3 курс / Фармакология / Пленочные_покрытия_таблеток_Флисюк_Е_В_,_Карбовская_Ю_В_2016

313.Hutchings, D. Studies of the using mechanical properties of free films prepared using an ethylcellulose pseudolatex coating system // Hutchings D., Clarson S., Sakr A. / Int. J. Pharm., 104 (3), 1994, p. 203-213.

314.Hüttlin, H. Der Hüttlin “Kugelcoater” – eine Fliebbettapparatur zum Beschihten, Trocknen und Überziehen fester Arzneiformen / Pharm. Ind. – 1985. – V. 47. – №5 – p. 512-514.

315.Hypromellose, Pharmacoat,Aquoat. Техническая информация фирмы Shin Etsu. – 2008.

316.Innojet – техническая информация фирмы Huttlin (2008).

317.Iones, B.E. The Manufacture of hard gelatin capsules // The Chemical Eng / – 1982. – №380. – p. 174-177.

318.Ivanova, E. Encapsulation of water sensitive products: effectiveness and assessment of fluid bed dry coating // E. Ivanova, E. Teunov, D. Porcelet / Jour. Of Food Egineering, Dec. 2004.

319.J. Yuan, Pharmaceutical Technology, Oct (2001).

320.Japan Pharmacopoeia XIV (2001).

321.Johnson, K. Effect of triacetin and polyethylene glycol 400 on some physical properties of hydroxypropylmethylcellulose free films // Keith Johnson, Royl Hathaway / International Journal of Pharmaceutics, Volume 73, Issue 3, 1991, p. 197-208.

322.Johnson, T. From solvent to aqueous film coatings // T. Johnson, R. Telli / European Journal of Pharmaceutical Sciences.

323.Jones, D.S. Casting solvent controlled release of chlorhexidine from ethylcellulose film prepared by solvent evaporation // Jones D.S., Medicott N.J. / International Journal of Pharmaceutics, Volume 76, 1991, p. 91-97.

324.Kala, H. Aufbau, Arbeitswiese und erate Enfahrungen mit einem Laborgerat zum Uberziehen von Partikeln in der Wirbelschicht./ Kala H., Hennig D., Moldenhauer H., Zessin G.// Pharmazie. – 1983. – 38. – №12. – s. 879-881.

325.Karbovskaya, Yu. V. Comparative study of tablet coating material drag-out in apparatus of various designs / E.V. Flisiyk, Yu. V. Karbovskaya // Pharmaceutical Chemistry Journal. – V.44. – №5. – p. 268-270.

326.Kawai, H. Studies on the saponins of Lonicera japonica Thunb. / H. Kawai K. Massanori// Chemical and pharmaceutical Bulletin. – 1988. – V.36, № 12. – P. 4769-4775.

327.Kibbe,A. H. Handbook of Pharmaceutical Excipients, 3rd ed.,American PharmaceuticalAssociation: Washington, DC. – 2000. – p. 401.

328.Lamparter, E. High-performance liquid chromatographic determination of mexiletine in film-coated tablets using a new polymeric stationary phase. Journal of ChromatographyA, Volume 635, Issue 1, 9April 1993, Pages 155-159.

170

329.Lamparter, Е. High-performance liquid chromatographic determination of mexiletine in film-coated tablets using a new polymeric stationary phase / Journal of Chromatography. – 1993. – V. 635. – Is. 1. – р. 155-159.

330.Lee, K.J. The structure of plant community in Kwangnung (Korea) forest (I): Analysis of the forest community of Soribong area by the classification and ordination techniques / Lee, K.J., J.C. Jo., B.S. Lee and D.S. Lee // Journal of the Korean Forestry Society. – 1990. – V. 79. – р. 173-186.

331.Lee, S.J. Anti-inflammatory activity of Lonicera japonica / S.J. Lee, H.W. Chang, S.S. Kang, H.P. Kim // Phototherapy Research. – 1998. – V. 12. – Is. 6. – p. 445-447.

332.Lehman, K. Fast disintegrating controlledrelease tablets from coated particles // Lehman K., Petereit H.-U., Dreher D. / Drug Made in Germany, 37, 1994, P. 53-60.

333.Lehman, K. New methacrylic acid copolymers for improved coating triethylcellulosehnology // Lehman K., Sufke T. / Pharm. Research, 12(9), 5-137, 1995.

