6 курс / Медицинская реабилитация, ЛФК, Спортивная медицина / Научные тренды продления жизни

Основные публикации

по теме

Alzheimer’s Disease Aβ Vaccine Reduces Central Nervous System Aβ Levels in a Non-Human

Primate, the Caribbean Vervet. Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom

JK, Leverone JF, Zheng JB, Seabrook TJ, Louard D, Li D, Selkoe DJ, Palmour RM, Ervin

FR. Am J Pathol. 2004 Jul;165(1):283-97.

Prevention and Treatment of Age-related Diseases C. Lemere Handbook

Open-ended question: is immortality exclusively inherent to the germline?--A mini-review. Lep-

perdinger G. Gerontology. 2008;55(1):114-7.

Aging stem cells and regenerative biomedicine: concepts, opportunities and technological ad-

vances. Lepperdinger G. Exp Gerontol. 2008 Nov;43(11):967.

The use of genetically engineered model systems for research on human aging. Lepperdinger G,

Berger P, Breitenbach M, Frohlich KU, Grillari J, Grubeck-Loebenstein B, Madeo F, Minois N,

Zwerschke W, Jansen-Durr P.Front Biosci. 2008 May 1;13:7022-31.

Aging of murine mesenchymal stem cells. Fehrer C, Laschober G, Lepperdinger G. Ann N Y

Acad Sci. 2006 May;1067:235-42.

normal aging in gerbils Hwang IK, Yoo KY, Choi JH, Park OK, Lee JC, Jeong YG, Lee IS,

Won MH.Cell Mol Neurobiol. 2009;29(5):665-72.

Age-related changes of calbindin D-28k-immunoreactive neurons in the myenteric plexus of

gerbil duodenum. Choi JH, Lee CH, Chung DW, Hwang IK, Won MH, Seong JK, Yoon YS,

Lee IS.8. J Vet Med Sci. 2008;Apr;70(4):343-8.

Maquoi E., Hansen L.B., Van Hoef B., Frederix L., Collen D. Arterioscler. Thromb. Vasc.

Biol. 2002; 22, 374-379.

Role of Gas6 in adipogenesis and nutritionally induced adipose tissue development in mice.

Maquoi E., Voros G., Carmeliet P., Collen D., Lijnen H.R. Arterioscler. Thromb. Vasc. Biol.

25, 1002-1007, 2005.

Impaired adipose tissue development in mice with inactivation of placental growth factor

function. Lijnen H.R., Christiaens V., Scroyen I., Voros G., Tjwa M., Carmeliet P., Collen D

Diabetes 55, 2698-2704, 2006.

Hypomethylation of retrotransposable elements correlates with genomic instability in non-small

cell lung cancer. Daskalos A, Nikolaidis G, Xinarianos G, Paraskevi P, Cassidy A, Zakopoulou

R, Kotsinas A, Gorgoulis V, Field JK, & Liloglou T. Int J Cancer, 124: 81-87,2009

Основные публикации

по теме

Deleting the 14-3-3 Protein Bmh1 Extends Life Span in Saccharomyces cerevisiae by Increas-

ing Stress Response. Wang C, Skinner C, Easlon E, Lin SJ. Genetics. 2009 Dec;183(4):1373-

84.

Tissue-specific regulation of SIRT1 by calorie restriction. Chen D, Bruno J, Easlon E, Lin SJ,

Cheng HL, Alt FW, Guarente L. Genes Dev. 2008 Jul 1;22(13):1753-7.

Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated

life span extension in Saccharomyces cerevisiae. Lu SP, Kato M, Lin SJ. J Biol Chem. 2009

Jun 19;284(25):17110-9.

Expert Opin Ther Targets. 2009 Apr;13(4):469-78. Review.

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal

infectious disease. Cowen LE, Singh SD, Köhler JR, Collins C, Zaas AK, Schell WA, Aziz

H, Mylonakis E, Perfect JR, Whitesell L, Lindquist S. Proc Natl Acad Sci U S A. 2009 Feb

24;106(8):2818-23.

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Steele

AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond GJ, Aguzzi A,

Lindquist S. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13626-31.

tumor formation. Sotgia F, Casimiro MC, Bonuccelli G, Liu M, Whitaker-Menezes D, Er O,

Daumer KM, Mercier I, Witkiewicz AK, Minetti C, Capozza F, Gormley M, Quong AA, Rui

H, Frank PG, Milliman JN, Knudsen ES, Zhou J, Wang C, Pestell RG, Lisanti MP. Am J

Pathol. 2009 Feb;174(2):613-29.

