6 курс / Медицинская реабилитация, ЛФК, Спортивная медицина / Научные тренды продления жизни

Основные публикации

по теме

Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway. Maggio M, Guralnik

JM, Longo DL, Ferrucci L. J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):575-84.

Aging and Estrogen: Modulation of Inflammatory Responses After Injury. Gomez CR, Plackett

TP, Kovacs EJ. Exp Gerontol. 2007 May;42(5):451-6.

Finkel, FEBS letters, 2000. Vol 470, Issue 1, 20-24

Free Radicals and Senescence. Teng Lu and Toren Finkel, Exp Cell Res. 2008, 314(9), 1918–

1922

Mitochondrial signaling, TOR, and life span. Schieke SM, Finkel T., Biol Chem. 2006,

387(10-11),1357-61.

Update on slow aging and negligible senescence--a mini-review. Finch CE. Gerontology.

2009;55(3):307-13.

Next-generation sequencing in aging research: Emerging applications, problems, pitfalls and

possible solutions. de Magalhães JP, Finch CE, Janssens G. Ageing Res Rev. 2009 Nov 10.

Progesterone receptors: form and function in brain. Brinton RD, Thompson RF, Foy MR,

Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J. Front

Neuroendocrinol. 2008 May;29(2):313-39.

The effects of caloric restriction– and exercise-induced weight loss on left ventricular diastolic

function. Riordan Matt M; Weiss Edward P; Meyer Timothy E; Ehsani Ali A; Racette Susan

B; Villareal Dennis T; Fontana Luigi; Holloszy John O; Kovács Sándor J. American journal of

physiology. Heart and circulatory physiology 2008;294(3):H1174-82.

Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized,

controlled trial. Fontana Luigi; Villareal Dennis T; Weiss Edward P; Racette Susan B; Steger-

May Karen; Klein Samuel; Holloszy John O; American journal of physiology. Endocrinology

and metabolism 2007;293(1):E197-202.

Caloric restriction in humans. Holloszy John O; Fontana Luigi. Experimental gerontology

2007;42(8):709-12.

Disparate effects on renal and oxidative parameters following RAGE deletion, AGE

accumulation inhibition or dietary AGE control in diabetic nephropathy. Tan AL, Sourris

KC, Harcourt BE, Thallas-Bonke V, Penfold S, Andrikopoulos S Phd, Thomas MC, O'Brien

RC, Bierhaus A, Cooper ME, Forbes JM, Coughlan MT. Am J Physiol Renal Physiol. 2009

Dec 16.

A new perspective on therapeutic inhibition of advanced glycation in diabetic microvascular

complications: common downstream endpoints achieved through disparate therapeutic

approaches? Sourris KC, Harcourt BE, Forbes JM. Am J Nephrol. 2009;30(4):323-35.

Scaffold-free vascular tissue engineering using bioprinting. Norotte C, Marga FS, Niklason

LE, Forgacs G. Biomaterials. 2009 Oct;30(30):5910-7

Tissue engineering by self-assembly of cells printed into topologically defined structures. Jakab

K, Norotte C, Damon B, Marga F, Neagu A, Besch-Williford CL, Kachurin A, Church KH,

Park H, Mironov V, Markwald R, Vunjak-Novakovic G, Forgacs G. Tissue Eng Part A. 2008

Mar;14(3):413-21.

Three-dimensional tissue constructs built by bioprinting. Jakab K, Damon B, Neagu A,

Kachurin A, Forgacs G. Biorheology. 2006;43(3-4):509-13

Основные публикации

по теме

Remyelination in the CNS: from biology to therapy. Franklin RJ, Ffrench-Constant C. Nat Rev

Neurosci. 2008 Nov;9(11):839-55.

Taking ageing into account in remyelination-based therapies for multiple sclerosis. Rist JM,

Franklin RJ. J Neurol Sci. 2008 Nov 15;274(1-2):64-7.

The biology of CNS remyelination: the key to therapeutic advances. Franklin RJ, Kotter MR. J

Neurol. 2008 Mar;255 Suppl 1:19-25.

The immune system in extreme longevity Sansoni P, Vescovini R, Fagnoni F, Biasini C,

Zanni F, Zanlari L, Telera A, Lucchini G, Passeri G, Monti D, Franceschi C, Passeri M. Exp

Gerontol. 2009; 43:61-65.

