- •Hematuria II: causes and investigation
- •Hematospermia
- •Lower urinary tract symptoms (LUTS)
- •Nocturia and nocturnal polyuria
- •Flank pain
- •Urinary incontinence in adults
- •Genital symptoms
- •Abdominal examination in urological disease
- •Digital rectal examination (DRE)
- •Lumps in the groin
- •Lumps in the scrotum
- •2 Urological investigations
- •Urine examination
- •Urine cytology
- •Radiological imaging of the urinary tract
- •Uses of plain abdominal radiography (KUB X-ray—kidneys, ureters, bladder)
- •Intravenous pyelography (IVP)
- •Other urological contrast studies
- •Computed tomography (CT) and magnetic resonance imaging (MRI)
- •Radioisotope imaging
- •Post-void residual urine volume measurement
- •3 Bladder outlet obstruction
- •Regulation of prostate growth and development of benign prostatic hyperplasia (BPH)
- •Pathophysiology and causes of bladder outlet obstruction (BOO) and BPH
- •Benign prostatic obstruction (BPO): symptoms and signs
- •Diagnostic tests in men with LUTS thought to be due to BPH
- •Why do men seek treatment for their symptoms?
- •Watchful waiting for uncomplicated BPH
- •Medical management of BPH: combination therapy
- •Medical management of BPH: alternative drug therapy
- •Minimally invasive management of BPH: surgical alternatives to TURP
- •Invasive surgical alternatives to TURP
- •TURP and open prostatectomy
- •Indications for and technique of urethral catheterization
- •Indications for and technique of suprapubic catheterization
- •Management of nocturia and nocturnal polyuria
- •High-pressure chronic retention (HPCR)
- •Bladder outlet obstruction and retention in women
- •Urethral stricture disease
- •4 Incontinence
- •Causes and pathophysiology
- •Evaluation
- •Treatment of sphincter weakness incontinence: injection therapy
- •Treatment of sphincter weakness incontinence: retropubic suspension
- •Treatment of sphincter weakness incontinence: pubovaginal slings
- •Overactive bladder: conventional treatment
- •Overactive bladder: options for failed conventional therapy
- •“Mixed” incontinence
- •Post-prostatectomy incontinence
- •Incontinence in the elderly patient
- •Urinary tract infection: microbiology
- •Lower urinary tract infection
- •Recurrent urinary tract infection
- •Urinary tract infection: treatment
- •Acute pyelonephritis
- •Pyonephrosis and perinephric abscess
- •Other forms of pyelonephritis
- •Chronic pyelonephritis
- •Septicemia and urosepsis
- •Fournier gangrene
- •Epididymitis and orchitis
- •Periurethral abscess
- •Prostatitis: presentation, evaluation, and treatment
- •Other prostate infections
- •Interstitial cystitis
- •Tuberculosis
- •Parasitic infections
- •HIV in urological surgery
- •6 Urological neoplasia
- •Pathology and molecular biology
- •Prostate cancer: epidemiology and etiology
- •Prostate cancer: incidence, prevalence, and mortality
- •Prostate cancer pathology: premalignant lesions
- •Counseling before prostate cancer screening
- •Prostate cancer: clinical presentation
- •PSA and prostate cancer
- •PSA derivatives: free-to-total ratio, density, and velocity
- •Prostate cancer: transrectal ultrasonography and biopsies
- •Prostate cancer staging
- •Prostate cancer grading
- •General principles of management of localized prostate cancer
- •Management of localized prostate cancer: watchful waiting and active surveillance
- •Management of localized prostate cancer: radical prostatectomy
- •Postoperative course after radical prostatectomy
- •Prostate cancer control with radical prostatectomy
- •Management of localized prostate cancer: radical external beam radiotherapy (EBRT)
- •Management of localized prostate cancer: brachytherapy (BT)
- •Management of localized and radiorecurrent prostate cancer: cryotherapy and HIFU
- •Management of locally advanced nonmetastatic prostate cancer (T3–4 N0M0)
- •Management of advanced prostate cancer: hormone therapy I