Clinical and translational implications of the caveolin gene family: lessons from mouse models

and human genetic disorders. Mercier I, Jasmin JF, Pavlides S, Minetti C, Flomenberg N,

Pestell RG, Frank PG, Sotgia F, Lisanti MP. Lab Invest. 2009 Jun;89(6):614-23.

Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers. Sotgia F, Rui H, Bo-

nuccelli G, Mercier I, Pestell RG, Lisanti MP; 2006 Nov

Exercise Stimulates Transcription Factors (Nrf2 & NFkB), Increases Antioxidant Defenses,

Decreases Oxidative Stress, and Restores Renal Dopamine D1 Receptor Function in Aging.

George L, Mohammad A., Lokhandwala M. The FASEB Journal. 2008;22:1159.6

Exercise decreases oxidative stress and inflammation and restores renal dophamine D1 receptor

function in old rats. Mohammad A., George L., Lokhandwala M. Am J Physiol Renal Physiol.

2007; 293:F914-F919

Exp Pharmacol. 2009;(188):197-213.

Natural regulatory T cells: number and function are normal in the majority of patients with

lupus nephritis. Yates J, Whittington A, Mitchell P, Lechler RI, Lightstone L, Lombardi G.

Clin Exp Immunol. 2008 Jul;153(1):44-55.

Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry

into the cell cycle. Ramasamy R, Fazekasova H, Lam EW, Soeiro I, Lombardi G, Dazzi F.

Transplantation. 2007 Jan 15;83(1):71-6.

Основные публикации

по теме

Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from

yeast to the mammalian brain. Parrella E, Longo VD. ScientificWorldJournal. 2010 Jan

21;10:161-77.

Life span extension by calorie restriction depends on Rim15 and transcription factors down-

stream of Ras/PKA, Tor, and Sch9. Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD.

PLoS Genet. 2008 Jan;4(1):e13.

The chronological life span of Saccharomyces cerevisiae. Fabrizio P, Longo VD. Methods Mol

Biol. 2007;371:89-95.

Accelerated ageing: from mechanism to therapy through animal models. Osorio FG, Obaya AJ,

López-Otín C, Freije JM. Transgenic Res. 2009 Feb;18(1):7-15.

The Degradome database: mammalian proteases and diseases of proteolysis. Quesada V, Or-

dóñez GR, Sánchez LM, Puente XS, López-Otín C. Nucleic Acids Res. 2009 Jan;37

Autophagy and aging: new lessons from progeroid mice. Mariño G, López-Otín C. Autophagy.

2008 Aug 16;4(6):807-9.

Aberrant regulation and modification of heat shock factor 1 in senescent human diploid fibro-

blasts. Lee YK, Liu DJ, Lu J, Chen KY, Liu AY. J Cell Biochem. 2009 Feb 1;106(2):267-78.

Neural differentiation and the attenuated heat shock response. Yang J, Oza J, Bridges K, Chen

KY, Liu AY. Brain Res. 2008 Apr 8;1203:39-50.

Dynamic regulation and involvement of the heat shock transcriptional response in arsenic car-

cinogenesis. Khalil S, Luciano J, Chen W, Liu AY. J Cell Physiol. 2006 May;207(2):562-9.

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial

targeting and apoptosis. Betin V., Lane J. Journal of Cell Science. 2009 122, 2554-2566

Postponing death: another failure to replicate Lane J. D. Lane R. Psychosomatic Medicine.

2004 66:973-974

Atg4D at the interface between autophagy and apoptosis. Betin VM, Lane JD. Autophagy.

2009 Oct 27;5(7).

ran O, Shrager J, Todorovski L, Pohorille A. Artif Intell Med. 2006 Jul;37(3):191-201.

Incorporating biological knowledge into evaluation of causal regulatory hypotheses. Chrisman

L, Langley P, Bay S, Pohorille A. Pac Symp Biocomput. 2003:128-39.

Adequacy of health-related quality of life measures in children under 5 years old: systematic

review.

Grange A, Bekker H, Noyes J, Langley P. J Adv Nurs. 2007 Aug;59(3):197-220.

Syntaxin 16 is enriched in neuronal dendrites and may have a role in neurite outgrowth. Chua

CE, Tang BL. Mol. Membr. Biol. 2008; 25: 35-45.

SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox. Neurobiol Aging. 2006;

27 (3):501-505.

Основные публикации

по теме

Enzymology and molecular biology of carbonyl metabolism. Introduction. Weiner H., Duester

G., Maser E., Plapp B. Chem Biol Interact. 2009 Mar 16;178(1-3):1.

Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver.

Kassner N., Huse K., Martin H.J., Gödtel-Armbrust U., Metzger A., Meineke I., Brock-

möller J., Klein K., Zanger U.M., Maser E., Wojnowski L. Drug Metab Dispos. 2008

Oct;36(10):2113-20.

Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydro-

genase/reductase superfamily. Hoffmann F., Maser E. Drug Metab Rev. 2007;39(1):87-144.

Action of food restriction in delaying the aging process. E. J. Masoro, B. P. Yu, and H. A. Ber-

trand.Sci. Aging Knowl. Environ., 8 January 2003.Vol. 2003, Issue 1, p. cp1

Caloric Restriction: A Key to Understanding and Modulating Aging. Edward J. Masoro.

ISBN: 978-0-444-51162-1

Handbook of the Biology of Aging. Edward J. Masoro, Steven N. Austad

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Wernig M, Meissner

A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R. .Nature.

2007 Jul 19;448(7151):318-24.

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.

Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T,

Wu LC, Townes TM, Jaenisch R. Science. 2007 Dec 21;318(5858):1920-3.

Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution.

Gu H, Bock C, Mikkelsen TS, Jäger N, Smith ZD, Tomazou E, Gnirke A, Lander ES, Meissner

A. Nat Methods. 2010 Jan 10 (in press).

T, Asnaghi MA, Rees LE, Cogan TA, Dodson A, Martorell J, Bellini S, Parnigotto PP,

Dickinson SC, Hollander AP, Mantero S, Conconi MT, Birchall MA. Lancet. 2008 Dec

13;372(9655):2023-30.

Structural and morphologic evaluation of a novel detergent-enzymatic tissue-engineered tra-

cheal tubular matrix. Jungebluth P, Go T, Asnaghi A, Bellini S, Martorell J, Calore C, Urbani

L, Ostertag H, Mantero S, Conconi MT, Macchiarini P. J Thorac Cardiovasc Surg. 2009

Sep;138(3):586-93

First human transplantation of a bioengineered airway tissue. Macchiarini P, Walles T, Bian-

cosino C, Mertsching H. J Thorac Cardiovasc Surg. 2004 Oct;128(4):638-41

SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical

development. Azim E., Jabaudon D., Fame R.M., Macklis J.D. Nat. Neurosci. 2009

Oct;12(10):1238-1247.

Neuronal subtype specification in the cerebral cortex. Molyneaux B.J., Arlotta P., Menezes

J.R., Macklis J.D. Nat .Rev. Neurosci. 2007 Jun;8(6):427-437.

Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells.

Sohur US, Emsley JG, Mitchell BD, Macklis JD. Philos. Trans. R. Soc. Lond. B Biol. Sci.

2006; 361(1473):1477-1497.

Основные публикации

по теме

Transforming growth factor-beta1 mediated up-regulation of lysyl oxidase in the kidneys of

hereditary nephrotic mouse with chronic renal fibrosis. Goto Y., Uchio-Yamada K. Anan S.,

Yamamoto Y., Ogura A., Manabe N. Virchows Arch. 2005 Nov;447(5):859-68.

Aging exacerbates restraint stress-induced inhibition of antigen-specific antibody production in

mice Ichihara Y, Okano M., Nishioka K., Manabe N., Ichihara N., Jitsunari F., Fujiwara T,

Nishizaki K. Allergol. Int. 2009 Mar;58(1):119-24.

A double-chamber rotating bioreactor for the development of tissue-engineered hollow organs:

from concept to clinical trial. Asnaghi M.A., Jungebluth P., Raimondi M.T., Dickinson S.C.,

Rees L.E., Go T., Cogan T.A., Dodson A., Parnigotto P.P., Hollander A.P., Birchall M.A.,

Conconi M.T., Macchiarini P., Mantero S. Biomaterials. 2009 Oct;30(29):5260-9.

Rotating versus perfusion bioreactor for the culture of engineered vascular constructs based on

hyaluronic acid. Arrigoni C., Chittò A., Mantero S,. Remuzzi A. Biotechnol. Bioeng. 2008 Aug

1;100(5):988-97.

Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.

Yang Q., She H., Gearing M., Colla E., Lee M., Shacka J.J., Mao Z. Science. 2009 Jan

2;323(5910):124-7.

Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3{beta} in

neuronal apoptosis. Wang X., She H., Mao Z. J. Biol. Chem. 2009 Sep 29;284(47):32619-26.