Human longevity and 11p15.5: a study in 1321 centenarians Lescai F, Blanché H, Nebel

A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino

G,Franceschi C. Eur J Hum Genet. 2009; 17: 1515–9.

Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes

mellitus. Sooparb S, Price SR, Shaoguang J, Franch HA. Kidney Int. 2004 Jun;65(6):2135-

44.

Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in

muscle cells: consequences on proteolysis. Franch HA, Raissi S, Wang X, Zheng B, Bailey JL,

Price SR. Am J Physiol Renal Physiol. 2004 Oct;287(4):F700-6.

Kidney growth during catabolic illness: what it does not destroy makes it grow stronger. Franch

HA. J Ren Nutr. 2007 May;17(3):167-72.

Nanotechnology, nanomedicine and nanosurgery. Freitas RA Jr. Int J Surg. 2005;3(4):243-6.

Epub 2005 Nov 28. No abstract available.

Medical nanorobot architecture based on nanobioelectronics. Cavalcanti A, Shirinzadeh B,

Freitas RA Jr, Kretly LC. Recent Pat Nanotechnol. 2007;1(1):1-10.

Algae extract-mediated stimulation and protection of proteasome activity within human

keratinocytes exposed to UVA and UVB irradiation. Bulteau AL, Moreau M, Saunois A,

Nizard C, Friguet B.Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):136-43.

The proteasome is an integral part of solar ultraviolet a radiation-induced gene

expressionCatalgol B, Ziaja I, Breusing N, Jung T, Hoehn A, Alpertunga B, Schroeder P,

Chondrogianni N, Gonos ES, Petropoulos I, Friguet B, Klotz LO, Krutmann J, Grune T. . J

Biol Chem. 2009 Aug 18.

Proteasome function in aging and oxidative stress: implications in protein maintenance

failure. Farout L, Friguet B. Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):205-16.

Extracellular glycation crosslinks: prospects for removal. Furber JD. Rejuvenation Res. 2006

Summer;9(2):274-8.

Основные публикации

по теме

Cryoprotectant toxicity neutralization. Fahy GM. Cryobiology. 2009 Jun 6.

Cryopreservation of rat precision-cut liver and kidney slices by rapid freezing and vitrification.

de Graaf IA, Draaisma AL, Schoeman O, Fahy GM, Groothuis GM, Koster HJ. Cryobiology.

2007 Feb;54(1):1-12.

MMP-7/HB-EGF signaling and increased formation of elastin-like structures. Bertram

C, Hass R. Mech Ageing Dev. 2009 Oct;130(10):657-69.

Rejuvenation in distinct cell populations – What does it mean? Hass R. Exp Gerontol. 2009

Oct;44(10):634-8

Retrodifferentiation--a mechanism for cellular regeneration? Hass R. Biol Chem. 2009 May-

Jun;390(5-6):409-16.

Genetic loci that regulate healing and regeneration in LG/J and SM/J mice. Blankenhorn EP,

Bryan G, Kossenkov AV, Clark LD, Zhang XM, Chang C, Horng W, Pletscher LS, Cheverud

JM, Showe LC, Heber-Katz E. Mamm Genome. 2009 Nov-Dec;20(11-12):720-33.

Altered CNS response to injury in the MRL/MpJ mouse. Hampton DW, Seitz A, Chen P,

Heber-Katz E, Fawcett JW. Neuroscience. 2004;127(4):821-32.

From Neurotransmitters to Neurotrophic Factors to Neurogenesis Hagg T. Neuroscientist. 2009

Feb;15(1):20-7.

Ciliary neurotrophic factor mediates dopamine D2 receptor-induced neurogenesis in the

adult mouse brain. Yang P, Arnold SA, Habas A, Hetman M, Hagg T. J Neurosci. 2008 Feb

27;28(9):2231-41.

Comparison of the Maturation of the Adrenergic and Serotonergic Neurotransmitter Systems

in the Brain: Implications for Differential Drug Effects on Juveniles and Adults Murrin

LC, Sanders JD, Bylund DB. Biochem Pharmacol. 2007 Apr 15;73(8):1225-36.