- •Management of advanced prostate cancer: hormone therapy II
- •Management of advanced prostate cancer: hormone therapy III
- •Management of advanced prostate cancer: androgen-independent/ castration-resistant disease
- •Palliative management of prostate cancer
- •Prostate cancer: prevention; complementary and alternative therapies
- •Bladder cancer: epidemiology and etiology
- •Bladder cancer: pathology and staging
- •Bladder cancer: presentation
- •Bladder cancer: diagnosis and staging
- •Muscle-invasive bladder cancer: surgical management of localized (pT2/3a) disease
- •Muscle-invasive bladder cancer: radical and palliative radiotherapy
- •Muscle-invasive bladder cancer: management of locally advanced and metastatic disease
- •Bladder cancer: urinary diversion after cystectomy
- •Transitional cell carcinoma (UC) of the renal pelvis and ureter
- •Radiological assessment of renal masses
- •Benign renal masses
- •Renal cell carcinoma: epidemiology and etiology
- •Renal cell carcinoma: pathology, staging, and prognosis
- •Renal cell carcinoma: presentation and investigations
- •Renal cell carcinoma: active surveillance
- •Renal cell carcinoma: surgical treatment I
- •Renal cell carcinoma: surgical treatment II
- •Renal cell carcinoma: management of metastatic disease
- •Testicular cancer: epidemiology and etiology
- •Testicular cancer: clinical presentation
- •Testicular cancer: serum markers
- •Testicular cancer: pathology and staging
- •Testicular cancer: prognostic staging system for metastatic germ cell cancer
- •Testicular cancer: management of non-seminomatous germ cell tumors (NSGCT)
- •Testicular cancer: management of seminoma, IGCN, and lymphoma
- •Penile neoplasia: benign, viral-related, and premalignant lesions
- •Penile cancer: epidemiology, risk factors, and pathology
- •Squamous cell carcinoma of the penis: clinical management
- •Carcinoma of the scrotum
- •Tumors of the testicular adnexa
- •Urethral cancer
- •Wilms tumor and neuroblastoma
- •7 Miscellaneous urological diseases of the kidney
- •Cystic renal disease: simple cysts
- •Cystic renal disease: calyceal diverticulum
- •Cystic renal disease: medullary sponge kidney (MSK)
- •Acquired renal cystic disease (ARCD)
- •Autosomal dominant (adult) polycystic kidney disease (ADPKD)
- •Ureteropelvic junction (UPJ) obstruction in adults
- •Anomalies of renal ascent and fusion: horseshoe kidney, pelvic kidney, malrotation
- •Renal duplications
- •8 Stone disease
- •Kidney stones: epidemiology
- •Kidney stones: types and predisposing factors
- •Kidney stones: mechanisms of formation
- •Evaluation of the stone former
- •Kidney stones: presentation and diagnosis
- •Kidney stone treatment options: watchful waiting
- •Stone fragmentation techniques: extracorporeal lithotripsy (ESWL)
- •Intracorporeal techniques of stone fragmentation (fragmentation within the body)
- •Kidney stone treatment: percutaneous nephrolithotomy (PCNL)
- •Kidney stones: open stone surgery
- •Kidney stones: medical therapy (dissolution therapy)
- •Ureteric stones: presentation
- •Ureteric stones: diagnostic radiological imaging
- •Ureteric stones: acute management
- •Ureteric stones: indications for intervention to relieve obstruction and/or remove the stone
- •Ureteric stone treatment
- •Treatment options for ureteric stones
- •Prevention of calcium oxalate stone formation
- •Bladder stones
- •Management of ureteric stones in pregnancy
- •Hydronephrosis
- •Management of ureteric strictures (other than UPJ obstruction)
- •Pathophysiology of urinary tract obstruction
- •Ureter innervation
- •10 Trauma to the urinary tract and other urological emergencies
- •Renal trauma: clinical and radiological assessment
- •Renal trauma: treatment
- •Ureteral injuries: mechanisms and diagnosis
- •Ureteral injuries: management
- •Bladder and urethral injuries associated with pelvic fractures
- •Bladder injuries
- •Posterior urethral injuries in males and urethral injuries in females