334.Lehman, K.. Formulation of controlled release tablets with acrylic resins. Act. Pharm. Fenn., 93, 1984, p. 55-74.

335.Lehmann, K. Coating of tablets and small particles with acrylic resins by fluid bed technology // Lehmann K., Dreher D. / Reprinted from International Journal of Pharmaceutics, Volume 2, Issue 4, 1981, p, 31-43.

336.Lehmann, K. The application and processing of acrylic coatings in form of aqueous dispersions compared with organic solutions// Acta Pharm. Fenn. – 1982. – V. 91. – №4. – p. 225-238.

337.Lehmann, K. The use of aqueous synthetic polymer dispersions for coating pharmaceutical dosage forms// Lehmann K., Dreher D. / Drugs made in Germany. – 1973. – V. 16. – p. 126, 131-134.

338.Lenenberger, H. Monitoring granulation // Manuf. chem. – 1984. – 55. – №5. – p. 67,69,71.

339.Lia, H. J. Determination of five major iridoid glucosides in Flos Lonicerae by high-performance liquid chromatography coupled with evaporative light scattering detection / H.J.Lia, P.Lia, W.Ca.Y // Journal of ChromatographyA. – 2003 – V 24 – Is. 6,-P. 167-172.

340.Lundren, P. Studies on the physical properties of tablet excipients. Film coating for protection of a high-sensitive tablet formulation// Lundren P., Nyqvist H., Nicklasson M, /Acta Pharm. Suec. – 1982. 0V. 19. – №3. – p. 223-228.

341.Lustre Clear / Техническая информация фирмы FMC. – 2007.

342.Madamba, MC. Characterization of Tablet Film Coatings Using a Laser-Induced Breakdown Spectroscopic Technique // MC. Madamba, WM Mullett, S Debnath, E Kwong. AAPS PharmSciTech.- 2007. – 8(4) – p. 323-326.

171

343.Madan, P.L. The design and evaluation of an apparatus for the determination disintegration time of tables. //Can. J. Pharm, Sci/ – 1978, – vol.13.

344.Maharaj, I.K. Simple rapid method for the preparation of enteric-coat- ed microspheres// Maharaj I.K., Nairn I.G., Cambell I.B. / I. Pharm. Sci. – 1984. – V. 73. – №1. – p. 39-42.

345.Martin,A. N. Diffusion and Dissolution. In Physical Pharmacy: Physical Chemical Principles in the Pharmaceutical Sciences, 4th ed.; Lippincott Williams & Wilkins: Philadelphia, 1993. – p. 335–336.

346.Masilungan, F.C. Evaluation of film coating compositions by thermomechanical analisys. I. Penetration mode. Internation Journal of Pharmaceutics, Volume 20, Issue 3, July 1984, Pages 295-305

347.McGinley, E.J. Enteric coating for pharmaceutical dosage forms. European Patent 0111103 Issued October 2 1990

348.McMahon, Niall M. Drug dissolution modeling // Niall M. McMahon, M. Crane / Ercim news 82 – on-line edition.

349.Methocel, Surelease, Opadry / Техническая информация фирмы COLORCON. – 2001.

350.Mitchell, K.A. «Manufacturing chemist», 26 march, 1965, p. 107.

351.Mohan T.Y., Huqk G.L. Drug Standarts, 1956, p. 24.

352.Mosharraf, M. The effect of particle size and the shape of the surface specific dissolution rate of microsized partically insoluble drugs // M. Mosharraf, C. Nystrom / Internation Juornal of Pharmaceutics. – 1995. – V. 122. – I. 1-2. – p. 35-47.

353.Nadkarni, Prakash D. Effect of surface roughness and coating solvent on film adhesion to tablets // D. Prakash Nadkarni, Dane O. Kildsig, Paul A. Kramer, Gilbert S.Banker / Journal of Pharmaceutical Sciences. – 1975. – V. 64. – №9. – p. 1554-1557.

354.Nakano, M. Sustained release of theophylline from hydroxypropyl cellulose tablets// Nakano M., Ohmori N. / I. Pharm. Sci. – 1983. – V. 72. – №4. – p. 378-380.

355.Neurath,A. Robert. Water dispersible microbidical cellulose acetate phthalate film // A. Robert Neurath, Nathan Strick / BMC Infectious diseases. – 2003. – №54 (3). – с. 217-224.