The complexity in regulation of MEF2D by chaperone-mediated autophagy. Yang Q., Mao Z.

Autophagy. 2009 Oct 15; 5(7):1073-4.

Equal potency ofтgammaretroviral and lentiviral SIN vectors for expression of O6-methylgua-

nine-DNA methyltransferase in hematopoietic cells. Schambach A..Bohne J.,Chandra S., Will

E.,Margison G. P., Williams D.A., Baum C, Mol.Ther.2006;13(2):391-400.

Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenua-

tion of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine– alkyltransferase.

DNA. Barvaux V.A., Lorigan P.,Ranson M.,Gillum A.M.; McElhinney R. S., McMurry T.

B.H., Margison G. P. Mol.Cancer Therap. 2004;3(10):1215-20.

Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against

the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolo-

mide. Chinnasamy D.,Fairbairn L. J., Neuenfeldt J., Treisman J.S., Hanson J.P.; Margison

G.P., Chinnasamy N. Hum.Gene Ther. 2004;15(8):758-69.

Suberylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of

prostate cancer cells in vitro and in vivo. Butler L.M., Agus D.B., Scher H.I., Higgins B.,

Rose A., Cordon-Cardo C., Thaler H.T., Rifkind R.A., Marks P.A., Richon V.M. Cancer Res.

2000 Sep 15;60(18):5165-70.

Histone deacetylase inhibitors.Marks P.A., Richon V.M., Miller T., Kelly W.K. Adv. Cancer

Res. 2004;137-168.

Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone

deacetylase inhibitor.

Xu, W., Ngo, L., Perez, G., Dokmanovic, M., Marks, P.A. Proc. Natl. Acad Sci USA 103:

15540-15545, 2006.

Основные публикации

по теме

Structural basis for sirtuin function: What we know and what we don't. Sanders B.D., Jackson

B., Marmorstein R. Biochim Biophys. Acta (in press)

Identification and characterization of novel sirtuin inhibitor scaffolds. Sanders B.D., Jackson

B., Brent M., Taylor A.M., Dang W., Berger S.L., Schreiber S.L., Howitz K., Marmorstein R.

Bioorg. Med. Chem. 2009; Oct 1;17(19):7031-41.

Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a

chromatin-remodeling pathway in senescent cells. Banumathy G., Somaiah N., Zhang R.,

Tang Y., Hoffmann J., Andrake M., Ceulemans H., Schultz D., Marmorstein R., Adams P.D.

Mol. Cell Biol. 2009 Feb;29(3):758-70.

Structural and functional characterization of a novel FE65 protein product up-regulated in

cognitively impaired knockout mice. Cool B.H., Zitnik G., Martin G.M., Hu Q. J. Neuro-

chem. 2010 Jan;112(2):410-9.

Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging.

Martin G.M. Aging Cell. 2009 Dec;8(6):761-4.

Genetic determinants of human health span and life span: progress and new opportunities.

Martin G.M., Bergman A., Barzilai N. PLoS Genet. 2007 Jul;3(7):e125.

Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2

neurons: involvement of transcription factors Nrf2 and NF-kappaB. Khodagholi F, Eftekharza-

deh B, Maghsoudi N, Rezaei PF. Mol Cell Biochem. 2009. Oct 21

Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apopto-

sis in melanoma cells through a p53-mediated pathway. Bandyopadhyay D., Mishra A., Me-

drano E.E. Cancer Res. 2004;64:7706-10.

The emerging role of epigenetics in cellular and organismal aging. Bandyopadhyay D., Me-

drano E.E. Exp. Gerontol. 2003;38:1299-307.

HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice. Wang

G.L., Salisbury E., Shi X., Timchenko L., Medrano E.E., Timchenko N.A. J.Biol.Chem.

2008; 283(38):26169-78.

Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth

factors by an NF kappa B– but not JNK-dependent mechanism.

Crisostomo PR, Wang Y, Markel TA, Wang M, Lahm T, Meldrum DR. Am J Physiol Cell

Physiol. 2008 294(3):C675-82. Epub 2008 Jan 30.

Differential IL-6 and VEGF secretion in adult and neonatal mesenchymal stem cells:

role of NFkB. Novotny NM, Markel TA, Crisostomo PR, Meldrum DR. Cytokine. 2008

Aug;43(2):215-9. Epub 2008 Jul 14.

Proinflammatory cytokine effects on mesenchymal stem cell therapy for the ischemic heart.