- •Anterior urethral injuries
- •Testicular injuries
- •Penile injuries
- •Torsion of the testis and testicular appendages
- •Paraphimosis
- •Malignant ureteral obstruction
- •Spinal cord and cauda equina compression
- •11 Infertility
- •Male reproductive physiology
- •Etiology and evaluation of male infertility
- •Lab investigation of male infertility
- •Oligospermia and azoospermia
- •Varicocele
- •Treatment options for male factor infertility
- •12 Disorders of erectile function, ejaculation, and seminal vesicles
- •Physiology of erection and ejaculation
- •Impotence: evaluation
- •Impotence: treatment
- •Retrograde ejaculation
- •Peyronie’s disease
- •Priapism
- •13 Neuropathic bladder
- •Innervation of the lower urinary tract (LUT)
- •Physiology of urine storage and micturition
- •Bladder and sphincter behavior in the patient with neurological disease
- •The neuropathic lower urinary tract: clinical consequences of storage and emptying problems
- •Bladder management techniques for the neuropathic patient
- •Catheters and sheaths and the neuropathic patient
- •Management of incontinence in the neuropathic patient
- •Management of recurrent urinary tract infections (UTIs) in the neuropathic patient
- •Management of hydronephrosis in the neuropathic patient
- •Bladder dysfunction in multiple sclerosis, in Parkinson disease, after stroke, and in other neurological disease
- •Neuromodulation in lower urinary tract dysfunction
- •14 Urological problems in pregnancy
- •Physiological and anatomical changes in the urinary tract
- •Urinary tract infection (UTI)
- •Hydronephrosis
- •15 Pediatric urology
- •Embryology: urinary tract
- •Undescended testes
- •Urinary tract infection (UTI)
- •Ectopic ureter
- •Ureterocele
- •Ureteropelvic junction (UPJ) obstruction
- •Hypospadias
- •Normal sexual differentiation
- •Abnormal sexual differentiation
- •Cystic kidney disease
- •Exstrophy
- •Epispadias
- •Posterior urethral valves
- •Non-neurogenic voiding dysfunction
- •Nocturnal enuresis
- •16 Urological surgery and equipment
- •Preparation of the patient for urological surgery
- •Antibiotic prophylaxis in urological surgery
- •Complications of surgery in general: DVT and PE
- •Fluid balance and management of shock in the surgical patient
- •Patient safety in the operating room
- •Transurethral resection (TUR) syndrome
- •Catheters and drains in urological surgery
- •Guide wires
- •JJ stents
- •Lasers in urological surgery
- •Diathermy
- •Sterilization of urological equipment
- •Telescopes and light sources in urological endoscopy
- •Consent: general principles
- •Cystoscopy
- •Transurethral resection of the prostate (TURP)
- •Transurethral resection of bladder tumor (TURBT)
- •Optical urethrotomy
- •Circumcision
- •Hydrocele and epididymal cyst removal
- •Nesbit procedure
- •Vasectomy and vasovasostomy
- •Orchiectomy
- •Urological incisions
- •JJ stent insertion
- •Nephrectomy and nephroureterectomy
- •Radical prostatectomy
- •Radical cystectomy
- •Ileal conduit
- •Percutaneous nephrolithotomy (PCNL)
- •Ureteroscopes and ureteroscopy
- •Pyeloplasty
- •Laparoscopic surgery
- •Endoscopic cystolitholapaxy and (open) cystolithotomy
- •Scrotal exploration for torsion and orchiopexy
- •17 Basic science of relevance to urological practice
- •Physiology of bladder and urethra
- •Renal anatomy: renal blood flow and renal function
- •Renal physiology: regulation of water balance
- •Renal physiology: regulation of sodium and potassium excretion
- •Renal physiology: acid–base balance
- •18 Urological eponyms
- •Index
8CHAPTER 1 Preliminary investigation
Hematospermia
Sometimes spelled “hemospermia,” hematospermia is the presence of blood in the semen. It can be bright red, coffee-colored, rusty, or darkened in appearance and may change as blood ages. Usually hematospermia is intermittent, benign, or self-limiting and has no cause identified.
