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612 CHAPTER 16 Urological surgery and equipment

Transurethral resection of the prostate (TURP)

Indications

Bothersome LUTS that fail to respond to changes in lifestyle or medical therapy

Recurrent acute urinary retention

Renal impairment due to bladder outlet obstruction (high-pressure chronic urinary retention)

Recurrent hematuria due to benign prostatic enlargement

Bladder stones due to prostatic obstruction

Postoperative care

A three-way catheter is left in situ after the operation, through which irrigation fluid (normal saline) is run to dilute the blood so that a clot will not form to block the catheter. The rate of inflow of the saline is adjusted to keep the outflow a pale pink rosé color and, as a rule, the rate of inflow can be cut down after about 20 minutes. The irrigation is continued for 712–24 hours.

The catheter is removed the day after (second postoperative day) if the urine has cleared to a normal color (trial without catheter [TWOC] or trial of void [TOV]).

Common postoperative complications and their management

Blocked catheter post-TURP

This is common. The catheter may become blocked with clot or a prostatic chip that was inadvertently left in the bladder at the end of the operation.

Apply a bladder syringe to the end of the catheter to try to dislodge the obstruction.

If this fails, withdraw some irrigant into the syringe and flush the catheter.

If this fails, change the catheter. The obstructing chip of prostate may be found stuck in one of the eyeholes of the catheter.

Pass a new catheter, on an introducer.

If the bladder has been allowed to become so full of clot that a simple bladder washout is unable to evacuate it all, return the patient to the operating room for clot evacuation.

Hemorrhage

Minor bleeding after TURP is common and will stop spontaneously. A simple system to allow communication between staff is to describe the color of the urine draining through the catheter as the same as a rosé wine (minor hematuria), a dark red wine (moderate hematuria), or frank blood (bright red bleeding, suggesting serious hemorrhage).

TRANSURETHRAL RESECTION OF THE PROSTATE (TURP) 613

The rosé urine requires no action. Dark red urine should be managed by increasing the flow of irrigant and by applying gentle traction to the catheter (with the balloon inflated to 40–50 mL), thereby pulling it onto the bladder neck or into the prostatic fossa to tamponade bleeding for 20 minutes or so. This will usually result in the urine clearing.

An attempt at controlling heavier bleeding by these techniques may be tried, but at the same time you should make preparations to return the patient to the operating room because it is unlikely that bleeding of this degree will stop. The bleeding vessel(s), if seen, is controlled with diathermy.

If bleeding persists, open surgical control is required—the prostatic capsule is opened, the bleeding vessels sutured, and the prostatic bed packed. Postoperative bleeding requiring a return to the operating room occurs in ~0.5% of cases.1

Procedure-specific consent form—recommended discussion of adverse events

Serious or frequently occurring complications of TURP

Temporary mild burning on passing urine, urinary frequency, hematuria

Retrograde ejaculation in 75% of patients

Failure of symptom resolution

Permanent inability to achieve an erection adequate for sexual activity

UTI requiring antibiotic therapy

10% of patients require re-do surgery for recurrent prostatic obstruction

Failure to pass urine after the postoperative catheter has been removed

In ~10% of patients, prostate cancer is found on subsequent pathological examination of the resected tissue.

Urethral stricture formation requiring subsequent treatment

Incontinence (loss of urinary control)—may be temporary or permanent

Absorption of irrigating fluid causing confusion and heart failure (TUR syndrome)

Very rarely, perforation of the bladder requiring a temporary urinary catheter or open surgical repair

Alternative therapy

This includes observation, drugs, a catheter, stent, or open operation.

1 Ryan PC, et al. (1994). The effects of acute and chronic JJ stent placement on upper urinary tract motility and calculus transit. Br J Urol 74:434–439.