Thiamine Pyrophosphate and Pyridoxamine Inhibit the Formation of Antigenic Advanced

Glycation End-Products: Comparison with Aminoguanidine. A. Ashley Booth, Raja G.

Khalifah and Billy G. Hudson. Biochem Biophys Res Commun. 1996 Mar 7;220(1):113-9.

Propagation of protein glycation damage involves modification of tryptophan residues

via reactive oxygen species: inhibition by pyridoxamine Chetyrkin SV, Mathis ME, Ham

AJ, Hachey DL, Hudson BG, Voziyan PA. Free Radic Biol Med. 2008 Apr 1;44(7):1276-85.

Retroviral restriction by APOBEC proteins. Harris, R.S. & M.T. Liddament (2004) Nature

Reviews Immunology, 4, 868-877.

AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity

Donna A. MacDuff, Zachary L. Demorest and Reuben S. Harris. Nucleic Acids Research,

2009, Vol. 37, No. 6

Основные публикации

по теме

Tart cherry juice decreases oxidative stress in healthy older men and women. Traustadóttir

T, Davies SS, Stock AA, Su Y, Heward CB, Roberts LJ 2nd, Harman SM. J Nutr. 2009;

139(10):1896-900.

Growth hormone and sex steroid effects on serum glucose, insulin, and lipid concentrations in

healthy older women and men.

Münzer T, Harman SM, Sorkin JD, Blackman MR. J Clin Endocrinol Metab. 2009;

94(10):3833-41.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Harrison

DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE,

Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Nature 2009 Jul

16;460(7253):392-5.

2005 June;205:220-228

CD4+ T Cells and Immunosenescence – A Mini-Review Maue A.C.,Haynes L.,Gerontology

2009;55:491-495

Hipkiss A, Brownson C. Biogerontology 20001:217-223

Reaction of carnosine with aged proteins. Hipkiss AR, Brownson C, Bertani MF, Ruiz E, Ferro

A. Annals NY Ac Sci 2002, 959:285-294

Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic

exercise. Song Y, Elias V, Loban A, Scrimgeour AG, Ho E. Free Radic Biol Med. 2009 Oct 28.

Aging is associated with altered dendritic cells subset distribution and impaired

proinflammatory cytokine production. Wong CP, Magnusson KR, Ho E. Exp Gerontol..

JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA. Aging

Cell. 2007 Feb;6(1):35-43.

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe

M, de Cabo R, Sinclair DA. Science. 2004 Jul 16;305(5682):390-2

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Howitz

KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung

P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Nature. 2003 Sep 11;425(6954):191-6.

Основные публикации

по теме

DNA double strand break repair: zooming in on the focus. van Gent DC, Hoeijmakers JH. Cell

женерия, морацию ДНК и стабиль-

Cycle. 2009 Dec;8(23):3813-5.

DNA damage, aging, and cancer. Hoeijmakers JH. N Engl J Med. 2009 Oct

8;361(15):1475-85.

Sealing the gap between nuclear DNA damage and longevity. Schumacher B, Hoeijmakers

JH, Garinis GA. Mol Cell Endocrinol. 2009 Feb 5;299(1):112-7.

Targeted pharmacological depletion of serum amyloid P component for treatment of human

amyloidosis. Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore

JR, Lovat LB, Bartfai T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross

RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis

A, Kolstoe S, Wood SP, Hawkins PN. Nature. 2002 May 16;417(6886):254-9.

Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid

P component. Kolstoe SE, Ridha BH, Bellotti V, Wang N, Robinson CV, Crutch SJ, Keir

G, Kukkastenvehmas R, Gallimore JR, Hutchinson WL, Hawkins PN, Wood SP, Rossor

MN, Pepys MB. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23.

Novel pharmacological strategies in amyloidosis. Lachmann HJ, Hawkins PN. Nephron Clin

Pract. 2003;94(4):c85-8.

Clinical transplantation of a tissue-engineered airway. Macchiarini P, Jungebluth P, Go

T, Asnaghi MA, Rees LE, Cogan TA, Dodson A, Martorell J, Bellini S, Parnigotto PP,

Dickinson SC, Hollander AP, Mantero S, Conconi MT, Birchall MA. Lancet. 2008 Dec

13;372(9655):2023-30.

