3 курс / Фармакология / Фармакотерапия_неотложных_состояний_Справочник_Чернов
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6 Ruˆiz“ J:“ Vaz–<my–iz“ aˆs<r˜ti<z“ fr<m“ t”e“ ˜erit<zea€“ –avity“ durizg“ dia€ysis[re€ated“ ˜erit<zitis “Perit Dial lnt“10: 8^[ 85 “1990 “
7 Sezzesae€“ JJ “ Maes“ VA “ Pierard“ D “ Deˆeuke€aer“ SH “ Verˆee€ez“ DŠ:“ Stre˜t<my–iz“ ˜”arma–<kizeti–s“iz“re€a˜sizg“my–<ˆa–terium“Ÿez<˜i“˜erit<zitis “Am J Nephrol“10:4 [4 5 “ 1990 “
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11 ;”az“GŠ; “Matzke“GR:“Effe–ts“<f“reza€“izsuffi–iez–y“<z“t”e“˜”arma–<kizeti–s“azd“ ˜”arma–<dyzami–s“<f“<˜i<id“aza€gesi–s “Drug Intell Clin Pharm“ 1:77^[78^ “1987 “
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1^ St “Peter“WŠ “Redi–[•i€€“•A “Ha€stezs<z“;E:“;€izi–a€“˜”arma–<kizeti–s“<f“aztiˆi<ti–s“iz“ ˜atiezts“wit”“im˜aired“reza€“fuz–ti<zs “Clin Pharmacokinet“ :169[ 10 “199 “
14 Buzke“;M “Ar<z<ff“GR “Šuft“F;:“P”arma–<kizeti–s“<f“–<mm<z“aztiˆi<ti–s“used“iz“ –<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis “Am J Kidney Dis“^:114[117 “198^ “
15 AHFS“Drug“Izf<rmati<z“9^“#“Ameri–az“H<s˜ita€“F<rmu€ary“Servi–e “Bet”esda “MD “ Ameri–az“S<–iety“<f“H<s˜ita€“P”arma–ists “199^ “
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17 Facts and Comparisons “Fa–ts“azd“;<m˜aris<zs “Iz– “St “Š<uis “199^ “
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19 A–”tert“G “S–”errmazz“JM “;”ristez“Mž:“P”arma–<kizeti–sZˆi<avai€aˆi€ity“<f“–<€–”i–ize“ iz“”ea€t”y“ma€e“v<€uzteers “Eur J Drug Metab Pharmacokinet“14:^17[^ “1989 “
0 Ag<st<z“S “Vazdezˆr<m“RHG “Wierda“JM•H:“;€izi–a€“˜”arma–<kizeti–s“<f“ zeur<mus–u€ar“ˆ€<–kizg“drugs “Clin Pharmacokinet“ :94[115 “199 “
1 Barrie“JR “M<usda€e“S:“;i˜r<f€<Ÿa–iz“€eve€s“iz“a“˜atiezt“uzderg<izg“vez<[vez<us“ ”aem<diafi€trati<z “Intensive Care Med“18:4^7[4^8 “199 “
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5 Brass“; “Ga€giazi“JN “B€as–”ke“TF “Defe€i–e“R “ž'Rei€€y“RA “Stevezs“DA:“Dis˜<siti<z“<f“ ket<–<zaz<€e “az“<ra€“aztifuzga€ “iz“”umazs “Antimicrob Agents Chemother“ 1:151[“158 “ 198 “