614 CHAPTER 16 Urological surgery and equipment

Transurethral resection of bladder tumor (TURBT)

Indications

Local control of non-muscle-invasive bladder cancer (i.e., stops bleeding tumors)

Staging of bladder cancer—to determine whether the cancer is nonmuscle invasive or muscle invasive, so that subsequent treatment and appropriate follow-up can be arranged

Postoperative care

A twoor three-way catheter is left in situ after the operation, depending on the size of the tumor and, therefore, on the likelihood that bleeding requiring irrigation will be required. As for TURP, normal saline is run through the catheter to dilute the blood so that a clot will not form to block the catheter. It is particularly important to avoid catheter blockage post-TURBT, since this could lead to distension of the bladder already weakened by resection of a tumor.

The period of irrigation is usually shorter than that required after TURP, and for small tumors the catheter may be removed the day after the TURBT. For larger tumors, remove it 2 days later.

Common operative and postoperative complications and their management

Bladder perforation during TURBT

Small perforations into the perivesical tissues (extraperitoneal) are not uncommon when resecting small tumors of the bladder. So long as you have secured good hemostasis and all the irrigating fluid is being recovered, no additional steps are required, except that perhaps one should leave the catheter in for 4 rather than 2 days.

Intraperitoneal perforations (through the wall of the bladder, through the peritoneum, and into the peritoneal cavity) are uncommon, but far more serious.

Is it an extraperitoneal or intraperitoneal perforation? Establishing this can be difficult. Both can cause marked distension of the lower abdo- men—an intraperitoneal perforation by allowing escape of irrigating solution directly into the abdominal cavity, and an extraperitoneal perforation by expanding the retroperitoneal space, with fluid then diffusing directly into the peritoneal cavity.

The fact that a suspected intraperitoneal perforation was actually extraperitoneal becomes apparent only at laparotomy when no hole can be found in the peritoneum overlying the bladder (the peritoneum over the bladder is not breached in an extraperitoneal perforation).

When there is no abdominal distension, the volume of extravasated fluid is likely to be low and, if the perforation is small, it is reasonable to manage the case conservatively. Achieve hemostasis and pass a catheter.

Make frequent postoperative assessments of the patient’s vital signs and abdomen (worsening abdominal pain, distension, and tenderness suggest the need for laparotomy).

TRANSURETHRAL RESECTION OF BLADDER TUMOR (TURBT) 615

Where there is marked abdominal distension, regardless of whether the perforation is extraperitoneal or intraperitoneal, explore the abdomen, principally to drain the large amount of fluid (which can compromise respiration in an elderly patient) by splinting the diaphragm, but also to check that loops of bowel adjacent to the site of perforation have not been injured at the same time.

Failing to make the diagnosis of an intraperitoneal perforation, particularly if bowel has been injured, is a worse situation than performing a laparotomy for a suspected intraperitoneal perforation but then finding that the perforation was “only” extraperitoneal.

Open bladder repair

Use a Pfannenstiel incision or lower midline abdominal incision, open the bladder, evacuate the clot, control bleeding, and repair the hole. Open the peritoneum and inspect the small and large bowel for perforations. Leave a urethral catheter and a drain in place.

Blocked catheter post-TURBT

The catheter may become blocked with clot. Use the same technique for unblocking it as for TURP, but avoid vigorous washouts of the bladder because of the risk of bladder perforation.

Hemorrhage

Minor bleeding after TURBT is common and will stop spontaneously. The only technique for controlling it is to ensure adequate flow of irrigant is maintained (to dilute the blood and thereby prevent clots from forming). If bleeding persists, return the patient to the OR for endoscopic control.

TUR syndrome

This is uncommon after TURBT, unless the tumor is large and the resection therefore long.

Procedure-specific consent form—recommended discussion of adverse events

Serious or frequently occurring complications of TURBT

Common complications

Mild burning on passing urine

Additional treatment (intravesical chemotherapy or immunotherapy) may be required to reduce the risk of future tumor recurrence.

UTI

No guarantee of bladder cancer cure

Tumor recurrence is common.

Rare complications

Delayed bleeding requiring removal of clots or further surgery

Damage to drainage tubes from kidney (ureters) requiring additional therapy

Development of a urethral stricture

Bladder perforation requiring a temporary urinary catheter or open surgical repair

Alternative treatment includes open removal of bladder, chemotherapy, and radiation.