A double-chamber rotating bioreactor for the development of tissue-engineered hollow organs:

from concept to clinical trial. Asnaghi MA, Jungebluth P, Raimondi MT, Dickinson SC, Rees

LE, Go T, Cogan TA, Dodson A, Parnigotto PP, Hollander AP, Birchall MA, Conconi MT,

Macchiarini P, Mantero S. Biomaterials. 2009 Oct;30(29):5260-9

Induction of cartilage integration by a chondrocyte/collagen-scaffold implant. Pabbruwe MB,

Esfandiari E, Kafienah W, Tarlton JF, Hollander AP. Biomaterials. 2009 Sep;30(26):4277-86.

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration

in humans Luigi Fontana, Edward P. Weiss, Dennis T. Villareal, Samuel Klein, and John O.

Holloszy Aging Cell. 2008 October; 7 (5) : 681–687.

Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2

diabetes mellitus. Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO. Am J Physiol

Endocrinol Metab. 2009 Jul;297(1):E151-6.

Is “fat-induced” muscle insulin resistance rapidly reversible? Han DH, Hancock CR, Jung SR,

Holloszy JO. Am. J. Physiol. Endocrinol. . Metab., 297:E236-E241, 2009.

Thematic review series: lipid posttranslational modifications. Lysosomal metabolism of lipid-

modified proteins. Lu JY, Hofmann SL. J Lipid Res. 2006 Jul;47(7):1352-7.

Inefficient cleavage of palmitoyl-protein thioesterase (PPT) substrates by aminothiols:

implications for treatment of infantile neuronal ceroid lipofuscinosis. Lu JY, Hofmann SL. J

Inherit Metab Dis. 2006 Feb;29(1):119-26.

Functional biology of the neuronal ceroid lipofuscinoses (NCL) proteins. Kyttälä A, Lahtinen

U, Braulke T, Hofmann SL. Biochim Biophys Acta. 2006 Oct;1762(10):920-33.

Основные публикации

по теме

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells.

Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, Khalil A, Rheinwald

JG, Hochedlinger K. Nature. 2009 Aug 27;460(7259):1145-8.

Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc.

Maherali N, Hochedlinger K. Curr Biol. 2009 Nov 3;19(20):1718-23.

Induced pluripotent stem cells and reprogramming: seeing the science through the hype.

Belmonte JC, Ellis J, Hochedlinger K, Yamanaka S. Nat Rev Genet. 2009 Dec;10(12):878-83.

Quantitative analysis of somatic mitochondrial DNA mutations by single-cell single-molecule

PCR. Kraytsberg Y, Bodyak N, Myerow S, Nicholas A, Ebralidze K, Khrapko K. Methods Mol

Biol. 2009;554:329-69.

Do mtDNA deletions drive premature aging in mtDNA mutator mice? Kraytsberg Y, Simon

DK, Turnbull DM, Khrapko K. Aging Cell. 2009 Aug;8(4):502-6. Epub 2009 Apr 22.

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure

in obese Zucker rats

Rivera L., Moron R., Zarzuelo A., Galisteo M. Biochem Pharmacol.2009 Mar 15;

77(6):1053-63

Stemina biomarker discovery. Cezar GG, Donley EL. Regen Med. 2008 Sep;3(5):665-9.

Embryonic stem cells in predictive cardiotoxicity: laser capture microscopy enables assay

development. Chaudhary KW, Barrezueta NX, Bauchmann MB, Milici AJ, Beckius G,

Stedman DB, Hambor JE, Blake WL, McNeish JD, Bahinski A, Cezar GG. Toxicol Sci. 2006

Mar;90(1):149-58.

High preprocedural non-HDL cholesterol is associated with enhanced oxidative stress and

monocyte activation after coronary angioplasty: possible implications in restenosis.

Cipollone F, Fazia M, Iezzi A, Pini B, Costantini F, De Cesare D, Paloscia L, Materazzo G,

D'Annunzio E, Bucciarelli T, Vecchiet J, Chiarelli F, Cuccurullo F, Mezzetti A. Heart. 2003

Jul;89(7):773-9.