356.Neurdth, R. Water dispersible microbicidal cellulose acetate phthalate film // Robert Neurdth, Nathan Strick, Yun-Yao Li. / BMC Infectious Diseases, New York, USA, NY 10021, P. 10-18.

357.Ochoa Machiste, E. Dynamic surface tension studies of hydroxypropylmethylcellulose film-coating solutions // E. Ochoa Machiste, G. Buckton / International Journal of Pharmaceutics, Volume 145, Issue 1-2, 6 December 1996, Pages 197-201.

172

358.Ohnishi, R. Effects of chlorogenic acid and its metobolities on spontaneous lomocotor activity in mice / R. Ohnishi // Biosci.Biotechnol.Biochem. – 2006. – V.70. – № 10. – p. 2560-2563.

359.Okor, R.S. Drug release through aqueous-based film coatings of acry- late-metacrylate, a water-insoluble copolymer. International Journal of Pharmaceutics, Volume 58, Issue 1, 15 January 1990, Pages 89-91.

360.Oldrige, W. Compression of enteric-coated pellets to disintegrating tablets / International Journal of Pharmaceutics. – 1996 – V. 143. – Is. 1. – P. 13-23.

361.Osmotic pumping release from KCl tablets coated with porous and non-porous ethylcellulose. International Journal of Pharmaceutics, Volume 67, Issue 1, 1 January 1991, Pages 21-27.

362.P280reducederytromycinreleaseandbioavailabilityfromfilmtablets stored under dried conditions, European Journal of Pharmaceutical Sciences, Volume 2, Issues 1-2, September 1994, Page 188.

363.Panchangula, R. Biopharmaceutics and pharmacokinetics in drug research // R. Panchangula, N.S.Thomas / Int. J. Pharm. – 2000. – №201 – 131-150.

364.Pandey, Р. Scale up of the pan-coating process //Р. Pandey, R. Turton, Nitin Joshi, E. Hammerman /AAPS PharmSciTech. – 2006. – 7(4) – p. 101-112.

365.Parametries of the tablet coating process in fluidized bed / техниче-

ская информация компании GEA. – 2007

366.Pat. 2648609 USA, MK A6IK9/32. Method of applying coating to odible tablets or the like/ D.E. Wurster (USA). Опубл. 11.08.53.

367.Pat. 3382093, MK A6IK9/33. Fluidized coating of fragile bodies/ Nack Herman (USA); Заявл. 22.02.65; Опубл. 7.05.68// РЖ Химия. – 1969. – №18. – с. 89. – H561.

368.Pat. 3741795 USA. MK A6IK9/35. Tablets of oral use coated with a stabilized shellac sealing coating/ Signorino Ch.A. (USA)// РЖ Химияю – 1974. – №19. – С. 117. – 1900315П.

369.Pat. 4457907 USA, MKA6IK9/30. Composition and method for protecting a therapeutic drug/ Porter G.L. (USA). – №405510; Заявл. 5.08.82; Опубл. 3.07.84.// РЖ Химия. – 1985. – №19 (12). – с. 59. – 120297 П.

370.Pat. 4555399 USA, MK A6IK9/29. Aspirin tablet/ Hsiao Ch.H. (USA). – №587533; Заявл. 8.03.84; Опубл. 26.11.85.// РЖ Химия. – 1986 – №19 (17). – с. 46. – 170201 П.

371.Paul W.S., Heng, Relationship between aggregation of HPMC coated spheroids and tackiness/viscosity/additives of the coating formulations // Paul W.S. Heng, Lucy S.C. Wan and Yvonn T.F. Tan / International Journal of Pharmaceutics, Volume 138, Issue 1, 12 July 1996, Pages 57-66.

372.Perez-Ramos, D. QuantitativeAnalysis of Film Coating in a Pan Coater Based on In-Line Sensor Measurements // European Journal of Pharma-

173

ceutics and Biopharmaceutics D. Perez-Ramos,W. Paul Findlay, Garnet Peck, Kenneth R. Morris. – 2005. – p. 78-83.

373.Pharmaceutical supplements / техническая нформация Ideal Curves. – 2005.

374.Pharmacopoeia of United States. The National Formulary. USPXXVI

(2003).

375.Physical and Mechanical Properties of Acrylic and Cellulosic Polymers Plasticized with Citrate Esters. Pharmaceutical Coating Bulletin 102-1, Morflex, Inc, 1995.