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7 Davez˜<rt“A “G<e€“S “Ma–kezzie“J;:“Neur<t<Ÿi–ity“<f“a–y–€<vir“iz“˜atiezts“wit”“ezd[stage“ reza€“fai€ure“treated“wit”“–<ztizu<us“amˆu€at<ry“˜erit<zea€“dia€ysis “Am J Kidney Dis“0:647[649 “199 “
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5 Murd<–”“D “M–Tavis”“D:“Sertra€ize “A“review“<f“its“˜”arma–<dyzami–“azd“˜”arma[“ –<kizeti–“˜r<˜erties “azd“t”era˜euti–“˜<teztia€“iz“de˜ressi<z“azd“<ˆsessive[–<m˜u€sive“ dis<rder “Drugs“44:604[6 4 “199 “
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““ %"=…, “ ,“C% $ƒ%"=…, 2 .…,*, …%› “2" ……% % !=ƒ- " …, ,… ,*=2%!%" C% 2" !› = 2 C! C% %› …, % 2% 2% C! - "!=? …, ,!%*,. › … %2 ,= $…/. “2/*%" " … C!%…, = / “% ,… …, ,ƒ … %2 ,= $…/. * 2%* %› 2 “%ƒ =2$ C! C 2“2",",› …, % *3 "…32!$ C=2% ,2%" (59-61) }2% "…32!,C …% - …% 3…2,!%"=…, %› 2 , 2$ ƒ…= …, , 3ƒ,, = $K3 ,…= , !3 ,. *!3C…/. % *3 "* = “" ƒ=……/ “ K *= , *=!- “2" ……/ C! C=!=2/ m=!3 …, 2% % .=…,ƒ = %› 2 C!,"% ,2$ * 3 …$ …, C …% …% % 2=K% ,ƒ = *=!“2" ……/. C! C=!=- 2%"
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D C! “2=" 2 “%K%L C% %? ……3 !=* , %ƒ/ = Cp — *%… …2!= , *=!“2" ……% % " ? “2"= " “%“2% …,, 3“2%L ,"% %,…= , “*% % !="…%" “, n ,… ,ƒ “C%“%K%" C%“! “2"% *%2%!%-% ƒ=K% "=…, C …, "%ƒ L“2"3 2 …= Vd O %K!=ƒ%"=…, =“ ,2= o!, 2% C!%,“.% ,2 3" , …, %K• = ›, *%“2…/. “! %! =- …,ƒ = j=* K/ % C%*=ƒ=…% 3 K% $…/. “ =“ ,2% …=K = 2“ - *!=2…% 3" , …, Vd C!%C!=…% % = "… ƒ=",“, %“2, %2 3!%"… % “" ƒ/"=…, “ K *= , (18)
a% $ ,…“2"% *=!“2" " C =ƒ *!%", %K!=2, % “" ƒ/"= 2“ “ K *= , O = $K3 ,…= , %K3 ,…= , *,“ / 1- ,*%C!%2 - ,…% ,C%C!%2 ,…= , !3 %C =ƒ ,…% 2!=…“ !!,…% j,“ /*=!“2"= %K/ …% “" ƒ/"= 2“ “ = $K3 ,…= , " 2% "! *=**=!“2" ……/. C! C=!=2%" “% ? % …%L ! =* , L K% .=!=*2 !…= “" ƒ$ “ *,“ / 1- ,*%C!%2 ,…% Š% $*% … “" ƒ=……/ *=!- “2" ……/ " ? “2"= “C%“%K…/ !=“C!%“2!=… 2$“ " 2*=… . , "/ƒ/"=2$=! =*% % , “*,L %2" 2 (68 8 84 1 6 150) o% 2% 3 “2 C …$ “" ƒ/"=…, “ K *= , %*=ƒ/"= 2 “3? “2" ……% " , …, …= .=!=*2 !=! =*% % , “*% % %2" 2= , C=!= 2!/ !=“C! …, *=!- “2" ……/. C! C=!=2%"