Causes
•Iatrogenic: following prostate biopsy, cystoscopy or prostate intervention (resection, hyperthermia), prostate brachytherapy or radiation; usually clears in weeks to months
•Age <40 years: usually inflammatory (e.g., prostatitis, epididymoorchitis, urethritis, urethral condylomata) or idiopathic (this cause likely reflects the limited investigation usually carried out in this age group). Rarely there is testicular tumor, or perineal or testicular trauma.
•Age >40 years: as for men aged <40, prostate cancer; bladder cancer; BPH with dilated veins in the prostatic urethra; prostatic or seminal vesicle (SV) calculi; hypertension; carcinoma of the seminal vesicles
•Rare causes at any age: bleeding diathesis; utricular cysts; Müllerian cysts; TB; schistosomiasis; amyloid of prostate or seminal vesicles; following therapeutic injection of hemorrhoids
Examination
Examine the testes, epididymis, prostate, and seminal vesicles. On digital rectal exam (DRE) evaluate for nodularity, tenderness, masses, midline and cystic structures. SV fullness can be associated with schistosomiasis (egg burden). Measure blood pressure.
Investigation
Send urine for culture. If the hematospermia resolves, an argument can be made for doing nothing else. If it recurs or persists, arrange a transrectal ultrasound (TRUS), flexible cystoscopy, and renal ultrasound. If hematuria coexists, investigate with an upper tract imaging study and cystoscopy (as described in Chapter 2). In general, evaluation in men >40 years of age should be more extensive.
Treatment
•Directed at the underlying abnormality, if found
•Watchful waiting in most men if no cause identified
•Empiric antibiotics (doxycycline or flouroqinolones) sometimes considered
Further reading
Ahmad I, Krishna NS (2007). Hemospermia. J Urol 177:1613–1618.
Kumar P, Kapoor S, Nargund V (2006). Haematospermia—a systemic review. Ann R Coll Surg Engl 88:339–342.
Leocadio DE, Stein BS (2009). Hematospermia: etiological and management considerations. Int Urol Nephrol 41(1):77–83.
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10 CHAPTER 1 Preliminary investigation
Lower urinary tract symptoms (LUTS)
Many terms have been coined to describe the symptom complex traditionally associated with prostatic obstruction due to BPH. The classic prostatic symptoms of hesitancy, poor flow, frequency, urgency, nocturia, and terminal dribbling have in the past been termed prostatism or simply BPH symptoms. One sometimes hears these symptoms being described as due to BPO (benign prostatic obstruction) or BPE (benign prostatic enlargement) or, more recently, LUTS/BPH.
However, these “classic” symptoms of prostatic disease bear little relationship to prostate size, urinary flow rate, residual urine volume, or urodynamic evidence of bladder outlet obstruction (BOO).1 Furthermore, age-matched men and women have similar “prostate” symptom scores;2 women obviously have no prostate.
Therefore, these terms are no longer used to describe the symptom complex of hesitancy, poor flow, etc. Instead, the preferred term today is lower urinary tract symptoms (LUTS), which is purely a descriptive term avoiding any implication about the possible underlying cause of these symptoms.3
The new terminology of LUTS is useful because it reminds the urologist to consider possible alternative causes of symptoms, which may have absolutely nothing to do with prostatic obstruction. It also reminds us to avoid operating on an organ, such as the prostate, when the cause of the symptoms may lie elsewhere.
