Лекция4_2013_Комплемент
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PAMP ( TLR)
IL-6, IL-1b, TNF
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( RP, SAP) |
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3 .) |
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2.
( ILC). .
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II. |
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1. ILC ( NK- ) |
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2. : 1, MZB |
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3. : , NKT |
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4. |
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LT-HSC – long term HSC
ST-HSC – short term
MPP – multipotent progenitor
CMP – common myeloid
LMPP – lymphoid primed MPP
ETP – early T-lineage
MEP – megakaryocyte-monocyte
CLP – common lymphoid
GMP – granulocyte-monocyte
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65-75% |
1-3% |
5-10% |
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–7-10 |
–7-10 |
- 1-2 |
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-3-5 |
-3-5 |
- 20-25 |
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10-15 |
12-15 |
12-17 |
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( 3) |
( 2) |
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CD13, CD14 |
CD9, CD35 |
CD14, D64,MHCII |
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TLR 1,2,4-10 |
TCR 1,4,7,9,10 |
TLR 1-10 |
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Fc RII-III, CR1,3,4 |
Fc II-III, Fc RI,II, |
Fc RI,II,III;CR1,3,4 |
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CXCR1-3,7 |
C5aR, CCR1-3, 5 |
CCR1-3,5,CX3CR1 |
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I. |
TLR 1-10, MR, DEC-205, DC-SIGN, |
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SR-1,2 |
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II. , |
(CCR1-8, CXCR, |
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CX3CR). : |
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E, P, , |
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1, 2, 7, ICAM-1-3 |
III. |
CSF (G-, M-, GM), IFN , |
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(IL-1, |
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TNF, IL-6 .) . |
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Fc- (Fc RI, Fc RII, Fc RIII); |
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(CR1, CR3, CR4) |
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V. , |
MHC I II. |
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CD40, CD80, CD86 |
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-« » (scavenger) |
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– ,
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– 3-
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, Fc- ,
Fc RI, Fc RII Fc RIII.
C3C3b,
, CR1 (CD35), CR3 (CD11b/CD18) CR4 (CD11c/CD18).