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› …$ …, “" ƒ/"=…, *=!“2" ……% % C! C=!=2= “ K *= , C =ƒ / “%C!%"%› = 2“ 3" , …, % *% , “2"= *%2%!% “C%- “%K…% !=“C! ,2$“ " 2*=… . Š=*, %K!=ƒ% 3" , ,"= 2“ *=- ›3?,L“ %K• !=“C! …, C! C=!=2= }2, ,ƒ … …, % 32 " , 2$ …= C !,% C% 3"/" …, ,*= …2%" … ƒ=",“, % %2 !3-,. C=!= 2!%" 2=K% ,ƒ = C%“*% $*3 "! C% 3"/" …, C! - C=!=2= (t1/2) ƒ=",“,2 *=* %2 C% …% % * ,! …“= ,ƒ *!%", (Cl) 2=* , %2 *=›3? %“ %K• = !=“C! …, (Vd):
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“%%2" 2“2",, “ =……%L ƒ=",“, %“2$ C !,% C% 3"/" …,*=!“2" ……/. " ? “2" %› 2 ""% ,2$ " ƒ=K 3› …, C!, C%C/2* %C! ,2$ .=!=*2 ! " , …, C=2% % ,, C …, …= C!% ““ ,. ,-,…= ,, m=C!, ! 3" , …, *=›3? %“ %K• = !=“C! …,*=!“2" ……% % “! “2"= %› 2 “%C!%"%› =2$“ 3" , …, C !,- % = % C% 3"/" …, C!, %2“32“2",, *=*,.- ,K% !3 ,. ! = $…/. ,ƒ … …,L 2=K% , “*%L , ,…= ,, Š=* 3 C= , …2%" “ ƒ=K%-"=…, , C …, …=K = 2“ 3" , …, C !,% = C% 3"/" …,%!=ƒ C= = (79) }2%2 …% … %› 2 K/2$ %K• “… … “*%! 3" ,-…, %K• = !=“C! …, ,*= …2= "“ “2", 3 …$ …, “" ƒ/"=…, " C =ƒ “…,› …, * ,! …“=
%C% … …, * "%ƒ L“2", …= !=“C! …, *=!“2" ,ƒ - … …, “2 C …, “" ƒ/"=…, “ K *= , %› 2 " , 2$ …= C!% ““/, ,…= ,, %ƒ!=“2=…, “"%K% …%L !=* ,, C! C=!=2= " *!%",%› 2 C!,"% ,2$ * C%"/ …, % %“23C…%“2, ! …2=2,"- …% % !=“? C …, , “%%2" 2“2" ……% * 3" , …, %K? % * ,! …- “= … *%2%!/. *=!“2" ` 2% " “"% % ! $ “%*!=?= 2 C !,% C% 3"/" …, C! C=!=2= … ƒ=",“, % %2 *=*,.- ,K% ,ƒ … …,L =*2,"…%“2, ! …2%" 3 =“2"3 ?,. " 2=K% ,ƒ *=!“2" ……/. " ? “2" “= % 3*%!% …, C !,% = C% 3"/" …, 2% K3- 2= , = C!, %“2!% ",!3“…% C=2,2 %K3“ %" …% ,“* ,2 $…% 3 …$ …, % “" ƒ/"=…, “ K *= , C =ƒ / (18 ) a/ % C%*=- ƒ=…% 2% … "ƒ,!= …= "%ƒ!=“2=…, %K? % * ,! …“= 2% K32= , = (“"%K% …% % + “" ƒ=……% %) “" ƒ/"=…, “ K *= , 3 …$ = 2“ = * ,! …“ “"%K% …% % C! C=!=2= %“2= 2“ … ,ƒ ……/
, …, “" ƒ/"=…, C! C=!=2%" “ K *= , C =ƒ / …= ,. =!-=*%*,… 2,*3 2!3 …% C! ", 2$ p *% … = ,, C% C!% …%ƒ,!%"=- …, " , …, C=2% % ,, C …, …= “" ƒ/"=…, ,*= …2%" " …=“2% ? "! %2“32“2"3 2 Š … … %›…% "/ ,2$