Overactive bladder is a newly defined symptom complex during which patients experience urgency with or without urge incontinence, usually accompanied by frequency and/or nocturia.4
Baseline symptoms can be measured using a validated symptom index. The most widely used in men is the International Prostate Symptom Score (IPSS), a modified version of the AUA Symptom Index5 (Fig. 1.1). It is useful for the initial evaluation and for determining the effectiveness of therapeutic intervention.
Other causes of LUTS
In broad terms, LUTS can be due to pathology in the prostate, the bladder, the urethra, or other pelvic organs (uterus, rectum) or to neurological disease affecting the nerves that innervate the bladder. These pathologic processes can include benign enlargement of the prostate causing bladder outflow obstruction (BPE causing BOO) and infective, inflammatory, and
1 Reynard JM, Yang Q, Donovan JL, et al. (1998) The ICS-‘BPH’ study: uroflowmetry, lower urinary tract symptoms and bladder outlet obstruction. Br J Urol 82:619–623.
2 Lepor H, Machi G (1993) Comparison of AUA symptom index in unselected males and females between fifty-five and seventy-nine years of age. Urology 42:36–41.
3 Abrams P (1994). New words for old—lower urinary tracy symptoms for ‘prostatism’. Br Med J 308:929–930.
4 Voelzke BB (2007). Overactive bladder; prevalence, pathophysiology, and pharmacotherapy. Urol Rep 1:16–22.
5 Barry MJ, Fowler FJ Jr, O’Leary MP, et al. (1992) The American Urological Association Symptom Index for benign prostatic hyperplasia. J Urol 148:1549–1557.
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Figure 1.1 The International Prostate Symptom Score (IPSS). This figure was published in Barry MJ, Fowler FJ Jr, O’Leary MP, et al. (1992). The American Urological Association symptom index for benign prostatic hyperplasia. J Urol 148(5):1549–1557. Copyright Elsevier 1992.
12 CHAPTER 1 Preliminary investigation
neoplastic conditions of the bladder, prostate, or urethra. While LUTS are, in general, relatively nonspecific for a particular disease, the associated symptoms can indicate their cause.
For example, LUTS in association with hematuria suggests a possibility of bladder cancer. This is more likely if irritative symptoms (urinary frequency, urgency), and bladder (suprapubic) pain are prominent. Carcinoma in situ of the bladder, a superficial, noninvasive, and potentially very aggressive form of bladder cancer, which very often progresses to muscle invasive or metastatic cancer, classically presents in this way.
Recent onset of bed wetting in an elderly man is often due to highpressure chronic retention. Visual inspection of the abdomen may show marked distension due to a grossly enlarged bladder. The diagnosis of chronic retention is confirmed by palpating the enlarged, tense bladder, which is dull to percussion; ultrasound measurement; and drainage of a large volume following catheterization.
Rarely, LUTS can be due to neurological disease.
Multiple sclerosis can cause urgency and urge incontinence.
Parkinson disease is associated with urinary symptoms and incontinence. Many patients also have detrusor overactivity and impaired contractility.
Spinal cord or cauda equina compression due to pelvic or sacral tumors can cause urinary symptoms. Associated symptoms include back pain, sciatica, ejaculatory disturbances, and sensory disturbances in the legs, feet, and perineum. In these rare cases, loss of pericoccygeal or perineal sensation (sacral nerve roots 2–4) indicates an interruption to the sensory innervation of the bladder, and an MRI scan often confirms the clinical suspicion that there is a neurological problem.
Further reading
Abrams P, et al. (2002). Lower urinary tract function. Neurourol Urodyn 21:167–178.
Gravas S, Melekos MD (2009). Male lower urinary tract symptoms: how do symptoms guide our choice of treatment? Curr Opin Urol. 19(1):49–54.
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