Basic Clinical
Radiobiology
N O I T I D E H T R U O F
Edited by
Michael Joiner
Professor of Radiobiology
Wayne State University
USA
Albert van der Kogel
Professor of Radiobiology Radboud University Nijmegen Medical Centre The Netherlands
First published in Great Britain in 1993 by Edward Arnold. Second edition published in Great Britain in 1997 by Arnold.
Third edition published in Great Britain in 2002 by Hodder Arnold.
This fourth edition published in Great Britain in 2009 by Hodder Arnold,
an imprint of Hodder Education, an Hachette UK Company, 338 Euston Road, London NW1 3BH.
http://www.hoddereducation.com
© 2009 Edward Arnold
All rights reserved. Apart from any use permitted under UK copyright law, this publication may only be reproduced, stored or transmitted, in any form, or by any means with prior permission in writing of the publishers or in the case of reprographic production in accordance with the terms of licences issued by the Copyright Licensing Agency. In the United Kingdom such licences are issued by the Copyright Licensing Agency: Saffron House, 6-10 Kirby Street, London EC1N 8TS.
Whilst the advice and information in this book are believed to be true and accurate at the date of going to press, neither the author[s] nor the publisher can accept any legal responsibility or liability for any errors or omissions that may be made. In particular (but without limiting the generality of the preceding disclaimer) every effort has been made to check drug dosages; however it is still possible that errors have been missed. Furthermore, dosage schedules are constantly being revised and new side-effects recognized. For these reasons the reader is strongly urged to consult the drug companies’ printed instructions before administering any of the drugs recommended in this book.
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A catalogue record for this book is available from the British Library
Library of Congress Cataloging-in-Publication Data
A catalog record for this book is available from the Library of Congress
ISBN 978 0 340 929 667 |
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1 2 3 4 5 6 7 8 9 10 |
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Commissioning Editor: |
Gavin Jamieson |
Project Editor: |
Francesca Naish |
Production Controller: |
Joanna Walker |
Cover Designer: |
Helen Townson |
Indexer: |
Laurence Erington |
Typeset in 10/12 pt Minion by Macmillan Publishing Solutions
Printed and bound in the UK by MPG Books
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Contents
Colour plates appear between pages 216 and 217 |
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|
List of contributors |
v |
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Preface |
vii |
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1 |
Introduction: the significance of radiobiology and radiotherapy for cancer treatment |
1 |
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MC Joiner, AJ van der Kogel and GG Steel |
|
2 |
Irradiation-induced damage and the DNA damage response |
11 |
|
BG Wouters and AC Begg |
|
3 |
Cell death after irradiation: how, when and why cells die |
27 |
|
BG Wouters |
|
4 |
Quantifying cell kill and cell survival |
41 |
|
MC Joiner |
|
5 |
Dose–response relationships in radiotherapy |
56 |
|
SM Bentzen |
|
6 |
Linear energy transfer and relative biological effectiveness |
68 |
|
MC Joiner |
|
7 |
Tumour growth and response to radiation |
78 |
|
D Zips |
|
8 |
Fractionation: the linear-quadratic approach |
102 |
|
MC Joiner and SM Bentzen |
|
9 |
The linear-quadratic approach in clinical practice |
120 |
|
SM Bentzen and MC Joiner |
|
10 |
Modified fractionation |
135 |
|
M Baumann and V Grégoire |
|
11 |
Time factors in normal-tissue responses to irradiation |
149 |
|
W Dörr |
|
12 |
The dose-rate effect |
158 |
|
AJ van der Kogel |
|
13 |
Pathogenesis of normal-tissue side-effects |
169 |
|
W Dörr |
|
iv |
Contents |
|
|
|
|
14 |
The volume effect in radiotherapy |
191 |
|
W Dörr and AJ van der Kogel |
|
15 |
The oxygen effect and fractionated radiotherapy |
207 |
|
MR Horsman, BG Wouters, MC Joiner and J Overgaard |
|
16 |
The tumour microenvironment and cellular hypoxia responses |
217 |
|
BG Wouters and M Koritzinsky |
|
17 |
Therapeutic approaches to tumour hypoxia |
233 |
|
MR Horsman and AJ van der Kogel |
|
18 |
Combined radiotherapy and chemotherapy |
246 |
|
V Grégoire and M Baumann |
|
19 |
Retreatment tolerance of normal tissues |
259 |
|
W Dörr and FA Stewart |
|
20 |
Molecular image-guided radiotherapy with positron emission tomography |
271 |
|
V Grégoire, K Haustermans and J Lee |
|
21 Molecular-targeted agents for enhancing tumour response |
287 |
|
|
M Baumann and V Grégoire |
|
22 |
Biological response modifiers: normal tissues |
301 |
|
W Dörr |
|
23 |
Molecular targeting and patient individualization |
316 |
|
AC Begg |
|
24 |
Protons and other ions in radiotherapy |
332 |
|
W Dörr and MC Joiner |
|
25 |
Second cancers after radiotherapy |
339 |
|
KR Trott |
|
Glossary of terms in radiation biology |
353 |
|
Index |
361 |
|
Contributors
M Baumann
Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology
Medical Faculty and University Hospital Carl Gustav Carus
Technical University Dresden Dresden
Germany
AC Begg
Division of Experimental Therapy
Netherlands Cancer Institute
Amsterdam
The Netherlands
SM Bentzen
Departments of Human Oncology, Medical Physics,
Biostatistics and Medical Informatics
University of Wisconsin School of Medicine and Public
Health
Madison, Wisconsin
USA
W Dörr
Department of Radiation Oncology
Medical Faculty and University Hospital Carl Gustav
Carus
Technical University Dresden
Dresden
Germany
V Grégoire
Department of Radiation Oncology and Centre for Molecular Imaging and Experimental Radiotherapy Université Catholique de Louvain, St. Luc University Hospital
Brussels
Belgium
K Haustermans
Department of Radiation Oncology, Leuven Cancer
Institute
University Hospital Gasthuisberg
Leuven
Belgium
MR Horsman
Department of Experimental Clinical
Oncology
Aarhus University Hospital
Aarhus
Denmark
MC Joiner
Department of Radiation Oncology and Karmanos
Cancer Institute
Wayne State University School of
Medicine
Detroit, Michigan
USA
M Koritzinsky
Department of Radiation Oncology, University of
Toronto
Princess Margaret Hospital/Ontario Cancer Institute,
University Health Network
Toronto, Ontario
Canada
J Lee
Centre for Molecular Imaging and Experimental Radiotherapy
Université Catholique de Louvain, St. Luc University Hospital
Brussels
Belgium
vi Contributors
J Overgaard |
AJ van der Kogel |
Department of Experimental Clinical Oncology |
Department of Radiation Oncology |
Aarhus University Hospital |
Radboud University Nijmegen Medical |
Aarhus |
Centre |
Denmark |
Nijmegen |
GG Steel |
The Netherlands |
|
Institute of Cancer Research
Royal Marsden Hospital
Sutton, Surrey
UK
FA Stewart
Division of Experimental Therapy
Netherlands Cancer Institute
Amsterdam
The Netherlands
KR Trott
Department of Oncology
University College
London
UK
BG Wouters
Departments of Radiation Oncology and Medical
Biophysics, University of Toronto
Princess Margaret Hospital/Ontario Cancer Institute,
University Health Network
Toronto, Ontario
Canada
D Zips
Department of Radiation Oncology
Medical Faculty and University Hospital Carl Gustav
Carus
Technical University Dresden
Dresden
Germany