376.Plasdone S-630 Copovidone // Техническая информация фирмы

ISP, 2004, 7 c.

377.Popescu, G. Invelisuri entrosolubile peutru pipule si tablet// Popescu G., Braileanu G., Stanescu V., Zubcov D. / Farmacia (RPR). – 1960. – V. 8. –

32.– p. 145.

378.Prakash D., Nadkarni. Effect of surface roughness and coating solvent on film adhesion to tablets // Prakash D. Nadkarni, Dane O. Kildsig, Paul A. Kramer, and Gilbert S. Banker / Journal of Pharmaceutical Sciences., V. 64., №9, September 1975, p. 1554-1557.

379.Provisional Technical Information Kollicoat MAE 100P. Fine Chemicals, November, 1995 (MPM), p, 2-9.

380.Rie, K. Structural analysis on the constituents of Lonicera japonica species / K. Rie, Y.Yasanont, M.K.Masao // Journal of Tohoku pharmaceutical university. – 2000. – №47. – p. 55-60.

381.Rosillo, V. Physicochemical characterization of ethylcellulose drug-loaded cast films // Rosillo V. Roblot-Trupel L., De Lourdes Costra M. / Journal of Controlled Release, 1988, Volume 7, P. 171-180

382.Rothe, W. Film – drageirung auf wasseriger Basis // Rothe W., Croppenbacher G. / Pharm. Ind. – 1972. – Bd.34. – №11-а. – S. 892-894.

383.Rupp, R. Flow and other properties of granulates// Bollettino chimico farmaceuco. – 1977. – 116. – №5. – p. 251-260.

384.Saivere, I. A.c. 13652 CCP Spusob vyrobi stabilnich pevnych kusovych peroralnich lekovych form / Saivere I., Licarova E., Kobbar K., Smidova H. (CCP)//

385.Sakellariou, P. The morphology of blends of ethylcellulose with hydroxypropyl methylcellulose as used in film coating // P. Sakellariou and R.C. Rowe. / International Journal of Pharmaceutics, Volume 125, Issue 2,

31October 1995, Pages 289-296.

386.Sangalli, М.Е. Different HPMC viscosity grades as coating agents for and oral time and/or site-controlled delivery system: a study on process parametres and in vitro performances // M.E. Sangalli, A. Manori / European Journal of Pharmaceutical Sciences. – 2004. – V. 34. – Is. 3. – p. 125-130.

174

387.Sangalli, M. Different HPMC viscosity grades as coating agents for and oral time and/or site-controlled delivery system: a study on process parametres and in vitro performances // M.E. Sangalli, A, Manori / European Journal of Pharmaceutical Sciences, In press, Corrected proof,Available online I July 2004.

388.Sangalli, M.E. Different HPMC viscosity grades as coating agents for an oral time and/or side-controlled delivery system: a study on process paramatres and in vitro performances // M.E. Sangalli, A.Maroni. / European Journal of Pharmaceutical Science, Volume 22, Issue 5,August 2004, Pages 469-476.

389.Schaefer, T. Control of fluidized bed granulation II. Estimation of droplet size of atomized binder solutions / Archiv for Pharmaci and Chemi Scientific edition 5. – p. 178-193.

390.Scheiffele,S.StudiescomparingKollicoatMAE30Dwithcommertial cellulose derivatives for enteric coating on caffiene core // Scheiffele S., Kolter K., Schepky G. / Drug Dev. Ind. Pharm., 1998, Sep.: 24(9): 807-818.

391.Seitavuopio, Paulus. Monitoring Tablet Surface Roughness During the Film Coating Process // Paulus Seitavuopio, Jyrki Heinämäki, Jukka Rantanen, Jouko Yliruusi / AAPS Pharm.Sci.Tech. – 2006. – V. 7. – Is. 2 – p. 1-6

392.Sheroni, D. A model of surface renewal with application to fluid bed coating of particles// Chem. Eng. Sc. – 1981. – V. 36. – №5. – p. 845-848.

393.Shinji, Ohmori. Development and evaluation of tablets coated with the novel formulation termed thin-layer sugarless coated tablets // Shinji Ohmori, Yasuo Ohno, Tadashi Makino / International Journal of Pharmaceutics, Volume 278, Issue 2, 8 July 2004, Pages 459-469.