Abarbanell AM, Coffey AC, Fehrenbacher JW, Beckman DJ, Herrmann JL, Weil B, Meldrum

DR. Ann Thorac Surg. 2009 Sep;88(3):1036-43.

Основные публикации

по теме

A minimal toolset for positional diamond mechanosynthesis. Freitas R.A. Jr. , Merkle R.C..

J.Comput.Theor. Nanoscience 2008;5:760–861

A High-level ab initio studies of hydrogen abstraction from prototype hydrocarbon sys-

tems. Temelso B., Sherrill C.D., Merkle R.C., Freitas R.A. Jr. J Phys Chem. 2006 Sep.

28;110(38):11160-73.

The technical feasibility of cryonics. Merkle RC. Med. Hypotheses. 1992 Sep;39(1):6-16.

HSP72 protects against obesity-induced insulin resistance. Chung J., Nguyen A.K., Henstridge

D.C., Holmes A.G., Chan M.H., Mesa J.L., Lancaster G.I., Southgate R.J., Bruce C.R.,

Duffy S.J., Horvath I,. Mestril R., Watt M.J., Hooper P.L., Kingwell B.A., Vigh L., Hevener

A., Febbraio M.A.Proc. Natl. Acad. Sci. USA. 2008 Feb 5;105(5):1739-44.

Influence of PKC-alpha overexpression on HSP70 and cardioprotection. Coaxum

S.D., Griffin T.M., Martin J.L., Mestril R. Am. J. Physiol. Heart Circ. Physiol. 2007

May;292(5):H2220-6..

Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age-

related muscle dysfunction. McArdle A., Dillmann W.H., Mestril R., Faulkner J.A., Jackson

M.J. FASEB J. 2004 Feb;18(2):355-7.

Heat shock factor 1 deficiency via its downstream target gene alphaB-crystallin (Hspb5) im-

pairs p53 degradation. Jin X, Moskophidis D, Hu Y, Phillips A, Mivechi NF. J Cell Biochem.

2009 Jun 1;107(3):504-15.

Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS

disease in hsf1-deficient mice. Homma S, Jin X, Wang G, Tu N, Min J, Yanasak N, Mivechi

NF. J Neurosci. 2007 Jul 25;27(30):7974-86.

Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue-specific regula-

tion for stress-inducible Hsp molecular chaperones. Zhang Y, Huang L, Zhang J, Moskophidis

D, Mivechi NF. J Cell Biochem. 2002;86(2):376-93.

Sir2 mediates apoptosis through JNK-dependent pathway in Drosophila. Griswold, A., Chang,

K.T., Runko A., Knight M., Min K-T. Proc. Natl. Acad. Sci. USA. 2008

Individual histone deacetylases in [i]Drosophila modulate transcription of distinct genes Cho,

Y., Griswold A., Campbell C., Min K-T. Genomics. 2005;86:606-17

Aberrant histone acetylation, altered transcription, and retinal degeneration in a Dro-

sophila model of polyglutamine disease are rescued by CREB-binding protein. Taylor, J.P.,

Taye, A.A.,Campbell, C. Kazemi-Esfarjani, P., Fischbeck, K.H., and Min, K-T. Genes &

Development 2003;17:1463-8.

Organ printing: tissue spheroids as building blocks. Mironov V., Visconti R.P., Kasyanov V.,

Forgacs G., Drake C.J., Markwald R.R. Biomaterials. 2009 Apr;30(12):2164-74

Bioreactor-free tissue engineering: directed tissue assembly by centrifugal casting. Mironov V.,

Kasyanov V., Markwald R.R., Prestwich G.D. Expert Opin. Biol. Ther. 2008 Feb;8(2):143-52

Rapid biofabrication of tubular tissue constructs by centrifugal casting in a decellularized nat-

ural scaffold with laser-machined micropores. Kasyanov V.A., Hodde J., Hiles M.C., Eisenberg

C., Eisenberg L., De Castro L.E., Ozolanta I., Murovska M., Draughn R.A., Prestwich G.D.,

Markwald R.R, Mironov V. J Mater. Sci. Mater. Med. 2009 Jan;20(1):329-37

Review: bioprinting: a beginning. Mironov V, Reis N, Derby B. Tissue Eng. 2006

Apr;12(4):631-4

Основные публикации

по теме

Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its in-

fancy. McGeer E.G., McGeer P.L. J. Alzheimers Dis. 2010 Jan;19(1):355-61.

Simple In Vitro Assays to Identify Amyloid-beta Aggregation Blockers for Alzheimer's Disease

Therapy. Guo J.P., Yu S., McGeer P.L. J. Alzheimers Dis.