows: (1) to the epithalamus, (2) to the dorsal thalamus,

and (3) to the mesencephalon. The claustrum develops, and a clear developmental relationship exists between it and the intermediate layer of the olfactory bulb. The globus pallidus externus moves towards a telencephalic position.

Important

Contrary to the opinion of certain authors in the past (including His), what appears to be a fusion between the cerebral hemisphere and the diencephalon is a thickening of the thalamic wall at the di-telencephalic sulcus as the internal capsular fibers begin to pass through it. This was appreciated by Hochstetter (1929) and Sharp (1959), as well as by Bartelmez (cited by Padget, 1957).

The Embryonic Human Brain: An Atlas of Developmental Stages, Third Edition. By O’Rahilly and Muller¨ Copyright C 2006 John Wiley & Sons, Inc.

205

206

C h a p t e r 2 2 : THE INTERNAL CAPSULE AND THE OLFACTORY BULBS

Figure 22–1. Right lateral view of the brain in a Born reconstruction. The midbrain is at the summit. The temporal and frontal poles of the cerebral hemisphere are evident.

M

b Di.

g

aT

Figure 22–2. Right lateral view of the brain. The cerebral hemispheres cover about three-quarters of the diencephalon. The three poles (α, β, γ ) are distinguishable. The mesencephalon is “ballooning out” (Bartelmez and Dekaban, 1962), sits on top of the brain, and is higher than the cerebellar plates. Its delineation, therefore, is easier than in earlier stages. The inferior colliculus forms a slight bulge on top of the Blindsack. The isthmus is markedly narrow. The posterolateral fissure, which delineates the future flocculus, has become a sharp boundary. The cerebellar plates are no longer as wide as the cerebral hemispheres (see inset). A reconstruction of the cranial nerves is available (Muller¨ and O’Rahilly, 1991, Fig. 4).

THE INTERNAL CAPSULE AND THE OLFACTORY BULBS

207

a

b

c

(a) Sulcus limitans

 

(b) Hypothalamic sulcus

 

(c) Marginal ridge

Figure 22–3. Graphic reconstruction prepared from transverse sections to show a median view of the brain. The asterisk indicates the junction with the spinal cord. The internal relief is shown, and the structures of the medial wall of the left hemisphere are projected as interrupted lines: the caudal extent of the cerebral hemispheres, the area dentata, and the hippocampus. The hippocampus extends between the occipital pole and the prosencephalic septum. The marginal ridge separates the diencephalon into halves: the dorsal thalamus on one side, and the ventral thalamus, subthalamus, and hypothalamus on the other. The pineal recess (arrow at right) is still undivided. The isthmic groove (upper arrow) and the isthmic recess (lower arrow) are also marked. The commissural plate has become thicker. No fusion takes place during the embryonic period proper between the cerebral hemispheres, as was clearly understood and stated by Hochstetter (1919).1 The approximate levels of Figures 22–7 to 22–12 are indicated, although the fit does not correspond completely, because these are from different embryos. (For example, in Figure 22–7 the interpeduncular fossa is slightly more dorsal than in Figure 22–3.) A three-dimensional reconstruction, prepared ultrasonically, of the ventricles in vivo in an embryo of 24 mm is illustrated by Blaas et al. (1995b).

1“Nicht der kleinste Umstand aber deutet darauf hin, dass die zu beobachtende Dickenzunahme etwa auf eine Verwachsung der unmittelbar an die Kommissurenplatte anschliessenden Abschnitte der medialen Hemispharenw¨ ande¨ zuruckzuf¨ uhren¨ ware”¨ (p. 109). See also definition of Massa commissuralis in the Glossary.