6 курс / Эндокринология / Диагностика_и_лечение_эндокринных_заболеваний
.pdf171
4.4.2.
-
).
: 400-600
, . 25%
, 40%
.
.
) ( 400-600 ) ,
. (40 ).
: 2 (20-25 )
10 (4-10 2).
, ,
.
( ) ( -
) - ,
.
,
.
.
4.5.1. 21-
,
95% . ,
(CYP21B), 6 .
1:11900, 1:55, 0,01%.
173
1
|
Na |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
" " |
|
|
|
|
|
|
|
2 |
|
|
|
17- |
|
|
|
|
|
|
|
" |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17- |
|
|
|
|
|
|
|
|
|
|
17- |
|
|
|
17- |
|
|
|
|
|
|
|
|
|
|
|
|
21-
( 9-10 ) 17-
( 13-16 ).
21-
.
( ) ;
- 9-
.
4.19.
21-
*
, |
|
|
|
|
|
|
|
1.
:
175
,
)
|
|
1 |
|
|
K Na |
|
K Na |
|
|
|
|
" |
|
2 |
|
17- |
|
17- |
|
" |
|
|
|
11- |
|
|
|
11-
4-10 2 3
: 6-8 25-40%, 14-15 20-25%, 21-23 40-50% .
11-
.
( : , ,
). 9- 25-50 2
.
9-
,
.
4.5.3.
( 1% )
4.21.).
4.21.
|
|
20,22- |
3- - |
17- |
|
17,20- |
|
|
|
|
|
|
|
||
|
|
15q |
|
1p13 |
|
10q24.3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
; |
|||
|
|
|
|
|
|
|
177
|
|
|
|
4.12) |
|
|
|
|
|
|
|
||
|
|
|
, |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4.12.) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
||||
|
, |
|||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4.6. .
,
- : , ,
. ,
.
4.7.
179
,
( , ,
, , ).
: ,
, .
20 .). (80%) - . 20%
, , (
) ( ).
,
.
4.8.
4.8.
|
|
|
|
+ |
|
|
||
|
||
- |
|
|
|
||
|
+ |
+