394.Simon, R. Thermal, mechanical and functional properties of cellulose acetate phthalate (CAP) coating obtained from neutralized aqueous solutions

//Simon R., Bechard, Lydia Levy / International Journal of Pharmaceutics, Volume 114, Issue 2, 1995, P. 205-213.

395.Sontaya, Limmatvapirat Modification of physicochemical and mechanical properties of shellac by partial hydrolysis // Sontaya Limmatvapirat, Chutima Limmatvapirat / International Journal of Pharmaceutics, Volume 278, Issue 1, 18 June 2004, Pages 41-49.

396.Spencer, J.A. Delayed release tablet dissolution related to coating thickness by pulsed image mapping // J. A. Spencer, Zongming Gao, Terry Moore / Juornal of Pharmaceutical Sciences. – 2008. – V.97. – Is. 4. – p. 1543-1550.

397.Staut, J. Effect of solids-polymer interactions on the properties of some aqueous-based tablet film coating formulations. Moisture permeability / International Journal of Pharmaceutics. – 1984. – V. 22. – Is. 2-3. – р. 273-281

398.Stehnton, M. Biphasic drug release from film-coated tablets / International Journal of Pharmaceutics. – 2003. – V. 250. – Is. 2. – P. 431-440.

399.Stozek, T. Porownaic narunkow badania uwalniania substancji leczniezej z tabletek in vitro z dostepnoscia biologiczna // Stozek T., Krowczynsky L., Bondanowicz T. /Acta pol. Pharm.- 1983. – T. 40. – №1. – p. 77-87.

175

400.Tambweker, K.R. Effect of different bioadhesive polymers on performance characteristics of vaginal tablets // Tambweker K.R., Gunjan V.A., Kandarapu R., Garg S. / Microbicids 2002. ConferenceAbstract 2002, p. 15

401.Tobiska, S. Coating uniformity and coating efficiency in a Bohle Lab-Coaterusing oval tablets // S. Tobiska, P. Kleinebudde / European Journal of Pharmaceutics and Biopharmaceutics. – 2003. – V. 56. – Is. 1. – p. 3-9.

402.Vinler, H. An alternative apparatus for aqueous film-coating/ Acta pharm.sci. – 1981. – 18. №2. – p. 104-105.

403.Vinter, H.An alternative apparatus for aqueous film-coating/Vinter H. And all//Acta pharm.suec. – 1981. – 18. – №2. – p. 104-105.

404.Voigt, R. Methodik zur Prufung der Resistenz filbildender Polimere gegenuber verdauungssaften// Voigt R., Wunsch G. / Pharmazic. – 1981. – Bd. 36. – №5. – s. 358-362.

405.Wang,Y.S. Pharmacological and applications of Chinese material media / Y.S. Wang.- B .: People’s Heath Publisher, 1983. – p. 703-709.

406.Wesseling, M. Tackness of acrilic and cellulosic polymer films used in coating of solid dosage forms // Wesseling M., Kuppler F., Bodmeier R. / Eur. J. Pharm. Biopharm, 1999 Jan; 47 (1): 39-50.

407.Wood, I.A. The adhesion of the film coating to the surfaces of compressed tablets // Wood I.A., Harder S.W. / Can. I. Pharm. Sei, 1981, V. 5, №1, p. 18-23.

408.Woodruff, C.W. Effect of environmental conditions and polymer ration water vapor transformation through free plasticized cellulose films.// Woodruff C.W., Pock G.E., Banker G.S. / I. Pharm. Sci. – 1972. – V. 61. – №12. – p. 1956.

409.XL™Lab / Техническая информация фирмы Manesty. – 2009.

410.Yi-Ming, Sun. Fluidized-bed spray coated porous hydrogel beads for sustained release of diclofenac sodium // Yi-Ming Sun, Chih-Cheng Chang / Journal of Controlled Release, Volume 47, Issue 3, 8 September 1997, Pages 247-260.

411.Yoshikawa, S. Evaluation of correlation between dissolution retes of the loxoprophen tablets and their surface morphology observed by scanning electron microscope and atomic force microscope // S. Yoshikawa, R. Murata, S. Shida, S. Uwai, T. Suzuki / Chem Pharm Bull. – 2010. – 58 (1). – p. 34-37.

412.Zhou, R.H. Chinese medical material / R.H.Zhou. – B.: сhinese medical and pharmaceutical sciences press, 1993. – 17 p.

