- •Hematuria II: causes and investigation
- •Hematospermia
- •Lower urinary tract symptoms (LUTS)
- •Nocturia and nocturnal polyuria
- •Flank pain
- •Urinary incontinence in adults
- •Genital symptoms
- •Abdominal examination in urological disease
- •Digital rectal examination (DRE)
- •Lumps in the groin
- •Lumps in the scrotum
- •2 Urological investigations
- •Urine examination
- •Urine cytology
- •Radiological imaging of the urinary tract
- •Uses of plain abdominal radiography (KUB X-ray—kidneys, ureters, bladder)
- •Intravenous pyelography (IVP)
- •Other urological contrast studies
- •Computed tomography (CT) and magnetic resonance imaging (MRI)
- •Radioisotope imaging
- •Post-void residual urine volume measurement
- •3 Bladder outlet obstruction
- •Regulation of prostate growth and development of benign prostatic hyperplasia (BPH)
- •Pathophysiology and causes of bladder outlet obstruction (BOO) and BPH
- •Benign prostatic obstruction (BPO): symptoms and signs
- •Diagnostic tests in men with LUTS thought to be due to BPH
- •Why do men seek treatment for their symptoms?
- •Watchful waiting for uncomplicated BPH
- •Medical management of BPH: combination therapy
- •Medical management of BPH: alternative drug therapy
- •Minimally invasive management of BPH: surgical alternatives to TURP
- •Invasive surgical alternatives to TURP
- •TURP and open prostatectomy
- •Indications for and technique of urethral catheterization
- •Indications for and technique of suprapubic catheterization
- •Management of nocturia and nocturnal polyuria
- •High-pressure chronic retention (HPCR)
- •Bladder outlet obstruction and retention in women
- •Urethral stricture disease
- •4 Incontinence
- •Causes and pathophysiology
- •Evaluation
- •Treatment of sphincter weakness incontinence: injection therapy
- •Treatment of sphincter weakness incontinence: retropubic suspension
- •Treatment of sphincter weakness incontinence: pubovaginal slings
- •Overactive bladder: conventional treatment
- •Overactive bladder: options for failed conventional therapy
- •“Mixed” incontinence
- •Post-prostatectomy incontinence
- •Incontinence in the elderly patient
- •Urinary tract infection: microbiology
- •Lower urinary tract infection
- •Recurrent urinary tract infection
- •Urinary tract infection: treatment
- •Acute pyelonephritis
- •Pyonephrosis and perinephric abscess
- •Other forms of pyelonephritis
- •Chronic pyelonephritis
- •Septicemia and urosepsis
- •Fournier gangrene
- •Epididymitis and orchitis
- •Periurethral abscess
- •Prostatitis: presentation, evaluation, and treatment
- •Other prostate infections
- •Interstitial cystitis
- •Tuberculosis
- •Parasitic infections
- •HIV in urological surgery
- •6 Urological neoplasia
- •Pathology and molecular biology
- •Prostate cancer: epidemiology and etiology
- •Prostate cancer: incidence, prevalence, and mortality
- •Prostate cancer pathology: premalignant lesions
- •Counseling before prostate cancer screening
- •Prostate cancer: clinical presentation
- •PSA and prostate cancer
- •PSA derivatives: free-to-total ratio, density, and velocity
- •Prostate cancer: transrectal ultrasonography and biopsies
- •Prostate cancer staging
- •Prostate cancer grading
- •General principles of management of localized prostate cancer
- •Management of localized prostate cancer: watchful waiting and active surveillance
- •Management of localized prostate cancer: radical prostatectomy
- •Postoperative course after radical prostatectomy
- •Prostate cancer control with radical prostatectomy
- •Management of localized prostate cancer: radical external beam radiotherapy (EBRT)
- •Management of localized prostate cancer: brachytherapy (BT)
- •Management of localized and radiorecurrent prostate cancer: cryotherapy and HIFU
- •Management of locally advanced nonmetastatic prostate cancer (T3–4 N0M0)
- •Management of advanced prostate cancer: hormone therapy I
- •Management of advanced prostate cancer: hormone therapy II
- •Management of advanced prostate cancer: hormone therapy III
- •Management of advanced prostate cancer: androgen-independent/ castration-resistant disease
- •Palliative management of prostate cancer
- •Prostate cancer: prevention; complementary and alternative therapies
- •Bladder cancer: epidemiology and etiology
- •Bladder cancer: pathology and staging
- •Bladder cancer: presentation
- •Bladder cancer: diagnosis and staging
- •Muscle-invasive bladder cancer: surgical management of localized (pT2/3a) disease
- •Muscle-invasive bladder cancer: radical and palliative radiotherapy
- •Muscle-invasive bladder cancer: management of locally advanced and metastatic disease