Relationship between musculoskeletal symptoms and blood markers of oxidative stress in

patients with chronic fatigue syndrome. Vecchiet J, Cipollone F, Falasca K, Mezzetti A,

Pizzigallo E, Bucciarelli T, De Laurentis S, Affaitati G, De Cesare D, Giamberardino MA.

Neurosci Lett. 2003 Jan 2;335(3):151-4.

Abnormal immunity and stem/progenitor cells in acquired aplastic anemia. Li JP, Zheng

CL, Han ZC. Crit Rev Oncol Hematol. 2009 Dec 30

Impact of sex, MHC, and age of recipients on the therapeutic effect of transferred leukocytes

from cancer-resistant SR/CR mice. Stehle JR Jr, Blanks MJ, Riedlinger G, Kim-Shapiro

JW, Sanders AM, Adams JM, Willingham MC, Cui Z. BMC Cancer. 2009 Sep 15;9:328.

Основные публикации

по теме

Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition

of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. Duan L,

Sterba K, Kolomeichuk S, Kim H, Brown PH, Chambers TC. Biochem Pharmacol. 2007 Feb

15;73(4):481-90.

Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced

apoptosis. Chu R, Upreti M, Ding WX, Yin XM, Chambers TC. Biochem Pharmacol. 2009

Aug 1;78(3):241-8

Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Fan

M, Chambers TC. Drug Resist Updat. 2001 Aug;4(4):253-67.

Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the

multifunctional enzyme CD38. Aksoy P, Escande C, White TA, Thompson M, Soares S, Benech

JC, Chini EN. Biochem Biophys Res Commun. 2006 Oct 13;349(1):353-9.

CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic

conditions.Chini EN. Curr Pharm Des. 2009;15(1):57-63.

NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for

in vivo generation of NAADP in myometrial cells. Soares S, тThompson M, White T, Isbell

A, Yamasaki M, Prakash Y, Lund FE, Galione A, Chini EN. Am J Physiol Cell Physiol. 2007

Jan;292(1):C227-39.

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and

protect dopaminergic neurons. Wu XF, Chen PS, Dallas S, Wilson B, Block ML, Wang CC,

Kinyamu H, Lu N, Gao X, Leng Y, Chuang D-M, Zhang WQ, Lu RB and Hong J-S. Int J

Neuropsychopharmacol. 2008; 11, 1123-1134.

Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and

attenuate. Chen PS, Wang CC, Bortner CD, Peng GS, Wu X, Pang H, Lu RB, Gean PW,

Chuang DM, Hong JS. Neuroscience. 2007 Oct 12;149(1):203-12

lipopolysaccharide-induced dopaminergic neurotoxicity. Neuroscience. 2007 Oct

12;149(1):203-12.

Ингибиторы деацетилаз гистонов проявляют противо воспалительный и нейро про-

текторный эффект в моделях удара на перманентно ишемических крысах Kim HJ,

Rowe M, Ren M, Hong JS, Chen PS, Chuang DM. Histone deacetylase inhibitors exhibit

anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke:

multiple mechanisms of action. J Pharmacol Exp Ther. 2007 Jun;321(3):892-901.

The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian

dentition. Myrto Denaxa, Paul T. Sharpe and Vassilis Pachnis. Developmental Biology. 2009.

vol. 333, no. 2, pp. 324–336.

Dental stem cells for tooth regeneration and repair Andrea Mantesso DDS PhD & Paul Sharpe

Expert Opinion on Biological Therapy. 2009vol. 9, no. 9, pp. 1143–1154.

Scube1 is expressed during facial development in the mouse Guilheme M. Xavier , Paul

T. Sharpe , Martyn T. Cobourne Journal of Experimental Zoology Part B: Molecular and

Developmental Evolution. 2009 vol. 312, no. 5, pp. 518–524.

Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Liu Y,

Sanoff HK, Cho H, Burd CE, Torrice C, Ibrahim JG, Thomas NE, Sharpless NE. Aging Cell.

2009;8:439-48.

A quantitative model for age-dependent expression of the p16INK4a tumor suppressor.

Tsygankov D, Liu Y, Sanoff HK, Sharpless NE, Elston TC. Proc Natl Acad Sci U S A.

2009;106:16562-7.