- •November 16, 2002
- •February 14, 2003
- •February 21
- •February 28
- •March 7
- •March 10
- •March 12
- •March 14
- •March 15
- •March 17
- •March 19
- •March 21
- •March 24
- •March 26
- •March 28
- •March 30
- •March 31
- •April 2
- •April 2
- •April 8-10
- •April 12
- •April 16
- •April 20
- •April 20
- •April 23
- •April 25
- •April 27
- •April 29
- •June 6
- •June 13
- •June 17
- •June 21
- •June 23
- •June 24
- •July 2
- •July 5
- •August 14
- •September 8
- •September 24
- •References
- •Virology
- •Discovery of the SARS Virus
- •Initial Research
- •The Breakthrough
- •Coronaviridae
- •SARS Co-V
- •Genome Sequence
- •Morphology
- •Organization
- •Detection
- •Stability and Resistance
- •Natural Host
- •Antiviral Agents and Vaccines
- •Antiviral Drugs
- •Vaccines
- •Outlook
- •References
- •Routes of Transmission
- •Factors Influencing Transmission
- •Patient Factors in Transmission
- •Asymptomatic Patients
- •Symptomatic Patients
- •Superspreaders
- •The Unsuspected Patients
- •High-Risk Activities
- •Transmission during Quarantine
- •Transmission after Recovery
- •Animal Reservoirs
- •Conclusion
- •References
- •Introduction
- •Modeling the Epidemic
- •Starting Point
- •Global Spread
- •Hong Kong
- •Vietnam
- •Toronto
- •Singapore, February 2003
- •China
- •Taiwan
- •Other Countries
- •Eradication
- •Outlook
- •References
- •Introduction
- •International Coordination
- •Advice to travelers
- •Management of SARS in the post-outbreak period
- •National Measures
- •Legislation
- •Extended Case Definition
- •Quarantine
- •Reduce travel between districts
- •Quarantine after Discharge
- •Infection Control in Healthcare Settings
- •General Measures
- •Protective Measures
- •Hand washing
- •Gloves
- •Face Masks
- •Additional protection
- •Getting undressed
- •Special Settings
- •Intensive Care Units
- •Intubating a SARS Patient
- •Anesthesia
- •Triage
- •Internet Sources
- •Additional information
- •Infection Control in Households
- •Possible Transmission from Animals
- •After the Outbreak
- •Conclusion
- •References
- •Case Definition
- •WHO Case Definition
- •Suspect case
- •Probable case
- •Exclusion criteria
- •Reclassification of cases
- •CDC Case Definition
- •Diagnostic Tests
- •Introduction
- •Laboratory tests
- •Molecular tests
- •Virus isolation
- •Antibody detection
- •Interpretation
- •Limitations
- •Biosafety considerations
- •Outlook
- •Table, Figures
- •References
- •Clinical Presentation and Diagnosis
- •Clinical Presentation
- •Hematological Manifestations
- •Atypical Presentation
- •Chest Radiographic Abnormalities
- •Chest Radiographs
- •CT Scans
- •Diagnosis
- •Clinical Course
- •Viral Load and Immunopathological Damage
- •Histopathology
- •Lung Biopsy
- •Postmortem Findings
- •Discharge and Follow-up
- •Psychosocial Issues
- •References
- •Appendix: Guidelines
- •WHO: Management of Severe Acute Respiratory Syndrome (SARS)
- •Management of Suspect and Probable SARS Cases
- •Definition of a SARS Contact
- •Management of Contacts of Probable SARS Cases
- •Management of Contacts of Suspect SARS Cases
- •SARS Treatment
- •Antibiotic therapy
- •Antiviral therapy
- •Ribavirin
- •Neuraminidase inhibitor
- •Protease inhibitor
- •Human interferons
- •Human immunoglobulins
- •Alternative medicine
- •Immunomodulatory therapy
- •Corticosteroids
- •Other immunomodulators
- •Assisted ventilation
- •Non-invasive ventilation
- •Invasive mechanical ventilation
- •Clinical outcomes
- •Outlook
- •Appendix 1
- •A standardized treatment protocol for adult SARS in Hong Kong
- •Appendix 2
- •A treatment regimen for SARS in Guangzhou, China
- •References
- •Pediatric SARS
- •Clinical Manifestation
- •Radiologic Features
- •Treatment
- •Clinical Course
- •References
98 Prevention
For more information, see the triage guidelines (http://www.cdc.gov/ncidod/sars/triage_interim_guidance.htm).
For home or residential setting:
Placing a surgical mask on suspect SARS patients during contact with others at home is recommended. If the patient is unable to wear a surgical mask, it may be prudent for household members to wear surgical masks when in close contact with the patient. Household members in contact with the patient should be reminded of the need for careful hand hygiene including hand washing with soap and water; if hands are not visibly soiled, alcohol-based handrubs may be used as an alternative to hand washing. For more information, see the household guidelines, http://www.cdc.gov/ncidod/sars/icclosecontacts.htm.
Case Definition for suspected Severe Acute Respiratory Syndrome (SARS)
Health-care personnel should apply appropriate infection control precautions for any contact with patients with suspected SARS. The case definition for suspected SARS is subject to change, particularly concerning travel history as transmission is reported in other geographic areas; the most current definition can be accessed at the Severe Acute Respiratory Syndrome (SARS) case definition web page, http://www.cdc.gov/ncidod/sars/casedefinition.htm.