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…=,K% “3? “2" ……/ ƒ=*%…% !…%“2,: =) “ , %C! ……% ƒ=- K% "=…, C …, …=!3 = 2 “" ƒ/"=…, “ K *= , “2 C …$ C%"! - › …, C …, K3 2 " , 2$ …= C!% …%“2$ “" ƒ/"=…, ,*=-…2%" “ K *= , C =ƒ /; b) ,ƒ … …, “2 C …, “" ƒ/"=…, “ C =ƒ ……/ , K *= , K3 32 K% $ , , .%!% % “" ƒ/"= /.,*= …2%" (>60œ) C %.% “" ƒ/"= /. (<60œ) „%22, %K?, C!=", = , 2 “"%, ,“* …, %…, C%ƒ"% 2 " … *%- 2%!%L “2 C …, % …,2$ " , …, C=2% % ,, C …, …= “" ƒ/"=…, “ K *= , C =ƒ /
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} , ,…= , *=!“2" ……% % C! C=!=2= %C! 2“ *=* % … - %K!=2, % 3K/"=…, " “2 ,ƒ ! …, , "* = 2 2=K% ,ƒ ,*“*! , =›…/ C=!= 2!% " 2“ * ,! …“ *%2%!/L %C! -2“ *=* %2…% …, *%… …2!= ,, *=!“2"= * “*%!%“2, ,-,…= ,, , " 2“ !%L *2,"…%“2, C!% ““= , ,…= ,, q %"=2 $…% %K?,L , , “,“2 …/L * ,! …“ ,ƒ ! 2“ *% , - “2"% C =ƒ / % ,?= %L %2 *=!“2" ……% % " ? “2"= " ,…, 3 "! …, }2= .=!=*2 !,“2,*= %› 2 K/2$ C% 3 …= C32 ,ƒ ! - …, *%… …2!= ,, *=!“2"= " C =ƒ C%“ "" …, % …%*!=2…%L%ƒ/ ( %! 3 = ) , , " !="…%" “…% “%“2% …,, C% %! 3 :
Cl ¡ “*%!%“2$ "" …, C! C=!=2= Z Cpss |
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Cpss O !="…%" “…= C =ƒ ……= *%… …2!= , *=!“2" ……% % " ? “2"= j ,! …“ … ƒ=",“,2 %2 ƒ= L“2"%"=……/. .=…,ƒ %" ,-,…= ,, , “ , %…= %“3? “2" 2“ … “*% $*, , C32 , 2% C! - C% = = 2 % …*3 “3 =!…% % *2= 2,. C!% ““%"
o!% ““ C!, *%2%!% “*%!%“2$ , ,…= ,, *=!“2"= C!%C%!-,%…= $…= % *%… …2!= ,, ,ƒ" “2 … *=* *,… 2,*= C !"% % C%- ! *= j,… 2,*= C !"% % C%! *= .=!=*2 !…= … "“ . *=!- “2" ……/. C! C=!=2%" d … *%2%!/. .=!=*2 !…= %ƒ%ƒ=",“, =, ,…= , j ,! …“ " 2,. “ 3 = . … ,… L…/L , % …$ "=!$,!3-2 " ƒ=",“, %“2, %2 %“2, …32%L *%… …2!= ,, C! C=!=2=
j ,! …“ %› 2 K/2$ 2=*› %K%ƒ…= … *=* *2,"…%“2$ 3 = - …, *=!“2" ……/. C! C=!=2%" ! ƒ %! =…/ , ,…= ,, (C …$ , C% *,) o …% …/L * ,! …“ (ClH) %2!=›= 2 *2,"…%“2$ … %K- !=2, % % 3 = …, ,ƒ *!%", *=!“2" C …$ n… %C! 2“!=* , L *=!“2"= 3 = %L ,ƒ *!%", "% "! C!%.%› …,! ƒ C …$ (E) = 2=*› C …% …/ *!%"%2%*% (QH) q%%2…% - …, 2,. C=!= 2!%" "/!=›= 2“ %! 3 %L:
ClH = QH E |
(4) |
k *=!“2"= C!, … / ˜er <s C! › %“2, $ “,“2 …% % *!%"%2%*= % ›…/ “…= = = C!%L2, ! ƒ C …$ o!, *“2!=* ,,*=!“2" ,ƒ *!%", " C!% ““ C!%.%› …,, ! ƒ C …$ !=*-, %“2, = ?= “,“2 …% % *!%"%2%*= (F) “2=…%",2“ …$ C!,… 2%L %ƒ/ d *=!“2" *%2%!/ C% …%“2$ "“=“/"= 2“ ,ƒ
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