7. Control:
7.1. An assessment of competences – knowledge.
7.1.1. Oral poll concerning a subject.
7.1.2. Test control – 2 options on 10 questions.
7.1.3. Write, what damages to a molecule of DNA are shown in the scheme:
7.1.4. Complete the table:
Types of repair Features
|
Характерные особенности |
photoreactivation
|
|
Excisional
|
|
postreplikative
|
|
Miss Match-repair
|
|
SOS-repair |
|
7.1.5. Problem Solving: Fill in the blanks in the following claims.
A. Most of the spontaneous DNA changes rapidly eliminated from the process ---------, only occasionally a mechanism to maintain constancy of the structure of DNA does not work, and appeared in the nucleotide sequence of the change is saved, it is called the ---------- .
d) DNA excision repair includes recognition of the modified strand of DNA by enzymes called ---------------; subsequent resynthesis of the remote site, and cross-linking enzyme ------------ the gap left in the DNA chain, the enzyme -------------.
7.1.6. Make a scheme of repair:
a) photoreactivation:
b) excision repair:
Lessons namber 3
1.Title: Fundamentals ontogenetic
2. Aims:Возможно, вы имели в виду: Tem Основы онкогенетики
Alpha
Generate students' current knowledge about the causes and molecular mechanisms of neoplastic cell transformation.
3.Learning objectives:
-to study the role by environmental (carcinogens) factors in the development of tumors --malignant.
-to study the classification of carcinogens
-to study the phase and molecular mechanisms of neoplastic cell transformation
Alpha
-to study the properties of malignant tumor cells
-to study the causes and mechanisms of transformation of proto-ontogenesis in ontogenesis
-to study the role of viruses in the oncogenesis
-to study the characteristics and functions antionkogens
-to study the importance of molecular genetic mechanisms of neoplastic transformation to diagnose, treat and prevent cancer.
4.Type of course: a conversation on the subjects fill the table, the job skills.
5.Key questions the theme:
5.1.Carcinogenic factors, classification, and their role in causing malignant transformation of cells
5.2. Proto-oncogenes and oncogenes, the concept, role in the origin and development of malignant transformation of cells
5.3. Oncoviruses, and their role in causing malignant transformation
5.4. Malignant tumors, stage of development properties
5.5. Antionkogens, the mechanisms of antitumor protection
5.6. The value of genetics in modern oncology.
6. Handout: test questions.
7. References:
The main:
7.1. Genetics. Under Ivanov VI editor M:,2006,p.557-568
7.2. Ginter EK "Medical Genetics" M: 2003.
7.3. IF Zhimulev "General and Molecular Genetics", Novosibirsk, 2007, pp400-411.
7.4. Kuandykov EW Fundamentals of general and medical genetics. Lectures, Almaty/2010, pp.59-62
7.5.Kuandykov E.U. Muminov T.A. Fundamentals of general and medical genetics. Lecture course, Almaty,2007 p. 201-216.
7.6. Mushkambarov N. "Molecular Biology" M: 2003. pp.501-520