Additional information
A power point file summarizing public health interventions has recently been presented at the WHO's Kuala Lumpur meeting:
"Severe Acute Respiratory Syndrome: Response from Hong", by Yeoh EK: http://SARSReference.com/link.php?id=14
Infection Control in Households
Healthcare workers should have a high index of suspicion if they or family members develop fever and features suggestive of severe acute respiratory syndrome. They should present themselves to hospitals
www.SARSreference.com
Infection Control in Households 99
rather than treating themselves at home and putting their family members at risk (Chan-Yeung).
To prevent secondary transmission, close contacts of SARS patients should be vigilant for fever or respiratory symptoms. If such symptoms develop, exposed persons should avoid contact with others, seek immediate medical attention, and practice the infection control precautions that are recommended for SARS patients. Household members and other close contacts of SARS patients should be actively monitored by the local health department for illness.
Consult frequently CDC's "SARS Infection Control and Exposure Management" guidelines, http://www.cdc.gov/ncidod/sars/ic.htm:
Interim Guidance on Infection Control Precautions for Patients with Suspected SARS and Close Contacts in Households (see below), http://www.cdc.gov/ncidod/sars/ic-closecontacts.htm
Interim Domestic Guidance on Persons Who May Have Been Exposed to Patients with Suspected SARS, http://www.cdc.gov/ncidod/sars/exposuremanagement.htm
Interim Domestic Guidance for Management of Exposures to SARS for Health-Care and Other Institutional Settings, http://www.cdc.gov/ncidod/sars/exposureguidance.htm
Contacts of proven cases should isolate themselves until the incubation period is over. After contact with patients with respiratory symptoms, careful hand hygiene is necessary, including washing with soap and water.
CDC: Interim Guidance on Infection Control Precautions for Patients with Suspected Severe Acute Respiratory Syndrome (SARS) and Close Contacts in Households
Revised: April 29
Check regularly for updates: http://www.cdc.gov/ncidod/sars/ic-closecontacts.htm
Patients with SARS pose a risk of transmission to close household contacts and health care personnel in close contact. The duration of
Kamps and Hoffmann (eds.)
100 Prevention
time before or after onset of symptoms during which a patient with SARS can transmit the disease to others is unknown. The following infection control measures are recommended for patients with suspected SARS in households or residential settings. These recommendations are based on the experience in the United States to date and may be revised as more information becomes available.
1.SARS patients should limit interactions outside the home and should not go to work, school, out-of-home child care, or other public areas until 10 days after the resolution of fever, provided respiratory symptoms are absent or improving. During this time, infection control precautions should be used, as described below, to minimize the potential for transmission.
2.All members of a household with a SARS patient should carefully follow recommendations for hand hygiene (e.g., frequent hand washing or use of alcohol-based hand rubs), particularly after contact with body fluids (e.g., respiratory secretions, urine, or feces). See the "Guideline for Hand Hygiene in Health-Care Settings" at http://www.cdc.gov/handhygiene/ for more details on hand hygiene.
3.Use of disposable gloves should be considered for any direct contact with body fluids of a SARS patient. However, gloves are not intended to replace proper hand hygiene. Immediately after activities involving contact with body fluids, gloves should be removed and discarded and hands should be cleaned. Gloves must never be washed or reused.
4.Each patient with SARS should be advised to cover his or her mouth and nose with a facial tissue when coughing or sneezing. If possible, a SARS patient should wear a surgical mask during close contact with uninfected persons to prevent spread of infectious droplets. When a SARS patient is unable to wear a surgical mask, household members should wear surgical masks when in close contact with the patient.
5.Sharing of eating utensils, towels, and bedding between SARS patients and others should be avoided, although such items can be used by others after routine cleaning (e.g., washing with soap and hot water). Environmental surfaces soiled by body fluids should be cleaned with a household disinfectant according to
www.SARSreference.com
Possible Transmission from Animals 101
manufacturer's instructions; gloves should be worn during this activity.
6.Household waste soiled with body fluids of SARS patients, including facial tissues and surgical masks, may be discarded as normal waste.
7.Household members and other close contacts of SARS patients should be actively monitored by the local health department for illness.
8.Household members or other close contacts of SARS patients should be vigilant for the development of fever or respiratory symptoms and, if these develop, should seek healthcare evaluation. In advance of evaluation, healthcare providers should be informed that the individual is a close contact of a SARS patient so arrangements can be made, as necessary, to prevent transmission to others in the healthcare setting. Household members or other close contacts with symptoms of SARS should follow the same precautions recommended for SARS patients.
9.At this time, in the absence of fever or respiratory symptoms, household members or other close contacts of SARS patients need not limit their activities outside the home.
Related Links:
SARS Information for Patients and Their Close Contacts, http://www.cdc.gov/ncidod/sars/closecontacts.htm
Possible Transmission from Animals
SARS Co-V was found in three animal species taken from a market in Southern China (masked palm civet and racoon-dog, Chinese ferret badger). As a precautionary measure, persons who might come into contact with these species or their products, including body fluids and excretions, should be aware of the possible health risks, particularly
Kamps and Hoffmann (eds.)