5 курс / Психиатрия и наркология для детей и взрослых (доп.) / Сон_и_его_расстройства_Ковальзон_В_М_,_Шеповальников_А_Н_2023_презентация
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Prolactin peaks associated with awakenings
Plasma Prolactin
µU/ml
% of Wake
Clock Time
Modified from Van Cauter, Hormones and Sleep, 1995
Plasma thyroid-stimulating hormone (µU/mL)
4
3
2
1 |
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18 |
22 |
02 |
06 |
10 |
14 |
18 |
22 |
02 |
06 |
10 |
14 |
18 |
22 |
CLOCK TIME
NOCTURNAL SLEEP
NOCTURNAL SLEEP DEPRIVATION
DAYTIME SLEEP
Modified from Van Cauter and Spiegel,
Regulation of sleep and circadian rhythms, 1999
Рекомендовано к изучению сайтом МедУнивер - https://meduniver.com/
Plasma renin activity
Brandenberger et al., J Hypertens, 1994
Ultradian oscillations in plasma renin activity
WREM
1
2
3 Plasma Renin 4
Activity (ng/ml:h)
2
1
0
23 |
24 |
01 |
02 |
03 |
04 |
05 |
06 |
07 |
08 |
Modified from Brandenberger et al., J Hypertens, 1994
Рекомендовано к изучению сайтом МедУнивер - https://meduniver.com/
Glucose levels and insulin secretion rate
130 |
PLASMA GLUCOSE (% of mean) |
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120 |
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110 |
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100 |
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90 |
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80 |
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18 |
22 |
02 |
06 |
10 |
14 |
18 |
22 |
02 |
06 |
10 |
14 |
18 |
22 |
160 |
ISR (% of mean) |
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140 |
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120 |
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100 |
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80 |
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60 |
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18 |
22 |
02 |
06 |
10 |
14 |
18 |
22 |
02 |
06 |
10 |
14 |
18 |
22 |
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CLOCK TIME |
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NOCTURNAL SLEEP
NOCTURNAL SLEEP DEPRIVATION
DAYTIME RECOVERY SLEEP
Modified from Van Cauter et al., J Clin Invest, 1991
Leptin and ghrelin
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9 |
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Leptin |
Meal Meal Meal |
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(ng/ml) |
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Satiety |
6 |
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3 
1200
Ghrelin (pg/ml)
800
Appetite
400 |
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21 |
1 |
5 |
9 |
13 |
17 |
21 |
Clock Time
Unpublished individual data
Рекомендовано к изучению сайтом МедУнивер - https://meduniver.com/
Daytime leptin and ghrelin levels
LEPTIN (ng/ml)
GHRELIN (ng/ml)
Continuous glucose infusion (5g/kg/24h)
3.5 |
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3.0 |
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2.5 |
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AFTER 2 DAYS OF |
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2.0 |
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10-H BEDTIMES |
1.5 |
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3.4 |
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AFTER 2 DAYS OF |
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4-H BEDTIMES |
2.8 |
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2.2 |
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9 |
11 |
13 |
15 |
17 |
19 |
21 |
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CLOCK TIME |
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p level % change |
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9-21 leptin levels (ng/ml) |
2.6 ± 0.5 |
2.1 ± 0.4 |
0.041 |
-19% |
12-21 ghrelin levels (ng/ml) |
2.6 ± 0.2 |
3.3 ± 0.2 |
0.038 |
+24% |
Modified from Spiegel et al., Ann Int Med, 2004
Heart rate variability (rRR)
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4 HOURS IN BED |
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12 HOURS IN BED |
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3h49’± 5’ OF SLEEP |
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9H03' ± 15’ OF SLEEP |
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0.80 |
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0.75 |
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0.70 |
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0.65 |
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0.60 |
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9 |
13 |
17 |
21 |
1 |
5 |
9 |
9 |
13 |
17 |
21 |
1 |
5 |
9 |
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CLOCK TIME |
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CLOCK TIME |
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High rRR = Decreased Heart Rate Variability =
Increased Sympathetic Nervous Activity and/or
Decreased Parasympathetic Nervous Activity
Modified from Spiegel et al., J Clin Endocrinol Metab, 2004
Рекомендовано к изучению сайтом МедУнивер - https://meduniver.com/
Leptin, cortisol, HOMA and sleep duration
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4 HOURS IN BED |
8 HOURS IN BED |
12 HOURS IN BED |
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3h48' OF SLEEP |
6h52' OF SLEEP |
8h52' OF SLEEP |
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5.5 |
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LEPTIN |
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(ng/ml) |
3.5 |
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1.5 |
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15 |
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CORTISOL |
10 |
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(µg/dL) |
5 |
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0 |
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40
HOMA (INSULIN (mU/L) * 20
GLUCOSE(mmol/L)
/ 22.5)
0
9 |
13 |
17 |
21 |
1 |
5 |
9 |
9 |
13 |
17 |
21 |
1 |
5 |
9 |
9 |
13 |
17 |
21 |
1 |
5 |
9 |
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CLOCK TIME |
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CLOCK TIME |
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CLOCK TIME |
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Modified from Spiegel et al., J Clin Endocrinol Metab, 2004
Тревожность и сон
Вербицкий Е.В.,
Институт аридных зон Южного научного центра РАН
Модульный курс программы TEMPUS «Сон и его расстройства, »
Ростов на Дону
Рекомендовано к изучению сайтом МедУнивер - https://meduniver.com/