- •Bladder cancer: urinary diversion after cystectomy
- •Transitional cell carcinoma (UC) of the renal pelvis and ureter
- •Radiological assessment of renal masses
- •Benign renal masses
- •Renal cell carcinoma: epidemiology and etiology
- •Renal cell carcinoma: pathology, staging, and prognosis
- •Renal cell carcinoma: presentation and investigations
- •Renal cell carcinoma: active surveillance
- •Renal cell carcinoma: surgical treatment I
- •Renal cell carcinoma: surgical treatment II
- •Renal cell carcinoma: management of metastatic disease
- •Testicular cancer: epidemiology and etiology
- •Testicular cancer: clinical presentation
- •Testicular cancer: serum markers
- •Testicular cancer: pathology and staging
- •Testicular cancer: prognostic staging system for metastatic germ cell cancer
- •Testicular cancer: management of non-seminomatous germ cell tumors (NSGCT)
- •Testicular cancer: management of seminoma, IGCN, and lymphoma
- •Penile neoplasia: benign, viral-related, and premalignant lesions
- •Penile cancer: epidemiology, risk factors, and pathology
- •Squamous cell carcinoma of the penis: clinical management
- •Carcinoma of the scrotum
- •Tumors of the testicular adnexa
- •Urethral cancer
- •Wilms tumor and neuroblastoma
- •7 Miscellaneous urological diseases of the kidney
- •Cystic renal disease: simple cysts
- •Cystic renal disease: calyceal diverticulum
- •Cystic renal disease: medullary sponge kidney (MSK)
- •Acquired renal cystic disease (ARCD)
- •Autosomal dominant (adult) polycystic kidney disease (ADPKD)
- •Ureteropelvic junction (UPJ) obstruction in adults
- •Anomalies of renal ascent and fusion: horseshoe kidney, pelvic kidney, malrotation
- •Renal duplications
- •8 Stone disease
- •Kidney stones: epidemiology
- •Kidney stones: types and predisposing factors
- •Kidney stones: mechanisms of formation
- •Evaluation of the stone former
- •Kidney stones: presentation and diagnosis
- •Kidney stone treatment options: watchful waiting
- •Stone fragmentation techniques: extracorporeal lithotripsy (ESWL)
- •Intracorporeal techniques of stone fragmentation (fragmentation within the body)
- •Kidney stone treatment: percutaneous nephrolithotomy (PCNL)
- •Kidney stones: open stone surgery
- •Kidney stones: medical therapy (dissolution therapy)
- •Ureteric stones: presentation
- •Ureteric stones: diagnostic radiological imaging
- •Ureteric stones: acute management
- •Ureteric stones: indications for intervention to relieve obstruction and/or remove the stone
- •Ureteric stone treatment
- •Treatment options for ureteric stones
- •Prevention of calcium oxalate stone formation
- •Bladder stones
- •Management of ureteric stones in pregnancy
- •Hydronephrosis
- •Management of ureteric strictures (other than UPJ obstruction)
- •Pathophysiology of urinary tract obstruction
- •Ureter innervation
- •10 Trauma to the urinary tract and other urological emergencies
- •Renal trauma: clinical and radiological assessment
- •Renal trauma: treatment
- •Ureteral injuries: mechanisms and diagnosis
- •Ureteral injuries: management
- •Bladder and urethral injuries associated with pelvic fractures
- •Bladder injuries
- •Posterior urethral injuries in males and urethral injuries in females
- •Anterior urethral injuries
- •Testicular injuries
- •Penile injuries
- •Torsion of the testis and testicular appendages
- •Paraphimosis
- •Malignant ureteral obstruction
- •Spinal cord and cauda equina compression
- •11 Infertility
- •Male reproductive physiology
- •Etiology and evaluation of male infertility
- •Lab investigation of male infertility
- •Oligospermia and azoospermia
- •Varicocele
- •Treatment options for male factor infertility
- •12 Disorders of erectile function, ejaculation, and seminal vesicles
- •Physiology of erection and ejaculation
- •Impotence: evaluation
- •Impotence: treatment
- •Retrograde ejaculation
- •Peyronie’s disease
- •Priapism
- •13 Neuropathic bladder
- •Innervation of the lower urinary tract (LUT)
- •Physiology of urine storage and micturition
- •Bladder and sphincter behavior in the patient with neurological disease
- •The neuropathic lower urinary tract: clinical consequences of storage and emptying problems
- •Bladder management techniques for the neuropathic patient
- •Catheters and sheaths and the neuropathic patient
- •Management of incontinence in the neuropathic patient
- •Management of recurrent urinary tract infections (UTIs) in the neuropathic patient
- •Management of hydronephrosis in the neuropathic patient
- •Bladder dysfunction in multiple sclerosis, in Parkinson disease, after stroke, and in other neurological disease
