Добавил:
Upload
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Oncology3.pdf
Principles of Systemic Therapy
Systemic therapy is one of the combined modality programs in the treatment of cancer
Chemotherapy
Endocrine therapy
Biotherapy
Molecular-targeted therapy
Cancer Chemotherapy
Development of chemotherapy is started in the 1950s
Chemotherapy could indeed cure cancer
Rationale for integrating chemotherapy into combined modality programs with surgery and RT in early stage of disease
Cancer Chemotherapy
Principal obstacles to clinical efficacy of chemotherapy:
àToxicity to normal tissues
àDevelopment of cellular drug resistance
Clinical Application of Chemotherapy
Primary induction chemotherapy
Neoadjuvant chemotherapy
Adjuvant chemotherapy
Direct instillation into sanctuary sites or sitedirected perfusion of specific regions of the body affected by cancer