- •November 16, 2002
- •February 14, 2003
- •February 21
- •February 28
- •March 7
- •March 10
- •March 12
- •March 14
- •March 15
- •March 17
- •March 19
- •March 21
- •March 24
- •March 26
- •March 28
- •March 30
- •March 31
- •April 2
- •April 2
- •April 8-10
- •April 12
- •April 16
- •April 20
- •April 20
- •April 23
- •April 25
- •April 27
- •April 29
- •June 6
- •June 13
- •June 17
- •June 21
- •June 23
- •June 24
- •July 2
- •July 5
- •August 14
- •September 8
- •September 24
- •References
- •Virology
- •Discovery of the SARS Virus
- •Initial Research
- •The Breakthrough
- •Coronaviridae
- •SARS Co-V
- •Genome Sequence
- •Morphology
- •Organization
- •Detection
- •Stability and Resistance
- •Natural Host
- •Antiviral Agents and Vaccines
- •Antiviral Drugs
- •Vaccines
- •Outlook
- •References
- •Routes of Transmission
- •Factors Influencing Transmission
- •Patient Factors in Transmission
- •Asymptomatic Patients
- •Symptomatic Patients
- •Superspreaders
- •The Unsuspected Patients
- •High-Risk Activities
- •Transmission during Quarantine
- •Transmission after Recovery
- •Animal Reservoirs
- •Conclusion
- •References
- •Introduction
- •Modeling the Epidemic
- •Starting Point
- •Global Spread
- •Hong Kong
- •Vietnam
- •Toronto
- •Singapore, February 2003
- •China
- •Taiwan
- •Other Countries
- •Eradication
- •Outlook
- •References
- •Introduction
- •International Coordination
- •Advice to travelers
- •Management of SARS in the post-outbreak period
- •National Measures
- •Legislation
- •Extended Case Definition
- •Quarantine
- •Reduce travel between districts
- •Quarantine after Discharge
- •Infection Control in Healthcare Settings
- •General Measures
- •Protective Measures
- •Hand washing
- •Gloves
- •Face Masks
- •Additional protection
- •Getting undressed
- •Special Settings
- •Intensive Care Units
- •Intubating a SARS Patient
- •Anesthesia
- •Triage
- •Internet Sources
- •Additional information
- •Infection Control in Households
- •Possible Transmission from Animals
- •After the Outbreak
- •Conclusion
- •References
- •Case Definition
- •WHO Case Definition
- •Suspect case
- •Probable case
- •Exclusion criteria
- •Reclassification of cases
- •CDC Case Definition
- •Diagnostic Tests
- •Introduction
- •Laboratory tests
- •Molecular tests
- •Virus isolation
- •Antibody detection
- •Interpretation
- •Limitations
- •Biosafety considerations
- •Outlook
- •Table, Figures
- •References
- •Clinical Presentation and Diagnosis
- •Clinical Presentation
- •Hematological Manifestations
- •Atypical Presentation
- •Chest Radiographic Abnormalities
- •Chest Radiographs
- •CT Scans
- •Diagnosis
- •Clinical Course
- •Viral Load and Immunopathological Damage
- •Histopathology
- •Lung Biopsy
- •Postmortem Findings
- •Discharge and Follow-up
- •Psychosocial Issues
- •References
- •Appendix: Guidelines
- •WHO: Management of Severe Acute Respiratory Syndrome (SARS)
- •Management of Suspect and Probable SARS Cases
- •Definition of a SARS Contact
- •Management of Contacts of Probable SARS Cases
- •Management of Contacts of Suspect SARS Cases
- •SARS Treatment
- •Antibiotic therapy
- •Antiviral therapy
- •Ribavirin
- •Neuraminidase inhibitor
- •Protease inhibitor
- •Human interferons
- •Human immunoglobulins
- •Alternative medicine
- •Immunomodulatory therapy
- •Corticosteroids
- •Other immunomodulators
- •Assisted ventilation
- •Non-invasive ventilation
- •Invasive mechanical ventilation
- •Clinical outcomes
- •Outlook
- •Appendix 1
- •A standardized treatment protocol for adult SARS in Hong Kong
- •Appendix 2
- •A treatment regimen for SARS in Guangzhou, China
- •References
- •Pediatric SARS
- •Clinical Manifestation
- •Radiologic Features
- •Treatment
- •Clinical Course
- •References
90 Prevention
is quarantined because of exposure, there will still be a clean team available to continue emergency work (Mukherjee).