- •Neuromodulation in lower urinary tract dysfunction
- •14 Urological problems in pregnancy
- •Physiological and anatomical changes in the urinary tract
- •Urinary tract infection (UTI)
- •Hydronephrosis
- •15 Pediatric urology
- •Embryology: urinary tract
- •Undescended testes
- •Urinary tract infection (UTI)
- •Ectopic ureter
- •Ureterocele
- •Ureteropelvic junction (UPJ) obstruction
- •Hypospadias
- •Normal sexual differentiation
- •Abnormal sexual differentiation
- •Cystic kidney disease
- •Exstrophy
- •Epispadias
- •Posterior urethral valves
- •Non-neurogenic voiding dysfunction
- •Nocturnal enuresis
- •16 Urological surgery and equipment
- •Preparation of the patient for urological surgery
- •Antibiotic prophylaxis in urological surgery
- •Complications of surgery in general: DVT and PE
- •Fluid balance and management of shock in the surgical patient
- •Patient safety in the operating room
- •Transurethral resection (TUR) syndrome
- •Catheters and drains in urological surgery
- •Guide wires
- •JJ stents
- •Lasers in urological surgery
- •Diathermy
- •Sterilization of urological equipment
- •Telescopes and light sources in urological endoscopy
- •Consent: general principles
- •Cystoscopy
- •Transurethral resection of the prostate (TURP)
- •Transurethral resection of bladder tumor (TURBT)
- •Optical urethrotomy
- •Circumcision
- •Hydrocele and epididymal cyst removal
- •Nesbit procedure
- •Vasectomy and vasovasostomy
- •Orchiectomy
- •Urological incisions
- •JJ stent insertion
- •Nephrectomy and nephroureterectomy
- •Radical prostatectomy
- •Radical cystectomy
- •Ileal conduit
- •Percutaneous nephrolithotomy (PCNL)
- •Ureteroscopes and ureteroscopy
- •Pyeloplasty
- •Laparoscopic surgery
- •Endoscopic cystolitholapaxy and (open) cystolithotomy
- •Scrotal exploration for torsion and orchiopexy
- •17 Basic science of relevance to urological practice
- •Physiology of bladder and urethra
- •Renal anatomy: renal blood flow and renal function
- •Renal physiology: regulation of water balance
- •Renal physiology: regulation of sodium and potassium excretion
- •Renal physiology: acid–base balance
- •18 Urological eponyms
- •Index
598 CHAPTER 16 Urological surgery and equipment
Lasers in urological surgery
Lasers involve light amplification by stimulated emission of radiation. Photons are emitted when an atom is stimulated by an external energy
source, and its electrons having been so excited revert to their steady state. In a laser the light is coherent (all the photons are in phase with one another), collimated (the photons travel parallel to each other), and of the same wavelength (monochromatic). The light energy is thus concentrated, allowing delivery of high energy at a desired target.
The holmium:YAG (yttrium aluminum garnet) laser is currently the principal urological laser. It has a wavelength of 2140 nm and is highly absorbed by water and thus by tissues, which are composed mainly of water. The majority of the holmium laser energy is absorbed superficially, resulting in a superficial cutting or ablation effect. The depth of the thermal effect is no greater than 1 mm.
The holmium:YAG laser produces a cavitation bubble that generates only a weak shock wave as it expands and collapses. Holmium laser lithotripsy occurs primarily through a photothermal mechanism that causes stone vaporization.
Lasers used in BPH treatments are summarized in Chapter 3 in the section entitled “Invasive Surgical Alternatives to TURP” (p. 86).
Uses
•Laser lithotripsy (ureteric stones, small intrarenal stones, bladder stones)
•Resection of the prostate (holmium laser prostatectomy)
•Division of urethral strictures
•Division of ureteric strictures, including PUJO
•Ablation of small bladder, ureteric, and intrarenal TCCs
Advantages
The holmium laser energy is delivered via a laser fiber (Fig. 16.12) that is thin enough to allow its use down a flexible instrument, without affecting the deflection of that instrument, and can therefore gain access to otherwise inaccessible parts of the kidney.
The zone of thermal injury adjacent to the tip of the laser fiber is limited to no more than 1 mm; the laser can safely be fired at a distance of 1 mm from the wall of the ureter.
A laser can be used for all stone types.
There is minimal stone migration effect because of minimal shock wave generation.
Disadvantages
•High cost
•Produces a dust cloud during stone fragmentation that temporarily obscures the view
•Can irreparably damage endoscopes if inadvertently fired near or within the scope
•Relatively slow stone fragmentation—the laser fiber must be “painted” over the surface of the stone to vaporize it.
