Antiallergic and Immunotropic Drugs

1. A patient has urticaria, which is treated with dimedrol. Which element of allergy pathogenesis is the therapeutic effect of dimedrol connected with?

*A. Interaction of histamine with receptors in organs

B. Histamine secration

C. Formation of the antigen-antibody complex

D. Synthesis of immunoglobulins

E. Activation of -lymphocytes

2. For treatment of joinds arthritis a physician prescribed a drug which belongs to non-steroid anti-inflammatory medicines. It mainly influences cyclooxygenase-2. It has no irritative influence on the mucous coat of the digestive system. What drug is it?

*A. Celecoxibum

B. Indometacinum

C. Diclofenac-natrium

D. Acidum acetylsalicylicum

E. Ibuprofenum

3. A second generation antihistaminic drug is a derivative of piperidine, taken once a day. It has no M-anticholinergic and adrenergic blocking effects. It shows antiallergenic, antiexudative, antipruritic action. What drug is this?

*A. Loratadinum

B. Dimedrolum

C. Diazolinum

D. Suprastinum

E. Retinoli acetas

4. A 45-year-old woman suffers from allergic seasonal coryza caused by the ambrosia blossoming. What adipose cells group stabilizer medicine can be used for prevention of this disease?

*A. Ketotifen

B. Dimedrol

C. Phencarol

D. Tavegyl

E. Diazoline

5. A patient with continuous bronchopneumonia was admitted to the tharapeutic department. Antibiotic therapy didn’t give much effect. What drug for improvement of immune state should be added to the complex treatment of this patient?

*A. Timaline

B. Benadryl

C. Sulfocamphocaine

D. Paracetamol

E. Analgin

6. Signs of gastropathy develop in the patient with rheumatoid arthritis who was treated with indometacin. What activity of the drug does cause this complication?

*A. Anticyclooxygenase

B. Antiserotonin

C. Local irritating

D. Antikinine

E. Antihistamine

7. Aspirin has antiinflammatory effect due to inhibition of the cyclooxygenase activity. Level of what biological active compounds will decrease?

*A. Prostaglandins

B. Catecholamines

C. Leucotrienes

D. Iodinethyronyns

E. Biogenic amines

8. A 52-year-old patient with bronchial asthma was treated with glucocorticoids. Fever reaction appeared as a result of postinjective abscess. The patient had subfebrile temperature, which didn’t correspond to latitude and severity of inflammatory process. Why did patient have low fever reaction?

*A. Inhibited endogen pyrogens production

B. Thermoregulation center inhibition

C. Violation of heat loss through lungs

D. Inflammatory barrier formation in injection place

E. Violation of heat-producing mechanisms

9. A 40-year-old woman appealed to a doctor with a complaint of pain in the knee joints. During examination the doctor revealed swelling, reddening, hyperthermia in these joints area. Laboratory tests showed positive acute phase reactions. What drugs have to be used for the treatment of the patient?

*A. Antiinflammatory agents of non-steroid structure

B. Opioid analgesics

C. Antidepressants

D. Antibiotics

E. Sulfamides

10. A 62-year-old man has been suffering from coxitis for a long time. A doctor prescribed him a new non-steroid anti-inflammatory agent celecoxib. It improved the patient’s state. what is the advantage of this drug?

*A. Selective blockade of cyclooxygenase-2

B. Depression of phosphodiesterase

C. Activation of adenylate cyclase

D. Depression of choline esterase

E. Activation of phosphodiesterase

11. A patient with rheumatoid arthritis had been taking glucocorticosteroid during several weeks. Then he suddenly stopped taking this drug. What complication can occur in this case?

*A. Withdrawal syndrome

B. Hypertension

C. Hyperglycemia

D. Exacerbation of chronic infection processes

E. Formation of ulcers on the mucous coat of the stomach and duodenum

12. Allergic dermatitis produces itching, hypostasis, reddening, and insomnia. What drug is expedient for prescribing to the patient?

*A. Dimedrolum

B. Phenobarbitalum

C. Nitrazepamum

D. Chlorali hydras

E. Natrii oxybutiras

13. 30-year-old male, who works as a driver, suffers from allergic rhinitis which is aggravated during spring. The doctor has prescribed to him an antihistamine drug with long duration of action (about 24 hours) and with insignificant sedative action. What drug was been prescribed?

*A. Loratadine

B. Dimedrolum

C. Heparin

D. Vicasolum

E. Oxytocin

14. The urticaria has developed in 40-year-old female after using of washing-up liquid. Simultaneously with local treatment, the dermatologist has recommended the antihistamine drug loratidine. What should be frequency of loratidine administration?

*A. 1 time daily

B. 2 times daily

C. 4 times daily

D. 1 time in 2 days

E. 1 time in a week

15. The female has appealed to doctor with complaints of nasal stuffiness, dacryagogue, weakness, and dizziness which arise in period of flowering of ambrosia. What antihistamine agent should be prescribed?