413.Zohn, T. Japonic medicine – B.: People’s health Publisher, 1978. – р. 342-367.

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СОДЕРЖАНИЕ

Глава 1. Характеристика и классификация пленочных покрытий . .3

1.1.Классификация пленочных покрытий. . . . . . . . . . . . 5

1.1.1.Защитные покрытия . . . . . . . . . . . . . . . . . .5

1.1.2.Кишечнорастворимые покрытия . . . . . . . . . . . . . 5

1.1.3.Покрытия, используемые для создания

пролонгированных лекарственных форм . . . . . . . . . . . .6

Глава 2. Состав пленочных покрытий . . . . . . . . . . . . . 7

2.1.Пленкообразователи для защитных покрытий . . . . . . . . . 9

2.1.1.Пленкообразователи, формирующие пленки,

растворимые в воде и пищеварительных соках . . . . . . . . . 10 2.1.2. Пленкообразователи, формирующие пленки, растворимые в воде, но не растворимые в пищеварительных соках . 20 2.1.3. Пленкообразователи, формирующие пленки,

нерастворимые в воде, но растворимые в пищеварительных соках. . 24 2.1.4. Пленкообразователи, формирующие пленки, нерастворимые в воде и кишечном соке, но растворимые в желудочном соке . . .24 2.1.5. Пленкообразующие композиции на основе природных соединений. . . . . . . . . . . . . . . . . . . 25

2.2.Пленкообразователи для кишечнорастворимых покрытий. . . 26

2.2.1.Природные пленкообразователи . . . . . . . . . . . . 26

2.2.2.Полусинтетические пленкообразователи . . . . . . . . .28 2.2.3.Синтетические пленкообразователи. . . . . . . . . . . 30

2.3.Пленкообразователи для покрытий

с модифицированными высвобождением . . . . . . . . . . . .36

2.4.Растворители . . . . . . . . . . . . . . . . . . . . . .37

2.5.Корригенты вкуса и запаха. . . . . . . . . . . . . . . . 37

2.6.Красители. . . . . . . . . . . . . . . . . . . . . . . 38

2.7.Пластификаторы . . . . . . . . . . . . . . . . . . . . 39

Глава 3. Алгоритм разработкиоптимального состава покрытия. . 42

3.1.Анализ качества таблеток-ядер . . . . . . . . . . . . . . 43

3.2.Изучение физико-химических свойств

пленкообразующих композиций . . . . . . . . . . . . . . . . 44

3.2.1.Изучение влияния вида и концентрации пленкообразователей и вспомогательных веществ на вязкость растворов . . . . . . .50

3.2.2.Изучение влияния вида и концентрации пленкообразователей и вспомогательных веществ на плотность растворов . . . . . . 52

3.2.3.Изучение влияния вида и концентрации пленкообразователей и вспомогательных веществ на поверхностное натяжение растворов .54

177

3.2.4. Изучение свойств пленок на основе пленкообразующих композиций . . . . . . . . . . . . . . . . . . . . .55

3.2.4.1.Изучение растворения пленок. . . . . . . . . . . . 56

3.2.4.2.Изучение паропроницаемости пленок . . . . . . . . 56

3.2.4.3.Определение микротвердости пленок . . . . . . . . 58

3.3.Изучение смачиваемости таблеток раствором полимера . . . .58

Глава 4. Аппаратурное оформление процесса нанесения пленочных покрытий на твердые лекарственные формы. . . . 62

4.1.Дражировочные котлы и барабаны . . . . . . . . . . . . .62

4.2.Аппараты псевдоожиженного слоя . . . . . . . . . . . . .64

4.3.Барабанные обволакивающие установки . . . . . . . . . . 79

Глава 5. Оценка равномерности покрытия таблеток . . . . . . 81 5.1. Современные методики оценки равномерности покрытия таблеток . . . . . . . . . . . . . . . . . . . . . 81 5.2. Изучение равномерности покрытия таблеток

впределах одной технологической серии . . . . . . . . . . . .85

5.2.1.Математическая модель процесса нанесения

пленочных покрытий . . . . . . . . . . . . . . . . . . . 86

покрытых оболочкой . . . . . . . . . . . . . . . . . . . .127

Глава 6. Дефекты оболочки, возникающие при нанесении покрытия на таблетки. . . . . . . . . . . . . . . . . . . . . . . . 142

Библиографический список . . . . . . . . . . . . . . . . .146

178