LASERS IN UROLOGICAL SURGERY 599
Figure 16.12 Holmium laser fiber.
600 CHAPTER 16 Urological surgery and equipment
Diathermy
Diathermy is the coagulation or cutting of tissues through heat.
Monopolar diathermy
When an electric current passes between two contacts on the body, there is an increase in temperature in the tissues through which the current flows. This increase in temperature depends on the volume of tissue through which the current passes, the resistance of the tissues, and the strength of the current. The stronger the current, the greater the rise in temperature.
If one contact is made large, the heat is dissipated over a wide area and the rise of temperature is insignificant. This is the earth or neutral electrode, and under this the rise in temperature is only 1 or 2°C. The working electrode or diathermy loop is thin, so that the current density is maximal and, therefore, so is the heating effect.
When a direct current is switched on or off, nerves are stimulated and muscles will twitch. If the switching on and off is rapid enough, there is the sustained contraction familiar to the physiology class as the tetanic contraction. If a high-frequency alternating current is used (300 kHz to 5 MHz), there is no time for the cell membranes of nerve or muscle to become depolarized, and nerves and muscles are not stimulated (they are stimulated at lower frequencies).
The effect of the diathermy current on the tissues depends on the heat generated under the diathermy loop. At relatively low temperatures, coagulation and distortion of small blood vessels occurs. If the current is increased to raise the temperature further, water within cells vaporizes and the cells explode. This explosive vaporization literally cuts the tissues apart.
Bipolar diathermy
Bipolar diathermy involves the passage of electrical current between two electrodes on the same handpiece. It is inherently safer than monopolar diathermy, since the current does not pass through the patient, and diathermy burns cannot therefore occur.
Potential problems with diathermy
The diathermy isn’t working
•Do not increase the current.
•Check that the irrigating fluid is glycine (sodium chloride conducts electricity, causing the diathermy to short-circuit).
•Check that the diathermy plate is making good contact with the skin of the patient.
•Check that the lead is undamaged.
•Check that the resectoscope loop is securely fixed to the contact.
Modern diathermy machines have warning circuits that sound an alarm when there is imperfect contact between the earth plate and the patient.
DIATHERMY 601
Diathermy burns
If current returns to earth through a small contact rather than the broad area of the earth pad, then the tissues through which the current passes will be heated just like those under the cutting loop. If the pad is making good contact, the current will find it easier to run to earth through the pad and no harm will arise, even when there is accidental contact with some metal object.
The real danger arises when the diathermy pad is not making good contact with the patient. It may not be plugged in, or its wire may be broken. Under these circumstances the current must find its way to earth somehow, and any contact may then become the site of a dangerous rise in temperature.
Pacemakers and diathermy
See Box 16.3 for diathermy problems and their prevention.
602 CHAPTER 16 Urological surgery and equipment
Box 16.3 Pacemakers and diathermy: problems and their prevention
•Pacemaker inhibition. The high frequency of diathermy current may simulate the electrical activity of myocardial contraction so the pacemaker can be inhibited. If the patient is pacemaker dependent, the heart may stop.
•Phantom reprogramming. The diathermy current may also simulate the radiofrequency impulse by which the pacemaker can be reprogrammed to different settings. The pacemaker may then start to function in an entirely different mode.
•The internal mechanism of the pacemaker may be damaged by the diathermy current if this is applied close to the pacemaker.
•Ventricular fibrillation. If the diathermy current is channeled along the pacemaker lead, ventricular fibrillation may be induced.
•Myocardial damage. Another potential effect of channeling of the diathermy current along the pacemaker lead is burning of the myocardium at the tip of the pacemaker lead. This can subsequently result in ineffective pacing.
It was formerly recommended that a magnet be placed over the pacemaker to overcome pacemaker inhibition and to make the pacemaker function at a fixed rate. This can, however, result in phantom reprogramming. For demand pacemakers, it is better to program the pacemaker to a fixed rate (as opposed to demand pacing) for the duration of the operation. Consult the patient’s cardiologist for advice.
Other precautions
•The patient plate should be sited such that the current path does not go right through the pacemaker. Ensure that the indifferent plate is correctly applied, as an improper connection can cause grounding of the diathermy current through the ECG monitoring leads, and this can affect pacemaker function. The indifferent plate should be placed as close as possible to the prostate (e.g., over the thigh or buttock).
•The diathermy machine should be placed well away from the pacemaker and should certainly not be used within 15 cm of it.
•The heartbeat should be continually monitored, and a defibrillator and external pacemaker should be at hand.
•Try to use short bursts of diathermy at the lowest effective output.
•Give antibiotic prophylaxis (as for patients with artificial heart valves).
•Because the pacemaker-driven heart will not respond to fluid overload in the normal way, the resection should be as quick as possible, and fluid overload should be avoided.
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