*A. Loratadine

B. Penicillin

C. Analginum

D. Metoprolol

E. Bisacodyl

16. The marked drowsiness has developed in female suffering from allergic dermatitis that uses certain antiallergic drug during a week. Indicate this drug.

*A. Dimedrolum

B. Essenciale

C. Aminazine

D. Adrenaline hydrochloride

E. Cromolyn sodium

17. After the penicillin administration, the Quincke's edema has developed in patient. What drug should be administered to patient immediately?

*A. Prednisolon

B. Ascorbic acid

C. No-spa

D. Sulfacyl-sodium

E. Rifampicin

18. An antihistamine drug of second generation was prescribed to the female suffering from allergic dermatitis. This drug does not render inhibitory influence upon the CNS. Identify this drug.

*A. Loratadine

B. Diazolinum

C. Tavegil

D. Dimedrolum

E. Ketotifen

19. A student came to see a doctor and asked to administer him a drug for treatment of allergic rhinitis that occurs in the period of linden flowering. What drug may be used?

*A. Loratadine

B. Ambroxol

C. Losartan

D. Noradrenaline hydrotartrate

E. Propranolol

20. The quantity of phagocytes and antibody level decrease in patient during long-time treatment of pneumonia with aminoglycosides and sulfonamides. Which drug should be given to patient?

*A. Methyluracilum

B. Coamidum

C. Ferrum-Lek

D. Prednisolone

E. Mercazolilum

21. The decrease of T-lymphocytes level is observed in patient after ionizing radiation. Which drug should be prescribed to patient?

*A. Thymalinum

B. Azathioprine

C. Natrii nucleinas

D. Ascorbic acid

E. Methyluracilum

22. A patient with agrevation of rheumatoid arthritis entered to hospital. Chronic hyperacidic gastritis is present in him anamnesis. Choose drug, the administration of which is most appropriate in this case:

*A. Ortoohenum (diclofenac-sodium)

B. Indomethacin

C. Acetylsalicylic acid

D. Prednisolone

E. Butadionum

23. Patient suffers from seasonal allergic rhinitis owing to flowering poplar. Which drug should be prescribed to him for prevention of seasonal agravation of allergy?

*A. Cromolyn sodium

B. Diazolinum

C. Ephedrine

D. Prednisolone

E. Ranitidine

24. A patient with acute rheumatism is treated with salicylates. After some time he had the insomnia. Doctor prescribes to treatment of insomnia phenobarbital. After several days of phenobarbital using, the antiinflammatory effect of salicylates decreased. What is cause of weekening of antiiflammatory effect?

*A. Induction of hepatic enzymes by phenobarbital

B. Chemical antagonism

C. Pharmaceutical antagonism

D. Inhibition of hepatic enzymes by phenobarbital

E. Increase of salicylates elimination

25. The cell-mediated immunity decreased in oncologic patient after radiation thrapy. Choose immunomodulator for treatment of this patient:

*A. Tactivinum

B. Prodigiosanum

C. Interferon-beta

D. Reaferon

E. Interferon

26. The gastric bleeding developed in 55-year-old patient in 4-th day after start of indomethacin intake. What is cause of this complication?

*A. Decrease of prostagladin E2 synthesis

B. Decrease of leukotriene synthesis

C. Decrease of prostaglandin E1 synthesis

D. Decrease of synthesis of cyclic endoperoxides

E. Decrease of synthesis of thromboxane

27. The following symptoms developed in patient after long-time treatment with acetylsalicylic acid: headache, dizziness, sonitus, nouasea, and epigastric pain. Which drug can cause these side effects?

*A. Acetylsalicylic acid

B. Vitamin C

C. Тaphthyzinum

D. Bromhexinum

E. Midantanum

28. 40-year-old woman has appealed to doctor with complains of pain in joints. Laboratory research has shown positive rheumatic test. Which group of drug should be prescribed first of all to woman?

*A. Nonsteroid antiinflammatory drugs

B. Opioid analgesics

C. H1-histamine receptor blockers

D. Glucocorticoids

E. Immunomodulators

29. Indomethacin was been prescribed to patieent with rheumatism. But owing to aggravation of accompanied disease, the doctor has canceled this agent. Which disease is contraindication for indomethacin?

*A. Alcer disease of stomach

B. Angina pectoris

C. Bronchitis

D. Diabetes mellitus

E. Hypertensive disease

30. A patient with rheumatoid arthritis suddenly stops the glucocorticoids intake after several weeks of treatment. Which complication can develop in this patient?

*A. Acute adrenal insufficiency

B. Hypertension

C. Hyperglycemia

D. Aggravation of chronic infections

E. Alceration of mucous membrane of stomach