Other measures include stopping hospital visitations, except for pediatric, obstetric, and selected other patients. For these patients, visitors are limited to a single person who must wear a mask and pass a temperature check; all other visits are by video conference. An audit of infection control practices is ongoing (Mukherjee).
Eventually, appropriate respiratory precautions will be instituted when assessing patients with undifferentiated respiratory conditions and their family members, in order to prevent the introduction of SARS in the hospital setting (Booth).
Protective Measures
Droplet infection seems to be the primary route of spread for the SARS virus in the healthcare setting (Seto). In a case control study in five Hong Kong hospitals, with 241 non-infected and 13 infected staff with documented exposures to 11 index patients, no infection was observed among 69 healthcare workers who reported the use of mask, gloves, gowns, and hand washing. N95 masks provided the best protection for exposed healthcare workers, whereas paper masks did not significantly reduce the risk of infection (Seto).
Table 1 shows a summary of precautions for droplet infection. The implementation of aggressive infection control measures was effective in preventing the further transmission of SARS (Hsu).
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Infection Control in Healthcare Settings 91
Table 1: Precautions for SARS prevention in healthcare settings (from ChanYeung, Outbreak of severe acute respiratory syndrome in Hong Kong Special Administrative Region: case report.)
Patients should wear N-95 masks once symptoms develop and be placed immediately in isolation facilities with negative pressure.
Healthcare workers should wear similar masks together with head cover, goggles, gowns, and gloves when caring for these patients.
Daily and terminal disinfection should be thorough, with careful washing and disinfection of the bed, handrails, bedside tables, floor, and equipment with hypochlorite solution (1000 ppm).
For intubated patients, the use of a closed suction system is essential to avoid air leakage and enhanced disease transmission.
For detailed information, see the CDC guidelines further below.
As the SARS virus may be viable in the environment for several days, precautionary measures, including rigorous disinfection and hygiene procedures should provide the highest standard of protection.
Hand washing
It is essential to wash hands before touching faces or eyes.
Gloves
Health Canada advises double gloving when attending a suspected SARS patient. Hands must be washed after de-gloving.
Face Masks
The N95 respirator/mask has a filter efficiency level of 95% or greater against particulate aerosols free of oil when tested against a 0.3 micron particle. It is fluid resistant, disposable and may be worn in surgery. The "N" means "Not resistant to oil". The "95" refers to a 95% filter efficiency. The following points have to be kept in mind (Health Canada):
An occlusive fit and a clean shave for men provide the best protection for the healthcare worker.
Kamps and Hoffmann (eds.)
92 Prevention
Masks should be tested for fit according to the manufacturer's recommendations. In addition, masks should be fit-checked each time the mask is put on. To check the mask, the wearer takes a quick, forceful inspiration to determine if the mask seals tightly to the face.
For instructions on how best to use the N95 mask or equivalent, refer to the handout provided by the manufacturer, or follow your provincial regulations.
There are no published data on the length of time the mask is effective for the wearer. Health Canada recommends masks should be changed if they become wet, interfere with breathing, are damaged or visibly soiled.
A respirator (mask) which has been exposed to a probable SARS case is considered contaminated and should be discarded.
When discarding the mask: Wash hands prior to handling the mask. Carefully remove the mask using the straps. Discard. Wash hands after handling the mask.
If re-using the mask: Place in a clean, dry location such as a paper bag. Do not mark the mask with a pen or marker. The name of the owner should be written on the outside of the paper bag to identify the mask. Hands should be washed after handling the mask.
Even for doctors in the community, it is advisable to wear a N95 mask when seeing any patient with respiratory symptoms (Chan-Yeung).
Additional protection
Theatre caps may reduce the risk of staff potentially contaminating their hands by touching their hair. The nature of the novel coronavirus is such that mucous membrane and eye spread is likely and therefore disposable fluid-resistant long sleeved gowns, goggles and disposable full-face shields are recommended for frontline medical staff at risk of exposure to SARS (Kamming).
Getting undressed
Getting undressed may seem easier than it is. The sequence that has to be followed − gloves first, gown next, wash your hands, take off your
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